| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Fabio Sias, Stefano Zoroddu, Rossana Migheli, Luigi Bagell. Untangling the Role of MYC in Sarcomas and Its Potential as a Promising Therapeutic Target. International journal of molecular sciences. vol 26. issue 5. 2025-03-13. PMID:40076599. |
myc interacts with critical pathways such as cell cycle regulation, apoptosis, and angiogenesis, amplifying tumor aggressiveness and resistance to standard therapies. |
2025-03-13 |
2025-03-15 |
Not clear |
| Cuicui Yang, Xiaowu Pang, Shaolei Teng, Shamel Wilson, Xinbin Gu, Guiqin Xi. MYC Overexpression Enhances Sensitivity to MEK Inhibition in Head and Neck Squamous Cell Carcinoma. International journal of molecular sciences. vol 26. issue 2. 2025-01-25. PMID:39859304. |
flow cytometry and protein analyses demonstrated that myc overexpression amplified trametinib-induced apoptosis and dna damage, as evidenced by elevated levels of pro-apoptotic markers (p53, cleaved parp, and bim) and γh2ax. |
2025-01-25 |
2025-01-28 |
Not clear |
| Xiao-Mei Ouyang, Jun-Hui Lin, Ying Lin, Xian-Ling Zhao, Ya-Ni Huo, Lai-Ying Liang, Yong-Dong Huang, Gui-Jing Xie, Peng Mi, Zhen-Yu Ye, Bayasi Gulen. The SERPINB4 gene mutation identified in twin patients with Crohn's disease impaires the intestinal epithelial cell functions. Scientific reports. vol 15. issue 1. 2025-01-22. PMID:39838210. |
transcriptome sequencing revealed that the expression of genes encoding proinflammatory proteins (il1b, il6, il17, il24, ccl2, and cxcr2) and key proteins in the immune response (s100a9, mmp3, and myc) was significantly upregulated during serpinb4 mutant-induced apoptosis. |
2025-01-22 |
2025-01-24 |
Not clear |
| Priya, Arun Kumar, Dhruv Kuma. Molecular heterogeneity and MYC dysregulation in triple-negative breast cancer: genomic advances and therapeutic implications. 3 Biotech. vol 15. issue 1. 2025-01-08. PMID:39777154. |
myc plays a critical role in regulating metabolism, differentiation, proliferation, cell growth, and apoptosis. |
2025-01-08 |
2025-01-13 |
Not clear |
| Simon T Jakobsen, Rasmus Siersbæ. Transcriptional regulation by MYC: an emerging new model. Oncogene. 2024-10-29. PMID:39468222. |
the transcription factor myc has long been recognized for its pivotal role in transcriptional regulation of genes fundamental for cellular processes such as cell cycle, apoptosis, and metabolism. |
2024-10-29 |
2024-10-31 |
Not clear |
| Atefeh Bahmei, Fatemeh Karimi, Seyed Moein Mahini, Hamed Irandoost, Parisa Tandel, Homa Niknam, Gholmhossein Tamaddo. Targeting telomerase with MST-312 leads to downregulation of CCND1, MDM2, MYC, and HSP90AA1 and induce apoptosis in Jurkat cell line. Medical oncology (Northwood, London, England). vol 41. issue 11. 2024-10-14. PMID:39400638. |
targeting telomerase with mst-312 leads to downregulation of ccnd1, mdm2, myc, and hsp90aa1 and induce apoptosis in jurkat cell line. |
2024-10-14 |
2024-10-16 |
Not clear |
| Atefeh Bahmei, Fatemeh Karimi, Seyed Moein Mahini, Hamed Irandoost, Parisa Tandel, Homa Niknam, Gholmhossein Tamaddo. Targeting telomerase with MST-312 leads to downregulation of CCND1, MDM2, MYC, and HSP90AA1 and induce apoptosis in Jurkat cell line. Medical oncology (Northwood, London, England). vol 41. issue 11. 2024-10-14. PMID:39400638. |
this study aimed to investigate the effects of mst-312 on apoptosis rates and the expression of telomerase target genes, ccnd1, mdm2, myc, and hsp90aa1, in jurkat cell line. |
2024-10-14 |
2024-10-16 |
Not clear |
| Atefeh Bahmei, Fatemeh Karimi, Seyed Moein Mahini, Hamed Irandoost, Parisa Tandel, Homa Niknam, Gholmhossein Tamaddo. Targeting telomerase with MST-312 leads to downregulation of CCND1, MDM2, MYC, and HSP90AA1 and induce apoptosis in Jurkat cell line. Medical oncology (Northwood, London, England). vol 41. issue 11. 2024-10-14. PMID:39400638. |
the results showed that mst-312 induced dose- and time-dependent apoptosis and downregulated the expression of ccnd1, mdm2, myc, and hsp90aa1in jurkat cell line. |
2024-10-14 |
2024-10-16 |
Not clear |
| Ziqiang Lin, Suo Wang, Yu Cao, Jialing Lin, Ailing Sun, Wei Huang, Jun Zhou, Qingxiong Hon. Bioinformatics and Validation Reveal the Potential Target of Curcumin in the Treatment of Diabetic Peripheral Neuropathy. Neuropharmacology. 2024-08-23. PMID:39179172. |
subsequently, qrt-pcr, mtt assay, flow cytometry, caspase-3 activity detection and westernblot showed that curcumin treatment increased rsc96 cell viability, reduced cell apoptosis, increased hmox1, pten, vegfa and myc expression, and up-regulated akt phosphorylation level under high glucose environment. |
2024-08-23 |
2024-08-27 |
rat |
| Ming Guo, Xin Li, Wenjun Tao, Fei Teng, Chenghua L. Vibrio splendidus infection promotes circRNA-FGL1-regulated coelomocyte apoptosis via competitive binding to Myc with the deubiquitinase OTUB1 in Apostichopus japonicus. PLoS pathogens. vol 20. issue 8. 2024-08-15. PMID:39146353. |
vibrio splendidus infection promotes circrna-fgl1-regulated coelomocyte apoptosis via competitive binding to myc with the deubiquitinase otub1 in apostichopus japonicus. |
2024-08-15 |
2024-08-18 |
Not clear |
| Ignacio Ruz-Caracuel, Tamara Caniego-Casas, Teresa Alonso-Gordoa, Irene Carretero-Barrio, Carmen Ariño-Palao, Almudena Santón, Marta Rosas, Héctor Pian, Javier Molina-Cerrillo, Patricia Luengo, José Palacio. Transcriptomic Differences in Medullary Thyroid Carcinoma According to Grade. Endocrine pathology. 2024-07-03. PMID:38958823. |
major pathways differentially expressed between high-grade and low-grade mtcs were dna damage repair, p53 signaling, cell cycle, apoptosis, and myc signaling. |
2024-07-03 |
2024-07-06 |
Not clear |
| Lin Liu, Wenbin Mo, Miao Chen, Yi Qu, Pingping Wang, Ying Liang, Xiaojing Ya. Targeted inhibition of DHODH is synergistic with BCL2 blockade in HGBCL with concurrent MYC and BCL2 rearrangement. BMC cancer. vol 24. issue 1. 2024-06-26. PMID:38918775. |
in this study, the dhodh inhibitor brequinar exhibited growth inhibition, cell cycle blockade, and apoptosis promotion in hgbcl cell lines with myc and bcl2 rearrangements. |
2024-06-26 |
2024-06-29 |
Not clear |
| Angelina T Regua, Shivani Bindal, Mariana K Najjar, Chuling Zhuang, Munazza Khan, Austin B J Arrigo, Anneliese O Gonzalez, Xinhai R Zhang, Jay-Jiguang Zhu, Kounosuke Watabe, Hui-Wen L. Dual Inhibition of the TrkA and JAK2 pathways using Entrectinib and Pacritinib suppresses the growth and metastasis of HER2-positive and triple-negative breast cancers. Cancer letters. 2024-06-09. PMID:38852701. |
the entrectinib-pacritinib combination inhibited the breast cancer stem cell subpopulation, reduced expression of stemness genes, sox2 and myc, and induced apoptosis. |
2024-06-09 |
2024-06-14 |
mouse |
| Angelina T Regua, Shivani Bindal, Mariana K Najjar, Chuling Zhuang, Munazza Khan, Austin B J Arrigo, Anneliese O Gonzalez, Xinhai R Zhang, Jay-Jiguang Zhu, Kounosuke Watabe, Hui-Wen L. Dual Inhibition of the TrkA and JAK2 pathways using Entrectinib and Pacritinib suppresses the growth and metastasis of HER2-positive and triple-negative breast cancers. Cancer letters. 2024-06-09. PMID:38852701. |
the entrectinib-pacritinib combination suppressed orthotopic growth of her2-positive trastuzumab-refractory breast cancer xenografts and basal patient-derived xenograft (pdxs), reduced tumoral sox2 and myc, and induced apoptosis in both mouse models. |
2024-06-09 |
2024-06-14 |
mouse |
| Shuang Wu, Jie Zhang, Shan Chen, Xinyi Zhou, Yankui Liu, Haiying Hua, Xiaowei Qi, Yong Mao, Ken H Young, Tingxun L. Low NDRG2, regulated by the MYC/MIZ-1 complex and methylation, predicts poor outcomes in DLBCL patients. Annals of hematology. 2024-06-06. PMID:38842567. |
myc and miz-1 promoted dlbcl cell proliferation, while ndrg2 induced apoptosis in ly8 cells. |
2024-06-06 |
2024-06-08 |
human |
| Shuang Wu, Jie Zhang, Shan Chen, Xinyi Zhou, Yankui Liu, Haiying Hua, Xiaowei Qi, Yong Mao, Ken H Young, Tingxun L. Low NDRG2, regulated by the MYC/MIZ-1 complex and methylation, predicts poor outcomes in DLBCL patients. Annals of hematology. 2024-06-06. PMID:38842567. |
together, our data demonstrate that the myc/miz-1 complex interplays with ndrg2 to influence the proliferation and apoptosis of dlbcl cells and show the characterizations of ndrg2, myc and miz-1 for metabolism features and prediction prognosis in dlbcl. |
2024-06-06 |
2024-06-08 |
human |
| Chunlan Liu, Fan Yang, Jingyu Wang, Renfei Zhu, Jiansheng Zhu, Mingtao Huan. Myclobutanil induces cardiotoxicity in developing zebrafish larvae by initiating oxidative stress and apoptosis: The protective role of curcumin. Ecotoxicology and environmental safety. vol 279. 2024-05-31. PMID:38820875. |
myc promoted oxidative stress through excessive reactive oxygen species (ros) accumulation and suppressed the activities of antioxidant enzymes, triggering cardiomyocytic apoptosis via upregulated expression of apoptosis-related genes. |
2024-05-31 |
2024-06-02 |
zebrafish |
| Thomas F Cyberski, Alka Singh, Michael Korzinkin, Vasudha Mishra, Frank Pun, Le Shen, Claudia Wing, Xiangying Cheng, Brandon Baird, Yuxuan Miao, Moshe Elkabets, Sara Kochanny, Wenji Guo, Emma Dyer, Alexander T Pearson, Aditya Juloori, Mark Lingen, Grayson Cole, Alex Zhavoronkov, Nishant Agrawal, Evgeny Izumchenko, Ari J Rosenber. Acquired resistance to immunotherapy and chemoradiation in MYC amplified head and neck cancer. NPJ precision oncology. vol 8. issue 1. 2024-05-26. PMID:38783041. |
the proto-oncogene myc encodes a nuclear transcription factor that has an important role in a variety of cellular processes, such as cell cycle progression, proliferation, metabolism, adhesion, apoptosis, and therapeutic resistance. |
2024-05-26 |
2024-05-27 |
Not clear |
| Jannatul Ferdoush, Rizwaan Abdul Kadir, Matthew Ogle, Ayan Sah. Regulation of eukaryotic transcription initiation in response to cellular stress. Gene. vol 924. 2024-05-26. PMID:38795856. |
several transcription factors such as p53, c/ebp homologous protein (chop), activating transcription factor 6 (atf6α), e2f, transforming growth factor (tgf)-β, adenomatous polyposis coli (apc), smad, and myc have been implicated in regulation of transcription of target genes involved in cell cycle progression, apoptosis, and dna damage repair pathways. |
2024-05-26 |
2024-05-31 |
human |
| Yichen Sun, Jianfeng Chen, Jing Han Hong, Rong Xiao, Yan Teng, Peili Wang, Peng Deng, Zhaoliang Yu, Jason Yongsheng Chan, Kelila Xin Ye Chai, Jiuping Gao, Yali Wang, Lu Pan, Lizhen Liu, Shini Liu, Bin Tean Teh, Qiang Yu, Soon Thye Lim, Wenyu Li, Banglao Xu, Choon Kiat Ong, Jing Ta. Targeting AURKA to induce synthetic lethality in CREBBP-deficient B-cell malignancies via attenuation of MYC expression. Oncogene. 2024-05-23. PMID:38783101. |
mechanistically, we found that co-targeting crebbp and aurka suppressed myc transcriptionally and post-translationally to induce replication stress and apoptosis. |
2024-05-23 |
2024-05-27 |
Not clear |