| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yuval Baumel, Hagar Grazya Yamin, Dana Cohe. Chemical suppression of harmaline-induced body tremor yields recovery of pairwise neuronal coherence in cerebellar nuclei neurons. Frontiers in systems neuroscience. vol 17. 2023-05-30. PMID:37251003. |
chemical suppression of harmaline-induced body tremor yields recovery of pairwise neuronal coherence in cerebellar nuclei neurons. |
2023-05-30 |
2023-08-14 |
rat |
| Alexander Fanning, Sheng-Han Ku. Clinical Heterogeneity of Essential Tremor: Understanding Neural Substrates of Action Tremor Subtypes. Cerebellum (London, England). 2023-04-06. PMID:37022657. |
within the cerebellum, three sets of cerebellar cortex-deep cerebellar nuclei connections are important for tremor. |
2023-04-06 |
2023-08-14 |
Not clear |
| Kathryn Woodward, Richard Apps, Marc Goodfellow, Nadia L Cerminar. Cerebello-Thalamo-Cortical Network Dynamics in the Harmaline Rodent Model of Essential Tremor. Frontiers in systems neuroscience. vol 16. 2022-08-15. PMID:35965995. |
eeg recordings from the sensorimotor cortex and local field potentials (lfp) from thalamic and medial cerebellar nuclei were simultaneously recorded in awake behaving rats, alongside measures of tremor using emg and accelerometery. |
2022-08-15 |
2023-08-14 |
rat |
| Kathryn Woodward, Richard Apps, Marc Goodfellow, Nadia L Cerminar. Cerebello-Thalamo-Cortical Network Dynamics in the Harmaline Rodent Model of Essential Tremor. Frontiers in systems neuroscience. vol 16. 2022-08-15. PMID:35965995. |
medial cerebellar nuclei and cerebellar vermis lfp coherence with tremor however remained unchanged from rest. |
2022-08-15 |
2023-08-14 |
rat |
| Eric J Lang, Adrian Handfort. Is the inferior olive central to essential tremor? Yes. International review of neurobiology. vol 163. 2022-06-24. PMID:35750361. |
much evidence shows that the olivocerebellar system is the main system capable of generating the widespread synchronous oscillatory purkinje cell (pc) complex spike (cs) activity across the cerebellar cortex that would be capable of generating the type of bursting cerebellar output from the deep cerebellar nuclei (dcn) that could underlie tremor. |
2022-06-24 |
2023-08-14 |
mouse |
| Yuval Baumel, Hagar G Yamin, Dana Cohe. Cerebellar nuclei neurons display aberrant oscillations during harmaline-induced tremor. Heliyon. vol 7. issue 10. 2021-10-22. PMID:34660929. |
cerebellar nuclei neurons display aberrant oscillations during harmaline-induced tremor. |
2021-10-22 |
2023-08-13 |
rat |
| Amanda M Brown, Joshua J White, Meike E van der Heijden, Joy Zhou, Tao Lin, Roy V Sillito. Purkinje cell misfiring generates high-amplitude action tremors that are corrected by cerebellar deep brain stimulation. eLife. vol 9. 2021-04-08. PMID:32180549. |
we show in awake behaving mice that the onset of tremor is coincident with rhythmic purkinje cell firing, which alters the activity of their target cerebellar nuclei cells. |
2021-04-08 |
2023-08-13 |
mouse |
| Amanda M Brown, Joshua J White, Meike E van der Heijden, Joy Zhou, Tao Lin, Roy V Sillito. Purkinje cell misfiring generates high-amplitude action tremors that are corrected by cerebellar deep brain stimulation. eLife. vol 9. 2021-04-08. PMID:32180549. |
modulating the altered activity with deep brain stimulation directed to the purkinje cell output in the cerebellar nuclei reduced tremor in freely moving mice. |
2021-04-08 |
2023-08-13 |
mouse |
| Mu Zhou, Maxwell D Melin, Wei Xu, Thomas C Südho. Dysfunction of parvalbumin neurons in the cerebellar nuclei produces an action tremor. The Journal of clinical investigation. vol 130. issue 10. 2021-02-26. PMID:32634124. |
dysfunction of parvalbumin neurons in the cerebellar nuclei produces an action tremor. |
2021-02-26 |
2023-08-13 |
mouse |
| Mu Zhou, Maxwell D Melin, Wei Xu, Thomas C Südho. Dysfunction of parvalbumin neurons in the cerebellar nuclei produces an action tremor. The Journal of clinical investigation. vol 130. issue 10. 2021-02-26. PMID:32634124. |
the synaptotagmin-2 deletion converted synchronous into asynchronous neurotransmitter release in projections from cerebellar nuclei neurons onto gigantocellular reticular nucleus neurons, which might produce an action tremor by causing signal oscillations during movement. |
2021-02-26 |
2023-08-13 |
mouse |
| Mu Zhou, Maxwell D Melin, Wei Xu, Thomas C Südho. Dysfunction of parvalbumin neurons in the cerebellar nuclei produces an action tremor. The Journal of clinical investigation. vol 130. issue 10. 2021-02-26. PMID:32634124. |
the tremor was rescued by completely blocking synaptic transmission with tetanus toxin in cerebellar nuclei, which also reversed the tremor phenotype in the traditional harmaline-induced essential tremor model. |
2021-02-26 |
2023-08-13 |
mouse |
| Mu Zhou, Maxwell D Melin, Wei Xu, Thomas C Südho. Dysfunction of parvalbumin neurons in the cerebellar nuclei produces an action tremor. The Journal of clinical investigation. vol 130. issue 10. 2021-02-26. PMID:32634124. |
combining brain region-specific and cell type-specific genetic manipulation methods, we found that deletion of synaptotagmin-2 from excitatory parvalbumin-positive neurons in cerebellar nuclei was sufficient to generate an action tremor. |
2021-02-26 |
2023-08-13 |
mouse |
| Nitish Kamble, Pramod Kumar Pa. Tremor syndromes: A review. Neurology India. vol 66. issue Supplement. 2019-09-17. PMID:29503326. |
involvement of the deep cerebellar nuclei, cerebellar outflow tracts and the cerebrocerebellar loops has been postulated in the cerebellar tremor production. |
2019-09-17 |
2023-08-13 |
Not clear |
| William S Gibson, Hang Joon Jo, Paola Testini, Shinho Cho, Joel P Felmlee, Kirk M Welker, Bryan T Klassen, Hoon-Ki Min, Kendall H Le. Functional correlates of the therapeutic and adverse effects evoked by thalamic stimulation for essential tremor. Brain : a journal of neurology. vol 139. issue Pt 8. 2017-06-05. PMID:27329768. |
thalamic deep brain stimulation resulted in activation within established nodes of the tremor circuit: sensorimotor cortex, thalamus, contralateral cerebellar cortex and deep cerebellar nuclei (fdr q < 0.05). |
2017-06-05 |
2023-08-13 |
Not clear |
| Aasef G Shaikh, Simon Hong, Ke Liao, Jing Tian, David Solomon, David S Zee, R John Leigh, Lance M Optica. Oculopalatal tremor explained by a model of inferior olivary hypertrophy and cerebellar plasticity. Brain : a journal of neurology. vol 133. issue Pt 3. 2010-04-13. PMID:20080879. |
oculopalatal tremor develops some time after a lesion in the brain that interrupts inhibition of the inferior olive by the deep cerebellar nuclei. |
2010-04-13 |
2023-08-12 |
Not clear |
| Aasef G Shaikh, Simon Hong, Ke Liao, Jing Tian, David Solomon, David S Zee, R John Leigh, Lance M Optica. Oculopalatal tremor explained by a model of inferior olivary hypertrophy and cerebellar plasticity. Brain : a journal of neurology. vol 133. issue Pt 3. 2010-04-13. PMID:20080879. |
simulations suggest that drug therapies designed to reduce electrotonic coupling within the inferior olive or reduce the disinhibition of the cerebellar cortex on the deep cerebellar nuclei could treat oculopalatal tremor. |
2010-04-13 |
2023-08-12 |
Not clear |
| H Wilms, J Sievers, G Deusch. Animal models of tremor. Movement disorders : official journal of the Movement Disorder Society. vol 14. issue 4. 1999-11-02. PMID:10435492. |
the tremor following experimental lesion of the ventromedial tegmentum in primates closely resembles holmes tremor in humans, whereas cerebellar intention tremor is mimicked by cooling of the lateral cerebellar nuclei. |
1999-11-02 |
2023-08-12 |
human |
| J F Lorden, J Lutes, V L Michela, J Ervi. Abnormal cerebellar output in rats with an inherited movement disorder. Experimental neurology. vol 118. issue 1. 1992-11-13. PMID:1397181. |
since the electrophysiological findings cannot be ascribed to a loss of the purkinje cells that normally provide an inhibitory input to the cerebellar nuclei, the results of this study indicate the presence of a functional defect in the control of cerebellar output in the dystonic rat that accounts for the failure of these animals to display harmaline tremor and which may be critical to the motor syndrome. |
1992-11-13 |
2023-08-11 |
rat |
| J Hore, D Flamen. Evidence that a disordered servo-like mechanism contributes to tremor in movements during cerebellar dysfunction. Journal of neurophysiology. vol 56. issue 1. 1986-10-22. PMID:3746391. |
the characteristics of discontinuities and tremor that occurred in elbow flexions during cooling of the lateral cerebellar nuclei were investigated in five cebus monkeys. |
1986-10-22 |
2023-08-11 |
monkey |
| R J Elble, M H Schieber, W T Thac. Activity of muscle spindles, motor cortex and cerebellar nuclei during action tremor. Brain research. vol 323. issue 2. 1985-04-15. PMID:6241010. |
activity of muscle spindles, motor cortex and cerebellar nuclei during action tremor. |
1985-04-15 |
2023-08-12 |
monkey |