| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sheng-Jie Hou, Ya-Ru Huang, Jie Zhu, Ying-Bo Jia, Xiao-Yun Niu, Jin-Ju Yang, Xiao-Lin Yu, Xiao-Yu Du, Shi-Yu Liang, Fang Cui, Ling-Jie Li, Chen Tian, Rui-Tian Li. Mouse serum albumin induces neuronal apoptosis and tauopathies. Acta neuropathologica communications. vol 12. issue 1. 2024-04-23. PMID:38654316. |
overall, our study here revealed that msa induced tau phosphorylation and neuron apoptosis based on msa-activated microglia and astrocytes, respectively, showing the critical roles of msa in initiating the occurrence of tauopathies and cognitive decline, and providing potential therapeutic targets for msa-induced neuropathology in multiple neurodegenerative disorders. |
2024-04-23 |
2024-04-26 |
mouse |
| Lun Zhang, Yongkang Gai, Yushuang Liu, Dongli Meng, Yi Zeng, Yong Luo, Huiliang Zhang, Zhuoqun Wang, Mengzhe Yang, Yunfan Li, Yi Liu, Yiwen Lai, Jiayu Yang, Gang Wu, Yu Chen, Jingtan Zhu, Shaojun Liu, Tingting Yu, Ji Zeng, Jianzhi Wang, Dan Zhu, Xiaochuan Wang, Xiaoli Lan, Rong Li. Tau induces inflammasome activation and microgliosis through acetylating NLRP3. Clinical and translational medicine. vol 14. issue 3. 2024-03-15. PMID:38488468. |
alzheimer's disease (ad) and related tauopathies are characterised by the pathologically hyperphosphorylated and aggregated microtubule-associated protein tau, which is accompanied by neuroinflammation mediated by activated microglia. |
2024-03-15 |
2024-03-17 |
Not clear |
| Katryna Pampuscenko, Ramune Morkuniene, Lukas Krasauskas, Vytautas Smirnovas, Guy C Brown, Vilmante Borutait. Extracellular tau stimulates phagocytosis of living neurons by activated microglia via Toll-like 4 receptor-NLRP3 inflammasome-caspase-1 signalling axis. Scientific reports. vol 13. issue 1. 2023-07-04. PMID:37402829. |
overall, our data indicate that extracellular tau protein stimulates microglia to phagocytose live neurons via toll-like 4 receptor-nlrp3 inflammasome-caspase-1 axis and nadph oxidase, each of which may serve as a potential molecular target for pharmacological treatment of tauopathies. |
2023-07-04 |
2023-08-14 |
Not clear |
| Deniz Karabag, Hannah Scheiblich, Angelika Griep, Francesco Santarelli, Stephanie Schwartz, Michael T Heneka, Christina Isin. Characterizing microglial senescence: Tau as a key player. Journal of neurochemistry. 2023-06-06. PMID:37278117. |
in addition, senescent microglia have been identified in the brains of tau-transgenic mice and patients suffering from tauopathies. |
2023-06-06 |
2023-08-14 |
mouse |
| Deniz Karabag, Hannah Scheiblich, Angelika Griep, Francesco Santarelli, Stephanie Schwartz, Michael T Heneka, Christina Isin. Characterizing microglial senescence: Tau as a key player. Journal of neurochemistry. 2023-06-06. PMID:37278117. |
while the contribution of senescent microglia to the development of tauopathies and other neurodegenerative diseases is a growing area of research, the effect of tau on microglial senescence remains elusive. |
2023-06-06 |
2023-08-14 |
mouse |
| Gunel Ayyubov. Dysfunctional microglia and tau pathology in Alzheimer's disease. Reviews in the neurosciences. 2022-10-27. PMID:36302379. |
extensive human studies and animal models show that chronic immune system stimulation involving microglia, inflammasome, complement activation, synthesis of cytokines, and reactive oxygen species exacerbates neurodegeneration in alzheimer's disease (ad) and other tauopathies. |
2022-10-27 |
2023-08-14 |
human |
| Chao Wang, Li Fan, Rabia R Khawaja, Bangyan Liu, Lihong Zhan, Lay Kodama, Marcus Chin, Yaqiao Li, David Le, Yungui Zhou, Carlo Condello, Lea T Grinberg, William W Seeley, Bruce L Miller, Sue-Ann Mok, Jason E Gestwicki, Ana Maria Cuervo, Wenjie Luo, Li Ga. Microglial NF-κB drives tau spreading and toxicity in a mouse model of tauopathy. Nature communications. vol 13. issue 1. 2022-04-13. PMID:35413950. |
activation of microglia is a prominent pathological feature in tauopathies, including alzheimer's disease. |
2022-04-13 |
2023-08-13 |
mouse |
| Valerie L Joers, Hannah Staley, Maclean Bassett, Brenda D Moore, Malu Gamez Tanse. The role of cannabinoid receptor 2 in microglial clearance of human tau. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35109165. |
microglia have been implicated in tauopathies as they may contribute to tau phosphorylation and aggregation and the uptake and spread of seed-competent tau to healthy neurons due to dysfunctional degradation. |
2022-02-03 |
2023-08-13 |
human |
| Juan R Perea, Marta Bolós, Raquel Cuadros, Esther García, Vega García-Escudero, Félix Hernández, Róisín M McManus, Michael T Heneka, Jesús Avil. p38 Inhibition Decreases Tau Toxicity in Microglia and Improves Their Phagocytic Function. Molecular neurobiology. 2022-01-10. PMID:35006531. |
alzheimer's disease (ad) and other tauopathies are histopathologically characterized by tau aggregation, along with a chronic inflammatory response driven by microglia. |
2022-01-10 |
2023-08-13 |
Not clear |
| Yasmine V Doust, Anna E King, Jenna M Ziebel. Implications for microglial sex differences in tau-related neurodegenerative diseases. Neurobiology of aging. vol 105. 2021-08-27. PMID:34174592. |
the sex differences in microglial functionality suggest that microglia may contribute to tauopathies which may differ between sexes. |
2021-08-27 |
2023-08-13 |
Not clear |
| Iain J Hartnell, David Blum, James A R Nicoll, Guillaume Dorothee, Delphine Boch. Glial cells and adaptive immunity in frontotemporal dementia with tau pathology. Brain : a journal of neurology. vol 144. issue 3. 2021-08-13. PMID:33527991. |
across experimental paradigms, there seems to be a consensus regarding the involvement of innate immunity in primary tauopathies, with increased microglia and astrocyte density and/or activation, as well as increases in pro-inflammatory markers. |
2021-08-13 |
2023-08-13 |
human |
| Timna Hitrec, Fabio Squarcio, Matteo Cerri, Davide Martelli, Alessandra Occhinegro, Emiliana Piscitiello, Domenico Tupone, Roberto Amici, Marco Lupp. Reversible Tau Phosphorylation Induced by Synthetic Torpor in the Spinal Cord of the Rat. Frontiers in neuroanatomy. vol 15. 2021-02-20. PMID:33603651. |
since tauopathies are also related to neuroinflammation, microglia activation was also assessed through morphometric analyses, but no st-induced microglia activation was found in the spco. |
2021-02-20 |
2023-08-13 |
rat |
| Juan R Perea, María Llorens-Martín, Jesús Ávila, Marta Boló. The Role of Microglia in the Spread of Tau: Relevance for Tauopathies. Frontiers in cellular neuroscience. vol 12. 2020-10-01. PMID:30042659. |
this review focuses on the role played by microglia in tauopathies, specifically in alzheimer's disease (ad), and how the uncoupling of activation/phagocytosis functions can have fatal consequences leading to the development of the pathology. |
2020-10-01 |
2023-08-13 |
Not clear |
| Juan R Perea, María Llorens-Martín, Jesús Ávila, Marta Boló. The Role of Microglia in the Spread of Tau: Relevance for Tauopathies. Frontiers in cellular neuroscience. vol 12. 2020-10-01. PMID:30042659. |
the role of microglia in the spread of tau: relevance for tauopathies. |
2020-10-01 |
2023-08-13 |
Not clear |
| Juan Ramón Perea, Esther López, José Carlos Díez-Ballesteros, Jesús Ávila, Félix Hernández, Marta Boló. Extracellular Monomeric Tau Is Internalized by Astrocytes. Frontiers in neuroscience. vol 13. 2020-10-01. PMID:31118883. |
however, in a group of neurodegenerative diseases named tauopathies - characterized by an increase in aggregated and/or hyperphosphorylated tau - the protein accumulates inside other cells, such as astrocytes and microglia. |
2020-10-01 |
2023-08-13 |
Not clear |
| Anna L Cranston, Adrianna Wysocka, Marta Steczkowska, Maciej Zadrożny, Ewelina Palasz, Charles R Harrington, Franz Theuring, Claude M Wischik, Gernot Riedel, Grazyna Niewiadomsk. Cholinergic and inflammatory phenotypes in transgenic tau mouse models of Alzheimer's disease and frontotemporal lobar degeneration. Brain communications. vol 2. issue 1. 2020-09-28. PMID:32954291. |
in addition, pro-inflammatory glial cells such as astrocytes and microglia may play a key role in the neurodegenerative cascade of alzheimer's disease and tauopathies. |
2020-09-28 |
2023-08-13 |
mouse |
| Thomas Vogels, Adriana-Natalia Murgoci, Tomáš Hromádk. Intersection of pathological tau and microglia at the synapse. Acta neuropathologica communications. vol 7. issue 1. 2020-07-30. PMID:31277708. |
this review describes the role of microglia in the pathobiology of tauopathies and the mechanism of action of potential therapeutics targeting the immune system in tauopathies. |
2020-07-30 |
2023-08-13 |
Not clear |
| W Richard Bevan-Jones, Thomas E Cope, P Simon Jones, Sanne S Kaalund, Luca Passamonti, Kieren Allinson, Oliver Green, Young T Hong, Tim D Fryer, Robert Arnold, Jonathan P Coles, Franklin I Aigbirhio, Andrew J Larner, Karalyn Patterson, John T O'Brien, James B Row. Neuroinflammation and protein aggregation co-localize across the frontotemporal dementia spectrum. Brain : a journal of neurology. vol 143. issue 3. 2020-07-06. PMID:32179883. |
we used pet in vivo with (i) 11c-pk-11195, a marker of activated microglia and a proxy index of neuroinflammation; and (ii) 18f-av-1451, a radioligand with increased binding to pathologically affected regions in tauopathies and tdp-43-related disease, and which is used as a surrogate marker of non-amyloid-β protein aggregation. |
2020-07-06 |
2023-08-13 |
human |
| Shahrnaz Kemal, Robert Vassa. Death by microglia. The Journal of experimental medicine. vol 216. issue 11. 2020-05-29. PMID:31645368. |
the roles of microglia and apoe in tauopathies, such as alzheimer's disease, remain elusive. |
2020-05-29 |
2023-08-13 |
mouse |
| Sara Castro-Sánchez, Ángel J García-Yagüe, Sebastian Kügler, Isabel Lastres-Becke. CX3CR1-deficient microglia shows impaired signalling of the transcription factor NRF2: Implications in tauopathies. Redox biology. vol 22. 2019-11-25. PMID:30769286. |
cx3cr1-deficient microglia shows impaired signalling of the transcription factor nrf2: implications in tauopathies. |
2019-11-25 |
2023-08-13 |
Not clear |