| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jing Yu, Stanley Wong, Zhinan Lin, Zhiming Shan, Chaoyang Fan, Zhengyuan Xia, Martin Cheung, Xiaowei Zhu, Jessica Aijia Liu, Chi Wai Cheun. High-Frequency Spinal Stimulation Suppresses Microglial Kaiso-P2X7 Receptor Axis-Induced Inflammation to Alleviate Neuropathic Pain in Rats. Annals of neurology. 2024-03-07. PMID:38450773. |
conventional spinal cord stimulation (con scs) often causes abnormal sensations and provides short analgesia, whereas high-frequency spinal cord stimulation (hf scs) is a newer therapy that effectively alleviates pain without paresthesia. |
2024-03-07 |
2024-03-09 |
rat |
| Changfang Zhu, Rosana Esteller, Jessica Block, Kristen Lechleiter, Robert Frey, Michael A Moffit. Exploratory evaluation of spinal cord stimulation with dynamic pulse patterns: a promising approach to improve stimulation sensation, coverage of pain areas, and expected pain relief. Frontiers in pain research (Lausanne, Switzerland). vol 4. 2024-02-16. PMID:38361978. |
these static parameters have limited ability to personalize the quality of paresthesia, the dermatomal coverage, and thus may affect scs efficacy. |
2024-02-16 |
2024-02-18 |
Not clear |
| Erika A Peterse. Spinal cord stimulation in painful diabetic neuropathy: An overview. Diabetes research and clinical practice. vol 206 Suppl 1. 2024-01-20. PMID:38245324. |
while low frequency scs has been shown to be potentially effective for treating pain associated with neuropathies, it masks pain perception by inducing paresthesia. |
2024-01-20 |
2024-01-23 |
Not clear |
| Boriss Sagalajev, Tianhe Zhang, Nooshin Abdollahi, Noosha Yousefpour, Laura Medlock, Dhekra Al-Basha, Alfredo Ribeiro-da-Silva, Rosana Esteller, Stéphanie Ratté, Steven A Prescot. Absence of paresthesia during high-rate spinal cord stimulation reveals importance of synchrony for sensations evoked by electrical stimulation. Neuron. 2023-11-16. PMID:37972595. |
however, paresthesia evoked by spinal cord stimulation (scs) at 40-60 hz becomes uncomfortable at high pulse amplitudes, limiting scs "dosage." |
2023-11-16 |
2023-11-20 |
rat |
| Boriss Sagalajev, Tianhe Zhang, Nooshin Abdollahi, Noosha Yousefpour, Laura Medlock, Dhekra Al-Basha, Alfredo Ribeiro-da-Silva, Rosana Esteller, Stéphanie Ratté, Steven A Prescot. Absence of paresthesia during high-rate spinal cord stimulation reveals importance of synchrony for sensations evoked by electrical stimulation. Neuron. 2023-11-16. PMID:37972595. |
kilohertz-frequency scs produces analgesia without paresthesia and is thought, therefore, not to activate afferent axons. |
2023-11-16 |
2023-11-20 |
rat |
| Boriss Sagalajev, Tianhe Zhang, Nooshin Abdollahi, Noosha Yousefpour, Laura Medlock, Dhekra Al-Basha, Alfredo Ribeiro-da-Silva, Rosana Esteller, Stéphanie Ratté, Steven A Prescot. Absence of paresthesia during high-rate spinal cord stimulation reveals importance of synchrony for sensations evoked by electrical stimulation. Neuron. 2023-11-16. PMID:37972595. |
in a pain patient, selectively increasing scs frequency abolished paresthesia and epidurally recorded evoked compound action potentials (ecaps). |
2023-11-16 |
2023-11-20 |
rat |
| Evan R Rogers, Ehsan Mirzakhalili, Scott F Lempk. Model-based analysis of subthreshold mechanisms of spinal cord stimulation for pain. Journal of neural engineering. 2023-10-31. PMID:37906966. |
for decades, scs maximized overlap between stimulation-induced paresthesias and the patient's painful areas. |
2023-10-31 |
2023-11-08 |
Not clear |
| Takafumi Tanei, Satoshi Maesawa, Yusuke Nishimura, Yoshitaka Nagashima, Tomotaka Ishizaki, Masahiko Ando, Yachiyo Kuwatsuka, Atsushi Hashizume, Shimon Kurasawa, Ryuta Sait. Efficacy of the latest new stimulation patterns of spinal cord stimulation for intractable neuropathic pain compared to conventional stimulation: study protocol for a clinical trial. Trials. vol 24. issue 1. 2023-09-23. PMID:37742013. |
the conventional paresthesia-based scs involves the application of tonic stimulation that induces a sense of paresthesia. |
2023-09-23 |
2023-10-07 |
Not clear |
| Takafumi Tanei, Satoshi Maesawa, Yusuke Nishimura, Yoshitaka Nagashima, Tomotaka Ishizaki, Masahiko Ando, Yachiyo Kuwatsuka, Atsushi Hashizume, Shimon Kurasawa, Ryuta Sait. Efficacy of the latest new stimulation patterns of spinal cord stimulation for intractable neuropathic pain compared to conventional stimulation: study protocol for a clinical trial. Trials. vol 24. issue 1. 2023-09-23. PMID:37742013. |
recently, new scs stimulation patterns without paresthesia have been developed. |
2023-09-23 |
2023-10-07 |
Not clear |
| Daehun Yun, Kaehong Lee, Ji Soo Kwak, Leegyeong Je, Taesan Kim, Yoon Sun Park, Jae Chul Ko. Burst stimulation for refractory angina pectoris. Anesthesia and pain medicine. 2023-07-19. PMID:37468198. |
however, scs is associated with undesired paresthesia. |
2023-07-19 |
2023-08-14 |
Not clear |
| Lisa Goudman, Koen Putman, Leen Van Doorslaer, Maxime Billot, Manuel Roulaud, Philippe Rigoard, Maarten Moen. Proportion of clinical holistic responders in patients with persistent spinal pain syndrome type II treated by subthreshold spinal cord stimulation compared to best medical treatment: a study protocol for a multicentric randomised controlled trial (TRADITION). Trials. vol 24. issue 1. 2023-02-21. PMID:36803412. |
paresthesia free) scs paradigms compared to standard scs. |
2023-02-21 |
2023-08-14 |
Not clear |
| Danielle Hewitt, Adam Byrne, Jessica Henderson, Kathryn Wilford, Rajiv Chawla, Manohar Lal Sharma, Bernhard Frank, Nicholas Fallon, Christopher Brown, Andrej Stanca. Pulse Intensity Effects of Burst and Tonic Spinal Cord Stimulation on Neural Responses to Brushing in Patients With Neuropathic Pain. Neuromodulation : journal of the International Neuromodulation Society. 2022-12-04. PMID:36464560. |
tonic spinal cord stimulation (scs) is accompanied by paresthesia in affected body regions. |
2022-12-04 |
2023-08-14 |
Not clear |
| Danielle Hewitt, Adam Byrne, Jessica Henderson, Kathryn Wilford, Rajiv Chawla, Manohar Lal Sharma, Bernhard Frank, Nicholas Fallon, Christopher Brown, Andrej Stanca. Pulse Intensity Effects of Burst and Tonic Spinal Cord Stimulation on Neural Responses to Brushing in Patients With Neuropathic Pain. Neuromodulation : journal of the International Neuromodulation Society. 2022-12-04. PMID:36464560. |
comparatively, the absence of paresthesia with burst scs suggests different involvement of the dorsal column system conveying afferent impulses from low-threshold mechanoreceptors. |
2022-12-04 |
2023-08-14 |
Not clear |
| Andrea M Yeung, Jingtong Huang, Kevin T Nguyen, Nicole Y Xu, Lorenzo T Hughes, Brajesh K Agrawal, Niels Ejskjaer, David C Klonof. Spinal Cord Stimulation for Painful Diabetic Neuropathy. Journal of diabetes science and technology. 2022-11-17. PMID:36384312. |
whereas traditional scs replaces pain with paresthesias, a new form of scs, called high-frequency 10-khz scs, first used for pain in 2015, can relieve pdn pain without causing paresthesias, although not all patients experience pain relief by scs. |
2022-11-17 |
2023-08-14 |
Not clear |
| Yevgeny Eugene Mironer, Justin Kelby Hutcheson, John C Haasis, Michael A Worobel, Emmanuel S Sakl. Epidural Laterality and Pain Relief With Burst Spinal Cord Stimulation. Neuromodulation : journal of the International Neuromodulation Society. 2022-09-30. PMID:36180323. |
the objective of this study was to examine the relationship between paresthesia locations and pain relief with burst scs in a prospective double-blind crossover design. |
2022-09-30 |
2023-08-14 |
Not clear |
| Amber N Edinoff, Sarah Kaufman, E Saunders Alpaugh, Jesse Lawson, Tucker L Apgar, Farnad Imani, Seyed-Hossein Khademi, Elyse M Cornett, Alan D Kay. Burst Spinal Cord Stimulation in the Management of Chronic Pain: Current Perspectives. Anesthesiology and pain medicine. vol 12. issue 2. 2022-09-26. PMID:36158139. |
burst scs mitigates traditional paresthesia due to expedited action potential and offers improved pain relief. |
2022-09-26 |
2023-08-14 |
Not clear |
| Amber N Edinoff, Sarah Kaufman, E Saunders Alpaugh, Jesse Lawson, Tucker L Apgar, Farnad Imani, Seyed-Hossein Khademi, Elyse M Cornett, Alan D Kay. Burst Spinal Cord Stimulation in the Management of Chronic Pain: Current Perspectives. Anesthesiology and pain medicine. vol 12. issue 2. 2022-09-26. PMID:36158139. |
burst scs has been shown in available studies to be non-inferior to the traditional scs, which can cause pain paresthesia in patients who already have chronic pain. |
2022-09-26 |
2023-08-14 |
Not clear |
| Amber N Edinoff, Sarah Kaufman, E Saunders Alpaugh, Jesse Lawson, Tucker L Apgar, Farnad Imani, Seyed-Hossein Khademi, Elyse M Cornett, Alan D Kay. Burst Spinal Cord Stimulation in the Management of Chronic Pain: Current Perspectives. Anesthesiology and pain medicine. vol 12. issue 2. 2022-09-26. PMID:36158139. |
burst scs does not seem to cause or need the paresthesia seen in traditional scs, making scs not tolerable to patients. |
2022-09-26 |
2023-08-14 |
Not clear |
| Rosalynn R Z Conic, Jacob Caylor, Christina L Cui, Zabrina Reyes, Eric Nelson, Sopyda Yin, Imanuel Lerma. Sex-specific differences in the efficacy of traditional low frequency versus high frequency spinal cord stimulation for chronic pain. Bioelectronic medicine. vol 8. issue 1. 2022-04-28. PMID:35484578. |
spinal cord stimulation (scs), an fda-approved therapy for chronic pain, uses paresthesia (low frequency scs (lf-scs)) or paresthesia-free (such as high-frequency scs (hf-scs)) systems, providing analgesia through partially-elucidated mechanisms, with recent studies indicating a sexual dimorphism in pain pathogenesis (bretherton et al., neuromodulation, 2021; paller et al., pain med 10:289-299, 2009; slyer et al., neuromodulation, 2019; van buyten et al., neuromodulation 20:642-649, 2017; mekhail et al., pain pract, 2021). |
2022-04-28 |
2023-08-13 |
Not clear |
| David L Cedeño, Courtney A Kelley, Krishnan Chakravarthy, Ricardo Vallej. Modulation of Glia-Mediated Processes by Spinal Cord Stimulation in Animal Models of Neuropathic Pain. Frontiers in pain research (Lausanne, Switzerland). vol 2. 2022-03-17. PMID:35295479. |
traditional scs therapies were developed based on the gate control theory of pain and rely on stimulating large aβ neurons to induce paresthesia in the painful dermatome intended to mask nociceptive input carried out by small sensory neurons. |
2022-03-17 |
2023-08-13 |
Not clear |