| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Serge Przedborsk. Molecular targets for neuroprotection. Amyotrophic lateral sclerosis and other motor neuron disorders : official publication of the World Federation of Neurology, Research Group on Motor Neuron Diseases. vol 5 Suppl 1. 2005-01-11. PMID:15512862. |
apoptosis has emerged as a significant pathogenic factor in several neurodegenerative diseases, including als. |
2005-01-11 |
2023-08-12 |
Not clear |
| Donald R Johns, Kathryn A Colb. Treatment of Leber's hereditary optic neuropathy: theory to practice. Seminars in ophthalmology. vol 17. issue 1. 2004-12-14. PMID:15513454. |
advances in neuroprotection, apoptosis, and neurodegenerative diseases may provide important clues for potential therapeutic agents for lhon. |
2004-12-14 |
2023-08-12 |
Not clear |
| Ying Wang, Xianting Li, Lu Wang, Peiguo Ding, Yingmei Zhang, Wenling Han, Dalong M. An alternative form of paraptosis-like cell death, triggered by TAJ/TROY and enhanced by PDCD5 overexpression. Journal of cell science. vol 117. issue Pt 8. 2004-12-10. PMID:15020679. |
accumulating reports demonstrate that apoptosis does not explain all the forms of programmed cell death (pcd), particularly in individual development and neurodegenerative disease. |
2004-12-10 |
2023-08-12 |
Not clear |
| Joaquin Castilla, Claudio Hetz, Claudio Sot. Molecular mechanisms of neurotoxicity of pathological prion protein. Current molecular medicine. vol 4. issue 4. 2004-11-24. PMID:15354870. |
transmissible spongiform encephalopathies or prion related disorders are fatal and infectious neurodegenerative diseases characterized by extensive neuronal apoptosis and accumulation of a misfolded form of the cellular prion protein (prp), denoted prp(sc). |
2004-11-24 |
2023-08-12 |
Not clear |
| Brigitte Onténient. Natural and synthetic inhibitors of caspases: targets for novel drugs. Current drug targets. CNS and neurological disorders. vol 3. issue 4. 2004-11-23. PMID:15379609. |
along with inflammation, apoptosis appears a common feature of cell death in non-infectious neurodegenerative diseases. |
2004-11-23 |
2023-08-12 |
Not clear |
| Christiane Charriaut-Marlangu. Apoptosis: a target for neuroprotection. Therapie. vol 59. issue 2. 2004-10-18. PMID:15359610. |
consistent with the proposal that apoptosis plays a central role in human neurodegenerative disease, caspase-3 activation has recently been observed in stroke, spinal cord trauma, head injury and alzheimer's disease. |
2004-10-18 |
2023-08-12 |
mouse |
| S Oyadomari, M Mor. Roles of CHOP/GADD153 in endoplasmic reticulum stress. Cell death and differentiation. vol 11. issue 4. 2004-10-14. PMID:14685163. |
here, we summarize the current understanding of the roles of chop/gadd153 in er stress-mediated apoptosis and in diseases including diabetes, brain ischemia and neurodegenerative disease. |
2004-10-14 |
2023-08-12 |
Not clear |
| M Francesca Cordeiro, Li Guo, Vy Luong, Glen Harding, Wei Wang, Helen E Jones, Stephen E Moss, Adam M Sillito, Frederick W Fitzk. Real-time imaging of single nerve cell apoptosis in retinal neurodegeneration. Proceedings of the National Academy of Sciences of the United States of America. vol 101. issue 36. 2004-09-30. PMID:15340151. |
we have been able to image changes occurring in nerve cell apoptosis over hours, days, and months and show that effects depend on the magnitude of the initial apoptotic inducer in several models of neurodegenerative disease in rat and primate. |
2004-09-30 |
2023-08-12 |
rat |
| J Emerit, M Edeas, F Bricair. Neurodegenerative diseases and oxidative stress. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 58. issue 1. 2004-09-28. PMID:14739060. |
cell energy impairment, apoptosis and overproduction of ros, is a final common pathogenic mechanism in aging and in neurodegenerative disease such as alzheimer's disease (ad), parkinson's disease (pd) and amyotrophic lateral sclerosis (als). |
2004-09-28 |
2023-08-12 |
Not clear |
| Wim Wätjen, Detmar Beyersman. Cadmium-induced apoptosis in C6 glioma cells: influence of oxidative stress. Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine. vol 17. issue 1. 2004-09-03. PMID:14977363. |
because both apoptosis and oxidative stress are thought to play important roles in neurodegenerative diseases, low concentrations of cadmium that initiate programmed cell death may lead to a selective cell death in distinct brain regions via generation of oxidative stress. |
2004-09-03 |
2023-08-12 |
Not clear |
| Dennis W Dickso. Apoptotic mechanisms in Alzheimer neurofibrillary degeneration: cause or effect? The Journal of clinical investigation. vol 114. issue 1. 2004-08-02. PMID:15232608. |
increasing evidence suggests that selective neuronal loss in neurodegenerative diseases involves activation of cysteine aspartyl proteases (caspases), which initiate and execute apoptosis. |
2004-08-02 |
2023-08-12 |
Not clear |
| Roberta De Simone, Maria Antonietta Ajmone-Cat, Luisa Minghett. Atypical antiinflammatory activation of microglia induced by apoptotic neurons: possible role of phosphatidylserine-phosphatidylserine receptor interaction. Molecular neurobiology. vol 29. issue 2. 2004-07-23. PMID:15126686. |
in the central nervous system (cns), apoptosis plays an important role during development and is a primary pathogenic mechanism in several adult neurodegenerative diseases. |
2004-07-23 |
2023-08-12 |
Not clear |
| Roberta De Simone, Maria Antonietta Ajmone-Cat, Luisa Minghett. Atypical antiinflammatory activation of microglia induced by apoptotic neurons: possible role of phosphatidylserine-phosphatidylserine receptor interaction. Molecular neurobiology. vol 29. issue 2. 2004-07-23. PMID:15126686. |
we propose that the anti-inflammatory microglial phenotype induced through the activation of the specific ps receptor (ptdserr), expressed by resting and activated microglial cells, could be relevant to the final outcome of neurodegenerative diseases, in which apoptosis seems to play a crucial role. |
2004-07-23 |
2023-08-12 |
Not clear |
| Alexandra Stolzing, Tilman Grun. Neuronal apoptotic bodies: phagocytosis and degradation by primary microglial cells. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 18. issue 6. 2004-07-15. PMID:14766802. |
neuronal loss via apoptosis is a key element in numerous neurodegenerative diseases. |
2004-07-15 |
2023-08-12 |
rat |
| Thomas Mronga, Thomas Stahnke, Olaf Goldbaum, Christiane Richter-Landsber. Mitochondrial pathway is involved in hydrogen-peroxide-induced apoptotic cell death of oligodendrocytes. Glia. vol 46. issue 4. 2004-07-14. PMID:15095374. |
mitochondria are considered as a central control point of apoptosis, and mitochondrial dysfunction has been linked to neurodegenerative disease. |
2004-07-14 |
2023-08-12 |
rat |
| Cristina Colombo, Marco Cosentino, Franca Marino, Emanuela Rasini, Maria Ossola, Fabio Blandini, Anna Mangiagalli, Alberta Samuele, Marco Ferrari, Raffaella Bombelli, Sergio Lecchini, Giuseppe Nappi, Gianmario Frig. Dopaminergic modulation of apoptosis in human peripheral blood mononuclear cells: possible relevance for Parkinson's disease. Annals of the New York Academy of Sciences. vol 1010. 2004-06-15. PMID:15033811. |
dopamine (da) modulates apoptosis in neuronal and non-neuronal cells, and dopaminergic pathways contribute to neurodegenerative disease. |
2004-06-15 |
2023-08-12 |
human |
| Siew Boon Cheng Chew, Pui Ying Leung, Ronald Ray Fiscu. Preincubation with atrial natriuretic peptide protects NG108-15 cells against the toxic/proapoptotic effects of the nitric oxide donor S-nitroso- N-acetylpenicillamine. Histochemistry and cell biology. vol 120. issue 3. 2004-06-10. PMID:14504961. |
this neuroprotective mechanism involving cgmp may be especially important in protecting against the development of neurodegenerative diseases in which excess no is thought to contribute to neuronal apoptosis. |
2004-06-10 |
2023-08-12 |
Not clear |
| Peter C Waldmeier, William G Tatto. Interrupting apoptosis in neurodegenerative disease: potential for effective therapy? Drug discovery today. vol 9. issue 5. 2004-06-02. PMID:14980539. |
interrupting apoptosis in neurodegenerative disease: potential for effective therapy? |
2004-06-02 |
2023-08-12 |
Not clear |
| Peter C Waldmeier, William G Tatto. Interrupting apoptosis in neurodegenerative disease: potential for effective therapy? Drug discovery today. vol 9. issue 5. 2004-06-02. PMID:14980539. |
however, it has been established that apoptosis contributes to neuronal loss in most neurodegenerative diseases. |
2004-06-02 |
2023-08-12 |
Not clear |
| Esther B E Becker, Azad Bonn. Cell cycle regulation of neuronal apoptosis in development and disease. Progress in neurobiology. vol 72. issue 1. 2004-05-10. PMID:15019174. |
here, we will review the molecular mechanisms of neuronal cell death and survival with a focus on recent findings on cell cycle regulation of neuronal apoptosis in primary cultures of neurons, mouse models of neuronal diseases, and human neurodegenerative diseases. |
2004-05-10 |
2023-08-12 |
mouse |