| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Gabriele Floris, Mary Tresa Zanda, Konrad R Dabrowski, Stephanie E Daw. Neuroinflammatory history results in overlapping transcriptional signatures with heroin exposure in the nucleus accumbens and alters responsiveness to heroin in male rats. Translational psychiatry. vol 14. issue 1. 2024-12-20. PMID:39702361. |
in this study, we have begun to address this critical knowledge gap by exploring the intersection between neuroinflammation and exposure to the opioid heroin, utilizing lipopolysaccharide (lps)-induced neuroinflammation, to investigate transcriptional changes in the nucleus accumbens (nac), an essential region in the mesolimbic dopamine system that mediates opioid reward. |
2024-12-20 |
2024-12-22 |
human |
| Lara Taniguchi, Caitlin Goodpaster, Gregory Bello De Carvalho, Matthew T Birnie, Yuncai Chen, Lulu Chen, Tallie Z Baram, Laura A DeNard. Sex-and Stress-Dependent Plasticity of a Corticotropin Releasing Hormone / GABA Projection from the Basolateral Amygdala to Nucleus Accumbens that Mediates Reward Behaviors. bioRxiv : the preprint server for biology. 2024-12-09. PMID:39651305. |
sex-and stress-dependent plasticity of a corticotropin releasing hormone / gaba projection from the basolateral amygdala to nucleus accumbens that mediates reward behaviors. |
2024-12-09 |
2024-12-12 |
mouse |
| Juan Enriquez-Traba, Miguel Arenivar, Hector E Yarur-Castillo, Chloe Noh, Rodolfo J Flores, Tenley Weil, Snehashis Roy, Ted B Usdin, Christina T LaGamma, Huikun Wang, Valerie S Tsai, Damien Kerspern, Amy E Moritz, David R Sibley, Andrew Lutas, Rosario Moratalla, Zachary Freyberg, Hugo A Tejed. Dissociable control of motivation and reinforcement by distinct ventral striatal dopamine receptors. Nature neuroscience. 2024-12-09. PMID:39653808. |
dopamine (da) release in striatal circuits, including the nucleus accumbens medial shell (mnacsh), tracks separable features of reward like motivation and reinforcement. |
2024-12-09 |
2024-12-12 |
mouse |
| Christiane Meyer, Konrad Schoettner, Shimon Ami. Effects of chronodisruption and alcohol consumption on gene expression in reward-related brain areas in female rats. Frontiers in molecular neuroscience. vol 17. 2024-12-03. PMID:39624490. |
to address this gap, adult female rats housed under an 11 h/11 h light-dark cycle (ld22) or standard light conditions (ld24, 12 h/12 h light-dark) were given access to an intermittent alcohol drinking protocol (ia20%) to assess the impact on gene expression in brain areas implicated in alcohol consumption and reward: the prefrontal cortex (pfc), nucleus accumbens (nac), and dorsal striatum (ds). |
2024-12-03 |
2024-12-06 |
human |
| Zhigang Chen, Shaoyi Duan, Jialu Li, Jianming Su, Hongyu Le. T-2 toxin triggers depression-like behaviors via upregulation of dopamine transporter in nucleus accumbens of male mice. Ecotoxicology and environmental safety. vol 289. 2024-12-01. PMID:39616663. |
in addition, the reduced dopamine (da) level and elevated dopamine transporter (dat) level were found in reward center nucleus accumbens (nac) receiving daergic projection from ventral tegmental area (vta) in brain after t-2 toxin administration, while there was no significant alteration in da synthesis-related tyrosine hydroxylase (th) and aromatic l-amino acid decarboxylase (aadc) in vta and da storage-related vesicle monoamine transporter 2 (vmat2) in nac. |
2024-12-01 |
2024-12-06 |
mouse |
| Katherine L Furman, Lorelei Baron, Hannah C Lyons, Timothy Cha, Jack R Evans, Jayeeta Manna, Limei Zhu, Joanna Mattis, Christian R Burges. Melanin concentrating hormone projections to the nucleus accumbens enhance the reward value of food consumption and do not induce feeding or REM sleep. bioRxiv : the preprint server for biology. 2024-11-28. PMID:39605522. |
melanin concentrating hormone projections to the nucleus accumbens enhance the reward value of food consumption and do not induce feeding or rem sleep. |
2024-11-28 |
2024-11-30 |
mouse |
| Refugio Cruz-Trujillo, Daniel Díaz-Urbina, José Alfredo Díaz-Gandarilla, Dolores Guadalupe Vidal-López, Rodrigo Erick Escartín-Pérez, Juan Manuel Mancilla-Diaz, Benjamín Florán, Juan Gabriel Tejas-Juáre. Stimulation of Dopamine D4 Receptors in the Nucleus Accumbens Shell Increases Palatable Food Intake in Satiated Male Rats: Modulation by NMDA and AMPA Receptors. Brain sciences. vol 14. issue 11. 2024-11-27. PMID:39595865. |
the nucleus accumbens (nac) plays a central role in this process, modulating reward mechanisms primarily via dopamine through d2-like receptors (d2r, d3r, d4r). |
2024-11-27 |
2024-11-29 |
rat |
| Nicolette Driscoll, Marc-Joseph Antonini, Taylor M Cannon, Pema Maretich, Greatness Olaitan, Valerie Doan Phi Van, Keisuke Nagao, Atharva Sahasrabudhe, Emmanuel Vargas Paniagua, Ethan J Frey, Ye Ji Kim, Sydney Hunt, Melissa Hummel, Sanju Mupparaju, Alan Jasanoff, B Jill Venton, Polina Anikeev. Multifunctional Neural Probes Enable Bidirectional Electrical, Optical, and Chemical Recording and Stimulation In Vivo. Advanced materials (Deerfield Beach, Fla.). 2024-11-07. PMID:39506430. |
their utility is demonstrated in studies of the mesolimbic reward pathway by interfacing with the ventral tegmental area and nucleus accumbens in mice and characterizing the neurophysiological effects of a stimulant drug. |
2024-11-07 |
2024-11-09 |
mouse |
| Matthew B Pomrenze, Sam Vaillancourt, Juliana S Salgado, Kendall B Raymond, Pierre Llorach, Gavin C Touponse, Daniel F Cardozo Pinto, Zahra Rastegar, Austen B Casey, Neir Eshel, Robert C Malenka, Boris D Heifet. 5-HT bioRxiv : the preprint server for biology. 2024-11-01. PMID:39484424. |
mdma-mediated 5-ht release in a major reward center, the nucleus accumbens (nac), drives prosocial behaviors via 5-ht1br activation. |
2024-11-01 |
2024-11-03 |
Not clear |
| E Caitlin Lloyd, Jonathan Posner, Janet Schebendach, Alexandra F Muratore, Susie Hong, Jessica Ojeda, Elizabeth Rafanello, Joanna E Steinglass, Karin Foerd. Food choice and neural reward systems in adolescents with anorexia nervosa and atypical anorexia nervosa. Journal of child psychology and psychiatry, and allied disciplines. 2024-10-31. PMID:39479886. |
the maturation of the reward system during adolescence combined with recent neurobiological models of an led to the hypothesis that early on in illness, restrictive food choices would be associated with activity in nucleus accumbens reward regions, rather than caudate regions identified among adults with an. |
2024-10-31 |
2024-11-02 |
Not clear |
| Terra A Schall, King-Lun Li, Xiguang Qi, Brian T Lee, William J Wright, Erin E Alpaugh, Rachel J Zhao, Jianwei Liu, Qize Li, Bo Zeng, Lirong Wang, Yanhua H Huang, Oliver M Schlüter, Eric J Nestler, Edward H Nieh, Yan Don. Temporal dynamics of nucleus accumbens neurons in male mice during reward seeking. Nature communications. vol 15. issue 1. 2024-10-29. PMID:39468146. |
temporal dynamics of nucleus accumbens neurons in male mice during reward seeking. |
2024-10-29 |
2024-10-31 |
mouse |
| Casey A Wilson, Bailey W Miller, Rachel M Renton, Kevin D Lominac, Karen K Szumlinsk. Investigation into the biomolecular bases of blunted cocaine-induced glutamate release within the nucleus accumbens elicited by adolescent exposure to phenylpropanolamine. Drug and alcohol dependence. vol 264. 2024-10-20. PMID:39427535. |
previously, we showed that a sensitization of cocaine-induced glutamate release within the nucleus accumbens (nac) and the expression of cocaine-conditioned reward is not apparent in adult mice with a prior history of repeated ppa exposure during adolescence. |
2024-10-20 |
2024-10-23 |
mouse |
| Meng-Qing Li, Xiao-Yu Lu, Jia-Yu Yao, Guang-Jing Zou, Ze-Hao Zeng, Lin-Xuan Zhang, Shi-Fen Zhou, Zhao-Rong Chen, Tian-Shu Zhao, Zi-Rui Guo, Yan-Hui Cui, Fang Li, Chang-Qi L. LASP1 in the nucleus accumbens modulates methamphetamine-induced conditioned place preference in mice. Neurochemistry international. 2024-10-17. PMID:39419179. |
methamphetamine (meth) is a highly addictive and widely abused drug that causes complex adaptive changes in the brain's reward system, such as the nucleus accumbens (nac). |
2024-10-17 |
2024-10-20 |
mouse |
| Jens Treutlein, Karolin E Einenkel, Bernd Krämer, Swapnil Awasthi, Oliver Grube. DNAJC13 influences responses of the extended reward system to conditioned stimuli: a genome-wide association study. European archives of psychiatry and clinical neuroscience. 2024-10-17. PMID:39417891. |
as a main finding, we identified the single nucleotide variant rs113408797 in the dnaj heat shock protein family member c13 gene [dnajc13], alias receptor-mediated endocytosis 8 [rme-8], that was associated with the activation strength of the ventral tegmental area (vta; p = 2.50e-07) and the nucleus accumbens (nacc; p = 5.31e-05) in response to conditioned reward stimuli. |
2024-10-17 |
2024-10-19 |
human |
| Karin Ademar, Lisa Ulenius, Anna Loftén, Bo Söderpalm, Louise Adermark, Mia Ericso. Separate mechanisms regulating accumbal taurine levels during baseline conditions and following ethanol exposure in the rat. Scientific reports. vol 14. issue 1. 2024-10-15. PMID:39406746. |
ethanol-induced dopamine release in the nucleus accumbens (nac) is associated with reward and reinforcement, and for ethanol to elevate nac dopamine levels, a simultaneous increase in endogenous taurine is required within the same brain region. |
2024-10-15 |
2024-10-18 |
rat |
| Jianhong Zhou, Di Luo, Yingjie An, Yuan Gao, Jichuan Zhang, Yanmei Che. Olfactory dysfunction decreased local field potential in the reward system and increased EtOH consumption in mice. Neurochemistry international. 2024-10-11. PMID:39393425. |
we also recorded local field potentials (lfps) from the brain reward system, the ventral tegmental area (vta), nucleus accumbens (nac), and piriform cortex (pir) one and four weeks after the induction of olfactory epithelium lesions using zinc sulfate (znso |
2024-10-11 |
2024-10-14 |
mouse |
| Leanne M Holt, Trevonn M Gyles, Eric M Parise, Angelica Minier-Toribio, Matthew Rivera, Tamara Markovic, Szu-Ying Yeh, Eric J Nestle. Astrocytic CREB in nucleus accumbens promotes susceptibility to chronic stress. Biological psychiatry. 2024-10-06. PMID:39369762. |
despite this, little is known about the transcriptional responses to stress of astrocytes within the nucleus accumbens (nac), a key brain reward region, and their influence on behavioral outcomes. |
2024-10-06 |
2024-10-09 |
human |
| Maximilian Tufvesson-Alm, Cajsa Aranäs, Sebastian Blid Sköldheden, Jesper Vestlund, Christian E Edvardsson, Elisabet Jerlha. LEAP2, a ghrelin receptor inverse agonist, and its effect on alcohol-related responses in rodents. Translational psychiatry. vol 14. issue 1. 2024-10-02. PMID:39358354. |
into the third ventricle) prevented the ability of alcohol to cause locomotor stimulation in male mice, suppressed the memory of alcohol reward and attenuated the dopamine release in the nucleus accumbens caused by alcohol. |
2024-10-02 |
2024-10-05 |
mouse |
| Yonca Cam, Courtney G Kocum, Ella R Konrad, Tim A Schweizer, Tabitha K Houska, Carlos A Sardina, Sanya K Suri, Matthew J Wil. Incentive motivation for palatable food blocked by intra-accumbens melanin-concentrating hormone (MCH) receptor-1 antagonist in female rats. Pharmacology, biochemistry, and behavior. 2024-09-28. PMID:39341509. |
here, we investigated the role of mchr1 within the acb in damgo-induced incentive motivation to obtain a sucrose pellet reward. |
2024-09-28 |
2024-10-01 |
rat |
| Jun Huang, Sylvain Crochet, Carmen Sandi, Carl C H Peterse. Dopamine dynamics in nucleus accumbens across reward-based learning of goal-directed whisker-to-lick sensorimotor transformations in mice. Heliyon. vol 10. issue 18. 2024-09-26. PMID:39323852. |
in the mammalian brain, dopamine release in nucleus accumbens is thought to contribute importantly to reward signals for learning and promoting synaptic plasticity. |
2024-09-26 |
2024-09-28 |
mouse |