| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Fatima Z Saddouk, Andrew P Kuzemczak, Junichi Saito, Daniel M Grei. Endothelial HIFα-PDGF-B to smooth muscle Beclin1 signaling sustains pathological muscularization in pulmonary hypertension. JCI insight. 2024-04-23. PMID:38652543. |
finally, smc-specific becn1 deletion induced apoptosis, reversing distal muscularization and ph mediated by hypoxia ± sugen 5416. |
2024-04-23 |
2024-04-26 |
mouse |
| Yuxuan Ma, Yining Chen, Yan Li, Shaoxian Chen, Chao Zhu, Qimin Liu, Long Li, Heran Cao, Zifang Wu, Wuzi Don. Seasonal modulation of the testis transcriptome reveals insights into hibernation and reproductive adaptation in Onychostoma macrolepis. Fish physiology and biochemistry. 2024-04-22. PMID:38649597. |
furthermore, in january, we observed the regulation of autophagy and apoptosis (becn1, casp13), which may have the function of protecting reproductive organs and ensuring their maturity for the breeding season. |
2024-04-22 |
2024-04-26 |
Not clear |
| Shufeng Lin, Huiyang Guo, Xiaoxuan You, Zefeng Zhang, Hui Y. SND1 aggravates mitochondrial damage, apoptosis and extracellular matrix degradation in IL-1β-stimulated chondrocytes via PINK1/BECN1 pathway. European journal of medical research. vol 28. issue 1. 2023-09-25. PMID:37749650. |
furthermore, we found that pink1 upregulated becn1 protein expression and that becn reversed the inhibitory effects of pink1 silencing on il-1β-induced mitochondrial damage, inflammatory reaction, apoptosis and extracellular matrix degradation. |
2023-09-25 |
2023-10-07 |
mouse |
| Sameh Saber, Mohannad Mohammad S Alamri, Jaber Alfaifi, Lobna A Saleh, Sameh Abdel-Ghany, Adel Mohamed Aboregela, Alshaimaa A Farrag, Abdulrahman H Almaeen, Masoud I E Adam, AbdulElah Al Jarallah AlQahtani, Ali M S Eleragi, Mustafa Ahmed Abdel-Reheim, Heba A Ramadan, Osama A Mohamme. (R,R)-BD-AcAc2 Mitigates Chronic Colitis in Rats: A Promising Multi-Pronged Approach Modulating Inflammasome Activity, Autophagy, and Pyroptosis. Pharmaceuticals (Basel, Switzerland). vol 16. issue 7. 2023-07-29. PMID:37513865. |
these effects were attributed to inhibiting nfκb and nlrp3 inflammasome activation and restraining pyroptosis and apoptosis while enhancing autophagy as revealed by reduced p62 and increased becn1. |
2023-07-29 |
2023-08-14 |
human |
| Pooja Popli, Ramakrishna Kommagan. Autophagy is required for stem-cell-mediated endometrial programming and the establishment of pregnancy. Autophagy. 2023-07-05. PMID:37405371. |
recently, we reported that becn1 (beclin1)-dependent autophagy, but not apoptosis, is crucial for stem cell-mediated endometrial programming and the establishment of pregnancy in mice. |
2023-07-05 |
2023-08-14 |
mouse |
| Rong Zhao, Yan Liu, Ziwei Wang, Jun Zhang, Wei Zhang, Xing Zhou, Sevjid Tsedendorj, Amarsanaa Enkhtur, Dilu Feng, Hongbo Wan. UBE2C-mediated autophagy inhibition via ubiquitination of SIRT1 contributes to endometrial cancer progression. Molecular cancer research : MCR. 2023-03-17. PMID:36930831. |
the results of cck-8, hoechst staining, and immunofluorescence assays further indicated that deletion of the autophagy-related gene becn1 significantly attenuates ube2c knockdown-induced cell apoptosis. |
2023-03-17 |
2023-08-14 |
mouse |
| Seyma Calis, Berna Dogan, Serdar Durdagi, Asuman Celebi, Ozlem Yapicier, Turker Kilic, Eda Tahir Turanli, Timucin Avsa. A novel BH3 mimetic Bcl-2 inhibitor promotes autophagic cell death and reduces in vivo Glioblastoma tumor growth. Cell death discovery. vol 8. issue 1. 2022-10-30. PMID:36309485. |
while abt-199 successfully induces apoptosis in high bcl2-expressing neuroblastoma shsy-5y cells, bau-243 triggered autophagic cell death rather than apoptosis in gbm a172 cells, indicated by the upregulation of becn1, atg5, and map1lc3b expression. |
2022-10-30 |
2023-08-14 |
Not clear |
| Amir Raoofi, Ali Delbari, Davood Nasiry, Rahim Golmohammadi, Sara Sadat Javadinia, Reza Sadrzadeh, Mohammad-Shafi Mojadadi, Auob Rustamzadeh, Amin Mousavi Khaneghah, Vahid Ebrahimi, Mohammad Jafar Rezai. Caffeine modulates apoptosis, oxidative stress, and inflammation damage induced by tramadol in cerebellum of male rats. Journal of chemical neuroanatomy. 2022-06-06. PMID:35660069. |
at the end of study (day 21), after performing rotarod behavioral test, cerebellum tissue samples were removed and prepared for further evaluations including biochemical profile markers (mda, gpx, and sod), immunohistochemistry for caspase-3, as well as the expression of genes involved in cellular processes such as inflammation markers (il-1β, hmgb1, il-6, and tnf), apoptosis markers (caspase-3, caspase-8, bax, and p21), and autophagy markers (lamp2, atg5, becn1, and atg12). |
2022-06-06 |
2023-08-14 |
rat |
| Juan Dong, Changquan Guo, Shuo Zhou, An Zhao, Jian Li, Yuling Mi, Caiqiao Zhan. Leukemia inhibitory factor prevents chicken follicular atresia through PI3K/AKT and Stat3 signaling pathways. Molecular and cellular endocrinology. 2022-01-06. PMID:34990741. |
further investigation revealed that lif inhibited the gc autophagic apoptosis by activating pi3k/akt and stat3 pathways, reflecting an increase of bcl-2 expression but a decrease in becn1. |
2022-01-06 |
2023-08-13 |
chicken |
| A Al Hargan, M H Daghestani, A H Harrat. Alterations in APC, BECN1, and TP53 gene expression levels in colon cancer cells caused by monosodium glutamate. Brazilian journal of biology = Revista brasleira de biologia. vol 83. 2021-12-15. PMID:34909835. |
tp53 is a tumor suppressor gene that functions in modifying dna errors and/or inducing apoptosis of damaged cells, and both apc and becn1 genes are involved in crc and are of importance in cellular growth and metastasis. |
2021-12-15 |
2023-08-13 |
Not clear |
| Mala Singh, Mohmmad Shoab Mansuri, Ashlesha Kadam, Sayantani P Palit, Mitesh Dwivedi, Naresh C Laddha, Rasheedunnisa Begu. Tumor Necrosis Factor-alpha affects melanocyte survival and melanin synthesis via multiple pathways in vitiligo. Cytokine. vol 140. 2021-08-20. PMID:33517195. |
tnf-α exposure stimulated cell apoptosis at 48 h and autophagy at 12 h, elevating atg12 and becn1 transcripts. |
2021-08-20 |
2023-08-13 |
Not clear |
| Xiaoqin Liu, Qingzhao Li, Lixin Sun, Limei Chen, Yue Li, Beibei Huang, Yunshuang Liu, Chunyang Jian. miR-30e-5p regulates autophagy and apoptosis by targeting Beclin1 involved in contrast-induced acute kidney injury. Current medicinal chemistry. 2021-05-27. PMID:34042027. |
this study aims to verify if mir-30e-5p targets beclin1 (becn1), a key regulator of autophagy, and investigate the function of mir-30e-5p and beclin1 through mediating autophagy and apoptosis in contrast-induced acute kidney injury (ci-aki). |
2021-05-27 |
2023-08-13 |
Not clear |
| Kamolchanok Deesrisak, Yodying Yingchutrakul, Sucheewin Krobthong, Sittiruk Roytrakul, Chawalit Chatupheeraphat, Paweena Subkorn, Usanarat Anurathapan, Dalina Tanyon. Bioactive peptide isolated from sesame seeds inhibits cell proliferation and induces apoptosis and autophagy in leukemic cells. EXCLI journal. vol 20. 2021-04-29. PMID:33907539. |
im-7 activated apoptosis and autophagy through the upregulation of casp3, ulk1 and becn1 and the downregulation of bcl2. |
2021-04-29 |
2023-08-13 |
Not clear |
| Javid Sadri Nahand, Layla Shojaie, Seyed Amirreza Akhlagh, Mohammad Saeid Ebrahimi, Hamid Reza Mirzaei, Hossein Bannazadeh Baghi, Maryam Mahjoubin-Tehran, Nima Rezaei, Michael R Hamblin, Vida Tajiknia, Neda Rahimian, Hamed Mirzae. Cell death pathways and viruses: Role of microRNAs. Molecular therapy. Nucleic acids. vol 24. 2021-04-28. PMID:33898103. |
several molecules (e.g., becn1 and b cell lymphoma 2 [bcl2] family members) are involved in both apoptosis and autophagy, while activation of anoikis leads to cell death similar to apoptosis. |
2021-04-28 |
2023-08-13 |
human |
| Yuehua Yang, Zunwen Lin, Jiangwei Cheng, Sheng Ding, Wei-Wei Mao, Sheng Shi, Biru Liang, Leisheng Jian. The roles of autophagy in osteogenic differentiation in rat ligamentum fibroblasts: Evidence and possible implications. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 34. issue 7. 2021-03-01. PMID:32510740. |
inhibition of autophagy with either pharmacologic inhibitors (bafilomycin a and 3-methyladenine) or belcin1 (becn1) knocking down weakened the mineralization capacity, decreased the gene expressions of col1a1, osteocalcin (ocn), and runt-related transcription factor 2 (runx2) in the ligamentum fibroblasts and increased cell apoptosis. |
2021-03-01 |
2023-08-13 |
rat |
| Marzena Ułamek-Kozioł, Stanisław J Czuczwar, Janusz Kocki, Sławomir Januszewski, Jacek Bogucki, Anna Bogucka-Kocka, Ryszard Plut. Dysregulation of Autophagy, Mitophagy, and Apoptosis Genes in the CA3 Region of the Hippocampus in the Ischemic Model of Alzheimer's Disease in the Rat. Journal of Alzheimer's disease : JAD. vol 72. issue 4. 2020-12-04. PMID:31707369. |
there is currently no knowledge about the expression profile of the autophagy (becn1), mitophagy (bnip3), and apoptosis (casp3) genes in the ca3 region of the hippocampus after cerebral ischemia. |
2020-12-04 |
2023-08-13 |
rat |
| Fanfan Yi, Yugui Hao, Xiaoyi Chong, Wei Zhon. Overexpression of microRNA-506-3p aggravates the injury of vascular endothelial cells in patients with hypertension by downregulating Beclin1 expression. Experimental and therapeutic medicine. vol 15. issue 3. 2020-10-01. PMID:29456688. |
by downregulating becn1 expression, mir-506-3p aggravates injury in vascular endothelial cells by inhibiting the proliferation and migration of huvecs, as well as promoting their apoptosis. |
2020-10-01 |
2023-08-13 |
human |
| Noelia P Leopardo, Mariela E Velazquez, Santiago Cortasa, Candela R González, Alfredo D Vitull. A dual death/survival role of autophagy in the adult ovary of Lagostomus maximus (Mammalia- Rodentia). PloS one. vol 15. issue 5. 2020-07-31. PMID:32469908. |
we report here our analysis of autophagy (becn1, lamp1 and lc3b-i/ii) and apoptosis (bcl2 and active caspase-3) markers which revealed interactive behaviors between both processes, with autophagy promoting survival or cell death depending on the ovarian structure. |
2020-07-31 |
2023-08-13 |
Not clear |
| Wei Huang, Chong Zeng, Jie Liu, Li Yuan, Weidong Liu, Lei Wang, Hecheng Zhu, Yang Xu, Yi Luo, Dan Xie, Xingjun Jiang, Caiping Re. Sodium butyrate induces autophagic apoptosis of nasopharyngeal carcinoma cells by inhibiting AKT/mTOR signaling. Biochemical and biophysical research communications. vol 514. issue 1. 2020-06-26. PMID:31023529. |
moreover, autophagy inhibition, achieved by 3-ma treatment or becn1 knockdown, can antagonize nabu induced apoptosis reflecting by re-deregulated cparp and apoptotic rates. |
2020-06-26 |
2023-08-13 |
Not clear |
| Hai Zhang, Xiaoqing Dong, Rui Zhao, Ruijie Zhang, Chong Xu, Xiaoxue Wang, Chunxiao Liu, Xiaoyu Hu, Shile Huang, Long Che. Cadmium results in accumulation of autophagosomes-dependent apoptosis through activating Akt-impaired autophagic flux in neuronal cells. Cellular signalling. vol 55. 2020-04-06. PMID:30578829. |
of note, inhibition of akt with akt inhibitor x, or ectopic expression of dominant negative akt (dn-akt), in the presence or absence of 3-ma, significantly alleviated cd-triggered phosphorylation of akt and becn1, autophagosomes, and apoptosis. |
2020-04-06 |
2023-08-13 |
Not clear |