| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| D C Tang, R Prauner, W Liu, K H Kim, R P Hirsch, M C Driscoll, G P Rodger. Polymorphisms within the angiotensinogen gene (GT-repeat) and the risk of stroke in pediatric patients with sickle cell disease: a case-control study. American journal of hematology. vol 68. issue 3. 2002-01-10. PMID:11754397. |
after informed consent was obtained, 63 patients (21 stroke subjects and 42 nonstroke control subjects matched according to age and sex) with scd followed at local pediatric hematology clinics were genotyped to test the association of specific gt-repeat alleles of the agt gene and occurrence of stroke. |
2002-01-10 |
2023-08-12 |
human |
| D C Tang, R Prauner, W Liu, K H Kim, R P Hirsch, M C Driscoll, G P Rodger. Polymorphisms within the angiotensinogen gene (GT-repeat) and the risk of stroke in pediatric patients with sickle cell disease: a case-control study. American journal of hematology. vol 68. issue 3. 2002-01-10. PMID:11754397. |
there were statistical differences in the distribution of the genotypes among stroke and nonstroke scd patients (chi(2) = 10.82, df = 11, p < 0.05). |
2002-01-10 |
2023-08-12 |
human |
| D C Tang, R Prauner, W Liu, K H Kim, R P Hirsch, M C Driscoll, G P Rodger. Polymorphisms within the angiotensinogen gene (GT-repeat) and the risk of stroke in pediatric patients with sickle cell disease: a case-control study. American journal of hematology. vol 68. issue 3. 2002-01-10. PMID:11754397. |
our results suggest that gt-repeat within the agt gene may be associated with risk of stroke in pediatric scd. |
2002-01-10 |
2023-08-12 |
human |
| D C Tang, R Prauner, W Liu, K H Kim, R P Hirsch, M C Driscoll, G P Rodger. Polymorphisms within the angiotensinogen gene (GT-repeat) and the risk of stroke in pediatric patients with sickle cell disease: a case-control study. American journal of hematology. vol 68. issue 3. 2002-01-10. PMID:11754397. |
if these data are substantiated in a larger cohort of patients, our results indicate that the determination of gt-repeat of agt gene may be a useful genetic marker to assess the risk for stroke of patients with scd. |
2002-01-10 |
2023-08-12 |
human |
| S T Miller, E A Macklin, C H Pegelow, T R Kinney, L A Sleeper, J A Bello, L D DeWitt, D M Gallagher, L Guarini, F G Moser, K Ohene-Frempong, N Sanchez, E P Vichinsky, W C Wang, D L Wethers, D P Younkin, R A Zimmerman, M R DeBau. Silent infarction as a risk factor for overt stroke in children with sickle cell anemia: a report from the Cooperative Study of Sickle Cell Disease. The Journal of pediatrics. vol 139. issue 3. 2001-10-18. PMID:11562618. |
to determine whether children with homozygous sickle cell anemia (scd) who have silent infarcts on magnetic resonance imaging (mri) of the brain are at increased risk for overt stroke. |
2001-10-18 |
2023-08-12 |
Not clear |
| R B Noll, L Stith, M A Gartstein, M D Ris, R Grueneich, K Vannatta, K Kalinya. Neuropsychological functioning of youths with sickle cell disease: comparison with non-chronically ill peers. Journal of pediatric psychology. vol 26. issue 2. 2001-06-28. PMID:11181883. |
to compare the neuropsychological functioning of children with sickle cell disease (scd) with no evidence of overt clinical stroke to that of classmates without a chronic illness matched on gender, race, and age. |
2001-06-28 |
2023-08-12 |
Not clear |
| A T Cheung, P Harmatz, T Wun, P C Chen, E C Larkin, R J Adams, E P Vichinsk. Correlation of abnormal intracranial vessel velocity, measured by transcranial Doppler ultrasonography, with abnormal conjunctival vessel velocity, measured by computer-assisted intravital microscopy, in sickle cell disease. Blood. vol 97. issue 11. 2001-06-28. PMID:11369629. |
the stroke prevention trial has confirmed that utilization of transcranial doppler ultrasonography (tcd), which examines blood flow in large intracranial vessels, can identify children with sickle cell disease (scd) who are at high risk of developing a premature stroke. |
2001-06-28 |
2023-08-12 |
Not clear |
| A T Cheung, P Harmatz, T Wun, P C Chen, E C Larkin, R J Adams, E P Vichinsk. Correlation of abnormal intracranial vessel velocity, measured by transcranial Doppler ultrasonography, with abnormal conjunctival vessel velocity, measured by computer-assisted intravital microscopy, in sickle cell disease. Blood. vol 97. issue 11. 2001-06-28. PMID:11369629. |
caim is a noninvasive quantitative technique that might contribute to the identification of scd patients at high risk of stroke. |
2001-06-28 |
2023-08-12 |
Not clear |
| R J Adam. Stroke prevention and treatment in sickle cell disease. Archives of neurology. vol 58. issue 4. 2001-04-26. PMID:11295986. |
while the problem of stroke in the patients with sickle cell disease (scd) has been known for more than 75 years, adequate preventive and treatment strategies are just now being tested. |
2001-04-26 |
2023-08-12 |
Not clear |
| R J Adam. Stroke prevention and treatment in sickle cell disease. Archives of neurology. vol 58. issue 4. 2001-04-26. PMID:11295986. |
recent data on prevalence and incidence have been obtained from the cooperative study of sickle cell disease of more than 4000 patients with scd observed in 23 us clinical centers over a 10-year period.1 the overall age-specific incidence of first stroke in scd (homozygous sickle cell anemia) is low (0.13%) at ages younger than 24 months, increasing to just over 1% at ages 2 to 5 years, with only a slight decrement to 0.79% at ages 6 to 9 years. |
2001-04-26 |
2023-08-12 |
Not clear |
| T P Nifong, M B Bongiovanni, G S Gerhar. Mathematical modeling and computer simulation of erythrocytapheresis for SCD. Transfusion. vol 41. issue 2. 2001-04-19. PMID:11239232. |
erythrocytapheresis is used to prevent acute chest syndrome and stroke in patients with sickle cell disease (scd). |
2001-04-19 |
2023-08-12 |
Not clear |
| D A White, C F Salorio, J Schatz, M DeBau. Preliminary study of working memory in children with stroke related to sickle cell disease. Journal of clinical and experimental neuropsychology. vol 22. issue 2. 2000-07-12. PMID:10779839. |
the verbal working memory abilities of children with stroke related to sickle cell disease (scd) (n = 20) were compared to those of control children with scd who had no history of stroke (n = 11). |
2000-07-12 |
2023-08-12 |
Not clear |
| P J Nietert, M R Abboud, M D Silverstein, S M Jackso. Bone marrow transplantation versus periodic prophylactic blood transfusion in sickle cell patients at high risk of ischemic stroke: a decision analysis. Blood. vol 95. issue 10. 2000-06-13. PMID:10807769. |
decision analysis was used to compare the number of quality-adjusted life years (qalys) experienced by a population of patients with scd at high risk for stroke who were treated with pbt or bmt. |
2000-06-13 |
2023-08-12 |
Not clear |
| R E Ware, S A Zimmerman, W H Schult. Hydroxyurea as an alternative to blood transfusions for the prevention of recurrent stroke in children with sickle cell disease. Blood. vol 94. issue 9. 1999-11-30. PMID:10556185. |
children with sickle cell disease (scd) and stroke receive chronic transfusions to prevent stroke recurrence. |
1999-11-30 |
2023-08-12 |
Not clear |
| R E Ware, S A Zimmerman, W H Schult. Hydroxyurea as an alternative to blood transfusions for the prevention of recurrent stroke in children with sickle cell disease. Blood. vol 94. issue 9. 1999-11-30. PMID:10556185. |
we previously used hydroxyurea (hu) and phlebotomy in two young adults with scd and stroke as an alternative to transfusions. |
1999-11-30 |
2023-08-12 |
Not clear |
| R E Ware, S A Zimmerman, W H Schult. Hydroxyurea as an alternative to blood transfusions for the prevention of recurrent stroke in children with sickle cell disease. Blood. vol 94. issue 9. 1999-11-30. PMID:10556185. |
we have now prospectively discontinued transfusions in 16 pediatric patients with scd and stroke. |
1999-11-30 |
2023-08-12 |
Not clear |
| R E Ware, S A Zimmerman, W H Schult. Hydroxyurea as an alternative to blood transfusions for the prevention of recurrent stroke in children with sickle cell disease. Blood. vol 94. issue 9. 1999-11-30. PMID:10556185. |
these preliminary data suggest some children with scd and stroke may discontinue chronic transfusions and use hu therapy to prevent stroke recurrence. |
1999-11-30 |
2023-08-12 |
Not clear |
| V V Balasa, R A Gruppo, P S Gartside, K A Kalinya. Correlation of the C677T MTHFR genotype with homocysteine levels in children with sickle cell disease. Journal of pediatric hematology/oncology. vol 21. issue 5. 1999-11-01. PMID:10524453. |
to determine the role of hyperhomocysteinemia in the pathogenesis of stroke in children with sickle cell disease (scd), hcy levels and c677t mthfr genotype were determined in 40 patients homozygous for hemoglobin ss and compared with 197 healthy children. |
1999-11-01 |
2023-08-12 |
Not clear |
| V V Balasa, R A Gruppo, P S Gartside, K A Kalinya. Correlation of the C677T MTHFR genotype with homocysteine levels in children with sickle cell disease. Journal of pediatric hematology/oncology. vol 21. issue 5. 1999-11-01. PMID:10524453. |
eleven of 40 patients with scd had a history of stroke. |
1999-11-01 |
2023-08-12 |
Not clear |
| V V Balasa, R A Gruppo, P S Gartside, K A Kalinya. Correlation of the C677T MTHFR genotype with homocysteine levels in children with sickle cell disease. Journal of pediatric hematology/oncology. vol 21. issue 5. 1999-11-01. PMID:10524453. |
in patients with scd and stroke, the median hcy level was 4.8 micromol/l versus 6.0 micromol/l in those without stroke (p = 0.44, mann-whitney rank sum test). |
1999-11-01 |
2023-08-12 |
Not clear |