| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| I V Smirnova, B A Citron, P M Arnold, B W Festof. Neuroprotective signal transduction in model motor neurons exposed to thrombin: G-protein modulation effects on neurite outgrowth, Ca(2+) mobilization, and apoptosis. Journal of neurobiology. vol 48. issue 2. 2001-08-30. PMID:11438939. |
effects on neuronal rounding and apoptosis were also detected, suggesting therapeutic utility may result from interference with downstream components of thrombin signaling pathways in human motor neuron disorders, and possibly other neurodegenerative diseases. |
2001-08-30 |
2023-08-12 |
human |
| C Volbracht, M Leist, S A Kolb, P Nicoter. Apoptosis in caspase-inhibited neurons. Molecular medicine (Cambridge, Mass.). vol 7. issue 1. 2001-08-30. PMID:11474126. |
there is growing evidence of apoptosis in neurodegenerative disease. |
2001-08-30 |
2023-08-12 |
Not clear |
| K Dikranian, M J Ishimaru, T Tenkova, J Labruyere, Y Q Qin, C Ikonomidou, J W Olne. Apoptosis in the in vivo mammalian forebrain. Neurobiology of disease. vol 8. issue 3. 2001-08-16. PMID:11447994. |
whether the cell death process in neurodegenerative diseases meets ultrastructural criteria for apoptosis has been given very little consideration. |
2001-08-16 |
2023-08-12 |
human |
| N P Baja. Cyclin-dependent kinase-5 (CDK5) and amyotrophic lateral sclerosis. Amyotrophic lateral sclerosis and other motor neuron disorders : official publication of the World Federation of Neurology, Research Group on Motor Neuron Diseases. vol 1. issue 5. 2001-08-09. PMID:11464850. |
apoptosis has been implicated as the final common pathway of cell death in a number of neurodegenerative diseases including als. |
2001-08-09 |
2023-08-12 |
Not clear |
| M Mota, M Reeder, J Chernoff, C E Bazene. Evidence for a role of mixed lineage kinases in neuronal apoptosis. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 21. issue 14. 2001-07-26. PMID:11438570. |
mlk3 therefore could be an interesting therapeutic target in a number of neurodegenerative diseases involving neuronal apoptosis. |
2001-07-26 |
2023-08-12 |
Not clear |
| L J Marti. Neuronal cell death in nervous system development, disease, and injury (Review). International journal of molecular medicine. vol 7. issue 5. 2001-06-14. PMID:11295106. |
the re-emergence of apoptosis may contribute to the neuronal degeneration in chronic neurodegenerative disease, such as amyotrophic lateral sclerosis and alzheimer's disease, and in neurological injury such as cerebral ischemia and trauma. |
2001-06-14 |
2023-08-12 |
Not clear |
| W G Tatton, R M Chalmers-Redman, M Elstner, W Leesch, F B Jagodzinski, D P Stupak, M M Sugrue, N A Tatto. Glyceraldehyde-3-phosphate dehydrogenase in neurodegeneration and apoptosis signaling. Journal of neural transmission. Supplementum. issue 60. 2001-04-12. PMID:11205159. |
pathologically, gapdh has been implicated in apoptosis, neurodegenerative disease, prostate cancer and viral pathogenesis (see sirover (1999) for a recent review of gapdh functions). |
2001-04-12 |
2023-08-12 |
Not clear |
| S Shimoham. Apoptosis in Alzheimer's disease--an update. Apoptosis : an international journal on programmed cell death. vol 5. issue 1. 2001-03-29. PMID:11227497. |
it is now generally accepted that massive neuronal death due to apoptosis is a commmon characteristic in the brains of patients suffering from neurodegenerative diseases, and apoptotic cell death has been found in neurons and glial cells in ad. |
2001-03-29 |
2023-08-12 |
human |
| A Sorisky, R Magun, A M Gagno. Adipose cell apoptosis: death in the energy depot. International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity. vol 24 Suppl 4. 2001-03-15. PMID:11126237. |
apoptosis is critical for mammalian tissue homeostasis, and its disruption has been linked to a wide variety of disorders, including cancer, neurodegenerative disease, autoimmune disease and diabetes. |
2001-03-15 |
2023-08-12 |
Not clear |
| D Offen, H Elkon, E Melame. Apoptosis as a general cell death pathway in neurodegenerative diseases. Journal of neural transmission. Supplementum. issue 58. 2001-02-22. PMID:11128605. |
apoptosis as a general cell death pathway in neurodegenerative diseases. |
2001-02-22 |
2023-08-12 |
human |
| C Schaper, Y Zhu, M Kouklei, C Culmsee, J Krieglstei. Stimulation of 5-HT(1A) receptors reduces apoptosis after transient forebrain ischemia in the rat. Brain research. vol 883. issue 1. 2001-02-01. PMID:11063986. |
since there is increasing evidence that apoptosis is involved in neurodegenerative diseases and stroke, we investigated whether the 5-ht(1a) agonist bay x 3702 could protect neurons against apoptotic damage in a rat model of transient forebrain cerebral ischemia. |
2001-02-01 |
2023-08-12 |
rat |
| Y H Chung, C Shin, M J Kim, B Lee, K H Park, C I Ch. Immunocytochemical study on the distribution of p53 in the hippocampus and cerebellum of the aged rat. Brain research. vol 885. issue 1. 2001-01-25. PMID:11121541. |
recent studies suggest that p53-associated apoptosis may be a common mechanism of cell loss in several important neurodegenerative diseases. |
2001-01-25 |
2023-08-12 |
rat |
| P T Danie. Dissecting the pathways to death. Leukemia. vol 14. issue 12. 2001-01-25. PMID:11187890. |
therapeutic applications of apoptosis manipulation include (1) the inhibition of caspases in acute and chronic neurodegenerative diseases, ie stroke, alzheimer's or huntington's disease by drugs and (2) sensitization of cancer cells for drug/radiation-induced apoptosis by modulation of survival signals and viral transfer of apoptosis promoting genes. |
2001-01-25 |
2023-08-12 |
Not clear |
| M Naoi, W Maruyama, Y Akao, J Zhang, H Parve. Apoptosis induced by an endogenous neurotoxin, N-methyl(R)salsolinol, in dopamine neurons. Toxicology. vol 153. issue 1-3. 2001-01-03. PMID:11090952. |
these results are discussed in relation to the role of apoptosis in neurodegenerative diseases and the involvement of the endogenous toxin in the pathogenesis of parkinson's disease. |
2001-01-03 |
2023-08-12 |
human |
| H P Deigner, U Haberkorn, R Kinscher. Apoptosis modulators in the therapy of neurodegenerative diseases. Expert opinion on investigational drugs. vol 9. issue 4. 2000-12-14. PMID:11060707. |
apoptosis modulators in the therapy of neurodegenerative diseases. |
2000-12-14 |
2023-08-12 |
human |
| P Nicoter. Caspase requirement for neuronal apoptosis and neurodegeneration. IUBMB life. vol 49. issue 5. 2000-12-07. PMID:10902574. |
the possibility of inhibiting apoptosis as strategy to treat neurodegenerative disease is discussed in this review. |
2000-12-07 |
2023-08-12 |
Not clear |
| P C Kam, N I Ferc. Apoptosis: mechanisms and clinical implications. Anaesthesia. vol 55. issue 11. 2000-12-06. PMID:11069335. |
excessive apoptosis is associated with ischaemic heart disease, stroke, neurodegenerative disease, sepsis and multiple organ dysfunction syndrome. |
2000-12-06 |
2023-08-12 |
Not clear |
| Y Sagot, N Toni, D Perrelet, S Lurot, B King, H Rixner, L Mattenberger, P C Waldmeier, A C Kat. An orally active anti-apoptotic molecule (CGP 3466B) preserves mitochondria and enhances survival in an animal model of motoneuron disease. British journal of pharmacology. vol 131. issue 4. 2000-12-05. PMID:11030721. |
apoptosis and mitochondrial dysfunction are thought to be involved in the aetiology of neurodegenerative diseases. |
2000-12-05 |
2023-08-12 |
mouse |
| S Martin, F Vallett. [Apoptosis and pathologies of the central nervous system]. Neuro-Chirurgie. vol 46. issue 4. 2000-11-30. PMID:11015674. |
in the past years, the involvement of apoptosis has been shown not only during the embryonic development of the nervous system, but also in neurodegenerative diseases. |
2000-11-30 |
2023-08-12 |
Not clear |
| J Yuan, B A Yankne. Apoptosis in the nervous system. Nature. vol 407. issue 6805. 2000-11-07. PMID:11048732. |
neuronal apoptosis sculpts the developing brain and has a potentially important role in neurodegenerative diseases. |
2000-11-07 |
2023-08-12 |
Not clear |