| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S A Lorens, L D Van de Ka. Differential effects of serotonin (5-HT1A and 5-HT2) agonists and antagonists on renin and corticosterone secretion. Neuroendocrinology. vol 45. issue 4. 1987-06-01. PMID:2952898. |
the present study was designed to investigate the effect of distinct serotonin (5-ht1a and 5-ht2) agonists and antagonists on renin and corticosterone secretion. |
1987-06-01 |
2023-08-11 |
Not clear |
| G A Kennett, C T Dourish, G Curzo. Antidepressant-like action of 5-HT1A agonists and conventional antidepressants in an animal model of depression. European journal of pharmacology. vol 134. issue 3. 1987-05-28. PMID:2883013. |
however, the 5-ht1a agonists buspirone and tvxq 7821 (ipsapirone) and the non-specific 5-ht agonist quipazine all possess similar properties to 8-oh-dpat in this test. |
1987-05-28 |
2023-08-11 |
rat |
| K B Asarch, J C Shi. Solubilization of serotonin1a and serotonin1b binding sites from bovine brain. Journal of neurochemistry. vol 48. issue 5. 1987-05-20. PMID:2951498. |
the density of [3h]dpat binding sites relative to the [3h]5-ht sites in the solubilized cortical membranes (35%) corresponds well with the proportion of 5-ht1a sites in the crude membranes determined by spiperone displacement (33%), suggesting that both the 5-ht1a and 5-ht1b binding sites have been cosolubilized. |
1987-05-20 |
2023-08-11 |
cattle |
| S D Mendelson, B B Gorzalk. Effects of 5-HT1A selective anxiolytics on lordosis behavior: interactions with progesterone. European journal of pharmacology. vol 132. issue 2-3. 1987-04-07. PMID:2880737. |
these data are consistent with the proposal that 5-ht1a receptors mediate lordosis-inhibiting effects of 5-ht, and further suggest that some 5-ht1a agonists may facilitate lordosis by activity at autoreceptors. |
1987-04-07 |
2023-08-11 |
rat |
| D G Spencer, J Trabe. The interoceptive discriminative stimuli induced by the novel putative anxiolytic TVX Q 7821: behavioral evidence for the specific involvement of serotonin 5-HT1A receptors. Psychopharmacology. vol 91. issue 1. 1987-04-06. PMID:2881318. |
the interoceptive discriminative stimuli induced by the novel putative anxiolytic tvx q 7821: behavioral evidence for the specific involvement of serotonin 5-ht1a receptors. |
1987-04-06 |
2023-08-11 |
rat |
| D G Spencer, J Trabe. The interoceptive discriminative stimuli induced by the novel putative anxiolytic TVX Q 7821: behavioral evidence for the specific involvement of serotonin 5-HT1A receptors. Psychopharmacology. vol 91. issue 1. 1987-04-06. PMID:2881318. |
tvx q 7821 is active in several behavioral models of anxiety in animals and has a high selective affinity for brain serotonin 5-ht1a receptors in binding assays. |
1987-04-06 |
2023-08-11 |
rat |
| R D Todd, R D Ciaranell. Multiple high-affinity [3H]serotonin binding sites in human frontal cortex. Brain research. vol 400. issue 2. 1987-04-02. PMID:3815073. |
high-affinity [3h]serotonin (5-hydroxytryptamine, 5-ht) binding sites from human frontal cortex can be divided into at least 3 pharmacological subtypes (5-ht1a, 5-ht1b and 5-ht3) based on affinity for [3h]serotonin and spiperone. |
1987-04-02 |
2023-08-11 |
human |
| G M Goodwin, R J De Souza, A J Wood, A R Gree. The enhancement by lithium of the 5-HT1A mediated serotonin syndrome produced by 8-OH-DPAT in the rat: evidence for a post-synaptic mechanism. Psychopharmacology. vol 90. issue 4. 1987-03-20. PMID:2949333. |
the enhancement by lithium of the 5-ht1a mediated serotonin syndrome produced by 8-oh-dpat in the rat: evidence for a post-synaptic mechanism. |
1987-03-20 |
2023-08-11 |
rat |
| G M Goodwin, R J DeSouza, A J Wood, A R Gree. Lithium decreases 5-HT1A and 5-HT2 receptor and alpha 2-adrenoceptor mediated function in mice. Psychopharmacology. vol 90. issue 4. 1987-03-20. PMID:3027734. |
by contrast with this reduction of 5-hydroxytryptamine (5-ht) function mediated by the 5-ht1a and 5-ht2 receptor sub-types, repeated lithium administration had no effect on the motor response to a putative 5-ht1b receptor agonist 5-methoxy-3(1,2,3,6-tetrahydropyridin-4-yl)1h indole (ru 24969, 3 mg/kg ip). |
1987-03-20 |
2023-08-11 |
mouse |
| D Vergé, G Daval, M Marcinkiewicz, A Patey, S el Mestikawy, H Gozlan, M Hamo. Quantitative autoradiography of multiple 5-HT1 receptor subtypes in the brain of control or 5,7-dihydroxytryptamine-treated rats. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 6. issue 12. 1987-02-10. PMID:2947981. |
these results are discussed in relation to the possible identity of 5-ht1a and/or 5-ht1b sites with the presynaptic 5-ht autoreceptors controlling nerve impulse flow and neurotransmitter release in serotoninergic neurons. |
1987-02-10 |
2023-08-11 |
rat |
| J S Sprouse, G K Aghajania. (-)-Propranolol blocks the inhibition of serotonergic dorsal raphe cell firing by 5-HT1A selective agonists. European journal of pharmacology. vol 128. issue 3. 1987-01-27. PMID:2878817. |
however, (-)-propranolol was a relatively weak antagonist of 5-ht itself, suggesting that the endogenous neurotransmitter may have actions on dorsal raphe neurons in addition to those mediated by 5-ht1a receptors. |
1987-01-27 |
2023-08-11 |
Not clear |
| P H Hutson, C T Dourish, G Curzo. Neurochemical and behavioural evidence for mediation of the hyperphagic action of 8-OH-DPAT by 5-HT cell body autoreceptors. European journal of pharmacology. vol 129. issue 3. 1987-01-22. PMID:2430815. |
administration of 60 micrograms/kg s.c. of the 5-ht1a agonist 8-hydroxy-2-(di-n-propylamino)-tetralin (8-oh-dpat), a dose previously shown to cause hyperphagia in satiated rats (but not to cause the 5-ht behavioural syndrome) decreased 5-hiaa and 5-hiaa/5-ht ratio in several brain regions, the most marked effects being in pons + medulla oblongata, a region containing 5-ht cell bodies and ascending 5-ht axons. |
1987-01-22 |
2023-08-11 |
rat |
| G Maura, M Raiter. Cholinergic terminals in rat hippocampus possess 5-HT1B receptors mediating inhibition of acetylcholine release. European journal of pharmacology. vol 129. issue 3. 1987-01-22. PMID:3780847. |
the 5-ht1 agonist 5-methoxy-3-[1,2,3,6-tetrahydropyridin-4-yl]-1h-indole (ru 24969) mimicked 5-ht, whereas the 5-ht1a selective agonist 8-hydroxy-2-(di-n-propylamino)tetralin (8-oh-dpat) was ineffective. |
1987-01-22 |
2023-08-11 |
rat |
| G Maura, M Raiter. Cholinergic terminals in rat hippocampus possess 5-HT1B receptors mediating inhibition of acetylcholine release. European journal of pharmacology. vol 129. issue 3. 1987-01-22. PMID:3780847. |
when used as a 5-ht1a/5-ht1b antagonist, (-)propranolol antagonized 5-ht whereas spiperone (a 5-ht1a displacer) did not. |
1987-01-22 |
2023-08-11 |
rat |
| G A Gudelsky, J I Koenig, H Jackman, H Y Meltze. Suppression of the hypo- and hyperthermic responses to 5-HT agonists following the repeated administration of monoamine oxidase inhibitors. Psychopharmacology. vol 90. issue 3. 1987-01-16. PMID:2947256. |
in view of the concept that the hypo- and hyperthermic responses to 5-ht agonists are mediated by 5-ht1a and 5-ht2 receptor subtypes, respectively, it is concluded that the responsiveness of these 5-ht receptor subtypes involved in thermoregulatory responses is decreased following chronic treatment of rats with monoamine oxidase inhibitors. |
1987-01-16 |
2023-08-11 |
rat |
| M G Palfreyman, A K Mir, M Kubina, D N Middlemiss, M Richards, M D Tricklebank, J R Fozar. Monoamine receptor sensitivity changes following chronic administration of MDL 72394, a site-directed inhibitor of monoamine oxidase. European journal of pharmacology. vol 130. issue 1-2. 1987-01-06. PMID:3780861. |
the effect of chronic mao inhibitor treatment on 5-ht1a receptors was associated with a decrease in the behavioural response to 8-hydroxy-2-(di-n-propylamino)tetralin and the decrease in 5-ht2 binding was related to a small reduction in the sensitivity of the inositol phosphate system to stimulation by 5-ht. |
1987-01-06 |
2023-08-11 |
rat |
| R Markstein, D Hoyer, G Enge. 5-HT1A-receptors mediate stimulation of adenylate cyclase in rat hippocampus. Naunyn-Schmiedeberg's archives of pharmacology. vol 333. issue 4. 1986-12-12. PMID:2945992. |
the rank order of potency of 13 agonists stimulating adenylate cyclase activity in homogenates of rat hippocampus was in good agreement with the rank order of affinity of these agonists for the 5-ht1a binding site: n,n-dipropyl-5-carboxamidotryptamine (dp-5-ct) greater than 5-carboxamidotryptamine (5-ct) greater than 8-oh-dpat greater than 5-ht greater than 5-methoxytryptamine (5-och3t) greater than d-lsd greater than 5-methoxy-3-(1,2,3,6-tetrahydro-4-pyridinyl)-1h-indole (ru 24969) greater than alpha-methylserotonin (alpha-ch3-5-ht) greater than dopamine greater than 2-methylserotonin (2-ch3-5-ht). |
1986-12-12 |
2023-08-11 |
rat |
| H O Kalkman, G Engel, D Hoye. Inhibition of 5-carboxamidotryptamine-induced relaxation of guinea-pig ileum correlates with [125I]LSD binding. European journal of pharmacology. vol 129. issue 1-2. 1986-12-11. PMID:3770071. |
the results suggest that the 5-ht receptor-mediating relaxation in the guinea-pig ileum can be labelled with [125i]lsd and that this receptor does not belong to the 5-ht2, 5-ht1a, 5-ht1b or 5-ht1c receptor subtypes. |
1986-12-11 |
2023-08-11 |
Not clear |
| M B Emerit, H Gozlan, A Marquet, M Hamo. Irreversible blockade of central 5-HT1A receptor binding sites by the photoaffinity probe 8-methoxy-3'-NAP-amino-PAT. European journal of pharmacology. vol 127. issue 1-2. 1986-11-10. PMID:2944752. |
in the dark, this compound, 8-methoxy-2-(n-n-propyl,n-3-(2-nitro-4-azidophenyl)aminopropyl) aminotetralin or 8-methoxy-3'-nap-amino-pat, displaced [3h]8-oh-dpat and [3h]5-ht bound to 5-ht1a and 5-ht1 sites in hippocampal membranes with ic50 values of 6.6 and 18.1 nm respectively. |
1986-11-10 |
2023-08-11 |
rat |
| M B Emerit, H Gozlan, A Marquet, M Hamo. Irreversible blockade of central 5-HT1A receptor binding sites by the photoaffinity probe 8-methoxy-3'-NAP-amino-PAT. European journal of pharmacology. vol 127. issue 1-2. 1986-11-10. PMID:2944752. |
under uv irradiation (lambda = 366 nm), 8-methoxy-3'-nap-amino-pat produced an irreversible blockade of 5-ht1a sites which could be prevented by prior site occupancy by a saturating concentration (10 microm) of reversible 5-ht ligands such as 5-ht itself, 8-oh-dpat or lsd. |
1986-11-10 |
2023-08-11 |
rat |