| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Bettina Wagner, Maria Sibili. Methods to study MAP kinase signalling in the central nervous system. Methods in molecular biology (Clifton, N.J.). vol 661. 2010-12-14. PMID:20812003. |
mapks and their upstream signalling receptors play also an important role in the development of neurodegenerative diseases due to their capacity to control neural cell apoptosis. |
2010-12-14 |
2023-08-12 |
Not clear |
| Hui-Juan Zhang, Michelle Kwan-Yee Siu, Li-Li Jiang, Victor Chun-Yin Mak, Hextan Yuen-Sheung Ngan, Annie Nga-Yin Cheun. Overexpression of the Parkinson disease protein DJ-1 and its regulator PTEN in gestational trophoblastic disease. International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists. vol 29. issue 5. 2010-12-10. PMID:20736773. |
dj-1 is found to be important in human neurodegenerative diseases and cancers by regulating oxidative damage and apoptosis. |
2010-12-10 |
2023-08-12 |
human |
| Lilian Kisiswa, Julie Albon, James E Morgan, Michael A Wrid. Cellular inhibitor of apoptosis (cIAP1) is down-regulated during retinal ganglion cell (RGC) maturation. Experimental eye research. vol 91. issue 5. 2010-11-05. PMID:20831867. |
apoptosis, is the main type of cell death that occurs in ageing and neurodegenerative disease, such as glaucoma. |
2010-11-05 |
2023-08-12 |
rat |
| Se-Eun Park, Seung Kim, Kumar Sapkota, Sung-Jun Ki. Neuroprotective effect of Rosmarinus officinalis extract on human dopaminergic cell line, SH-SY5Y. Cellular and molecular neurobiology. vol 30. issue 5. 2010-09-16. PMID:20563702. |
these findings indicate that r. officinalis is able to protect the neuronal cells against h2o2-induced injury and suggest that r. officinalis might potentially serve as an agent for prevention of several human neurodegenerative diseases caused by oxidative stress and apoptosis. |
2010-09-16 |
2023-08-12 |
human |
| Sayaka Suzuki, Utako Yokoyama, Takaya Abe, Hiroshi Kiyonari, Naoya Yamashita, Yuko Kato, Reiko Kurotani, Motohiko Sato, Satoshi Okumura, Yoshihiro Ishikaw. Differential roles of Epac in regulating cell death in neuronal and myocardial cells. The Journal of biological chemistry. vol 285. issue 31. 2010-09-14. PMID:20516079. |
because the disruption of epac exerted a protective effect on neuronal apoptosis in vivo, the inhibition of epac may be a consideration in designing a therapeutic strategy for the treatment of neurodegenerative diseases. |
2010-09-14 |
2023-08-12 |
mouse |
| Gunnar P H Diet. Cell-penetrating peptide technology to deliver chaperones and associated factors in diseases and basic research. Current pharmaceutical biotechnology. vol 11. issue 2. 2010-08-05. PMID:20166965. |
the delivery of heat shock proteins (hsp) using cpp has been applied in models for apoptosis, necrosis, oxidative stress, neurodegenerative diseases, stroke, cystic fibrosis, smooth muscle relaxation, myocardial injury, scar formation, and others. |
2010-08-05 |
2023-08-12 |
Not clear |
| Rawan Tarawneh, James E Galvi. Potential future neuroprotective therapies for neurodegenerative disorders and stroke. Clinics in geriatric medicine. vol 26. issue 1. 2010-07-15. PMID:20176298. |
although neurodegenerative diseases such as alzheimer disease, parkinson disease, and huntington disease each have distinct clinical symptoms and pathologies, they all share common mechanisms such as protein aggregation, oxidative injury, inflammation, apoptosis, and mitochondrial injury that contribute to neuronal loss. |
2010-07-15 |
2023-08-12 |
Not clear |
| Michal Levy, Anthony H Futerma. Mammalian ceramide synthases. IUBMB life. vol 62. issue 5. 2010-07-13. PMID:20222015. |
different cers also display remarkable differences in their biological properties, with each of them playing distinct roles in processes as diverse as cancer and tumor suppression, in the response to chemotherapeutic drugs, in apoptosis, and in neurodegenerative diseases. |
2010-07-13 |
2023-08-12 |
Not clear |
| M T Viscomi, S Oddi, L Latini, E Bisicchia, M Maccarrone, M Molinar. The endocannabinoid system: a new entry in remote cell death mechanisms. Experimental neurology. vol 224. issue 1. 2010-06-28. PMID:20353775. |
endocannabinoids constitute a novel class of lipids that regulate mammalian cell apoptosis and the pathogenesis of neuroinflammatory and neurodegenerative diseases. |
2010-06-28 |
2023-08-12 |
human |
| Eun-Mee Kim, Eun-Jung Shin, Ji Hyun Choi, Hyo Jin Son, Il-Seon Park, Tong H Joh, Onyou Hwan. Matrix metalloproteinase-3 is increased and participates in neuronal apoptotic signaling downstream of caspase-12 during endoplasmic reticulum stress. The Journal of biological chemistry. vol 285. issue 22. 2010-06-17. PMID:20368330. |
although endoplasmic reticulum (er) stress-induced apoptosis has been associated with pathogenesis of neurodegenerative diseases, the cellular components involved have not been well delineated. |
2010-06-17 |
2023-08-12 |
Not clear |
| M Laburthe, T Voisin, A El Fira. Orexins/hypocretins and orexin receptors in apoptosis: a mini-review. Acta physiologica (Oxford, England). vol 198. issue 3. 2010-06-14. PMID:19719798. |
finally, this mini-review will also speculate on: (1) the potential importance of tyrosine-based motifs in the large family of gpcrs; (2) the interest of orexin receptors as therapeutic targets in cancer therapy; (3) the possible role of orexin receptor-mediated apoptosis in physiology and pathophysiology in the brain (neurodevelopment, neurodegenerative diseases) and in the periphery. |
2010-06-14 |
2023-08-12 |
Not clear |
| Gustav J Strijkers, Geralda A F van Tilborg, Tessa Geelen, Chris P M Reutelingsperger, Klaas Nicola. Current applications of nanotechnology for magnetic resonance imaging of apoptosis. Methods in molecular biology (Clifton, N.J.). vol 624. 2010-06-14. PMID:20217606. |
insufficient apoptosis is important in the pathology of various disorders such as cancer and autoimmune diseases, whereas a high apoptotic activity is associated with myocardial infarction, neurodegenerative diseases, and advanced atherosclerotic lesions. |
2010-06-14 |
2023-08-12 |
Not clear |
| Heng Du, Shirley ShiDu Ya. Mitochondrial medicine for neurodegenerative diseases. The international journal of biochemistry & cell biology. vol 42. issue 5. 2010-06-11. PMID:20067840. |
commonly seen types of mitochondrial dysfunction in neurodegenerative diseases include excessive free radical generation, lowered atp production, mitochondrial permeability transition, mitochondrial dna lesions, perturbed mitochondrial dynamics and apoptosis. |
2010-06-11 |
2023-08-12 |
Not clear |
| Tingting Yan, Yan Feng, Qiwei Zha. Axon degeneration: Mechanisms and implications of a distinct program from cell death. Neurochemistry international. vol 56. issue 4. 2010-05-25. PMID:20117162. |
axon degeneration has been proposed to be a new therapeutic target for neurodegenerative diseases, because it usually occurs earlier than neuronal cell body death with a distinct active program from apoptosis and necrosis. |
2010-05-25 |
2023-08-12 |
mouse |
| Yan-Ping Zou, Yan-Hua Lu, Dong-Zhi We. Protective effects of a flavonoid-rich extract of Hypericum perforatum L. against hydrogen peroxide-induced apoptosis in PC12 cells. Phytotherapy research : PTR. vol 24 Suppl 1. 2010-05-10. PMID:19548287. |
these results suggested that fehp possessed protective effects against h2o2-induced apoptosis in pc12 cells and fehp might be useful in the treatment of oxidative stress-related neurodegenerative diseases such as parkinson's disease and alzheimer's disease. |
2010-05-10 |
2023-08-12 |
rat |
| Shehua Zhang, Junli Ye, Guoxiong Don. Neuroprotective effect of baicalein on hydrogen peroxide-mediated oxidative stress and mitochondrial dysfunction in PC12 cells. Journal of molecular neuroscience : MN. vol 40. issue 3. 2010-05-07. PMID:19731100. |
taken together, these results suggest that baicalein can block h2o2-induced apoptosis by prevention of oxidative stress as well as regulation of bcl-2 family members and suppression of mitochondria dysfunction, which might be beneficial for the treatment of oxidative stress in aging and age-associated neurodegenerative diseases. |
2010-05-07 |
2023-08-12 |
Not clear |
| Johanna Vrielink, Mariette S Heins, Rita Setroikromo, Eva Szegezdi, Margaret M Mullally, Afshin Samali, Wim J Qua. Synthetic constrained peptide selectively binds and antagonizes death receptor 5. The FEBS journal. vol 277. issue 7. 2010-05-04. PMID:20156289. |
dysregulation of apoptosis is implicated in the pathogenesis of diseases such as cancer, neurodegenerative diseases and autoimmune disorders. |
2010-05-04 |
2023-08-12 |
Not clear |
| Maria-Mihaela Bădulescu, Andreea-Roxana Lupu, Lidia Cremer, Ana Călugăru, Natalia Simona Apetrei, M Moscovici, Georgeta Mocanu, G Szegl. The modulation of reactive oxygen species production from human polymorphonuclear cells by curdlan derivatives as dectin-1 agonists/antagonists. Roumanian archives of microbiology and immunology. vol 68. issue 2. 2010-05-04. PMID:20361523. |
reactive oxygen species (ros) are well known to be cytotoxic and have been implicated in the etiology of a wide array of human diseases including diabetes, neurodegenerative diseases, cancer and also influence central cellular processes such as proliferation, apoptosis, senescence etc. |
2010-05-04 |
2023-08-12 |
human |
| Robert B Campeno. NGF uptake and retrograde signaling mechanisms in sympathetic neurons in compartmented cultures. Results and problems in cell differentiation. vol 48. 2010-04-22. PMID:19343309. |
apoptosis resulting from the loss of retrograde ngf signaling contributes to the elimination of excess and misconnected neurons during development and to the death of neurons during the course of neurodegenerative diseases. |
2010-04-22 |
2023-08-12 |
Not clear |
| Knut H Lauritzen, Olve Moldestad, Lars Eide, Harald Carlsen, Gaute Nesse, Johan F Storm, Isabelle M Mansuy, Linda H Bergersen, Arne Klunglan. Mitochondrial DNA toxicity in forebrain neurons causes apoptosis, neurodegeneration, and impaired behavior. Molecular and cellular biology. vol 30. issue 6. 2010-04-09. PMID:20065039. |
mitochondrial dysfunction underlying changes in neurodegenerative diseases is often associated with apoptosis and a progressive loss of neurons, and damage to the mitochondrial genome is proposed to be involved in such pathologies. |
2010-04-09 |
2023-08-12 |
mouse |