| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Muhammad Shahdaat Bin Sayeed, Qasim Alhadidi, Zahoor A Sha. Cofilin signaling in hemin-induced microglial activation and inflammation. Journal of neuroimmunology. vol 313. 2017-11-29. PMID:29153608. |
intracerebral hemorrhage (ich) is the most severe form of stroke and is further exacerbated by the secondary injury involving inflammatory response due to the activation of microglia. |
2017-11-29 |
2023-08-13 |
Not clear |
| Maria L Cotrina, Nanghong Lou, Jessica Tome-Garcia, James Goldman, Maiken Nedergaar. Direct comparison of microglial dynamics and inflammatory profile in photothrombotic and arterial occlusion evoked stroke. Neuroscience. vol 343. 2017-11-17. PMID:28003156. |
two groups of heterozygote cx3cr1-gfp reporter mice (to follow microglia) were subject to stroke injury either with coagulator-mediated occlusion or photothrombotic mca damage. |
2017-11-17 |
2023-08-13 |
mouse |
| Maria L Cotrina, Nanghong Lou, Jessica Tome-Garcia, James Goldman, Maiken Nedergaar. Direct comparison of microglial dynamics and inflammatory profile in photothrombotic and arterial occlusion evoked stroke. Neuroscience. vol 343. 2017-11-17. PMID:28003156. |
photothrombotic stroke delayed microglial and astrocytic invasion of the ischemic core and accumulation of phagocytic microglia. |
2017-11-17 |
2023-08-13 |
mouse |
| Medha M Pathak, Truc Tran, Liang Hong, Béla Joós, Catherine E Morris, Francesco Tombol. The Hv1 proton channel responds to mechanical stimuli. The Journal of general physiology. vol 148. issue 5. 2017-10-19. PMID:27799320. |
in microglia, for example, hv1 activity is potentiated by cell swelling and causes an increase in brain damage after stroke. |
2017-10-19 |
2023-08-13 |
Not clear |
| Medha M Pathak, Truc Tran, Liang Hong, Béla Joós, Catherine E Morris, Francesco Tombol. The Hv1 proton channel responds to mechanical stimuli. The Journal of general physiology. vol 148. issue 5. 2017-10-19. PMID:27799320. |
hv1 mechanosensitivity thus provides a mechanistic link between channel activation in microglia and brain damage after stroke. |
2017-10-19 |
2023-08-13 |
Not clear |
| Ming Huang, Yan Wan, Ling Mao, Quan-Wei He, Yuan-Peng Xia, Man Li, Ya-Nan Li, Hui-Juan Jin, Bo H. Inhibiting the Migration of M1 Microglia at Hyperacute Period Could Improve Outcome of tMCAO Rats. CNS neuroscience & therapeutics. vol 23. issue 3. 2017-10-19. PMID:27991729. |
to study whether inhibiting microglia migration to the ischemic boundary zone (ibz) at the early phase could improve neurological outcomes after stroke. |
2017-10-19 |
2023-08-13 |
rat |
| Rebecca Klein, Nicolas Mahlberg, Maurice Ohren, Anne Ladwig, Bernd Neumaier, Rudolf Graf, Mathias Hoehn, Morten Albrechtsen, Stephen Rees, Gereon Rudolf Fink, Maria Adele Rueger, Michael Schroete. The Neural Cell Adhesion Molecule-Derived (NCAM)-Peptide FG Loop (FGL) Mobilizes Endogenous Neural Stem Cells and Promotes Endogenous Regenerative Capacity after Stroke. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. vol 11. issue 4. 2017-10-18. PMID:27352075. |
here we investigated the effect of subcutaneously injected fgl on cellular compartments affected by degeneration and regeneration after stroke due to middle cerebral artery occlusion (mcao), namely endogenous neural stem cells (nsc), oligodendrocytes, and microglia. |
2017-10-18 |
2023-08-13 |
Not clear |
| Lauren J Simmons, Monique C Surles-Zeigler, Yonggang Li, Gregory D Ford, Gale D Newman, Byron D For. Regulation of inflammatory responses by neuregulin-1 in brain ischemia and microglial cells in vitro involves the NF-kappa B pathway. Journal of neuroinflammation. vol 13. issue 1. 2017-10-10. PMID:27596278. |
over-activation of brain microglia can induce pro-inflammatory gene expression by activation of transcriptional regulators following stroke. |
2017-10-10 |
2023-08-13 |
rat |
| Xiaoyan Jiang, Hongjian Pu, Xiaoming Hu, Zhishuo Wei, Dandan Hong, Wenting Zhang, Yanqin Gao, Jun Chen, Yejie Sh. A Post-stroke Therapeutic Regimen with Omega-3 Polyunsaturated Fatty Acids that Promotes White Matter Integrity and Beneficial Microglial Responses after Cerebral Ischemia. Translational stroke research. vol 7. issue 6. 2017-09-26. PMID:27714669. |
notably, the improved white matter integrity and increased m2 microglia were strongly linked to the mitigation of sensorimotor deficits after stroke upon n-3 pufa treatments. |
2017-09-26 |
2023-08-13 |
mouse |
| Eunhee Kim, Sunghee Ch. Microglia and Monocyte-Derived Macrophages in Stroke. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. vol 13. issue 4. 2017-09-22. PMID:27485238. |
microglia and monocyte-derived macrophages in stroke. |
2017-09-22 |
2023-08-13 |
Not clear |
| Daojing Li, Chunjiong Wang, Yang Yao, Li Chen, Guiyou Liu, Rongxin Zhang, Qiang Liu, Fu-Dong Shi, Junwei Ha. mTORC1 pathway disruption ameliorates brain inflammation following stroke via a shift in microglia phenotype from M1 type to M2 type. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 30. issue 10. 2017-09-08. PMID:27342766. |
mtorc1 pathway disruption ameliorates brain inflammation following stroke via a shift in microglia phenotype from m1 type to m2 type. |
2017-09-08 |
2023-08-13 |
mouse |
| Wei-Na Jin, Samuel Xiang-Yu Shi, Zhiguo Li, Minshu Li, Kristofer Wood, Rayna J Gonzales, Qiang Li. Depletion of microglia exacerbates postischemic inflammation and brain injury. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 37. issue 6. 2017-08-11. PMID:28273719. |
although depletion of microglia has been linked to worse stroke outcomes, it remains unclear to what extent and by what mechanisms activated microglia influence ischemia-induced inflammation and injury in the brain. |
2017-08-11 |
2023-08-13 |
mouse |
| Rosana S Lopes, Marcelo M Cardoso, Arthur O Sampaio, Mario Santos Barbosa, Celice C Souza, Michelle C DA Silva, Elane Magno N Ferreira, Marco Aurelio M Freire, Rafael Rodrigues Lima, Walace Gomes-Lea. Indomethacin treatment reduces microglia activation and increases numbers of neuroblasts in the subventricular zone and ischaemic striatum after focal ischaemia. Journal of biosciences. vol 41. issue 3. 2017-03-15. PMID:27581930. |
our results suggest that indomethacin treatment modulates microglia activation, contributing to increased neuroblast proliferation in the svz and migration to the ischaemic striatum following stroke. |
2017-03-15 |
2023-08-13 |
rat |
| Le Li, Creed M Star. Targeting Glial Mitochondrial Function for Protection from Cerebral Ischemia: Relevance, Mechanisms, and the Role of MicroRNAs. Oxidative medicine and cellular longevity. vol 2016. 2017-03-13. PMID:27777645. |
astrocytes and microglia play crucial roles in the response to cerebral ischemia and are effective targets for stroke therapy in animal models. |
2017-03-13 |
2023-08-13 |
Not clear |
| Yanni Lv, Yisong Qian, Aijun Ou-Yang, Longsheng F. Hydroxysafflor Yellow A Attenuates Neuron Damage by Suppressing the Lipopolysaccharide-Induced TLR4 Pathway in Activated Microglial Cells. Cellular and molecular neurobiology. vol 36. issue 8. 2017-02-21. PMID:26754542. |
microglia activation initiates a neurological deficit cascade that contributes to substantial neuronal damage and impairment following ischemia stroke. |
2017-02-21 |
2023-08-13 |
Not clear |
| Ana-Maria Buga, Ovidiu Ciobanu, George Mihai Bădescu, Catalin Bogdan, Ria Weston, Mark Slevin, Mario Di Napoli, Aurel Popa-Wagne. Up-regulation of serotonin receptor 2B mRNA and protein in the peri-infarcted area of aged rats and stroke patients. Oncotarget. vol 7. issue 14. 2017-02-09. PMID:27013593. |
we hypothesize that htr2b expression in the infarcted territory may render degenerating neurons susceptible to attack by activated microglia and thus aggravate the consequences of stroke. |
2017-02-09 |
2023-08-13 |
human |
| Bettina Hjelm Clausen, Kate Lykke Lambertsen, Frederik Dagnæs-Hansen, Alicia Anne Babcock, Christian Ulrich von Linstow, Michael Meldgaard, Bjarne Winther Kristensen, Tomas Deierborg, Bente Finse. Cell therapy centered on IL-1Ra is neuroprotective in experimental stroke. Acta neuropathologica. vol 131. issue 5. 2017-01-06. PMID:26860727. |
taken together, our results attribute distinct neuroprotective or neurotoxic functions to segregated subsets of microglia and suggest that treatment strategies increasing the production of il-1ra by infiltrating leukocytes or microglia may also be neuroprotective if applied early after stroke onset in patients. |
2017-01-06 |
2023-08-13 |
mouse |
| Maria Pannell, Maria Almut Meier, Frank Szulzewsky, Vitali Matyash, Matthias Endres, Golo Kronenberg, Vincent Prinz, Sonia Waiczies, Susanne A Wolf, Helmut Kettenman. The subpopulation of microglia expressing functional muscarinic acetylcholine receptors expands in stroke and Alzheimer's disease. Brain structure & function. vol 221. issue 2. 2016-12-14. PMID:25523105. |
the subpopulation of microglia expressing functional muscarinic acetylcholine receptors expands in stroke and alzheimer's disease. |
2016-12-14 |
2023-08-13 |
mouse |
| Sean I Savitz, Charles S Co. Concise Review: Cell Therapies for Stroke and Traumatic Brain Injury: Targeting Microglia. Stem cells (Dayton, Ohio). vol 34. issue 3. 2016-12-13. PMID:26844424. |
concise review: cell therapies for stroke and traumatic brain injury: targeting microglia. |
2016-12-13 |
2023-08-13 |
Not clear |
| Sean I Savitz, Charles S Co. Concise Review: Cell Therapies for Stroke and Traumatic Brain Injury: Targeting Microglia. Stem cells (Dayton, Ohio). vol 34. issue 3. 2016-12-13. PMID:26844424. |
we present a model hypothesis of how several types of cell therapies may target microglia as one of the principal cell types contributing to the inflammatory response after brain injury and discuss how imaging of brain inflammation could potentially be applied to develop biomarkers in patients with stroke and tbi enrolled into stem cell clinical trials. |
2016-12-13 |
2023-08-13 |
Not clear |