| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Natalia Kurhalu. Tricarboxylic Acid Cycle Intermediates and Individual Ageing. Biomolecules. vol 14. issue 3. 2024-03-28. PMID:38540681. |
this review also demonstrated the role of the krebs cycle as a key component of cellular energy and ageing, which is closely associated with the development of various age-related pathologies, such as cancer, type 2 diabetes, and cardiovascular or neurodegenerative diseases where the mtor pathway plays a key role. |
2024-03-28 |
2024-03-30 |
Not clear |
| Nitesh Kumar Poddar, Arshma Khan, Falak Fatima, Anshulika Saxena, Garima Ghaley, Shahanavaj Kha. Association of mTOR Pathway and Conformational Alterations in C-Reactive Protein in Neurodegenerative Diseases and Infections. Cellular and molecular neurobiology. 2023-09-04. PMID:37665407. |
association of mtor pathway and conformational alterations in c-reactive protein in neurodegenerative diseases and infections. |
2023-09-04 |
2023-09-07 |
Not clear |
| Olha Kostiuchenko, Iryna Lushnikova, Magdalena Kowalczyk, Galyna Skib. mTOR/α-ketoglutarate-mediated signaling pathways in the context of brain neurodegeneration and neuroprotection. BBA advances. vol 2. 2023-04-21. PMID:37082603. |
mechanistic target of rapamycin (mtor) signaling is one of the most crucial factors in the regulation of energy homeostasis and its imbalance is linked with a variety of neurodegenerative diseases. |
2023-04-21 |
2023-08-14 |
Not clear |
| Li Deng, Ling Ding, Xianlai Duan, Yousong Pen. Shared molecular signatures between coronavirus infection and neurodegenerative diseases provide targets for broad-spectrum drug development. Scientific reports. vol 13. issue 1. 2023-04-04. PMID:37015947. |
seven genes including hsp90aa1, aldh2, cav1, comt, mtor, igf2r and hspa1a, and several inflammation and stress response-related molecular functions such as mapk signaling pathway, nf-kappa b signaling pathway, responses to oxidative or chemical stress were common to both coronavirus infection and neurodegenerative diseases. |
2023-04-04 |
2023-08-14 |
human |
| Wuhui He, Fan Wu, Hao Xiong, Junbo Zeng, Yiming Gao, Ziyi Cai, Jiaqi Pang, Yiqing Zhen. Promoting TFEB nuclear localization with curcumin analog C1 attenuates sensory hair cell injury and delays age-related hearing loss in C57BL/6 mice. Neurotoxicology. 2023-02-15. PMID:36792013. |
transcription factor eb (tfeb), an autophagy regulator and the downstream target of mammalian target of rapamycin (mtor), is involved in the pathological development of neurodegenerative disease. |
2023-02-15 |
2023-08-14 |
mouse |
| Pol Garcia-Segura, Cristina Malagelad. STAT3 and REDD1: an unconventional story of gene repression. The FEBS journal. 2023-01-30. PMID:36715132. |
these findings are crucial to expand the knowledge of the stress-induced short-lived redd1 protein that inactivates mtor and the consequences of this fine-tuned regulation in the context of pathological conditions such as cancer or neurodegenerative diseases. |
2023-01-30 |
2023-08-14 |
Not clear |
| Yipin Wang, Nicholas Siu Kay Fung, Wai-Ching Lam, Amy Cheuk Yin L. mTOR Signalling Pathway: A Potential Therapeutic Target for Ocular Neurodegenerative Diseases. Antioxidants (Basel, Switzerland). vol 11. issue 7. 2022-07-27. PMID:35883796. |
mtor signalling pathway: a potential therapeutic target for ocular neurodegenerative diseases. |
2022-07-27 |
2023-08-14 |
Not clear |
| Yipin Wang, Nicholas Siu Kay Fung, Wai-Ching Lam, Amy Cheuk Yin L. mTOR Signalling Pathway: A Potential Therapeutic Target for Ocular Neurodegenerative Diseases. Antioxidants (Basel, Switzerland). vol 11. issue 7. 2022-07-27. PMID:35883796. |
in combining the current basic and clinical research results, we provided a more complete picture of mtor as a potential therapeutic target for ocular neurodegenerative diseases. |
2022-07-27 |
2023-08-14 |
Not clear |
| Charlotte Schömig, Laura Oberholz, Gregor Fink, Jenny Voggel, Maria Wohlfarth, Jörg Dötsch, Kai-Dietrich Nüsken, Eva Nüske. Hippocampal mTOR Dysregulation and Morphological Changes in Male Rats after Fetal Growth Restriction. Nutrients. vol 14. issue 3. 2022-03-12. PMID:35276811. |
to determine long-term effects, we additionally examined mtor signaling and tau phosphorylation, which is altered in neurodegenerative diseases, on pnd 180, but did not find any changes among the experimental groups. |
2022-03-12 |
2023-08-13 |
rat |
| Ahmad Movahedpour, Omid Vakili, Masoomeh Khalifeh, Pegah Mousavi, Amir Mahmoodzadeh, Mortaza Taheri-Anganeh, Saeed Razmeh, Zahra Shabaninejad, Fatemeh Yousefi, Hamid Behrouj, Hassan Ghasemi, Seyyed Hossein Khatam. Mammalian target of rapamycin (mTOR) signaling pathway and traumatic brain injury: A novel insight into targeted therapy. Cell biochemistry and function. 2022-03-08. PMID:35258097. |
neurodegenerative diseases), as well as the mtor signaling-tbi relationship. |
2022-03-08 |
2023-08-13 |
Not clear |
| Maria Rosaria Rizzo, Irene Di Meo, Rita Polito, Maria Chiara Auriemma, Antonio Gambardella, Gabriella di Mauro, Annalisa Capuano, Giuseppe Paoliss. Cognitive impairment and Type 2 Diabetes Mellitus: Focus of SGLT2 Inhibitors Treatment. Pharmacological research. 2022-01-12. PMID:35017046. |
in addition, sglt2i could bring back mtor to a physiological state of activation, stopping neurodegenerative diseases' onset or progression. |
2022-01-12 |
2023-08-13 |
mouse |
| T M Khlebodarov. The molecular view of mechanical stress of brain cells, local translation, and neurodegenerative diseases. Vavilovskii zhurnal genetiki i selektsii. vol 25. issue 1. 2021-12-13. PMID:34901706. |
in further consideration of the role of the local translation system in the development of neuropsychic and neurodegenerative diseases, an original hypothesis was put forward that one of the possible causes of synaptopathies is impaired proteome stability associated with mtor hyperactivity and formation of complex dynamic modes of de novo protein synthesis in response to synapse-stimulating factors, including chronic mechanical stress. |
2021-12-13 |
2023-08-13 |
Not clear |
| Danna Wang, Jin Ye, Renjie Shi, Beita Zhao, Zhigang Liu, Wei Lin, Xuebo Li. Dietary protein and amino acid restriction: Roles in metabolic health and aging-related diseases. Free radical biology & medicine. 2021-12-10. PMID:34890767. |
whereas comprehensive reviews of the underlying mechanisms are limited, protein restriction and methionine (met) restriction improve metabolic health and aging-related neurodegenerative diseases, and may be associated with fgf21, mtor and autophagy, improved mitochondrial function and oxidative stress. |
2021-12-10 |
2023-08-13 |
mouse |
| Rohan Gupta, Rashmi K Ambasta, Pravir Kuma. Autophagy and apoptosis cascade: which is more prominent in neuronal death? Cellular and molecular life sciences : CMLS. vol 78. issue 24. 2021-11-30. PMID:34741624. |
further, extensive research on autophagy and apoptotic machinery excavates the implementation of selective biomarkers, for instance, mtor, bcl-2, bh3 family members, caspases, ampk, pi3k/akt/gsk3β, and p38/jnk/mapk, in the pathogenesis and progression of neurodegenerative diseases. |
2021-11-30 |
2023-08-13 |
human |
| Kenneth Maies. Dysregulation of metabolic flexibility: The impact of mTOR on autophagy in neurodegenerative disease. International review of neurobiology. vol 155. 2021-10-11. PMID:32854851. |
dysregulation of metabolic flexibility: the impact of mtor on autophagy in neurodegenerative disease. |
2021-10-11 |
2023-08-13 |
Not clear |
| Zofia Chrienova, Eugenie Nepovimova, Kamil Kuc. The role of mTOR in age-related diseases. Journal of enzyme inhibition and medicinal chemistry. vol 36. issue 1. 2021-09-01. PMID:34309456. |
recently, it has become obvious that mtor dysregulation is involved in several age-related diseases, such as cancer, neurodegenerative diseases, and type 2 diabetes mellitus. |
2021-09-01 |
2023-08-13 |
Not clear |
| Asmaa Abdullah, Nuraqila Mohd Murshid, Suzana Makpo. Antioxidant Modulation of mTOR and Sirtuin Pathways in Age-Related Neurodegenerative Diseases. Molecular neurobiology. vol 57. issue 12. 2021-07-01. PMID:32865663. |
antioxidant modulation of mtor and sirtuin pathways in age-related neurodegenerative diseases. |
2021-07-01 |
2023-08-13 |
human |
| Shile Huan. mTOR Signaling in Metabolism and Cancer. Cells. vol 9. issue 10. 2021-04-02. PMID:33065976. |
deregulated mtor signaling is implicated in a variety of disorders, such as cancer, obesity, diabetes, and neurodegenerative diseases. |
2021-04-02 |
2023-08-13 |
human |
| David Heras-Sandoval, Jazmin M Pérez-Rojas, José Pedraza-Chaverr. Novel compounds for the modulation of mTOR and autophagy to treat neurodegenerative diseases. Cellular signalling. vol 65. 2021-02-05. PMID:31639492. |
novel compounds for the modulation of mtor and autophagy to treat neurodegenerative diseases. |
2021-02-05 |
2023-08-13 |
Not clear |
| David Heras-Sandoval, Jazmin M Pérez-Rojas, José Pedraza-Chaverr. Novel compounds for the modulation of mTOR and autophagy to treat neurodegenerative diseases. Cellular signalling. vol 65. 2021-02-05. PMID:31639492. |
the phosphoinositide 3-kinase (pi3k)/ protein kinase b (akt) pathway, which promotes cellular survival, is the main modulator upstream of mtor, and alterations in this pathway are common in neurodegenerative diseases, e.g. |
2021-02-05 |
2023-08-13 |
Not clear |