| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Agnieszka Zagórska, Marcin Kołaczkowski, Adam Bucki, Agata Siwek, Grzegorz Kazek, Grzegorz Satała, Andrzej J Bojarski, Anna Partyka, Anna Wesołowska, Maciej Pawłowsk. Structure-activity relationships and molecular studies of novel arylpiperazinylalkyl purine-2,4-diones and purine-2,4,8-triones with antidepressant and anxiolytic-like activity. European journal of medicinal chemistry. vol 97. 2016-04-12. PMID:25965777. |
a novel series of arylpiperazinylalkyl purine-2,4-diones (4-27) and purine-2,4,8-triones (31-38) was synthesized and tested to evaluated their affinity for the serotoninergic (5-ht1a, 5-ht6, 5-ht7) and dopaminergic (d2) receptors. |
2016-04-12 |
2023-08-13 |
Not clear |
| Agnieszka Zagórska, Marcin Kołaczkowski, Adam Bucki, Agata Siwek, Grzegorz Kazek, Grzegorz Satała, Andrzej J Bojarski, Anna Partyka, Anna Wesołowska, Maciej Pawłowsk. Structure-activity relationships and molecular studies of novel arylpiperazinylalkyl purine-2,4-diones and purine-2,4,8-triones with antidepressant and anxiolytic-like activity. European journal of medicinal chemistry. vol 97. 2016-04-12. PMID:25965777. |
a spectrum of receptor activities was observed for compounds with a substituent at the 7-position of the imidazo[2,1-f]purine-2,4-dione system and some potent 5-ht1a (18, 25), 5-ht7 (14) and mixed 5-ht1a/5-ht7 (8, 9) receptor ligands with additional affinity for dopamine d2 receptors (15) has been identified. |
2016-04-12 |
2023-08-13 |
Not clear |
| N K Popova, E G Ponimaskin, V S Naumenk. [CROSS-TALK BETWEEN 5-HT1A AND 5-HT7 RECEPTORS: ROLE IN THE AUTOREGULATION OF THE BRAIN SEROTONIN SYSTEM AND IN MECHANISM OF ANTIDEPRESSANTS ACTION]. Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova. vol 101. issue 11. 2016-04-08. PMID:26995955. |
[cross-talk between 5-ht1a and 5-ht7 receptors: role in the autoregulation of the brain serotonin system and in mechanism of antidepressants action]. |
2016-04-08 |
2023-08-13 |
Not clear |
| N K Popova, E G Ponimaskin, V S Naumenk. [CROSS-TALK BETWEEN 5-HT1A AND 5-HT7 RECEPTORS: ROLE IN THE AUTOREGULATION OF THE BRAIN SEROTONIN SYSTEM AND IN MECHANISM OF ANTIDEPRESSANTS ACTION]. Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova. vol 101. issue 11. 2016-04-08. PMID:26995955. |
the results described in the present review indicate that: i) dimerization and formation of mobile receptor complexes is a common feature for the members of g-protein coupled receptor superfamily; ii) 5-ht7 receptor appears to be a modulator for 5-ht1a receptor - the key autoregulator of the brain serotonin system; iii) 5-ht1a/5-ht7 receptor complexes formation is one of the mechanisms for inactivation and desensitization of the 5-htia receptors in the brain; iv) differences in the 5-ht7 receptor and 5-htia/5-ht7 heterodimers density define different sensitivity of pre- and postsynaptic 5-htla receptors to chronic treatment with selective serotonin reuptake inhibitors. |
2016-04-08 |
2023-08-13 |
Not clear |
| Anna Czopek, Marcin Kołaczkowski, Adam Bucki, Hanna Byrtus, Maciej Pawłowski, Grzegorz Kazek, Andrzej J Bojarski, Agata Piaskowska, Justyna Kalinowska-Tłuścik, Anna Partyka, Anna Wesołowsk. Novel spirohydantoin derivative as a potent multireceptor-active antipsychotic and antidepressant agent. Bioorganic & medicinal chemistry. vol 23. issue 13. 2016-02-26. PMID:25936259. |
a series of novel spirohydantoin derivatives with arylpiperazinylbutyl moiety were synthesized and evaluated for serotonin 5-ht1a, 5-ht2a, 5-ht7 and dopamine d2 receptors. |
2016-02-26 |
2023-08-13 |
mouse |
| Mostafa El Mansari, Maurice Lecours, Pierre Blie. Effects of acute and sustained administration of vortioxetine on the serotonin system in the hippocampus: electrophysiological studies in the rat brain. Psychopharmacology. vol 232. issue 13. 2016-02-02. PMID:25665528. |
vortioxetine is a novel multimodal antidepressant that is a 5-ht1b receptor partial agonist, a 5-ht1a receptor agonist, an inhibitor of the serotonin (5-ht) transporter, and a 5-ht1d, 5-ht3, and 5-ht7 receptor antagonist in vitro. |
2016-02-02 |
2023-08-13 |
rat |
| Paweł Żmudzki, Grażyna Chłoń-Rzepa, Andrzej J Bojarski, Małgorzata Zygmunt, Grzegorz Kazek, Barbara Mordyl, Maciej Pawłowsk. Structure-5-HT receptor affinity relationship in a new group of 7-arylpiperazynylalkyl and 7-tetrahydroisoquinolinylalkyl derivatives of 8-amino-1,3-dimethyl-1H-purine-2,6(3H,7H)-dione. Archiv der Pharmazie. vol 348. issue 4. 2016-01-21. PMID:25773578. |
in order to examine the influence of the substituent in the position 8 of the purine moiety on the affinity for the serotonin 5-ht1a , 5-ht2a , and 5-ht7 receptors, a series of 7-arylpiperazynylalkyl and 7-tetrahydroisoquinolinylalkyl (thiq) derivatives of 8-amino-1,3-dimethyl-1h-purine-2,6(3h,7h)-dione were synthesized. |
2016-01-21 |
2023-08-13 |
Not clear |
| Paweł Żmudzki, Grażyna Chłoń-Rzepa, Andrzej J Bojarski, Małgorzata Zygmunt, Grzegorz Kazek, Barbara Mordyl, Maciej Pawłowsk. Structure-5-HT receptor affinity relationship in a new group of 7-arylpiperazynylalkyl and 7-tetrahydroisoquinolinylalkyl derivatives of 8-amino-1,3-dimethyl-1H-purine-2,6(3H,7H)-dione. Archiv der Pharmazie. vol 348. issue 4. 2016-01-21. PMID:25773578. |
all the final compounds were investigated in in vitro competition binding experiments for serotonin 5-ht1a , 5-ht2a , and 5-ht7 receptors. |
2016-01-21 |
2023-08-13 |
Not clear |
| Grażyna Chłoń-Rzepa, Agnieszka Zagórska, Adam Bucki, Marcin Kołaczkowski, Maciej Pawłowski, Grzegorz Satała, Andrzej J Bojarski, Anna Partyka, Anna Wesołowska, Elżbieta Pękala, Karolina Słoczyńsk. New arylpiperazinylalkyl derivatives of 8-alkoxy-purine-2,6-dione and dihydro[1,3]oxazolo[2,3-f]purinedione targeting the serotonin 5-HT1A /5-HT2A /5-HT7 and dopamine D2 receptors. Archiv der Pharmazie. vol 348. issue 4. 2016-01-21. PMID:25773907. |
to obtain potential antidepressants and/or antipsychotics, a series of new long-chain arylpiperazine derivatives of 8-alkoxy-purine-2,6-dione (10-24) and dihydro[1,3]oxazolo[2,3-f]purinedione (30-34) were synthesized and their serotonin (5-ht1a , 5-ht2a , 5-ht6 , 5-ht7 ) and dopamine (d2 ) receptor affinities were determined. |
2016-01-21 |
2023-08-13 |
mouse |
| Ichiro Kusumi, Shuken Boku, Yoshito Takahash. Psychopharmacology of atypical antipsychotic drugs: From the receptor binding profile to neuroprotection and neurogenesis. Psychiatry and clinical neurosciences. vol 69. issue 5. 2016-01-18. PMID:25296946. |
a variety of serotonin (5-ht) receptors, such as 5-ht2a / 2c , 5-ht1a , 5-ht6 and 5-ht7 receptors, may contribute to the mechanisms of action of 'atypicality'. |
2016-01-18 |
2023-08-13 |
Not clear |
| Antony Loebel, Leslie Citrom. Lurasidone: a novel antipsychotic agent for the treatment of schizophrenia and bipolar depression. BJPsych bulletin. vol 39. issue 5. 2016-01-12. PMID:26755968. |
in addition to full antagonist activity at dopamine d2 (k i(d2) = 1 nm) and serotonin 5-ht2a (k i(5-ht2a) = 0.5 nm) receptors, the pharmacodynamic profile of lurasidone is notable for its high affinity for serotonin 5-ht7 receptors (k i(5-ht7) = 0.5 nm) and its partial agonist activity at 5-ht1a receptors (k i(5-ht1a) = 6.4 nm). |
2016-01-12 |
2023-08-13 |
Not clear |
| Cécile Bétry, Adeline Etiévant, Alan Pehrson, Connie Sánchez, Nasser Haddjer. Effect of the multimodal acting antidepressant vortioxetine on rat hippocampal plasticity and recognition memory. Progress in neuro-psychopharmacology & biological psychiatry. vol 58. 2016-01-05. PMID:25524057. |
vortioxetine is a multimodal acting antidepressant that functions as a 5-ht3 and 5-ht7 and 5-ht1d receptor antagonist, 5-ht1b receptor partial agonist, 5-ht1a receptor agonist and inhibitor of the 5-ht transporter. |
2016-01-05 |
2023-08-13 |
human |
| Maria N Modica, Sebastiano Intagliata, Valeria Pittalà, Loredana Salerno, Maria A Siracusa, Alfredo Cagnotto, Mario Salmona, Giuseppe Rome. Synthesis and binding properties of new long-chain 4-substituted piperazine derivatives as 5-HT₁A and 5-HT₇ receptor ligands. Bioorganic & medicinal chemistry letters. vol 25. issue 7. 2015-12-21. PMID:25759032. |
new long-chain 4-substituted piperazines linked to a thienopyrimidine or a quinazoline system were synthesized and tested for their binding properties on human cloned 5-ht1a and 5-ht7 serotonin receptors. |
2015-12-21 |
2023-08-13 |
human |
| Katarzyna Panczyk, Sylwia Golda, Anna Waszkielewicz, Dorota Zelaszczyk, Agnieszka Gunia-Krzyzak, Henryk Maron. Serotonergic system and its role in epilepsy and neuropathic pain treatment: a review based on receptor ligands. Current pharmaceutical design. vol 21. issue 13. 2015-11-23. PMID:25412650. |
so far, participation in the epileptogenesis and maintenance of epilepsy was proved for 5-ht1a, 5-ht2c, 5-ht3, 5-ht4 and 5-ht7 receptors as well as 5-htt serotonin transporter. |
2015-11-23 |
2023-08-13 |
Not clear |
| Clinton E Canal, Daniel E Felsing, Yue Liu, Wanying Zhu, JodiAnne T Wood, Charles K Perry, Rajender Vemula, Raymond G Boot. Correction to an orally active phenylaminotetralin-chemotype serotonin 5-HT7 and 5-HT1A receptor partial agonist that corrects motor stereotypy in mouse models. ACS chemical neuroscience. vol 6. issue 8. 2015-10-27. PMID:26225542. |
correction to an orally active phenylaminotetralin-chemotype serotonin 5-ht7 and 5-ht1a receptor partial agonist that corrects motor stereotypy in mouse models. |
2015-10-27 |
2023-08-13 |
mouse |
| Anna Partyka, Grażyna Chłoń-Rzepa, Anna Wasik, Magdalena Jastrzębska-Więsek, Adam Bucki, Marcin Kołaczkowski, Grzegorz Satała, Andrzej J Bojarski, Anna Wesołowsk. Antidepressant- and anxiolytic-like activity of 7-phenylpiperazinylalkyl-1,3-dimethyl-purine-2,6-dione derivatives with diversified 5-HT₁A receptor functional profile. Bioorganic & medicinal chemistry. vol 23. issue 1. 2015-10-22. PMID:25435254. |
continuing our earlier study in a group of purine-2,6-dione derivatives of long chain arylpiperazines (lcaps), a series of 8-unsubstituted 7-phenylpiperazin-4-yl-alkyl (4-14) and 7-tetrahydroisoquinolinyl-alkyl (15-17) analogues were synthesized and their serotonin 5-ht1a, 5-ht2a, 5-ht6, 5-ht7 and dopamine d2 receptor affinities were determined. |
2015-10-22 |
2023-08-13 |
mouse |
| Anna Partyka, Grażyna Chłoń-Rzepa, Anna Wasik, Magdalena Jastrzębska-Więsek, Adam Bucki, Marcin Kołaczkowski, Grzegorz Satała, Andrzej J Bojarski, Anna Wesołowsk. Antidepressant- and anxiolytic-like activity of 7-phenylpiperazinylalkyl-1,3-dimethyl-purine-2,6-dione derivatives with diversified 5-HT₁A receptor functional profile. Bioorganic & medicinal chemistry. vol 23. issue 1. 2015-10-22. PMID:25435254. |
the study allowed us to identify some potent 5-ht1a receptor ligands with additional moderate affinity for 5-ht2a, 5-ht7 and dopamine d2 receptors. |
2015-10-22 |
2023-08-13 |
mouse |
| Stephen M Stah. Modes and nodes explain the mechanism of action of vortioxetine, a multimodal agent (MMA): enhancing serotonin release by combining serotonin (5HT) transporter inhibition with actions at 5HT receptors (5HT1A, 5HT1B, 5HT1D, 5HT7 receptors). CNS spectrums. vol 20. issue 2. 2015-09-15. PMID:25831967. |
modes and nodes explain the mechanism of action of vortioxetine, a multimodal agent (mma): enhancing serotonin release by combining serotonin (5ht) transporter inhibition with actions at 5ht receptors (5ht1a, 5ht1b, 5ht1d, 5ht7 receptors). |
2015-09-15 |
2023-08-13 |
Not clear |
| Asres Berhan, Alex Barke. Vortioxetine in the treatment of adult patients with major depressive disorder: a meta-analysis of randomized double-blind controlled trials. BMC psychiatry. vol 14. 2015-09-02. PMID:25260373. |
it is a selective serotonin (5-ht) 3a and 5-ht7 receptor antagonist, 5-ht1b receptor partial agonist, 5-ht1a receptor agonist and inhibitor of serotonin transporters. |
2015-09-02 |
2023-08-13 |
Not clear |
| Ashish Dhir, Jayrajsinh Sarvaiy. The efficacy of vortioxetine for the treatment of major depressive disorder. Expert review of neurotherapeutics. vol 14. issue 12. 2015-09-01. PMID:25418918. |
vortioxetine is an agonist of 5-ht1a, a partial agonist of 5-ht1b and an antagonist of 5-ht1d, 5-ht3 and 5-ht7 serotoninergic receptors. |
2015-09-01 |
2023-08-13 |
Not clear |