| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Claire L Perriton, Nicola Powles, Chin Chiang, Mark K Maconochie, Martin J Coh. Sonic hedgehog signaling from the urethral epithelium controls external genital development. Developmental biology. vol 247. issue 1. 2002-07-22. PMID:12074550. |
in the absence of shh signaling, fgf8, bmp2, bmp4, fgf10, and wnt5a are downregulated, and apoptosis is enhanced in the genitalia. |
2002-07-22 |
2023-08-12 |
mouse |
| A Ishizuya-Oka, S Ueda, T Inokuchi, T Amano, S Damjanovski, M Stolow, Y B Sh. Thyroid hormone-induced expression of sonic hedgehog correlates with adult epithelial development during remodeling of the Xenopus stomach and intestine. Differentiation; research in biological diversity. vol 69. issue 1. 2002-05-24. PMID:11776392. |
our results indicate that the epithelial-specific expression of shh in the intestine spatiotemporally correlates well with active proliferation and/or initial differentiation of the secondary (adult) epithelial primordia that originate from stem cells, but not with apoptosis of the primary (larval) epithelium. |
2002-05-24 |
2023-08-12 |
xenopus_laevis |
| A R Paganelli, O H Ocaña, M I Prat, P G Franco, S L López, L Morelli, A M Adamo, M M Riccomagno, E Matsubara, M Shoji, J L Affranchino, E M Castaño, A E Carrasc. The Alzheimer-related gene presenilin-1 facilitates sonic hedgehog expression in Xenopus primary neurogenesis. Mechanisms of development. vol 107. issue 1-2. 2001-12-04. PMID:11520668. |
both shh and presenilin promoted cell proliferation and apoptosis, but the effects of shh were widely distributed, while those resulting from presenilin injection coincided with the range of shh signaling. |
2001-12-04 |
2023-08-12 |
xenopus_laevis |
| A R Paganelli, O H Ocaña, M I Prat, P G Franco, S L López, L Morelli, A M Adamo, M M Riccomagno, E Matsubara, M Shoji, J L Affranchino, E M Castaño, A E Carrasc. The Alzheimer-related gene presenilin-1 facilitates sonic hedgehog expression in Xenopus primary neurogenesis. Mechanisms of development. vol 107. issue 1-2. 2001-12-04. PMID:11520668. |
we suggest that presenilin may modulate primary neurogenesis, proliferation, and apoptosis in the neural plate, through the enhancement of shh signaling. |
2001-12-04 |
2023-08-12 |
xenopus_laevis |
| A Pirskanen, J C Kiefer, S D Hauschk. IGFs, insulin, Shh, bFGF, and TGF-beta1 interact synergistically to promote somite myogenesis in vitro. Developmental biology. vol 224. issue 2. 2000-09-18. PMID:10926759. |
further studies indicate that insulin, igfs, bfgf, and shh also stimulate somite cell proliferation and influence apoptosis. |
2000-09-18 |
2023-08-12 |
chicken |
| G M Cann, J W Lee, F E Stockdal. Sonic hedgehog enhances somite cell viability and formation of primary slow muscle fibers in avian segmented mesoderm. Anatomy and embryology. vol 200. issue 3. 1999-10-12. PMID:10463340. |
furthermore, it was demonstrated that apoptosis is a dominant fate of somite cells, but not somitic muscle fibers, when cultured in the absence of the neural tube, and that application of shh protein to somites reduced apoptosis. |
1999-10-12 |
2023-08-12 |
Not clear |
| G M Cann, J W Lee, F E Stockdal. Sonic hedgehog enhances somite cell viability and formation of primary slow muscle fibers in avian segmented mesoderm. Anatomy and embryology. vol 200. issue 3. 1999-10-12. PMID:10463340. |
the block to apoptosis by shh is a manifestation of the maturity of the somite with a progressive increase in the block as somites are displaced rostrally from somite iii forward. |
1999-10-12 |
2023-08-12 |
Not clear |