| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Stéphane Bach, Marie Knockaert, Jens Reinhardt, Olivier Lozach, Sophie Schmitt, Blandine Baratte, Marcel Koken, Stephen P Coburn, Lin Tang, Tao Jiang, Dong-Cai Liang, Hervé Galons, Jean-Francois Dierick, Lorenzo A Pinna, Flavio Meggio, Frank Totzke, Christoph Schächtele, Andrea S Lerman, Amancio Carnero, Yongqin Wan, Nathanael Gray, Laurent Meije. Roscovitine targets, protein kinases and pyridoxal kinase. The Journal of biological chemistry. vol 280. issue 35. 2005-10-25. PMID:15975926. |
besides its use as a biological tool in cell cycle, neuronal functions, and apoptosis studies, it is currently evaluated as a potential drug to treat cancers, neurodegenerative diseases, viral infections, and glomerulonephritis. |
2005-10-25 |
2023-08-12 |
Not clear |
| Gonzalo Arboleda, Catherine Waters, Rosemary M Gibso. Metabolic activity: a novel indicator of neuronal survival in the murine dopaminergic cell line CAD. Journal of molecular neuroscience : MN. vol 27. issue 1. 2005-10-13. PMID:16055947. |
apoptosis is implicated in many neurodegenerative diseases, including parkinson's disease (pd). |
2005-10-13 |
2023-08-12 |
Not clear |
| Ravi Shankar Akundi, Eduardo Candelario-Jalil, Sandra Hess, Michael Hüll, Klaus Lieb, Peter J Gebicke-Haerter, Bernd L Fiebic. Signal transduction pathways regulating cyclooxygenase-2 in lipopolysaccharide-activated primary rat microglia. Glia. vol 51. issue 3. 2005-09-08. PMID:15800925. |
this potential nature of ceramides in activating microglia suggests that endogenously produced ceramides during neuronal apoptosis in ischemia or neurodegenerative diseases could also contribute to the amplification of neuroinflammatory events. |
2005-09-08 |
2023-08-12 |
rat |
| Pascale Gaillard, Isabelle Jeanclaude-Etter, Vittoria Ardissone, Steve Arkinstall, Yves Cambet, Montserrat Camps, Christian Chabert, Dennis Church, Rocco Cirillo, Denise Gretener, Serge Halazy, Anthony Nichols, Cedric Szyndralewiez, Pierre-Alain Vitte, Jean-Pierre Gottelan. Design and synthesis of the first generation of novel potent, selective, and in vivo active (benzothiazol-2-yl)acetonitrile inhibitors of the c-Jun N-terminal kinase. Journal of medicinal chemistry. vol 48. issue 14. 2005-08-16. PMID:15999997. |
several lines of evidence support the hypothesis that c-jun n-terminal kinase (jnks) plays a critical role in a wide range of diseases including cell death (apoptosis)-related disorders (neurodegenerative diseases, brain, heart, and renal ischemia, epilepsy) and inflammatory disorders (multiple sclerosis, rheumatoid arthritis, inflammatory bowel diseases). |
2005-08-16 |
2023-08-12 |
rat |
| Jin Zhong, Jixian Deng, Jennifer Phan, Stephen Dlouhy, Huangbing Wu, Weiguo Yao, Ping Ye, A Joseph D'Ercole, Wei-Hua Le. Insulin-like growth factor-I protects granule neurons from apoptosis and improves ataxia in weaver mice. Journal of neuroscience research. vol 80. issue 4. 2005-07-25. PMID:15846777. |
these results confirm our previous suggestion that a lack of igf-i activity contributes to apoptosis of weaver granule neurons in vivo and supports igf-i's potential therapeutic use in neurodegenerative disease. |
2005-07-25 |
2023-08-12 |
mouse |
| Min Deng, Jin Yuan Zhao, Peng Fei Tu, Yong Jiang, Zheng Bin Li, Yao Hong Wan. Echinacoside rescues the SHSY5Y neuronal cells from TNFalpha-induced apoptosis. European journal of pharmacology. vol 505. issue 1-3. 2005-05-16. PMID:15556132. |
thus, echinacoside has the neuroprotective capacity to antagonize tnfalpha-induced apoptosis in shsy5y cells and may be useful in treating some neurodegenerative diseases. |
2005-05-16 |
2023-08-12 |
human |
| De-Maw Chuang, Christopher Hough, Vladimir V Senatoro. Glyceraldehyde-3-phosphate dehydrogenase, apoptosis, and neurodegenerative diseases. Annual review of pharmacology and toxicology. vol 45. 2005-05-12. PMID:15822178. |
glyceraldehyde-3-phosphate dehydrogenase, apoptosis, and neurodegenerative diseases. |
2005-05-12 |
2023-08-12 |
Not clear |
| Manus W Ward, Donat Kögel, Jochen H M Preh. Neuronal apoptosis: BH3-only proteins the real killers? Journal of bioenergetics and biomembranes. vol 36. issue 4. 2005-04-20. PMID:15377860. |
at present there is a poor understanding of the events that lead up to neuronal apoptosis that occurs in neurodegenerative diseases and following acute ischemic episodes. |
2005-04-20 |
2023-08-12 |
Not clear |
| Alfons Lawen, Jennifer D Ly, Darius J R Lane, Kristof Zarschler, Angela Messina, Vito De Pint. Voltage-dependent anion-selective channel 1 (VDAC1)--a mitochondrial protein, rediscovered as a novel enzyme in the plasma membrane. The international journal of biochemistry & cell biology. vol 37. issue 2. 2005-03-29. PMID:15474974. |
regulation of the enzyme will have impacts on cancer and autoimmune diseases (insufficient apoptosis) as well as neurodegenerative diseases (excessive apoptosis). |
2005-03-29 |
2023-08-12 |
Not clear |
| Rebecca Clayton, John B Clark, Martyn Sharp. Cytochrome c release from rat brain mitochondria is proportional to the mitochondrial functional deficit: implications for apoptosis and neurodegenerative disease. Journal of neurochemistry. vol 92. issue 4. 2005-03-21. PMID:15686486. |
cytochrome c release from rat brain mitochondria is proportional to the mitochondrial functional deficit: implications for apoptosis and neurodegenerative disease. |
2005-03-21 |
2023-08-12 |
rat |
| Anne Marcilha. [Intracellular signaling pathways, apoptosis and neurodegenerative diseases]. Psychologie & neuropsychiatrie du vieillissement. vol 2. issue 3. 2005-03-01. PMID:15689335. |
[intracellular signaling pathways, apoptosis and neurodegenerative diseases]. |
2005-03-01 |
2023-08-12 |
Not clear |
| Thomas Rückle, Marco Biamonte, Tania Grippi-Vallotton, Steve Arkinstall, Yves Cambet, Montserrat Camps, Christian Chabert, Dennis J Church, Serge Halazy, Xuliang Jiang, Isabelle Martinou, Anthony Nichols, Wolfgang Sauer, Jean-Pierre Gottelan. Design, synthesis, and biological activity of novel, potent, and selective (benzoylaminomethyl)thiophene sulfonamide inhibitors of c-Jun-N-terminal kinase. Journal of medicinal chemistry. vol 47. issue 27. 2005-02-14. PMID:15615541. |
several lines of evidence support the hypothesis that c-jun n-terminal kinases (jnks) play a critical role in a wide range of disease states including cell death (apoptosis)-related and inflammatory disorders (epilepsy, brain, heart and renal ischemia, neurodegenerative diseases, multiple sclerosis, rheumatoid arthritis, and inflammatory bowel syndrome). |
2005-02-14 |
2023-08-12 |
Not clear |
| Tetsumori Yamashim. Ca2+-dependent proteases in ischemic neuronal death: a conserved 'calpain-cathepsin cascade' from nematodes to primates. Cell calcium. vol 36. issue 3-4. 2005-01-27. PMID:15261484. |
recent data suggest that necrosis rather than apoptosis appear to be the crucial component of the damage to the nervous system during human ischemic injuries and neurodegenerative diseases. |
2005-01-27 |
2023-08-12 |
human |
| Fumitaka Osakada, Asami Hashino, Toshiaki Kume, Hiroshi Katsuki, Shuji Kaneko, Akinori Akaik. Alpha-tocotrienol provides the most potent neuroprotection among vitamin E analogs on cultured striatal neurons. Neuropharmacology. vol 47. issue 6. 2005-01-13. PMID:15527824. |
oxidative stress and apoptosis play pivotal roles in the pathogenesis of neurodegenerative diseases. |
2005-01-13 |
2023-08-12 |
rat |
| Serge Przedborsk. Molecular targets for neuroprotection. Amyotrophic lateral sclerosis and other motor neuron disorders : official publication of the World Federation of Neurology, Research Group on Motor Neuron Diseases. vol 5 Suppl 1. 2005-01-11. PMID:15512862. |
apoptosis has emerged as a significant pathogenic factor in several neurodegenerative diseases, including als. |
2005-01-11 |
2023-08-12 |
Not clear |
| Donald R Johns, Kathryn A Colb. Treatment of Leber's hereditary optic neuropathy: theory to practice. Seminars in ophthalmology. vol 17. issue 1. 2004-12-14. PMID:15513454. |
advances in neuroprotection, apoptosis, and neurodegenerative diseases may provide important clues for potential therapeutic agents for lhon. |
2004-12-14 |
2023-08-12 |
Not clear |
| Ying Wang, Xianting Li, Lu Wang, Peiguo Ding, Yingmei Zhang, Wenling Han, Dalong M. An alternative form of paraptosis-like cell death, triggered by TAJ/TROY and enhanced by PDCD5 overexpression. Journal of cell science. vol 117. issue Pt 8. 2004-12-10. PMID:15020679. |
accumulating reports demonstrate that apoptosis does not explain all the forms of programmed cell death (pcd), particularly in individual development and neurodegenerative disease. |
2004-12-10 |
2023-08-12 |
Not clear |
| Joaquin Castilla, Claudio Hetz, Claudio Sot. Molecular mechanisms of neurotoxicity of pathological prion protein. Current molecular medicine. vol 4. issue 4. 2004-11-24. PMID:15354870. |
transmissible spongiform encephalopathies or prion related disorders are fatal and infectious neurodegenerative diseases characterized by extensive neuronal apoptosis and accumulation of a misfolded form of the cellular prion protein (prp), denoted prp(sc). |
2004-11-24 |
2023-08-12 |
Not clear |
| Brigitte Onténient. Natural and synthetic inhibitors of caspases: targets for novel drugs. Current drug targets. CNS and neurological disorders. vol 3. issue 4. 2004-11-23. PMID:15379609. |
along with inflammation, apoptosis appears a common feature of cell death in non-infectious neurodegenerative diseases. |
2004-11-23 |
2023-08-12 |
Not clear |
| Christiane Charriaut-Marlangu. Apoptosis: a target for neuroprotection. Therapie. vol 59. issue 2. 2004-10-18. PMID:15359610. |
consistent with the proposal that apoptosis plays a central role in human neurodegenerative disease, caspase-3 activation has recently been observed in stroke, spinal cord trauma, head injury and alzheimer's disease. |
2004-10-18 |
2023-08-12 |
mouse |