| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Juan Ramón Perea, Jesús Ávila, Marta Boló. Dephosphorylated rather than hyperphosphorylated Tau triggers a pro-inflammatory profile in microglia through the p38 MAPK pathway. Experimental neurology. vol 310. 2019-03-21. PMID:30138606. |
activated microglia and elevated levels of pro-inflammatory molecules are also pathological hallmarks of tauopathies. |
2019-03-21 |
2023-08-13 |
Not clear |
| Nicole Cortés, Víctor Andrade, Leonardo Guzmán-Martínez, Matías Estrella, Ricardo B Maccion. Neuroimmune Tau Mechanisms: Their Role in the Progression of Neuronal Degeneration. International journal of molecular sciences. vol 19. issue 4. 2018-09-04. PMID:29570615. |
since microglial cells play a preponderant role in innate immunity and are the main source of proinflammatory factors in the central nervous system (cns), the alterations in the cross-talks between microglia and neuronal cells are the main focus of studies concerning the origins of tauopathies. |
2018-09-04 |
2023-08-13 |
Not clear |
| Nicole Maphis, Guixiang Xu, Olga N Kokiko-Cochran, Astrid E Cardona, Richard M Ransohoff, Bruce T Lamb, Kiran Bhaska. Loss of tau rescues inflammation-mediated neurodegeneration. Frontiers in neuroscience. vol 9. 2015-06-19. PMID:26089772. |
activated microglia spatially coexist with microtubule-associated protein tau (mapt or tau)-burdened neurons in the brains of human ad and non-ad tauopathies. |
2015-06-19 |
2023-08-13 |
mouse |
| Isabel Lastres-Becker, Nadia G Innamorato, Tomasz Jaworski, Alberto Rábano, Sebastian Kügler, Fred Van Leuven, Antonio Cuadrad. Fractalkine activates NRF2/NFE2L2 and heme oxygenase 1 to restrain tauopathy-induced microgliosis. Brain : a journal of neurology. vol 137. issue Pt 1. 2014-03-11. PMID:24277722. |
our combined results indicate that fractalkine mobilizes nrf2 to limit over-activation of microglia and identify this new target to control unremitting neuroinflammation in tauopathies. |
2014-03-11 |
2023-08-12 |
mouse |
| Atsushi Sasaki, Takeshi Kawarabayashi, Tetsuro Murakami, Etsuro Matsubara, Masaki Ikeda, Haruo Hagiwara, David Westaway, Peter S George-Hyslop, Mikio Shoji, Yoichi Nakazat. Microglial activation in brain lesions with tau deposits: comparison of human tauopathies and tau transgenic mice TgTauP301L. Brain research. vol 1214. 2008-09-19. PMID:18457819. |
in human tauopathies, iba1- and major histocompatibility complex (mhc) class ii-positive activated microglia increased in regions of phosphorylated tau (at8) accumulation. |
2008-09-19 |
2023-08-12 |
mouse |
| Atsushi Sasaki, Takeshi Kawarabayashi, Tetsuro Murakami, Etsuro Matsubara, Masaki Ikeda, Haruo Hagiwara, David Westaway, Peter S George-Hyslop, Mikio Shoji, Yoichi Nakazat. Microglial activation in brain lesions with tau deposits: comparison of human tauopathies and tau transgenic mice TgTauP301L. Brain research. vol 1214. 2008-09-19. PMID:18457819. |
the aim of this study is to clarify the relationship of microglia to phosphorylated tau accumulation and the characteristics of microglial activation in brain lesions of human tauopathies in comparison to mutant tau transgenic (tg) mice. |
2008-09-19 |
2023-08-12 |
mouse |
| Atsushi Sasaki, Takeshi Kawarabayashi, Tetsuro Murakami, Etsuro Matsubara, Masaki Ikeda, Haruo Hagiwara, David Westaway, Peter S George-Hyslop, Mikio Shoji, Yoichi Nakazat. Microglial activation in brain lesions with tau deposits: comparison of human tauopathies and tau transgenic mice TgTauP301L. Brain research. vol 1214. 2008-09-19. PMID:18457819. |
this comparative study of human tauopathies and tau tg mice indicated that microglial activation was closely related to phosphorylated tau accumulation, and that activated microglia of the tg mice may have the low expression of mhc class ii and sra compared with those of human tauopathies. |
2008-09-19 |
2023-08-12 |
mouse |