| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Y Kubo, Y Kikuchi, H Mitani, E Kobayashi, T Kobayashi, O Hin. Allelic loss at the tuberous sclerosis (Tsc2) gene locus in spontaneous uterine leiomyosarcomas and pituitary adenomas in the Eker rat model. Japanese journal of cancer research : Gann. vol 86. issue 9. 1995-12-06. PMID:7591959. |
we identified the germline mutated tuberous sclerosis (tsc2) gene as the predisposing eker gene and revealed the tumor suppressor nature of tsc2 gene function in renal carcinogenesis. |
1995-12-06 |
2023-08-12 |
rat |
| E P Henske, H P Neumann, B W Scheithauer, E W Herbst, M P Short, D J Kwiatkowsk. Loss of heterozygosity in the tuberous sclerosis (TSC2) region of chromosome band 16p13 occurs in sporadic as well as TSC-associated renal angiomyolipomas. Genes, chromosomes & cancer. vol 13. issue 4. 1995-11-22. PMID:7547639. |
loss of heterozygosity in the tuberous sclerosis (tsc2) region of chromosome band 16p13 occurs in sporadic as well as tsc-associated renal angiomyolipomas. |
1995-11-22 |
2023-08-12 |
Not clear |
| O Hino, E Kobayashi, M Nishizawa, Y Kubo, T Kobayashi, Y Hirayama, S Takai, Y Kikuchi, H Tsuchiya, K Orimot. Renal carcinogenesis in the Eker rat. Journal of cancer research and clinical oncology. vol 121. issue 9-10. 1995-11-22. PMID:7559744. |
we recently reported that a germline insertion in the rat homologue of the human tuberous sclerosis (tsc2) gene gives rise to the dominantly inherited cancer in the eker rat model. |
1995-11-22 |
2023-08-12 |
human |
| L Xu, C Sterner, M M Maheshwar, P J Wilson, M Nellist, P M Short, J L Haines, J R Sampson, V Rames. Alternative splicing of the tuberous sclerosis 2 (TSC2) gene in human and mouse tissues. Genomics. vol 27. issue 3. 1995-11-14. PMID:7558029. |
alternative splicing of the tuberous sclerosis 2 (tsc2) gene in human and mouse tissues. |
1995-11-14 |
2023-08-12 |
mouse |
| L Xu, C Sterner, M M Maheshwar, P J Wilson, M Nellist, P M Short, J L Haines, J R Sampson, V Rames. Alternative splicing of the tuberous sclerosis 2 (TSC2) gene in human and mouse tissues. Genomics. vol 27. issue 3. 1995-11-14. PMID:7558029. |
the recently isolated gene for tuberous sclerosis 2 (tsc2) encodes a 5.5-kb transcript that is widely expressed. |
1995-11-14 |
2023-08-12 |
mouse |
| O Hino, E Kobayashi, Y Hirayama, T Kobayashi, Y Kubo, H Tsuchiya, Y Kikuchi, H Mitan. Molecular genetic basis of renal carcinogenesis in the Eker rat model of tuberous sclerosis (Tsc2). Molecular carcinogenesis. vol 14. issue 1. 1995-11-06. PMID:7546221. |
molecular genetic basis of renal carcinogenesis in the eker rat model of tuberous sclerosis (tsc2). |
1995-11-06 |
2023-08-12 |
rat |
| O Hino, E Kobayashi, Y Hirayama, T Kobayashi, Y Kubo, H Tsuchiya, Y Kikuchi, H Mitan. Molecular genetic basis of renal carcinogenesis in the Eker rat model of tuberous sclerosis (Tsc2). Molecular carcinogenesis. vol 14. issue 1. 1995-11-06. PMID:7546221. |
we have recently identified on rat chromosome 10q a germline mutation in the tuberous sclerosis gene (tsc2), the gene predisposing to renal carcinoma (rc) in the eker rat. |
1995-11-06 |
2023-08-12 |
rat |
| R S Yeung, G H Xiao, J I Everitt, F Jin, C L Walke. Allelic loss at the tuberous sclerosis 2 locus in spontaneous tumors in the Eker rat. Molecular carcinogenesis. vol 14. issue 1. 1995-11-06. PMID:7546222. |
in the eker rat, spontaneous tumors of the kidney, uterus, and spleen develop as a result of a germline mutation of the tuberous sclerosis 2 (tsc2) gene. |
1995-11-06 |
2023-08-12 |
rat |
| M van Slegtenhorst, B Janssen, M Nellist, S Ramlakhan, C Hermans, A Hesseling, A van den Ouweland, D Kwiatkowski, B Eussen, J Sampso. Cosmid contigs from the tuberous sclerosis candidate region on chromosome 9q34. European journal of human genetics : EJHG. vol 3. issue 2. 1995-10-30. PMID:7552145. |
tuberous sclerosis (tsc) is a heterogeneous multisystem disorder with loci on 9q34 (tsc1) and 16p13.3 (tsc2). |
1995-10-30 |
2023-08-12 |
Not clear |
| T Kobayashi, M Nishizawa, Y Hirayama, E Kobayashi, O Hin. cDNA structure, alternative splicing and exon-intron organization of the predisposing tuberous sclerosis (Tsc2) gene of the Eker rat model. Nucleic acids research. vol 23. issue 14. 1995-09-27. PMID:7651821. |
cdna structure, alternative splicing and exon-intron organization of the predisposing tuberous sclerosis (tsc2) gene of the eker rat model. |
1995-09-27 |
2023-08-12 |
human |
| T Kobayashi, M Nishizawa, Y Hirayama, E Kobayashi, O Hin. cDNA structure, alternative splicing and exon-intron organization of the predisposing tuberous sclerosis (Tsc2) gene of the Eker rat model. Nucleic acids research. vol 23. issue 14. 1995-09-27. PMID:7651821. |
we recently reported that a germline insertion in the rat homologue of the human tuberous sclerosis gene (tsc2) gives rise to the dominantly inherited cancer in the eker rat model. |
1995-09-27 |
2023-08-12 |
human |
| G H Xiao, F Jin, R S Yeun. Germ-line Tsc2 mutation in a dominantly inherited cancer model defines a novel family of rat intracisternal-A particle elements. Oncogene. vol 11. issue 1. 1995-08-29. PMID:7624135. |
the genetic basis of this germline mutation was found to involve the tuberous sclerosis 2 (tsc2) gene. |
1995-08-29 |
2023-08-12 |
rat |
| A Pilz, P Glenister, S Povey, M Lyon, C Abbot. The mouse homologue of the human tuberous sclerosis 2 (TSC2) gene maps to chromosome 17, but does not fall within the tw18 or th20 deletions. Genomics. vol 26. issue 2. 1995-08-08. PMID:7601476. |
the mouse homologue of the human tuberous sclerosis 2 (tsc2) gene maps to chromosome 17, but does not fall within the tw18 or th20 deletions. |
1995-08-08 |
2023-08-12 |
mouse |
| J I Everitt, D C Wolf, S R Howe, T L Goldsworthy, C Walke. Rodent model of reproductive tract leiomyomata. Clinical and pathological features. The American journal of pathology. vol 146. issue 6. 1995-07-13. PMID:7778693. |
the tumors develop as a result of a germline mutation in the tuberous sclerosis 2 (tsc2) gene, and predisposition to tumor development is inherited in an autosomal dominant fashion. |
1995-07-13 |
2023-08-12 |
human |
| T Kobayashi, Y Hirayama, E Kobayashi, Y Kubo, O Hin. A germline insertion in the tuberous sclerosis (Tsc2) gene gives rise to the Eker rat model of dominantly inherited cancer. Nature genetics. vol 9. issue 1. 1995-05-11. PMID:7704028. |
a germline insertion in the tuberous sclerosis (tsc2) gene gives rise to the eker rat model of dominantly inherited cancer. |
1995-05-11 |
2023-08-12 |
human |
| T Kobayashi, Y Hirayama, E Kobayashi, Y Kubo, O Hin. A germline insertion in the tuberous sclerosis (Tsc2) gene gives rise to the Eker rat model of dominantly inherited cancer. Nature genetics. vol 9. issue 1. 1995-05-11. PMID:7704028. |
we have previously established a new conserved linkage group on rat chromosome 10q and human chromosome 16p13.3, and shown that the eker mutation is tightly linked to the tuberous sclerosis (tsc2) gene. |
1995-05-11 |
2023-08-12 |
human |
| P T Brook-Carter, B Peral, C J Ward, P Thompson, J Hughes, M M Maheshwar, M Nellist, V Gamble, P C Harris, J R Sampso. Deletion of the TSC2 and PKD1 genes associated with severe infantile polycystic kidney disease--a contiguous gene syndrome. Nature genetics. vol 8. issue 4. 1995-04-26. PMID:7894481. |
major genes which cause tuberous sclerosis (tsc) and autosomal dominant polycystic kidney disease (adpkd), known as tsc2 and pkd1 respectively, lie immediately adjacent to each other on chromosome 16p. |
1995-04-26 |
2023-08-12 |
Not clear |
| Y Kubo, F Klimek, Y Kikuchi, P Bannasch, O Hin. Early detection of Knudson's two-hits in preneoplastic renal cells of the Eker rat model by the laser microdissection procedure. Cancer research. vol 55. issue 5. 1995-03-30. PMID:7867009. |
we previously reported that ionizing radiation induces additional tumors (large adenomas and carcinomas) in a linear dose-response relationship and that loss of heterozygosity (loh) at chromosome 10, where the predisposing tuberous sclerosis (tsc2) gene is localized, was found in the renal cell carcinomas which developed from hybrid f1 rats carrying the eker mutation, indicating that in heterozygotes two events (one inherited, one somatic) are necessary to produce at least large adenomas and carcinomas. |
1995-03-30 |
2023-08-12 |
rat |
| A J Green, P H Johnson, J R Yate. The tuberous sclerosis gene on chromosome 9q34 acts as a growth suppressor. Human molecular genetics. vol 3. issue 10. 1995-03-16. PMID:7849709. |
we have previously demonstrated allele loss in hamartomas from patients with tuberous sclerosis for markers spanning the tuberous sclerosis gene on chromosome 16q13.3 (tsc2). |
1995-03-16 |
2023-08-12 |
Not clear |
| A J Green, P H Johnson, J R Yate. The tuberous sclerosis gene on chromosome 9q34 acts as a growth suppressor. Human molecular genetics. vol 3. issue 10. 1995-03-16. PMID:7849709. |
germline deletions in the tsc2 gene have been shown in 5% of patients with tuberous sclerosis (tsc). |
1995-03-16 |
2023-08-12 |
Not clear |