All Relations between Huntington Disease and htt
| Publication | Sentence | Publish Date | Extraction Date | Species |
|---|---|---|---|---|
| François G Gervais, Roshni Singaraja, Steven Xanthoudakis, Claire-Anne Gutekunst, Blair R Leavitt, Martina Metzler, Abigail S Hackam, John Tam, John P Vaillancourt, Vicky Houtzager, Dita M Rasper, Sophie Roy, Michael R Hayden, Donald W Nicholso. Recruitment and activation of caspase-8 by the Huntingtin-interacting protein Hip-1 and a novel partner Hippi. Nature cell biology. vol 4. issue 2. 2002-08-08. PMID:11788820. | in huntington disease, polyglutamine expansion of the protein huntingtin (htt) leads to selective neurodegenerative loss of medium spiny neurons throughout the striatum by an unknown apoptotic mechanism. | 2002-08-08 | 2023-08-12 | Not clear |
| Aleksey Kazantsev, Heli A Walker, Natalia Slepko, James E Bear, Elizabeth Preisinger, Joan S Steffan, Ya-Zhen Zhu, Frank B Gertler, David E Housman, J Lawrence Marsh, Leslie M Thompso. A bivalent Huntingtin binding peptide suppresses polyglutamine aggregation and pathogenesis in Drosophila. Nature genetics. vol 30. issue 4. 2002-05-02. PMID:11925563. | huntington disease is caused by the expansion of a polyglutamine repeat in the huntingtin protein (htt) that leads to degeneration of neurons in the central nervous system and the appearance of visible aggregates within neurons. | 2002-05-02 | 2023-08-12 | drosophila_melanogaster |
| B R Leavitt, C L Wellington, M R Hayde. Recent insights into the molecular pathogenesis of Huntington disease. Seminars in neurology. vol 19. issue 4. 2000-03-30. PMID:10716661. | huntington disease (hd) is a neurodegenerative disorder caused by a cag repeat expansion in the hd gene resulting in expression of an uninterrupted polyglutamine stretch within the n-terminus of its protein product huntingtin (htt). | 2000-03-30 | 2023-08-12 | mouse |