| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Rui Dong, Renxuan Huang, Jiaoqi Wang, Hongyu Liu, Zhongxin X. Effects of Microglial Activation and Polarization on Brain Injury After Stroke. Frontiers in neurology. vol 12. 2021-07-20. PMID:34276530. |
therefore, investigation of the activation and polarizing mechanisms of microglia plays a critical role in treating stroke. |
2021-07-20 |
2023-08-13 |
Not clear |
| Rui Dong, Renxuan Huang, Jiaoqi Wang, Hongyu Liu, Zhongxin X. Effects of Microglial Activation and Polarization on Brain Injury After Stroke. Frontiers in neurology. vol 12. 2021-07-20. PMID:34276530. |
the aim of this article was to investigate the significance of microglial phenotype regulation in stroke treatment by summarizing the activation, polarizing mechanisms, and general microglia characteristics. |
2021-07-20 |
2023-08-13 |
Not clear |
| Lalita Subedi, Bhakta Prasad Gair. Phytochemicals as regulators of microglia/macrophages activation in cerebral ischemia. Pharmacological research. vol 165. 2021-07-16. PMID:33450385. |
the latest studies in animal stroke models demonstrate that this group of bioactive phytochemicals exerts their anti-inflammatory effects via attenuation of brain proinflammatory microglia and macrophages m1 polarization while promoting anti-inflammatory microglial and macrophages m2 polarization. |
2021-07-16 |
2023-08-13 |
Not clear |
| Zongping Fang, Di Wu, Jiao Deng, Qianzi Yang, Xijing Zhang, Jian Chen, Shiquan Wang, Sijun Hu, Wugang Hou, Siming Ning, Yi Ding, Zhongmin Fan, Zhenhua Jiang, Junjun Kang, Yingying Liu, Jinlin Miao, Xunming Ji, Hailong Dong, Lize Xion. An MD2-perturbing peptide has therapeutic effects in rodent and rhesus monkey models of stroke. Science translational medicine. vol 13. issue 597. 2021-07-12. PMID:34108252. |
here, we report that the expression of myeloid differentiation protein 2 (md2), which is traditionally regarded to be expressed only in microglia in the normal brain, was markedly increased in cortical neurons after stroke. |
2021-07-12 |
2023-08-13 |
mouse |
| Dongxue Wang, Fei Liu, Liyun Zhu, Ping Lin, Fanyi Han, Xue Wang, Xianxi Tan, Li Lin, Ye Xion. FGF21 alleviates neuroinflammation following ischemic stroke by modulating the temporal and spatial dynamics of microglia/macrophages. Journal of neuroinflammation. vol 17. issue 1. 2021-07-09. PMID:32867781. |
therefore, we investigated whether rhfgf21 improves ischemic outcomes in experimental stroke by targeting microglia and macrophages. |
2021-07-09 |
2023-08-13 |
human |
| Ling-Zhi Li, Yu-You Huang, Zhen-Hong Yang, Si-Jia Zhang, Zi-Ping Han, Yu-Min Lu. Potential microglia-based interventions for stroke. CNS neuroscience & therapeutics. vol 26. issue 3. 2021-06-30. PMID:32064759. |
microglia are the principal immune cells in the brain and are the first line of defense against the pathophysiology induced by stroke. |
2021-06-30 |
2023-08-13 |
human |
| Ling-Zhi Li, Yu-You Huang, Zhen-Hong Yang, Si-Jia Zhang, Zi-Ping Han, Yu-Min Lu. Potential microglia-based interventions for stroke. CNS neuroscience & therapeutics. vol 26. issue 3. 2021-06-30. PMID:32064759. |
increasing evidence has suggested that microglia play diverse roles that depend on dynamic interactions with neurons, astrocytes, and other neighboring cells both in the normal brain and under pathological conditions, including stroke. |
2021-06-30 |
2023-08-13 |
human |
| Débora D S Vogel, Nancy N Ortiz-Villatoro, Noemi S Araújo, Márcia Jonathas Guimarães Marques, Flavio Aimbire, Fúlvio A Scorza, Carla A Scorza, Regiane Albertin. Transcranial low-level laser therapy in an in vivo model of stroke: Relevance to the brain infarct, microglia activation and neuroinflammation. Journal of biophotonics. vol 14. issue 6. 2021-06-28. PMID:33580734. |
transcranial low-level laser therapy in an in vivo model of stroke: relevance to the brain infarct, microglia activation and neuroinflammation. |
2021-06-28 |
2023-08-13 |
rat |
| Cristina Barca, Amanda J Kiliaan, Claudia Foray, Lydia Wachsmuth, Sven Hermann, Cornelius Faber, Michael Schaefers, Maximilian Wiesmann, Andreas H Jacobs, Bastian Zinnhard. A longitudinal PET/MR imaging study of colony stimulating factor-1 receptor-mediated microglia depletion in experimental stroke. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2021-06-25. PMID:34168016. |
a longitudinal pet/mr imaging study of colony stimulating factor-1 receptor-mediated microglia depletion in experimental stroke. |
2021-06-25 |
2023-08-13 |
Not clear |
| Gonzalo Garcia-Martin, Berta Alcover-Sanchez, Francisco Wandosell, Beatriz Cubelo. Pathways involved in remyelination after cerebral ischemia. Current neuropharmacology. 2021-06-21. PMID:34151767. |
for this reason, we will put some context into how microglia and astrocytes react against stroke and influence oligodendrogenesis to highlight the relevance of remyelination in the ischemic brain. |
2021-06-21 |
2023-08-13 |
Not clear |
| Max Rudolph, Christian W Schmeer, Madlen Günther, Florus Woitke, Carolin Kathner-Schaffert, Lina Karapetow, Julia Lindner, Thomas Lehmann, Gustav Jirikowski, Otto W Witte, Christoph Redecker, Silke Keine. Microglia-mediated phagocytosis of apoptotic nuclei is impaired in the adult murine hippocampus after stroke. Glia. vol 69. issue 8. 2021-06-09. PMID:33942391. |
here, we evaluated the effect of a prefrontal stroke lesion on the phagocytic activity of microglia in the dentate gyrus (dg) of the hippocampus. |
2021-06-09 |
2023-08-13 |
mouse |
| Jianhua Wu, Zhuoze Wu, Aodi He, Tongmei Zhang, Ping Zhang, Jing Jin, Sisi Li, Gaigai Li, Xinyan Li, Shiqi Liang, Lei Pei, Rong Liu, Qing Tian, Ximiao He, Youming Lu, Zhouping Tang, Hao L. Genome-Wide Screen and Validation of Microglia Pro-Inflammatory Mediators in Stroke. Aging and disease. vol 12. issue 3. 2021-06-08. PMID:34094642. |
genome-wide screen and validation of microglia pro-inflammatory mediators in stroke. |
2021-06-08 |
2023-08-13 |
mouse |
| Jianhua Wu, Zhuoze Wu, Aodi He, Tongmei Zhang, Ping Zhang, Jing Jin, Sisi Li, Gaigai Li, Xinyan Li, Shiqi Liang, Lei Pei, Rong Liu, Qing Tian, Ximiao He, Youming Lu, Zhouping Tang, Hao L. Genome-Wide Screen and Validation of Microglia Pro-Inflammatory Mediators in Stroke. Aging and disease. vol 12. issue 3. 2021-06-08. PMID:34094642. |
stroke activates microglia pro-inflammatory response that not only induces the early neuronal injuries but also causes the secondary brain infarction. |
2021-06-08 |
2023-08-13 |
mouse |
| Jianhua Wu, Zhuoze Wu, Aodi He, Tongmei Zhang, Ping Zhang, Jing Jin, Sisi Li, Gaigai Li, Xinyan Li, Shiqi Liang, Lei Pei, Rong Liu, Qing Tian, Ximiao He, Youming Lu, Zhouping Tang, Hao L. Genome-Wide Screen and Validation of Microglia Pro-Inflammatory Mediators in Stroke. Aging and disease. vol 12. issue 3. 2021-06-08. PMID:34094642. |
yet, the underlying mechanisms for how microglia become activated in stroke are still unknown. |
2021-06-08 |
2023-08-13 |
mouse |
| Jianhua Wu, Zhuoze Wu, Aodi He, Tongmei Zhang, Ping Zhang, Jing Jin, Sisi Li, Gaigai Li, Xinyan Li, Shiqi Liang, Lei Pei, Rong Liu, Qing Tian, Ximiao He, Youming Lu, Zhouping Tang, Hao L. Genome-Wide Screen and Validation of Microglia Pro-Inflammatory Mediators in Stroke. Aging and disease. vol 12. issue 3. 2021-06-08. PMID:34094642. |
inhibition of either hmgb2 or ctss blocks microglia pro-inflammatory response and protects against brain damages and improves the neurological functions of stroke mice. |
2021-06-08 |
2023-08-13 |
mouse |
| Jianhua Wu, Zhuoze Wu, Aodi He, Tongmei Zhang, Ping Zhang, Jing Jin, Sisi Li, Gaigai Li, Xinyan Li, Shiqi Liang, Lei Pei, Rong Liu, Qing Tian, Ximiao He, Youming Lu, Zhouping Tang, Hao L. Genome-Wide Screen and Validation of Microglia Pro-Inflammatory Mediators in Stroke. Aging and disease. vol 12. issue 3. 2021-06-08. PMID:34094642. |
this study uncovers hmgb2 and ctss as the major microglia inflammatory response mediators in stroke and hence warrants the promising targets for stroke therapies. |
2021-06-08 |
2023-08-13 |
mouse |
| Bella M Gonzales-Portillo, Jea-Young Lee, Arthur A Vandenbark, Halina Offner, Cesario V Borlonga. Major histocompatibility complex Class II-based therapy for stroke. Brain circulation. vol 7. issue 1. 2021-06-05. PMID:34084976. |
drmq was observed to attenuate behavioral deficits and decrease microglia activation and proinflammatory cytokines, illustrating its ability to mitigate the secondary cell death following stroke. |
2021-06-05 |
2023-08-13 |
Not clear |
| Wenguang Xie, Xiao-Ting Gong, Xiaofeng Cheng, Jingjing Cao, Jin Zhao, Hao-Li Zhang, Shengxiang Zhan. LIMPID: a versatile method for visualization of brain vascular networks. Biomaterials science. vol 9. issue 7. 2021-05-14. PMID:33595547. |
we have successfully applied this method to acquire cortical vasculature images simultaneously with the neurons or microglia, as well as to evaluate vascular damage in a mouse model of stroke. |
2021-05-14 |
2023-08-13 |
mouse |
| Li-Rong Liu, Jia-Chen Liu, Jin-Shuang Bao, Qin-Qin Bai, Gai-Qing Wan. Interaction of Microglia and Astrocytes in the Neurovascular Unit. Frontiers in immunology. vol 11. 2021-05-05. PMID:32733433. |
during neuroinflammation, induced by stroke or lipopolysaccharides, microglia are more sensitive to pathogens, or damage; they are thus initially activated into the m1 phenotype and produce common inflammatory signals such as il-1 and tnf-α to trigger reactive astrocytes into the a1 phenotype. |
2021-05-05 |
2023-08-13 |
Not clear |
| Yang Jiao, Jianjian Wang, Huixue Zhang, Yuze Cao, Yang Qu, Siyu Huang, Xiaotong Kong, Chang Song, Jie Li, Qian Li, Heping Ma, Xiaoyu Lu, Lihua Wan. Inhibition of microglial receptor-interacting protein kinase 1 ameliorates neuroinflammation following cerebral ischaemic stroke. Journal of cellular and molecular medicine. vol 24. issue 21. 2021-05-04. PMID:32990414. |
microglia are rapidly activated following ischaemic stroke and participate in the induction of neuroinflammation, which exacerbates the injury of ischaemic stroke. |
2021-05-04 |
2023-08-13 |
human |