| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Fateme Tehrani, Nahideh Khosroshahi, Zarrin Keihani Doust, Soheila Dabiran, Mohammad Reza Zarkes. The Efficacy and Safety of Rapamycin in Children with Tuberous Sclerosis: A Cross-sectional Study. Iranian journal of child neurology. vol 17. issue 2. 2023-04-24. PMID:37091468. |
mutations in tsc1 or tsc2 genes have been proposed as the main causative factors responsible for developing tuberous sclerosis complex (tsc). |
2023-04-24 |
2023-08-14 |
Not clear |
| Elisa Montaguti, Valentina Gesuete, Antonella Perolo, Anna Balducci, Marta Fiorentini, Andrea Donti, Gianluigi Pil. A case of massive fetal cardiac rhabdomyoma: ultrasound features and management. The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians. vol 36. issue 1. 2023-04-09. PMID:37031967. |
fetal echoencephalography and brain magnetic resonance did not show any further fetal anomalies, but molecular genetic testing at amniocentesis revealed a heterozygotic missense variant of gene tsc2 associated with tuberous sclerosis. |
2023-04-09 |
2023-08-14 |
Not clear |
| Nyamdelger Sukhbaatar, Maria Schöller, Stephanie Deborah Fritsch, Monika Linke, Stefanie Horer, Manuela Träger, Mario Mazic, Stephan Forisch, Karine Gonzales, Jan Pascal Kahler, Carina Binder, Caroline Lassnig, Birgit Strobl, Mathias Mueller, Barbara Scheiber-Mojdehkar, Claudia Gundacker, Stefanie Dabsch, Renate Kain, Markus Hengstschläger, Steven Verhelst, Günter Weiss, Igor Theurl, Thomas Weichhar. Duodenal macrophages control dietary iron absorption via local degradation of transferrin. Blood. 2023-04-05. PMID:37018657. |
by assessing mice that harbor a macrophage-specific deletion of the tuberous sclerosis complex 2 (tsc2), a negative regulator of mtorc1, we found that these mice possessed various defects in iron metabolism including defective steady state erythropoiesis and a reduced saturation of transferrin with iron. |
2023-04-05 |
2023-08-14 |
mouse |
| Keiko Nishikawa, Yoshihiro Mezawa, Toshiyuki Kobayash. Bcat1 is controlled by Tsc2/mTORC1 pathway at expression levels and its deficiency together with Bcat2 inactivation suppresses the growth of a Tsc2 Genes to cells : devoted to molecular & cellular mechanisms. 2023-03-25. PMID:36965015. |
bcat1 is controlled by tsc2/mtorc1 pathway at expression levels and its deficiency together with bcat2 inactivation suppresses the growth of a tsc2 the tuberous sclerosis complex (tsc) gene products (tsc1/tsc2) negatively regulate mtorc1. |
2023-03-25 |
2023-08-14 |
Not clear |
| Lijun Lv, Jiyu Guan, Ruixue Zhen, Pin Lv, Mengshi Xu, Xingyuan Liu, Shishi He, Ziyu Fang, Zi Li, Yungang Lan, Huijun Lu, Wenqi He, Feng Gao, Kui Zha. Orf virus induces complete autophagy to promote viral replication via inhibition of AKT/mTOR and activation of the ERK1/2/mTOR signalling pathway in OFTu cells. Veterinary research. vol 54. issue 1. 2023-03-15. PMID:36918891. |
moreover, orfv-induced autophagic activity was found to rely on an increase in the phosphorylation of tuberous sclerosis complex 2 (tsc2) and a decrease in the phosphorylation of mammalian target of rapamycin (mtor), which is mediated by the suppression of the pi3k/akt/mtor signalling pathway and activation of the erk1/2/mtor signalling pathway. |
2023-03-15 |
2023-08-14 |
Not clear |
| Eduardo Félix Martins Santana, Ana Maria Faria Esteves, Daniella Guerra Delorenzo, Celso Hygino, Heron Werner, Edward Araujo Júnio. Tuberous Sclerosis Complex: Prenatal Diagnosis Using Ultrasound and Magnetic Resonance Imaging-A Report of Two Cases. The Indian journal of radiology & imaging. vol 33. issue 1. 2023-03-01. PMID:36855718. |
tuberous sclerosis complex (tsc) is a multiple system neurocutaneous syndrome with a genetic disorder caused by different mutations in tsc1 or tsc2. |
2023-03-01 |
2023-08-14 |
Not clear |
| Gesabel Yaneth Navarro-Velasco, Antonio Di Pietro, Manuel Sánchez López-Berge. Constitutive activation of TORC1 signalling attenuates virulence in the cross-kingdom fungal pathogen Fusarium oxysporum. Molecular plant pathology. 2023-02-25. PMID:36840362. |
inactivation of the negative regulator tuberous sclerosis complex 2 (tsc2), but not constitutive activation of the positive regulator gtr1, in f. oxysporum resulted in inappropriate activation of torc1 signalling under nutrient-limiting conditions. |
2023-02-25 |
2023-08-14 |
Not clear |
| Chao Gao, Bernadeta Zabielska, Fuyong Jiao, Daoqi Mei, Xiaona Wang, Katarzyna Kotulska, Sergiusz Jozwia. Subependymal Giant Cell Astrocytomas in Tuberous Sclerosis Complex-Current Views on Their Pathogenesis and Management. Journal of clinical medicine. vol 12. issue 3. 2023-02-11. PMID:36769603. |
introduction, tuberous sclerosis complex (tsc) is an autosomal-dominant disorder caused by mutations inactivating tsc1 or tsc2 genes and characterized by the presence of tumors involving many organs, including the brain, heart, kidneys, and skin. |
2023-02-11 |
2023-08-14 |
Not clear |
| Hirofumi Kashii, Shinya Kasai, Atsushi Sato, Yoko Hagino, Yasumasa Nishito, Toshiyuki Kobayashi, Okio Hino, Masashi Mizuguchi, Kazutaka Iked. Tsc2 mutation rather than Tsc1 mutation dominantly causes a social deficit in a mouse model of tuberous sclerosis complex. Human genomics. vol 17. issue 1. 2023-02-03. PMID:36732866. |
tsc2 mutation rather than tsc1 mutation dominantly causes a social deficit in a mouse model of tuberous sclerosis complex. |
2023-02-03 |
2023-08-14 |
mouse |
| Hirofumi Kashii, Shinya Kasai, Atsushi Sato, Yoko Hagino, Yasumasa Nishito, Toshiyuki Kobayashi, Okio Hino, Masashi Mizuguchi, Kazutaka Iked. Tsc2 mutation rather than Tsc1 mutation dominantly causes a social deficit in a mouse model of tuberous sclerosis complex. Human genomics. vol 17. issue 1. 2023-02-03. PMID:36732866. |
tuberous sclerosis complex is caused by pathogenic germline mutations of either the tsc1 or tsc2 gene, but somatic mutations were identified in both genes, and the combined effects of tsc1 and tsc2 mutations have been unknown. |
2023-02-03 |
2023-08-14 |
mouse |
| Meng Liu, Jing-Wen Mai, De-Xing Luo, Guan-Xi Liu, Ting Xu, Wen-Jun Xin, Su-Yan Lin, Zhen-Yu L. NFATc2-dependent Epigenetic Downregulation of the TSC2/Beclin-1 Pathway is Involved in Neuropathic Pain Induced by Oxaliplatin. Molecular pain. 2023-02-03. PMID:36733258. |
utilizing chromatin immunoprecipitation-sequencing (chip-seq) assay combined with bioinformatics analysis, we found that nfatc2 negatively regulated the transcription of tuberous sclerosis complex protein 2 (tsc2), which contributed to the oxaliplatin-induced beclin-1 downregulation. |
2023-02-03 |
2023-08-14 |
rat |
| Chun-Pu Lin, Joleen J H Traets, David W Vredevoogd, Nils L Visser, Daniel S Peepe. TSC2 regulates tumor susceptibility to TRAIL-mediated T-cell killing by orchestrating mTOR signaling. The EMBO journal. 2023-01-30. PMID:36715448. |
here, we use whole-genome crispr-cas9 knockout data to uncover an important role for tuberous sclerosis complex 2 (tsc2) in determining tumor susceptibility to cytotoxic t lymphocyte (ctl) killing in human melanoma cells. |
2023-01-30 |
2023-08-14 |
human |
| Satoru Meguro, Tomoyuki Koguchi, Yusuke Hakozaki, Akifumi Onagi, Kanako Matsuoka, Seiji Hoshi, Junya Hata, Yuichi Sato, Hidenori Akaihata, Masao Kataoka, Soichiro Ogawa, Yoshiyuki Kojim. Concurrent Reduced Expression of Contiguous Cancer genomics & proteomics. vol 20. issue 1. 2022-12-29. PMID:36581342. |
concurrent reduced expression of contiguous several cases of concurrent reduction of expression of polycystin 1 (pkd1) and tuberous sclerosis complex 2 (tsc2) that are contiguous in chromosome 16p13 have been previously reported. |
2022-12-29 |
2023-08-14 |
Not clear |
| Iya Ghassib, Honghao Zhang, Shuqun Qi, Rawan Moshen, Yuji Mishina, Teresita Bellido, Fei Li. Off-target activity of the 8 kb Dmp1-Cre results in the deletion of Tsc1 gene in mouse intestinal mesenchyme. Transgenic research. 2022-12-22. PMID:36547785. |
histological examination shows the presence of colon polyps in tsc1-deficient mice in association with significantly larger colon and narrower lumen, which recapitulates the common polyps pathology in tuberous sclerosis, an autosomal dominant disorder caused by mutations in either tsc1 or tsc2. |
2022-12-22 |
2023-08-14 |
mouse |
| Fei Li, Yifan Zhang, Zhoujun Lin, Lizhong Yan, Qiao Liu, Yin Li, Xiaolin Pei, Ya Feng, Xiao Han, Juan Yang, Fangxu Zheng, Tianjiao Li, Yupeng Zhang, Zhenkun Fu, Di Shao, Jane Yu, Chenggang L. Targeting SPHK1/S1PR3-regulated S-1-P metabolic disorder triggers autophagic cell death in pulmonary lymphangiomyomatosis (LAM). Cell death & disease. vol 13. issue 12. 2022-12-21. PMID:36543771. |
lymphangioleiomyomatosis (lam), a progressive pulmonary disease exclusively affecting females, is caused by defects or mutations in the coding gene tuberous sclerosis complex 1 (tsc1) or tsc2, causing the mammalian target of rapamycin complex 1 (mtorc1) activation and autophagy inhibition. |
2022-12-21 |
2023-08-14 |
Not clear |
| Yuanjun Shen, Dmitry A Goncharov, Andressa Pena, Jeffrey Baust, Andres Chavez Barragan, Arnab Ray, Analise Rode, Timothy N Bachman, Baojun Chang, Lifeng Jiang, Paul Dieffenbach, Laura E Fredenburgh, Mauricio Rojas, Horace DeLisser, Ana L Mora, Tatiana V Kudryashova, Elena A Goncharov. Cross-talk between TSC2 and the extracellular matrix controls pulmonary vascular proliferation and pulmonary hypertension. Science signaling. vol 15. issue 763. 2022-12-06. PMID:36473049. |
because cell growth mediated by the mtor-containing mtorc1 complex is inhibited by tuberous sclerosis complex 2 (tsc2), we investigated the role of this gtpase-activating protein in pah pathology. |
2022-12-06 |
2023-08-14 |
mouse |
| Huawen Xu, Yang Zhao, Qingjie Zhao, Mingpu Shi, Zhaoqi Zhang, Wenjun Ding, Yong Zha. Tuberous Sclerosis Complex 1 Deficiency in Macrophages Promotes Unclassical Inflammatory Response to Lipopolysaccharide Aging and disease. vol 13. issue 6. 2022-12-05. PMID:36465179. |
tuberous sclerosis complex 1 deficiency in macrophages promotes unclassical inflammatory response to lipopolysaccharide human tuberous sclerosis (tsc) is mainly caused by genetic mutations of tuberous tsc1or tsc2. |
2022-12-05 |
2023-08-14 |
mouse |
| Canyang Zhan, Lihua Che. [Analysis of TSC2 gene variant in a neonate with tuberous sclerosis complex]. Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics. vol 39. issue 12. 2022-12-01. PMID:36453965. |
[analysis of tsc2 gene variant in a neonate with tuberous sclerosis complex]. |
2022-12-01 |
2023-08-14 |
Not clear |
| Xue Liu, Yan Liu, Rui-Xue Yang, Xiang-Jiu Ding, Er-Shun Lian. Loss of myeloid Tsc2 predisposes to angiotensin II-induced aortic aneurysm formation in mice. Cell death & disease. vol 13. issue 11. 2022-11-18. PMID:36400753. |
genetic studies have proved the involvement of tuberous sclerosis complex subunit 2 (tsc2) in aortic aneurysm. |
2022-11-18 |
2023-08-14 |
mouse |
| Shengzhao Hu, Yingli Chen, Shipeng Huang, Min Liu, Ying Liu, Shaofang Huan. Sodium Danshensu protects against oxygen glucose deprivation/reoxygenation-induced astrocytes injury through regulating NOD-like receptor pyrin domain containing 3 (NLRP3) inflammasome and tuberous sclerosis complex-2 (TSC2)/mammalian target of rapamycin (mTOR) pathways. Annals of translational medicine. vol 10. issue 20. 2022-11-17. PMID:36388798. |
sodium danshensu protects against oxygen glucose deprivation/reoxygenation-induced astrocytes injury through regulating nod-like receptor pyrin domain containing 3 (nlrp3) inflammasome and tuberous sclerosis complex-2 (tsc2)/mammalian target of rapamycin (mtor) pathways. |
2022-11-17 |
2023-08-14 |
Not clear |