| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mouna Tabebi, Bodour Khabou, Hanen Boukadi, Mariam Ben Hamad, Bochra Ben Rhouma, Slim Tounsi, Abdellatif Maalej, Hassen Kamoun, Leila Keskes-Ammar, Mohamed Abid, Mouna Mnif, Faiza Fakhfak. Association study of apoptosis gene polymorphisms in mitochondrial diabetes: A potential role in the pathogenicity of MD. Gene. vol 639. 2017-12-27. PMID:28987347. |
we found 10 selected polymorphisms (p53 (rs1042522 and rs17878362), bcl2 (rs2279115), bax (rs1805419), bak1 (rs210132 and rs2227925), casp3 (rs1405937), casp7 (rs2227310), casp8 (rs1045485) and casp10 (rs13006529)) with a potential apoptosis effect in md patients compared to control population. |
2017-12-27 |
2023-08-13 |
Not clear |
| Ji-Liang Zhang, Christopher Laurence Souders, Nancy D Denslow, Christopher J Martyniu. Quercetin, a natural product supplement, impairs mitochondrial bioenergetics and locomotor behavior in larval zebrafish (Danio rerio). Toxicology and applied pharmacology. vol 327. 2017-06-13. PMID:28450151. |
there were no changes in transcripts related to apoptosis (bcl2, bax, casp3, casp7), but we did observe a decrease in mrna levels for catalase (cat) in fish exposed to each dose, supporting an oxidative stress response. |
2017-06-13 |
2023-08-13 |
cat |
| Khurrum Shahzad, Fabian Bock, Moh'd Mohanad Al-Dabet, Ihsan Gadi, Shrey Kohli, Sumra Nazir, Sanchita Ghosh, Satish Ranjan, Hongjie Wang, Thati Madhusudhan, Peter P Nawroth, Berend Iserman. Caspase-1, but Not Caspase-3, Promotes Diabetic Nephropathy. Journal of the American Society of Nephrology : JASN. vol 27. issue 8. 2017-05-24. PMID:26832955. |
accordingly, analysis of gene expression data in the nephromine database revealed persistently elevated glomerular expression of inflammasome markers (nlrp3, casp1, pycard, il-18, il-1β), but not of apoptosis markers (casp3, casp7, parp1), in patients with and murine models of dnp. |
2017-05-24 |
2023-08-13 |
mouse |
| João Pereira de Lima, Susana N Silva, José Rueff, Marta Pingarilh. Glycidamide genotoxicity modulated by Caspases genes polymorphisms. Toxicology in vitro : an international journal published in association with BIBRA. vol 34. 2017-03-23. PMID:27062911. |
the present study intended to correlate the role of key polymorphic genes of apoptosis (casp7, casp8, casp9, casp10, lta and tnfrsf1b) with biomarkers of effect of dna damage, namely the sister chromatid exchange assay (sce) and the comet assay in whole blood cells exposed to ga. |
2017-03-23 |
2023-08-13 |
human |
| Giuliana Castello Coatti, Juliana Cristina Marcarini, Daniele Sartori, Queli Cristina Fidelis, Dalva Trevisan Ferreira, Mário Sérgio Mantovan. Cytotoxicity, genotoxicity and mechanism of action (via gene expression analysis) of the indole alkaloid aspidospermine (antiparasitic) extracted from Aspidosperma polyneuron in HepG2 cells. Cytotechnology. vol 68. issue 4. 2016-07-26. PMID:25894792. |
there was no significant modulation of the expression of the following genes: gstp1 and gpx1 (xenobiotic metabolism); cat (oxidative stress); tp53 and ccna2 (cell cycle); hspa5, ern1, eif2ak3 and traf2 (endoplasmic reticulum stress); casp8, casp9, casp3, casp7, bcl-2, bcl-xl bax and bax (apoptosis); and pcbp4, ercc4, ogg1, rad21 and mlh1 (dna repair). |
2016-07-26 |
2023-08-13 |
human |
| Natasha R Catlin, Susan M Huse, Kim Boekelheid. The stage-specific testicular germ cell apoptotic response to low-dose radiation and 2,5-hexanedione combined exposure. II: qRT-PCR array analysis reveals dose dependent adaptive alterations in the apoptotic pathway. Toxicologic pathology. vol 42. issue 8. 2015-08-11. PMID:24670816. |
the apoptosis pcr arrays identified significant dose-dependent treatment effects on several genes, with downregulation of death receptor 5 (dr5), naip2, sphk2, casp7, aven, birc3, and upregulation of fas. |
2015-08-11 |
2023-08-12 |
rat |
| Hongyan Sun, Guomin Zhang, Fulu Dong, Feng Wang, Wenguang Ca. Reprogramming sertoli cells into pluripotent stem cells. Cellular reprogramming. vol 16. issue 3. 2015-01-02. PMID:24802333. |
moreover, no prevented scipscs from undergoing apoptosis by activating the antiapoptotic genes bcl2 and bcl2lll, downregulating the proapoptotic genes bak1 and casp7, and blocking the activation of the proapoptotic gene bac. |
2015-01-02 |
2023-08-13 |
mouse |
| Shreyasi Choudhury, Sonali Nashine, Yogesh Bhootada, Mansi Motiwale Kunte, Oleg Gorbatyuk, Alfred S Lewin, Marina Gorbatyu. Modulation of the rate of retinal degeneration in T17M RHO mice by reprogramming the unfolded protein response. Advances in experimental medicine and biology. vol 801. 2014-07-24. PMID:24664731. |
in addition, the casp7 ablation leads to the inhibition of cjun mediated apoptosis, while the ablation of chop induces an increase in the hdac. |
2014-07-24 |
2023-08-12 |
mouse |
| Meng-Yun Wang, Mei-Ling Zhu, Jing He, Ting-Yan Shi, Qiao-Xin Li, Ya-Nong Wang, Jin Li, Xiao-Yan Zhou, Meng-Hong Sun, Xiao-Feng Wang, Ya-Jun Yang, Jiu-Cun Wang, Li Jin, Qing-Yi We. Potentially functional polymorphisms in the CASP7 gene contribute to gastric adenocarcinoma susceptibility in an eastern Chinese population. PloS one. vol 8. issue 9. 2014-06-15. PMID:24040159. |
caspase 7 (casp7) is an important regulator and executioner in the apoptosis pathway and plays a crucial role in cancer development and progression. |
2014-06-15 |
2023-08-12 |
Not clear |
| Yuan-Feng Lin, Tsung-Ching Lai, Chih-Kang Chang, Chi-Long Chen, Ming-Shyan Huang, Chih-Jen Yang, Hon-Ge Liu, Jhih-Jhong Dong, Yi-An Chou, Kuo-Hsun Teng, Shih-Hsun Chen, Wei-Ting Tian, Yi-Hua Jan, Michael Hsiao, Po-Huang Lian. Targeting the XIAP/caspase-7 complex selectively kills caspase-3-deficient malignancies. The Journal of clinical investigation. vol 123. issue 9. 2013-11-26. PMID:23979166. |
because casp3/dr cancer cells rely heavily on the activity of caspase-7 (casp7) to initiate apoptosis, inhibition of activated casp7 (p19/p12-casp7) by x-linked inhibitor of apoptosis protein (xiap) is a potential mechanism by which apoptosis is prevented in those cancer cells. |
2013-11-26 |
2023-08-12 |
Not clear |
| Songyu Cao, Cheng Wang, Xinen Huang, Juncheng Dai, Lingmin Hu, Yao Liu, Jiaping Chen, Hongxia Ma, Guangfu Jin, Zhibin Hu, Lin Xu, Hongbing She. Prognostic assessment of apoptotic gene polymorphisms in non-small cell lung cancer in Chinese. Journal of biomedical research. vol 27. issue 3. 2013-07-04. PMID:23720679. |
to test this hypothesis, we selected 38 potentially functional single nucleotide polymorphisms (snps) from 12 genes (bax, bcl2, bid, casp3, casp6, casp7, casp8, casp9, casp10, fas, faslg and mcl1) involved in apoptosis to assess their prognostic significance in lung cancer in a chinese case cohort with 568 non-small cell lung cancer (nsclc) patients. |
2013-07-04 |
2023-08-12 |
Not clear |
| Yanxia Ning, Rebecca B Riggins, Jennifer E Mulla, Haniee Chung, Alan Zwart, Robert Clark. IFNgamma restores breast cancer sensitivity to fulvestrant by regulating STAT1, IFN regulatory factor 1, NF-kappaB, BCL2 family members, and signaling to caspase-dependent apoptosis. Molecular cancer therapeutics. vol 9. issue 5. 2010-08-20. PMID:20457620. |
this molecular signaling is associated with the activation of signal transducer and activator of transcription 1 and leads to increased mitochondrial membrane permeability; activation of caspase-7 (casp7), casp8, and casp9; and induction of apoptosis but not autophagy. |
2010-08-20 |
2023-08-12 |
Not clear |
| Chen-Yu Liu, Michael C Wu, Feng Chen, Monica Ter-Minassian, Kofi Asomaning, Rihong Zhai, Zhaoxi Wang, Li Su, Rebecca S Heist, Matthew H Kulke, Xihong Lin, Geoffrey Liu, David C Christian. A Large-scale genetic association study of esophageal adenocarcinoma risk. Carcinogenesis. vol 31. issue 7. 2010-07-12. PMID:20453000. |
snps of rs3127075 in caspase-7 (casp7) and rs4661636 in caspase-9 (casp9) genes that play a critical role in apoptosis were found to be associated with an increased risk of ea. |
2010-07-12 |
2023-08-12 |
Not clear |
| Chen-Yu Liu, Michael C Wu, Feng Chen, Monica Ter-Minassian, Kofi Asomaning, Rihong Zhai, Zhaoxi Wang, Li Su, Rebecca S Heist, Matthew H Kulke, Xihong Lin, Geoffrey Liu, David C Christian. A Large-scale genetic association study of esophageal adenocarcinoma risk. Carcinogenesis. vol 31. issue 7. 2010-07-12. PMID:20453000. |
in conclusion, this study suggests that the genetic variants of casp7 and casp9 in the apoptosis pathway may be important predictive markers for ea susceptibility and that pgr in the sex hormone signaling pathway may be associated with the gender differences in ea risk. |
2010-07-12 |
2023-08-12 |
Not clear |
| Sunanda R Babu, Fei Bao, Christine M Roberts, Allison K Martin, Katherine Gowan, George S Eisenbarth, Pamela R Fai. Caspase 7 is a positional candidate gene for IDDM 17 in a Bedouin Arab family. Annals of the New York Academy of Sciences. vol 1005. 2004-01-16. PMID:14679087. |
casp7 is involved in the activation cascade of caspases responsible for apoptosis execution. |
2004-01-16 |
2023-08-12 |
Not clear |