| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hedie Abolghasemi, Pariya Shahani, Roghayeh Mozafari, Nooshin Barikrow, Batool Ghorbani Yekta, Abbas Haghparas. The dopaminergic and opioidergic interactions in the nucleus accumbens in the suppression of pain affect: exploring their impact on formalin-induced pain in rats. Physiology & behavior. 2025-03-29. PMID:40157441. |
recent studies suggest that the nucleus accumbens (nac) may influence the brain's response to pain signals, indicating a role beyond motivation and reward. |
2025-03-29 |
2025-04-02 |
rat |
| Freddyson J Martínez-Rivera, Leanne M Holt, Angélica Minier-Toribio, Molly Estill, Szu-Ying Yeh, Solange Tofani, Rita Futamura, Caleb J Browne, Philipp Mews, Li Shen, Eric J Nestle. Transcriptional characterization of cocaine withdrawal versus extinction within nucleus accumbens in male rats. Nature communications. vol 16. issue 1. 2025-03-26. PMID:40133300. |
cocaine use disorder (cud) exemplifies this phenomenon in which reward regions such as nucleus accumbens (nac) undergo withdrawal-associated modifications. |
2025-03-26 |
2025-03-28 |
rat |
| Lefan Yu, Mengmeng Feng, Yi Shang, Zhaohai Ren, Hanqi Xing, Yue Chang, Ke Dong, Yao Xiao, Hui Da. Reduced Functional Connectivity in Nucleus Accumbens Subregions Associates With Cognitive Changes in Alzheimer's Disease. Brain and behavior. vol 15. issue 3. 2025-03-26. PMID:40135639. |
the nucleus accumbens (nac), an important component of the reward circuit, is believed to play an indispensable role in alzheimer's disease (ad). |
2025-03-26 |
2025-03-28 |
Not clear |
| Kasey L Brida, Emily T Jorgensen, Robert A Phillips Iii, Catherine E Newman, Jennifer J Tuscher, Emily K Morring, Morgan E Zipperly, Lara Ianov, Kelsey D Montgomery, Madhavi Tippani, Thomas M Hyde, Kristen R Maynard, Keri Martinowich, Jeremy J Da. Reelin marks cocaine-activated striatal neurons, promotes neuronal excitability, and regulates cocaine reward. Science advances. vol 11. issue 13. 2025-03-26. PMID:40138397. |
drugs of abuse activate defined neuronal populations in reward structures such as the nucleus accumbens (nac), which promote the enduring synaptic, circuit, and behavioral consequences of drug exposure. |
2025-03-26 |
2025-03-30 |
Not clear |
| Shervin Assari, Alexandra Donova. Nucleus Accumbens Resting State Functional Connectivity is Linked to Family Income, Reward Salience, and Substance Use. Journal of cellular neuroscience. vol 2. issue 1. 2025-03-14. PMID:40084187. |
nucleus accumbens resting state functional connectivity is linked to family income, reward salience, and substance use. |
2025-03-14 |
2025-03-16 |
Not clear |
| Shervin Assari, Alexandra Donova. Nucleus Accumbens Resting State Functional Connectivity is Linked to Family Income, Reward Salience, and Substance Use. Journal of cellular neuroscience. vol 2. issue 1. 2025-03-14. PMID:40084187. |
as a central component of the brain's reward system, nucleus accumbens (nacc) plays a crucial role in reward salience and substance use behaviors. |
2025-03-14 |
2025-03-16 |
Not clear |
| Kauê Machado Costa, Zhewei Zhang, Douglas Deutsch, Yizhou Zhuo, Guochuan Li, Yulong Li, Geoffrey Schoenbau. Dopamine and acetylcholine correlations in the nucleus accumbens depend on behavioral task states. Current biology : CB. 2025-03-04. PMID:40037349. |
dopamine release in the nucleus accumbens (nacc) changes quickly in response to errors in predicting events like reward delivery |
2025-03-04 |
2025-03-07 |
Not clear |
| Charles T Shoemaker, Alexander D Friedman, Bryan Lu, Qiaochu Jiang, Jiwon Kim, Shuangyan Li, Shaolin Ruan, Henry H Yi. A2A-positive neurons in the nucleus accumbens core regulate effort exertion. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2025-03-03. PMID:40032523. |
previous work has implicated the nucleus accumbens (nac) in the regulation of effort, defined as the amount of work an animal is willing to perform for a given reward, but little is known about the specific contributions of neuronal populations within the nac to effort regulation. |
2025-03-03 |
2025-03-06 |
mouse |
| Ravid Doron, Lilach Rozevich, Noa Bregman-Yemini, Gal Yadi. The influence of chronic or acute DHEA exposure on β-Endorphin levels in the Nucleus Accumbens. European journal of pharmacology. 2025-03-01. PMID:40023360. |
as drug addiction manifestation is affected by upregulation of β-endorphin levels in the nucleus accumbens (nac), which is vital for the brain's reward system and to the rewarding properties of drugs, the current study aims to determine the effects of dhea on β-endorphin levels in the nac and its implications for cocaine addiction treatment. |
2025-03-01 |
2025-03-05 |
Not clear |
| T W Faust, A Mohebi, J D Berk. Reward expectation and receipt differentially modulate the spiking of accumbens D1+ and D2+ neurons. Current biology : CB. 2025-02-28. PMID:40020662. |
the nucleus accumbens (nac) helps govern motivation to pursue reward. |
2025-02-28 |
2025-03-04 |
rat |
| Hsin-Yu Lin, Hoki Fung, Yifan Wang, Roger Chun-Man Ho, Shen-Hsing Annabel Che. A Functional Magnetic Resonance Imaging Investigation of Hot and Cool Executive Functions in Reward and Competition. Sensors (Basel, Switzerland). vol 25. issue 3. 2025-02-13. PMID:39943445. |
in addition, reward processing deficits are associated with atypical connectivity between the nucleus accumbens and the dorsofrontal regions. |
2025-02-13 |
2025-02-15 |
Not clear |
| Ethan M Anderson, Evgeny Tsvetkov, Daniel Wood, Rose Marie Akiki, Karim Al Hasanieh, Lauren M McCue, Makoto Taniguchi, Antonieta Lavin, Christopher W Cowa. Heroin regulates the voltage-gated sodium channel auxiliary subunit, SCN1b, to modulate nucleus accumbens medium spiny neuron intrinsic excitability and cue-induced heroin seeking. eNeuro. 2025-02-13. PMID:39947903. |
opioids are reported to alter the intrinsic excitability of medium spiny neurons (msns) in the nucleus accumbens (nac), a key brain reward region linked to drug seeking, but how opioids alter nac msn neuronal excitability and the impact of altered msn excitability on relapse-like opioid seeking remain unclear. |
2025-02-13 |
2025-02-16 |
rat |
| Nikte Requejo-Mendoza, José-Antonio Arias-Montaño, Ranier Gutierre. Nucleus accumbens D2-expressing neurons: Balancing reward and licking disruption through rhythmic optogenetic stimulation. PloS one. vol 20. issue 2. 2025-02-07. PMID:39919051. |
nucleus accumbens d2-expressing neurons: balancing reward and licking disruption through rhythmic optogenetic stimulation. |
2025-02-07 |
2025-02-10 |
mouse |
| Nikte Requejo-Mendoza, José-Antonio Arias-Montaño, Ranier Gutierre. Nucleus accumbens D2-expressing neurons: Balancing reward and licking disruption through rhythmic optogenetic stimulation. PloS one. vol 20. issue 2. 2025-02-07. PMID:39919051. |
nucleus accumbens (nac) dopamine d1 receptor-expressing neurons are known to be critical for processing reward and regulating food intake. |
2025-02-07 |
2025-02-10 |
mouse |
| Lyonna F Parise, Sergio D Iñiguez, Brandon L Warren, Eric M Parise, Ryan K Bachtell, David M Dietz, Eric J Nestler, Carlos A Bolaños-Guzmá. ERK2 Signaling in the Nucleus Accumbens Facilitates Stress Susceptibility and Cocaine Reinstatement. Biological psychiatry global open science. vol 5. issue 2. 2025-02-03. PMID:39896237. |
because the nucleus accumbens (nac) integrates reward valence, we investigated how erk2 (extracellular signal-regulated protein kinase-2) signaling affects the development of stress-related comorbidities, including negative affect and drug sensitivity. |
2025-02-03 |
2025-02-05 |
Not clear |
| Zhenlei Peng, Qiyu Jia, Junxiong Mao, Xiao Luo, Anqi Huang, Hao Zheng, Shijie Jiang, Qi Ma, Chuang Ma, Qizhong Y. Neurotransmitters crosstalk and regulation in the reward circuit of subjects with behavioral addiction. Frontiers in psychiatry. vol 15. 2025-01-29. PMID:39876994. |
the neurobiological underpinnings of bads primarily involve impairments in the reward circuitry, encompassing the ventral tegmental area, nucleus accumbens in the ventral striatum, and prefrontal cortex. |
2025-01-29 |
2025-01-31 |
human |
| Estefani Saint-Jour, Marie-Charlotte Allichon, Andry Andrianarivelo, Enrica Montalban, Claire Martin, Lisa Huet, Nicolas Heck, Anna M Hagenston, Aisha Ravenhorst, Mélanie Marias, Nicolas Gervasi, Faustine Arrivet, Adèle Vilette, Katleen Pinchaud, Sandrine Betuing, Thomas Lissek, Jocelyne Caboche, Hilmar Bading, Peter Vanhoutt. Nuclear calcium signaling in D1 receptor-expressing neurons of the nucleus accumbens regulates molecular, cellular and behavioral adaptations to cocaine. Biological psychiatry. 2025-01-26. PMID:39864789. |
the persistence of cocaine-evoked adaptations relies on gene regulations within the reward circuit, especially in the ventral striatum (i.e., nucleus accumbens (nac)). |
2025-01-26 |
2025-01-29 |
Not clear |
| Jessalyn Pla-Tenorio, Bethzaly Velazquez-Perez, Yainira Mendez-Borrero, Myrella L Cruz, Marian T Sepulveda-Orengo, Richard J Noe. Astrocytic HIV-1 Nef Expression Decreases Glutamate Transporter Expression in the Nucleus Accumbens and Increases Cocaine-Seeking Behavior in Rats. Pharmaceuticals (Basel, Switzerland). vol 18. issue 1. 2025-01-25. PMID:39861103. |
this study investigates the relationship among nef, glutamate homeostasis, and cocaine in the nucleus accumbens (nac), a critical brain region associated with drug motivation and reward. |
2025-01-25 |
2025-01-28 |
rat |
| Dylan Patterson, Nisma Khan, Emily A Collins, Norman R Stewart, Kian Sassaninejad, Dylan Yeates, Andy C H Lee, Rutsuko It. Ventral hippocampus to nucleus accumbens shell circuit regulates approach decisions during motivational conflict. PLoS biology. vol 23. issue 1. 2025-01-24. PMID:39854559. |
in this study, we sought to target the vhpc ca1 projection pathway to the nucleus accumbens (nac) to delineate its contribution to aac decision-making, particularly in the arbitration of learned reward and punishment signals, as well as innate signals. |
2025-01-24 |
2025-01-27 |
human |
| Kurt M Fraser, Val Collins, Amy R Wolff, David J Ottenheimer, Kaisa N Bornhoft, Fiona Pat, Bridget J Chen, Patricia H Janak, Benjamin T Saunder. Contextual cues facilitate dynamic value encoding in the mesolimbic dopamine system. Current biology : CB. 2025-01-24. PMID:39855205. |
moreover, dopamine release in the nucleus accumbens following the conditioned stimulus only occurred when the occasion setter indicated it would predict reward and did not reflect its average expected value. |
2025-01-24 |
2025-01-28 |
rat |