| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Andrew Sunters, Silvia Fernández de Mattos, Marie Stahl, Jan J Brosens, Georgia Zoumpoulidou, Catherine A Saunders, Paul J Coffer, René H Medema, R Charles Coombes, Eric W-F La. FoxO3a transcriptional regulation of Bim controls apoptosis in paclitaxel-treated breast cancer cell lines. The Journal of biological chemistry. vol 278. issue 50. 2004-01-15. PMID:14527951. |
foxo3a transcriptional regulation of bim controls apoptosis in paclitaxel-treated breast cancer cell lines. |
2004-01-15 |
2023-08-12 |
Not clear |
| Andrew Sunters, Silvia Fernández de Mattos, Marie Stahl, Jan J Brosens, Georgia Zoumpoulidou, Catherine A Saunders, Paul J Coffer, René H Medema, R Charles Coombes, Eric W-F La. FoxO3a transcriptional regulation of Bim controls apoptosis in paclitaxel-treated breast cancer cell lines. The Journal of biological chemistry. vol 278. issue 50. 2004-01-15. PMID:14527951. |
western blotting revealed that in a panel of nine breast cancer cell lines expression of foxo1a and foxo3a correlated with the expression of the pro-apoptotic foxo target bim, which was associated with paclitaxel-induced apoptosis. |
2004-01-15 |
2023-08-12 |
Not clear |
| Andrew Sunters, Silvia Fernández de Mattos, Marie Stahl, Jan J Brosens, Georgia Zoumpoulidou, Catherine A Saunders, Paul J Coffer, René H Medema, R Charles Coombes, Eric W-F La. FoxO3a transcriptional regulation of Bim controls apoptosis in paclitaxel-treated breast cancer cell lines. The Journal of biological chemistry. vol 278. issue 50. 2004-01-15. PMID:14527951. |
in mcf-7 cells, which were paclitaxel-sensitive, the already high basal levels of foxo3a and bim protein increased dramatically after drug treatment, as did bim mrna, which correlated with apoptosis induction. |
2004-01-15 |
2023-08-12 |
Not clear |
| Andrew Sunters, Silvia Fernández de Mattos, Marie Stahl, Jan J Brosens, Georgia Zoumpoulidou, Catherine A Saunders, Paul J Coffer, René H Medema, R Charles Coombes, Eric W-F La. FoxO3a transcriptional regulation of Bim controls apoptosis in paclitaxel-treated breast cancer cell lines. The Journal of biological chemistry. vol 278. issue 50. 2004-01-15. PMID:14527951. |
gene silencing experiments showed that small interference rna (sirna) specific for foxo3a reduced the levels of foxo3a and bim protein as well as inhibited apoptosis in paclitaxel-treated mcf-7 cells. |
2004-01-15 |
2023-08-12 |
Not clear |
| Andrew Sunters, Silvia Fernández de Mattos, Marie Stahl, Jan J Brosens, Georgia Zoumpoulidou, Catherine A Saunders, Paul J Coffer, René H Medema, R Charles Coombes, Eric W-F La. FoxO3a transcriptional regulation of Bim controls apoptosis in paclitaxel-treated breast cancer cell lines. The Journal of biological chemistry. vol 278. issue 50. 2004-01-15. PMID:14527951. |
this is the first demonstration that up-regulation of foxo3a by paclitaxel can result in increased levels of bim mrna and protein, which can be a direct cause of apoptosis in breast cancer cells. |
2004-01-15 |
2023-08-12 |
Not clear |
| Céline Charvet, Isabelle Alberti, Frederic Luciano, Arnaud Jacquel, Alain Bernard, Patrick Auberger, Marcel Decker. Proteolytic regulation of Forkhead transcription factor FOXO3a by caspase-3-like proteases. Oncogene. vol 22. issue 29. 2003-08-19. PMID:12881712. |
here, we show that foxo3a (also known as fkhrl1) is a new substrate of caspase-3-like proteases during apoptosis in t lymphocytes. |
2003-08-19 |
2023-08-12 |
Not clear |
| Céline Charvet, Isabelle Alberti, Frederic Luciano, Arnaud Jacquel, Alain Bernard, Patrick Auberger, Marcel Decker. Proteolytic regulation of Forkhead transcription factor FOXO3a by caspase-3-like proteases. Oncogene. vol 22. issue 29. 2003-08-19. PMID:12881712. |
whereas full-length foxo3a enhanced forkhead response element-dependent transcription and apoptosis in jurkat cells, both fragments were inactive to promote gene activation and cell death. |
2003-08-19 |
2023-08-12 |
Not clear |
| Saghi Ghaffari, Zainab Jagani, Claire Kitidis, Harvey F Lodish, Roya Khosravi-Fa. Cytokines and BCR-ABL mediate suppression of TRAIL-induced apoptosis through inhibition of forkhead FOXO3a transcription factor. Proceedings of the National Academy of Sciences of the United States of America. vol 100. issue 11. 2003-07-16. PMID:12750477. |
cytokines and bcr-abl mediate suppression of trail-induced apoptosis through inhibition of forkhead foxo3a transcription factor. |
2003-07-16 |
2023-08-12 |
Not clear |
| Zivotije Radisavljevi. Nitric oxide suppression triggers apoptosis through the FKHRL1 (FOXO3A)/ROCK kinase pathway in human breast carcinoma cells. Cancer. vol 97. issue 5. 2003-05-29. PMID:12599246. |
nitric oxide suppression triggers apoptosis through the fkhrl1 (foxo3a)/rock kinase pathway in human breast carcinoma cells. |
2003-05-29 |
2023-08-12 |
human |
| Zivotije Radisavljevi. Nitric oxide suppression triggers apoptosis through the FKHRL1 (FOXO3A)/ROCK kinase pathway in human breast carcinoma cells. Cancer. vol 97. issue 5. 2003-05-29. PMID:12599246. |
the winged helix/forkhead transcriptional factor fkhrl1 (foxo3a) triggers apoptosis, but its mode of action is not well understood. |
2003-05-29 |
2023-08-12 |
human |