| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jack Jia, Weidong L. Molecular network of neuronal autophagy in the pathophysiology and treatment of depression. Neuroscience bulletin. vol 31. issue 4. 2016-05-02. PMID:26254058. |
dysregulation of autophagic pathways, such as the mammalian target of rapamycin (mtor) signaling pathway and the beclin pathway, has been studied in neurodegenerative diseases. |
2016-05-02 |
2023-08-13 |
Not clear |
| Shan Wang, Shan-lei Zhou, Fang-yuan Min, Jin-ju Ma, Xia-jie Shi, Erika Bereczki, Jing W. mTOR-mediated hyperphosphorylation of tau in the hippocampus is involved in cognitive deficits in streptozotocin-induced diabetic mice. Metabolic brain disease. vol 29. issue 3. 2015-10-16. PMID:24682776. |
abnormal levels of mammalian target of rapamycin (mtor) signaling have been recently implicated in the pathophysiology of neurodegenerative diseases, such as alzheimer's disease (ad). |
2015-10-16 |
2023-08-12 |
mouse |
| Michael N Moor. Do airborne biogenic chemicals interact with the PI3K/Akt/mTOR cell signalling pathway to benefit human health and wellbeing in rural and coastal environments? Environmental research. vol 140. 2015-09-25. PMID:25825132. |
when overactive, akt and mtor (mtorc1) can lead to many pathological processes including cancers, diabetes, inflammation, immunosuppression, and neurodegenerative diseases. |
2015-09-25 |
2023-08-13 |
human |
| Anna Latacz, John A Russell, Ewa Ocłon, Joanna Zubel-łojek, Krystyna Pierzchała-Kozie. mTOR Pathway - Novel Modulator of Astrocyte Activity. Folia biologica. vol 63. issue 2. 2015-08-27. PMID:26255461. |
abnormal activity of mtor kinase can cause many neuropathologies, including brain tumours and neurodegenerative diseases. |
2015-08-27 |
2023-08-13 |
Not clear |
| E A Dunlop, A R Te. mTOR and autophagy: a dynamic relationship governed by nutrients and energy. Seminars in cell & developmental biology. vol 36. 2015-08-24. PMID:25158238. |
it is clear that mtor and autophagy are closely integrated within cells, where defects in signalling through both pathways are known to drive the onset of a range of human diseases, such as cancer and neurodegenerative disease. |
2015-08-24 |
2023-08-13 |
human |
| David Heras-Sandoval, Jazmin M Pérez-Rojas, Jacqueline Hernández-Damián, José Pedraza-Chaverr. The role of PI3K/AKT/mTOR pathway in the modulation of autophagy and the clearance of protein aggregates in neurodegeneration. Cellular signalling. vol 26. issue 12. 2015-08-06. PMID:25173700. |
upstream of mtor the survival pi3k/akt pathway modulates mtor activity that is also altered in neurodegenerative diseases of alzheimer and parkinson. |
2015-08-06 |
2023-08-13 |
Not clear |
| Yukiko Sasazawa, Natsumi Sato, Kazuo Umezawa, Siro Simiz. Conophylline protects cells in cellular models of neurodegenerative diseases by inducing mammalian target of rapamycin (mTOR)-independent autophagy. The Journal of biological chemistry. vol 290. issue 10. 2015-05-18. PMID:25596530. |
conophylline protects cells in cellular models of neurodegenerative diseases by inducing mammalian target of rapamycin (mtor)-independent autophagy. |
2015-05-18 |
2023-08-13 |
Not clear |
| Fengying Yang, Xiaolei Chu, Miaomiao Yin, Xiaolei Liu, Hairui Yuan, Yanmei Niu, Li F. mTOR and autophagy in normal brain aging and caloric restriction ameliorating age-related cognition deficits. Behavioural brain research. vol 264. 2014-11-05. PMID:24525424. |
mammalian target of rapamycin (mtor) signaling, which is recognized as the most important negative regulator of autophagy, is also involved in neurodegenerative diseases. |
2014-11-05 |
2023-08-12 |
mouse |
| Qin Lu, Lu Gao, Lijie Huang, Linhui Ruan, Jianjing Yang, Weilong Huang, Zhenxing Li, Yongliang Zhang, Kunlin Jin, Qichuan Zhug. Inhibition of mammalian target of rapamycin improves neurobehavioral deficit and modulates immune response after intracerebral hemorrhage in rat. Journal of neuroinflammation. vol 11. 2014-09-16. PMID:24602288. |
mtor is also dysregulated in several neurological diseases, such as traumatic brain injury (tbi), stroke, and neurodegenerative disease. |
2014-09-16 |
2023-08-12 |
rat |
| Michael Won. Mammalian target of rapamycin (mTOR) pathways in neurological diseases. Biomedical journal. vol 36. issue 2. 2013-12-10. PMID:23644232. |
finally, the mtor pathway may also be involved in the pathogenesis of cognitive dysfunction and other neurological deficits in developmental disorders and neurodegenerative diseases. |
2013-12-10 |
2023-08-12 |
Not clear |
| Lele Yin, Shasha Ye, Zhen Chen, Yaoying Zen. Rapamycin preconditioning attenuates transient focal cerebral ischemia/reperfusion injury in mice. The International journal of neuroscience. vol 122. issue 12. 2013-05-07. PMID:22901235. |
rapamycin, an mtor inhibitor and immunosuppressive agent in clinic, has protective effects on traumatic brain injury and neurodegenerative diseases. |
2013-05-07 |
2023-08-12 |
mouse |
| Robert T Abraha. Regulation of the mTOR signaling pathway: from laboratory bench to bedside and back again. F1000 biology reports. vol 1. 2011-06-13. PMID:20948608. |
recent publications have moved us significantly closer to a complete understanding of the mammalian target of rapamycin (mtor) signaling pathway, which plays a central role in the control of growth and metabolism and is dysregulated in a broad spectrum of human diseases, including cancer, tuberous sclerosis, diabetes, and cardiovascular and neurodegenerative diseases. |
2011-06-13 |
2023-08-12 |
human |
| Long Chen, Baoshan Xu, Lei Liu, Yan Luo, Hongyu Zhou, Wenxing Chen, Tao Shen, Xiuzhen Han, Christopher D Kontos, Shile Huan. Cadmium induction of reactive oxygen species activates the mTOR pathway, leading to neuronal cell death. Free radical biology & medicine. vol 50. issue 5. 2011-05-06. PMID:21195169. |
the findings suggest that inhibitors of pi3k and mtor, activators of ampk, or antioxidants may be exploited for the prevention of cd-induced neurodegenerative diseases. |
2011-05-06 |
2023-08-12 |
Not clear |
| Michael G Garelick, Brian K Kenned. TOR on the brain. Experimental gerontology. vol 46. issue 2-3. 2011-04-29. PMID:20849946. |
in mice, reduced mtor signaling by chronic rapamycin treatment leads to life span extension, raising the possibility that rapamycin and its analogs may benefit the aging brain and serve as effective treatments of age-related neurodegenerative diseases. |
2011-04-29 |
2023-08-12 |
mouse |
| Belen Tizon, Susmita Sahoo, Haung Yu, Sebastien Gauthier, Asok R Kumar, Panaiyur Mohan, Matthew Figliola, Monika Pawlik, Anders Grubb, Yasuo Uchiyama, Urmi Bandyopadhyay, Ana Maria Cuervo, Ralph A Nixon, Efrat Lev. Induction of autophagy by cystatin C: a mechanism that protects murine primary cortical neurons and neuronal cell lines. PloS one. vol 5. issue 3. 2011-01-11. PMID:20352108. |
our findings show that cysc plays a protective role under conditions of neuronal challenge by inducing autophagy via mtor inhibition and are consistent with cysc being neuroprotective in neurodegenerative diseases. |
2011-01-11 |
2023-08-12 |
human |
| L G T Morris, S Veeriah, T A Cha. Genetic determinants at the interface of cancer and neurodegenerative disease. Oncogene. vol 29. issue 24. 2010-07-01. PMID:20418918. |
pathways that have emerged as having critical roles in both cancer and neurodegenerative disease include those involving genes such as park2, atm, pten, ptprd, and mtor. |
2010-07-01 |
2023-08-12 |
human |
| Daniel Zemke, Seema Azhar, Arshad Maji. The mTOR pathway as a potential target for the development of therapies against neurological disease. Drug news & perspectives. vol 20. issue 8. 2008-03-27. PMID:18080036. |
many neurodegenerative diseases are characterized by neuronal death via apoptosis, and it is possible that modulation of mtor activity may offer some protection against their effects. |
2008-03-27 |
2023-08-12 |
Not clear |
| Sovan Sarkar, R Andres Floto, Zdenek Berger, Sara Imarisio, Axelle Cordenier, Matthieu Pasco, Lynnette J Cook, David C Rubinsztei. Lithium induces autophagy by inhibiting inositol monophosphatase. The Journal of cell biology. vol 170. issue 7. 2005-12-05. PMID:16186256. |
this novel pharmacologic strategy for autophagy induction is independent of mtor, and may help treatment of neurodegenerative diseases, like huntington's disease, where the toxic protein is an autophagy substrate. |
2005-12-05 |
2023-08-12 |
Not clear |