| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Roland G W Staal, Jonathan R Weinstein, Megan Nattini, Manuel Cajina, Gamini Chandresana, Thomas Mölle. Senicapoc: Repurposing a Drug to Target Microglia K Neurochemical research. vol 42. issue 9. 2018-07-09. PMID:28364331. |
senicapoc: repurposing a drug to target microglia k stroke is the leading cause of serious long-term disability and the fifth leading cause of death in the united states. |
2018-07-09 |
2023-08-13 |
Not clear |
| Roland G W Staal, Jonathan R Weinstein, Megan Nattini, Manuel Cajina, Gamini Chandresana, Thomas Mölle. Senicapoc: Repurposing a Drug to Target Microglia K Neurochemical research. vol 42. issue 9. 2018-07-09. PMID:28364331. |
neuroinflammation mediated by microglia and infiltrating peripheral immune cells is a major component of stroke pathophysiology. |
2018-07-09 |
2023-08-13 |
Not clear |
| Jenni E Anttila, Keith W Whitaker, Emily S Wires, Brandon K Harvey, Mikko Airavaar. Role of microglia in ischemic focal stroke and recovery: focus on Toll-like receptors. Progress in neuro-psychopharmacology & biological psychiatry. vol 79. issue Pt A. 2018-07-06. PMID:27389423. |
role of microglia in ischemic focal stroke and recovery: focus on toll-like receptors. |
2018-07-06 |
2023-08-13 |
Not clear |
| Jenni E Anttila, Keith W Whitaker, Emily S Wires, Brandon K Harvey, Mikko Airavaar. Role of microglia in ischemic focal stroke and recovery: focus on Toll-like receptors. Progress in neuro-psychopharmacology & biological psychiatry. vol 79. issue Pt A. 2018-07-06. PMID:27389423. |
this division encompasses the spatial and temporal dynamics of microglia as they participate in the pathophysiological changes that contribute to the symptoms and sequela of a stroke. |
2018-07-06 |
2023-08-13 |
Not clear |
| Jenni E Anttila, Keith W Whitaker, Emily S Wires, Brandon K Harvey, Mikko Airavaar. Role of microglia in ischemic focal stroke and recovery: focus on Toll-like receptors. Progress in neuro-psychopharmacology & biological psychiatry. vol 79. issue Pt A. 2018-07-06. PMID:27389423. |
increasing evidence shows that microglia have a complex role in stroke pathophysiology, and they mediate both detrimental and beneficial effects on stroke outcome. |
2018-07-06 |
2023-08-13 |
Not clear |
| Claudia Espinosa-Garcia, Iqbal Sayeed, Seema Yousuf, Fahim Atif, Elena G Sergeeva, Gretchen N Neigh, Donald G Stei. Stress primes microglial polarization after global ischemia: Therapeutic potential of progesterone. Brain, behavior, and immunity. vol 66. 2018-06-06. PMID:28648389. |
preclinical research suggests that stress primes microglia, resulting in an enhanced reactivity to a subsequent insult and potentially increasing vulnerability to stroke. |
2018-06-06 |
2023-08-13 |
rat |
| Murielle G Kluge, Laura Kracht, Mahmoud Abdolhoseini, Lin Kooi Ong, Sarah J Johnson, Michael Nilsson, Frederick R Walke. Impaired microglia process dynamics post-stroke are specific to sites of secondary neurodegeneration. Glia. vol 65. issue 12. 2018-06-05. PMID:28836304. |
in this study, we used acute slice based multiphoton imaging, to investigate microglia dynamic process movement in mice 14 days after a photothrombotic stroke. |
2018-06-05 |
2023-08-13 |
mouse |
| Masato Kanazawa, Itaru Ninomiya, Masahiro Hatakeyama, Tetsuya Takahashi, Takayoshi Shimohat. Microglia and Monocytes/Macrophages Polarization Reveal Novel Therapeutic Mechanism against Stroke. International journal of molecular sciences. vol 18. issue 10. 2018-05-30. PMID:29027964. |
microglia and monocytes/macrophages polarization reveal novel therapeutic mechanism against stroke. |
2018-05-30 |
2023-08-13 |
Not clear |
| Masato Kanazawa, Itaru Ninomiya, Masahiro Hatakeyama, Tetsuya Takahashi, Takayoshi Shimohat. Microglia and Monocytes/Macrophages Polarization Reveal Novel Therapeutic Mechanism against Stroke. International journal of molecular sciences. vol 18. issue 10. 2018-05-30. PMID:29027964. |
cell-based therapies, using microglia and monocytes/macrophages preconditioned by optimal stimuli and/or any therapies targeting these cells, might be an ideal therapeutic strategy for managing stroke. |
2018-05-30 |
2023-08-13 |
Not clear |
| Masato Kanazawa, Itaru Ninomiya, Masahiro Hatakeyama, Tetsuya Takahashi, Takayoshi Shimohat. Microglia and Monocytes/Macrophages Polarization Reveal Novel Therapeutic Mechanism against Stroke. International journal of molecular sciences. vol 18. issue 10. 2018-05-30. PMID:29027964. |
cell-based therapies using m2-like microglia and monocytes/macrophages might be protective therapeutic strategies against stroke for three reasons. |
2018-05-30 |
2023-08-13 |
Not clear |
| Masato Kanazawa, Itaru Ninomiya, Masahiro Hatakeyama, Tetsuya Takahashi, Takayoshi Shimohat. Microglia and Monocytes/Macrophages Polarization Reveal Novel Therapeutic Mechanism against Stroke. International journal of molecular sciences. vol 18. issue 10. 2018-05-30. PMID:29027964. |
although future translational studies are required, m2-like microglia and monocytes/macrophages therapies are attractive for managing stroke based on their protective functions. |
2018-05-30 |
2023-08-13 |
Not clear |
| Jan-Kolja Strecker, Antje Schmidt, Wolf-Rüdiger Schäbitz, Jens Minneru. Neutrophil granulocytes in cerebral ischemia - Evolution from killers to key players. Neurochemistry international. vol 107. 2018-04-03. PMID:27884770. |
we further report of new findings regarding the interaction of pmns with resident microglia, immigrating macrophages and t cells after stroke. |
2018-04-03 |
2023-08-13 |
Not clear |
| Jin Hwan Lee, Zheng Z Wei, Wenyuan Cao, Soonmi Won, Xiaohuan Gu, Megan Winter, Thomas A Dix, Ling Wei, Shan Ping Y. Regulation of therapeutic hypothermia on inflammatory cytokines, microglia polarization, migration and functional recovery after ischemic stroke in mice. Neurobiology of disease. vol 96. 2018-02-09. PMID:27659107. |
seven days after focal cortical ischemia, microglia activation in the penumbra reached a peak level, which was significantly attenuated by th treatments commenced 30min after stroke. |
2018-02-09 |
2023-08-13 |
mouse |
| Jianguo Xu, Handong Wang, Seok Joon Won, Jayinee Basu, David Kapfhamer, Raymond A Swanso. Microglial activation induced by the alarmin S100B is regulated by poly(ADP-ribose) polymerase-1. Glia. vol 64. issue 11. 2018-01-04. PMID:27444121. |
brain injury resulting from stroke or trauma can be exacerbated by the release of proinflammatory cytokines, proteases, and reactive oxygen species by activated microglia. |
2018-01-04 |
2023-08-13 |
Not clear |
| Muhammad Shahdaat Bin Sayeed, Qasim Alhadidi, Zahoor A Sha. Cofilin signaling in hemin-induced microglial activation and inflammation. Journal of neuroimmunology. vol 313. 2017-11-29. PMID:29153608. |
intracerebral hemorrhage (ich) is the most severe form of stroke and is further exacerbated by the secondary injury involving inflammatory response due to the activation of microglia. |
2017-11-29 |
2023-08-13 |
Not clear |
| Maria L Cotrina, Nanghong Lou, Jessica Tome-Garcia, James Goldman, Maiken Nedergaar. Direct comparison of microglial dynamics and inflammatory profile in photothrombotic and arterial occlusion evoked stroke. Neuroscience. vol 343. 2017-11-17. PMID:28003156. |
two groups of heterozygote cx3cr1-gfp reporter mice (to follow microglia) were subject to stroke injury either with coagulator-mediated occlusion or photothrombotic mca damage. |
2017-11-17 |
2023-08-13 |
mouse |
| Maria L Cotrina, Nanghong Lou, Jessica Tome-Garcia, James Goldman, Maiken Nedergaar. Direct comparison of microglial dynamics and inflammatory profile in photothrombotic and arterial occlusion evoked stroke. Neuroscience. vol 343. 2017-11-17. PMID:28003156. |
photothrombotic stroke delayed microglial and astrocytic invasion of the ischemic core and accumulation of phagocytic microglia. |
2017-11-17 |
2023-08-13 |
mouse |
| Medha M Pathak, Truc Tran, Liang Hong, Béla Joós, Catherine E Morris, Francesco Tombol. The Hv1 proton channel responds to mechanical stimuli. The Journal of general physiology. vol 148. issue 5. 2017-10-19. PMID:27799320. |
in microglia, for example, hv1 activity is potentiated by cell swelling and causes an increase in brain damage after stroke. |
2017-10-19 |
2023-08-13 |
Not clear |
| Medha M Pathak, Truc Tran, Liang Hong, Béla Joós, Catherine E Morris, Francesco Tombol. The Hv1 proton channel responds to mechanical stimuli. The Journal of general physiology. vol 148. issue 5. 2017-10-19. PMID:27799320. |
hv1 mechanosensitivity thus provides a mechanistic link between channel activation in microglia and brain damage after stroke. |
2017-10-19 |
2023-08-13 |
Not clear |
| Ming Huang, Yan Wan, Ling Mao, Quan-Wei He, Yuan-Peng Xia, Man Li, Ya-Nan Li, Hui-Juan Jin, Bo H. Inhibiting the Migration of M1 Microglia at Hyperacute Period Could Improve Outcome of tMCAO Rats. CNS neuroscience & therapeutics. vol 23. issue 3. 2017-10-19. PMID:27991729. |
to study whether inhibiting microglia migration to the ischemic boundary zone (ibz) at the early phase could improve neurological outcomes after stroke. |
2017-10-19 |
2023-08-13 |
rat |