| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xing-Hui Shen, Yong-Xun Jin, Shuang Liang, Jeong-Woo Kwon, Ji-Wei Zhu, Lei Lei, Nam-Hyung Ki. Autophagy is required for proper meiosis of porcine oocytes maturing in vitro. Scientific reports. vol 8. issue 1. 2019-10-21. PMID:30135500. |
moreover, becn1 knockdown and treatment with the autophagy inhibitor, ly294002, during maturation of porcine oocytes in vitro impaired polar body extrusion, disturbed mitochondrial function, triggered the dna damage response, and induced early apoptosis in porcine oocytes. |
2019-10-21 |
2023-08-13 |
Not clear |
| Cheng-Lin Wu, Shi-Meng Zhang, Li Lin, Shan-Shan Gao, Kai-Fei Fu, Xiao-Dan Liu, Yan Liu, Li-Jun Zhou, Ping-Kun Zho. BECN1-knockout impairs tumor growth, migration and invasion by suppressing the cell cycle and partially suppressing the epithelial-mesenchymal transition of human triple-negative breast cancer cells. International journal of oncology. vol 53. issue 3. 2018-11-26. PMID:30015871. |
functional analysis revealed that complete loss of becn1 suppressed mda‑mb‑231 proliferation and colony formation via inducing g0/g1 cell cycle arrest, not apoptosis, in vitro. |
2018-11-26 |
2023-08-13 |
mouse |
| Rui Zhong, Bing Liang, Rui Xin, Xuanji Zhu, Zhuo Liu, Qiao Chen, Yufei Hou, Zhao Jin, Mu Qi, Shumei Ma, Xiaodong Li. Deoxycytidine kinase participates in the regulation of radiation-induced autophagy and apoptosis in breast cancer cells. International journal of oncology. vol 52. issue 3. 2018-08-31. PMID:29393406. |
taken together, our findings indicate that phosphorylated and activated dck inhibits ir-induced total cell death and apoptosis, and promotes ir-induced autophagy through the mtor pathway and by inhibiting the binding of bcl‑2 protein to becn1. |
2018-08-31 |
2023-08-13 |
Not clear |
| Jie Yuan, Xueyan Zhao, Yujuan Hu, Haiying Sun, Guoqing Gong, Xiang Huang, Xubo Chen, Mingyu Xia, Chen Sun, Qilin Huang, Yu Sun, Wen Kong, Weijia Kon. Autophagy regulates the degeneration of the auditory cortex through the AMPK-mTOR-ULK1 signaling pathway. International journal of molecular medicine. vol 41. issue 4. 2018-08-29. PMID:29344647. |
compared with the age‑matched ns group, the d‑gal group demonstrated significantly increased levels of the autophagy‑related proteins, lc3 and beclin 1 (becn1) and the anti‑apoptotic proteins b‑cell lymphoma (bcl)2 and bcl‑extra large (bcl‑xl) at 3 months, with no obvious changes in cell apoptosis level and neuron ultrastructural morphology. |
2018-08-29 |
2023-08-13 |
rat |
| Jie Yuan, Xueyan Zhao, Yujuan Hu, Haiying Sun, Guoqing Gong, Xiang Huang, Xubo Chen, Mingyu Xia, Chen Sun, Qilin Huang, Yu Sun, Wen Kong, Weijia Kon. Autophagy regulates the degeneration of the auditory cortex through the AMPK-mTOR-ULK1 signaling pathway. International journal of molecular medicine. vol 41. issue 4. 2018-08-29. PMID:29344647. |
however, lc3, becn1, bcl2 and bcl‑xl were decreased at 15 months in the d-gal group, with cell apoptosis significantly increased and substantial neuron degeneration. |
2018-08-29 |
2023-08-13 |
rat |
| Yoshinari Okada, Shunsuke Kato, Yasuhiro Sakamoto, Takayuki Oishi, Chikashi Ishiok. Synthetic lethal interaction of CDK inhibition and autophagy inhibition in human solid cancer cell lines. Oncology reports. vol 38. issue 1. 2018-04-06. PMID:28560460. |
in the cell lines showing autophagy, which was induced by cdk4 inhibitor, the combination of cdk4 inhibitor and autophagy inhibition by either chloroquine (cq) or knockdown of atg5 or becn1 induced apoptosis. |
2018-04-06 |
2023-08-13 |
human |
| Boris Reljic, Stephanie Conos, Erinna F Lee, Jean-Marc Garnier, Li Dong, Guillaume Lessene, W Douglas Fairlie, David L Vaux, Lisa M Lindqvis. BAX-BAK1-independent LC3B lipidation by BH3 mimetics is unrelated to BH3 mimetic activity and has only minimal effects on autophagic flux. Autophagy. vol 12. issue 7. 2018-01-16. PMID:27172402. |
here we confirm that small molecule bh3 mimetics can induce bax- and bak1-independent map1lc3b/lc3b lipidation, but this only occurred at concentrations far greater than required to induce apoptosis and dissociate canonical bh3 domain-containing proteins that bind more tightly than becn1. |
2018-01-16 |
2023-08-13 |
Not clear |
| Yang Mei, Karen Glover, Minfei Su, Sangita C Sinh. Conformational flexibility of BECN1: Essential to its key role in autophagy and beyond. Protein science : a publication of the Protein Society. vol 25. issue 10. 2017-07-10. PMID:27414988. |
becn1 (beclin 1), a highly conserved eukaryotic protein, is a key regulator of autophagy, a cellular homeostasis pathway, and also participates in vacuolar protein sorting, endocytic trafficking, and apoptosis. |
2017-07-10 |
2023-08-13 |
Not clear |
| Roberto D V S Morais, Ralph G Thomé, Hélio B Santos, Nilo Bazzoli, Elizete Rizz. Relationship between bcl-2, bax, beclin-1, and cathepsin-D proteins during postovulatory follicular regression in fish ovary. Theriogenology. vol 85. issue 6. 2016-12-13. PMID:26719039. |
morphometric analysis of the immunolabeling revealed a more intense reaction for bcl-2 and beclin-1 (becn1) in pofs at 0 to 1 dps and for bax at 2 to 3 dps (p < 0.001), the later period being the peak of apoptosis of the follicular cells. |
2016-12-13 |
2023-08-13 |
Not clear |
| Roberto D V S Morais, Ralph G Thomé, Hélio B Santos, Nilo Bazzoli, Elizete Rizz. Relationship between bcl-2, bax, beclin-1, and cathepsin-D proteins during postovulatory follicular regression in fish ovary. Theriogenology. vol 85. issue 6. 2016-12-13. PMID:26719039. |
double labeling for becn1 and caspase-3 indicated a shift in the relationship between autophagy and apoptosis at 2 to 3 dps, a critical period in determining the fate of follicular cells in pofs. |
2016-12-13 |
2023-08-13 |
Not clear |
| Bilal Rah, Reyaz ur Rasool, Debasis Nayak, Syed Khalid Yousuf, Debaraj Mukherjee, Lekha Dinesh Kumar, Anindya Goswam. PAWR-mediated suppression of BCL2 promotes switching of 3-azido withaferin A (3-AWA)-induced autophagy to apoptosis in prostate cancer cells. Autophagy. vol 11. issue 2. 2016-01-26. PMID:25803782. |
second, higher toxic concentrations of 3-awa stimulated er stress in cap cells to turn on apoptosis within 12 h by elevating the expression of the proapoptotic protein pawr, which in turn suppressed the autophagy-related proteins bcl2 and becn1. |
2016-01-26 |
2023-08-13 |
Not clear |
| Michela Guglielmotto, Debora Monteleone, Antonio Piras, Valeria Valsecchi, Marta Tropiano, Stefania Ariano, Michele Fornaro, Alessandro Vercelli, Julien Puyal, Ottavio Arancio, Massimo Tabaton, Elena Tamagn. Aβ1-42 monomers or oligomers have different effects on autophagy and apoptosis. Autophagy. vol 10. issue 10. 2015-05-19. PMID:25136804. |
monomers also inhibit apoptosis and allow autophagy with intracellular accumulation of autophagosomes and elevation of levels of becn1 and lc3-ii, resulting in an inhibition of substrate degradation due to an inhibitory action on lysosomal activity. |
2015-05-19 |
2023-08-13 |
Not clear |
| Hong Liu, Su Mi, Zhe Li, Fang Hua, Zhuo-Wei H. Interleukin 17A inhibits autophagy through activation of PIK3CA to interrupt the GSK3B-mediated degradation of BCL2 in lung epithelial cells. Autophagy. vol 9. issue 5. 2013-11-22. PMID:23514933. |
here we report that the phosphorylation of b-cell cll/lymphoma 2 (bcl2), an apoptosis regulatory protein, was inhibited in the presence of il17a in lung epithelial cells, and this reduction suppressed the ubiquitination degradation of bcl2, which subsequently attenuated autophagy by promoting the interaction of bcl2 and becn1. |
2013-11-22 |
2023-08-12 |
Not clear |
| Ming-Hui Zou, Zhonglin Xi. Regulation of interplay between autophagy and apoptosis in the diabetic heart: new role of AMPK. Autophagy. vol 9. issue 4. 2013-09-24. PMID:23380689. |
we conclude that dissociation of bcl2 from becn1 through activation of mapk8-bcl2 signaling may be an important mechanism by which ampk activation restores autophagy, protects against cardiac apoptosis, and prevents diabetic cardiomyopathy. |
2013-09-24 |
2023-08-12 |
Not clear |
| Aurore Trocoli, Julie Mathieu, Muriel Priault, Josy Reiffers, Sylvie Souquère, Gérard Pierron, Françoise Besançon, Mojgan Djavaheri-Mergn. ATRA-induced upregulation of Beclin 1 prolongs the life span of differentiated acute promyelocytic leukemia cells. Autophagy. vol 7. issue 10. 2012-03-30. PMID:21691148. |
small interfering rna-mediated knockdown of becn1 expression enhances apoptosis triggered by atra in nb4 cells but does not affect the differentiation process. |
2012-03-30 |
2023-08-12 |
Not clear |
| Thomas R Gawriluk, Amber N Hale, Jodi A Flaws, Christopher P Dillon, Douglas R Green, Edmund B Rucke. Autophagy is a cell survival program for female germ cells in the murine ovary. Reproduction (Cambridge, England). vol 141. issue 6. 2011-09-26. PMID:21464117. |
although previous models have determined roles for apoptosis in male and female fertility, we find that compromised autophagy within the perinatal ovary, through the loss of becn1 or atg7, results in the premature loss of female germ cells. |
2011-09-26 |
2023-08-12 |
mouse |
| Qian Jiang, Yuhan Wang, Tianjiao Li, Kejian Shi, Zhushi Li, Yushi Ma, Feng Li, Hui Luo, Yang Yang, Caimin X. Heat shock protein 90-mediated inactivation of nuclear factor-κB switches autophagy to apoptosis through becn1 transcriptional inhibition in selenite-induced NB4 cells. Molecular biology of the cell. vol 22. issue 8. 2011-08-16. PMID:21346199. |
heat shock protein 90-mediated inactivation of nuclear factor-κb switches autophagy to apoptosis through becn1 transcriptional inhibition in selenite-induced nb4 cells. |
2011-08-16 |
2023-08-12 |
human |
| Qian Jiang, Yuhan Wang, Tianjiao Li, Kejian Shi, Zhushi Li, Yushi Ma, Feng Li, Hui Luo, Yang Yang, Caimin X. Heat shock protein 90-mediated inactivation of nuclear factor-κB switches autophagy to apoptosis through becn1 transcriptional inhibition in selenite-induced NB4 cells. Molecular biology of the cell. vol 22. issue 8. 2011-08-16. PMID:21346199. |
excessive or insufficient expression indicates that hsp90 protects nb4 cells from selenite-induced apoptosis, and selenite-induced decreases in the expression of hsp90, especially in nb4 cells, inhibit the activities of the iκb kinase/nuclear factor-κb (ikk/nf-κb) signaling pathway, leading to less nuclear translocation and inactivation of nf-κb and the subsequent weak binding of the becn1 promoter, which facilitates the transition from autophagy to apoptosis. |
2011-08-16 |
2023-08-12 |
human |
| Antonia P Sagona, Ioannis P Nezis, Kristi G Bache, Kaisa Haglund, Anne Cathrine Bakken, Rolf I Skotheim, Harald Stenmar. A tumor-associated mutation of FYVE-CENT prevents its interaction with Beclin 1 and interferes with cytokinesis. PloS one. vol 6. issue 3. 2011-07-25. PMID:21455500. |
the tumor suppressor activity of beclin 1 (becn1), a subunit of class iii phosphatidylinositol 3-kinase complex, has been attributed to its regulation of apoptosis and autophagy. |
2011-07-25 |
2023-08-12 |
Not clear |
| Anatasha C Crawford, Rebecca B Riggins, Ayesha N Shajahan, Alan Zwart, Robert Clark. Co-inhibition of BCL-W and BCL2 restores antiestrogen sensitivity through BECN1 and promotes an autophagy-associated necrosis. PloS one. vol 5. issue 1. 2010-05-20. PMID:20062536. |
following bcl-w+bcl2 co-inhibition, suppression of functional autophagy by 3-methyladenine or becn1 shrna reduces ici-induced necrosis but restores the ability of resistant cells to die through apoptosis. |
2010-05-20 |
2023-08-12 |
Not clear |