| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Nuh Mehmet Bozkurt, Gokhan Una. Vortioxetine Improved Negative and Cognitive Symptoms of Schizophrenia in Subchronic MK-801 Induced Schizophrenia Model in Rats. Behavioural brain research. 2023-03-01. PMID:36858318. |
vortioxetine is a new multimodal antidepressant with 5-ht1a agonism, 5-ht1b partial agonism, 5-ht3, 5-ht7, and 5-ht1d antagonism, and serotonin reuptake inhibition. |
2023-03-01 |
2023-08-14 |
rat |
| Cheng-Jie Li, Li-Ge Zhang, Lu-Bing Liu, Meng-Qi An, Li-Guo Dong, Han-Ying Gu, Yong-Ping Dai, Fen Wang, Cheng-Jie Mao, Chun-Feng Li. Inhibition of Spinal 5-HT3 Receptor and Spinal Dorsal Horn Neuronal Excitability Alleviates Hyperalgesia in a Rat Model of Parkinson's Disease. Molecular neurobiology. 2022-09-28. PMID:36168076. |
several 5-ht receptor subtypes have been confirmed to be associated with nociception in the spinal cord, such as 5-ht1a receptor, 5-ht1b receptor, 5-ht2 receptor, 5-ht3 receptor, and 5-ht7 receptor. |
2022-09-28 |
2023-08-14 |
rat |
| Daniela Adamo, Elena Calabria, Noemi Coppola, Giuseppe Pecoraro, Michele Davide Mignogn. Vortioxetine as a new frontier in the treatment of chronic neuropathic pain: a review and update. Therapeutic advances in psychopharmacology. vol 11. 2021-09-10. PMID:34497709. |
this drug inhibits the serotonin transporter with a high affinity, antagonises the 5-ht3, 5-ht1d and 5ht7 serotonin receptors, and activates the 5-ht1a and 5-ht1b receptors. |
2021-09-10 |
2023-08-13 |
Not clear |
| Anna Rita Zuena, Daniela Maftei, Giovanni Sebastiano Alemà, Francesca Dal Moro, Roberta Lattanzi, Paola Casolini, Ferdinando Nicolett. Multimodal antidepressant vortioxetine causes analgesia in a mouse model of chronic neuropathic pain. Molecular pain. vol 14. 2019-02-20. PMID:30289053. |
vortioxetine is a multimodal antidepressant that potently antagonizes 5-ht3 serotonin receptors, inhibits the high-affinity serotonin transporter, activates 5-ht1a and 5-ht1b receptors, and antagonizes 5-ht1d and 5-ht7 receptors. |
2019-02-20 |
2023-08-13 |
mouse |
| Miriam A Snider, David L Harmon, James L Klot. Pharmacologic assessment of bovine ruminal and mesenteric vascular serotonin receptor populations. Journal of animal science. vol 96. issue 4. 2018-10-09. PMID:29471490. |
to determine what 5-ht receptors are involved in vasoconstriction of gut vasculature, contractility of ruminal and mesenteric arteries and veins collected from cattle was evaluated in the presence of agonists selective for 5-ht1b (cp 93129), 5-ht1d (l-694, 247), 5-ht2a (tcb-2), 5-ht2b (bw 723c86), 5-ht4 (bimu-8), and 5-ht7 (lp 44) receptors. |
2018-10-09 |
2023-08-13 |
cattle |
| Lauren Hatherall, Connie Sánchez, David A Morila. Chronic Vortioxetine Treatment Reduces Exaggerated Expression of Conditioned Fear Memory and Restores Active Coping Behavior in Chronically Stressed Rats. The international journal of neuropsychopharmacology. vol 20. issue 4. 2018-05-18. PMID:27927740. |
vortioxetine, a novel multimodal antidepressant, is a serotonin transporter inhibitor; 5-ht3, 5-ht7, and 5-ht1d receptor antagonist; 5-ht1b partial agonist; and 5-ht1a agonist. |
2018-05-18 |
2023-08-13 |
rat |
| Laura Orsolini, Carmine Tomasetti, Alessandro Valchera, Felice Iasevoli, Elisabetta Filomena Buonaguro, Michele Fornaro, Annastasia L C Fiengo, Giovanni Martinotti, Federica Vellante, Ilaria Matarazzo, Roberta Vecchiotti, Giampaolo Perna, Marco Di Nicola, Alessandro Carano, Andrea Di Bartolomeis, Massimo De Giannantonio, Domenico De Berardi. Current and Future Perspectives on the Major Depressive Disorder: Focus on the New Multimodal Antidepressant Vortioxetine. CNS & neurological disorders drug targets. vol 16. issue 1. 2018-02-09. PMID:27781949. |
vortioxetine (vrx) is a multimodal antidepressant that acts as serotonin (5ht) transporter inhibitor as well as 5ht3a and 5ht7 receptors antagonist, 5ht1a and 5ht1b receptors partial agonist. |
2018-02-09 |
2023-08-13 |
Not clear |
| Andrea de Bartolomeis, Andrea Fagiolini, Giuseppe Main. [Vortioxetine in the treatment of major depression]. Rivista di psichiatria. vol 51. issue 6. 2017-11-20. PMID:27996982. |
vortioxetine is a multi-modal antidepressant that functions both as serotonin transporter (sert) inhibitor and as 5-ht3, 5-ht7 and 5-ht1d receptors antagonist, 5-ht1a receptor agonist and 5-ht1b receptor partial agonist. |
2017-11-20 |
2023-08-13 |
Not clear |
| Annina Huser, Melanie Eschment, Nazli Güllü, Katharina A N Collins, Kathrin Böpple, Lyubov Pankevych, Emilia Rolsing, Andreas S Thu. Anatomy and behavioral function of serotonin receptors in Drosophila melanogaster larvae. PloS one. vol 12. issue 8. 2017-10-10. PMID:28777821. |
our data suggest that 5-ht1a, 5-ht1b, and 5-ht7 are dispensable for larval naïve olfactory and gustatory choice behaviors as well as for appetitive and aversive associative olfactory learning and memory. |
2017-10-10 |
2023-08-13 |
drosophila_melanogaster |
| Laura Orsolini, Carmine Tomasetti, Alessandro Valchera, Felice Iasevoli, Elisabetta Filomena Buonaguro, Federica Vellante, Michele Fornaro, Annastasia Fiengo, Monica Mazza, Roberta Vecchiotti, Giampaolo Perna, Andrea de Bartolomeis, Giovanni Martinotti, Massimo Di Giannantonio, Domenico De Berardi. New advances in the treatment of generalized anxiety disorder: the multimodal antidepressant vortioxetine. Expert review of neurotherapeutics. vol 16. issue 5. 2017-06-27. PMID:27050932. |
vortioxetine (vrx) is a multimodal antidepressant with a unique mechanism of action, by acting as 5-ht3a, 5-ht1d and 5-ht7 receptor antagonist, partial agonist at the 5-ht1a and 5-ht1b receptors and inhibitor at the 5-ht transporter. |
2017-06-27 |
2023-08-13 |
Not clear |
| Dioneia Araldi, Luiz F Ferrari, Jon D Levin. Gi-protein-coupled 5-HT1B/D receptor agonist sumatriptan induces type I hyperalgesic priming. Pain. vol 157. issue 8. 2017-03-13. PMID:27075428. |
the prolongation of pge2 hyperalgesia induced by sumatriptan was partially prevented by coinjection of antagonists for the 5-ht1b and 5-ht1d, but not 5-ht7, serotonin receptors and completely prevented by coadministration of a combination of the 5-ht1b and 5-ht1d antagonists. |
2017-03-13 |
2023-08-13 |
rat |
| Gennady N Smagin, Dekun Song, David P Budac, Jessica A Waller, Yan Li, Alan L Pehrson, Connie Sánche. Histamine may contribute to vortioxetine's procognitive effects; possibly through an orexigenic mechanism. Progress in neuro-psychopharmacology & biological psychiatry. vol 68. 2017-01-02. PMID:26945513. |
vortioxetine is a novel multimodal antidepressant that acts as a serotonin (5-ht)3, 5-ht7, and 5-ht1d receptor antagonist; 5-ht1b receptor partial agonist; 5-ht1a receptor agonist; and 5-ht transporter inhibitor in vitro. |
2017-01-02 |
2023-08-13 |
rat |
| J A García-Pedraza, M García, M L Martín, A Rodríguez-Barbero, A Morá. 5-HT2 receptor blockade exhibits 5-HT vasodilator effects via nitric oxide, prostacyclin and ATP-sensitive potassium channels in rat renal vasculature. Vascular pharmacology. vol 79. 2016-12-13. PMID:26586311. |
agonists 5-ct (5-ht1/7), cgs-12066b (5-ht1b), l-694,247 (5-ht1d) or as-19 (5-ht7) mimicked renal 5-ht vasodilator effect. |
2016-12-13 |
2023-08-13 |
rat |
| J A García-Pedraza, M García, M L Martín, A Rodríguez-Barbero, A Morá. 5-HT2 receptor blockade exhibits 5-HT vasodilator effects via nitric oxide, prostacyclin and ATP-sensitive potassium channels in rat renal vasculature. Vascular pharmacology. vol 79. 2016-12-13. PMID:26586311. |
our data suggest that 5-ht exerts renal vasodilator effect in the in situ autoperfused sarpogrelate-treated rat kidney, mediated by 5-ht1d, 5-ht1b and 5-ht7 receptors, involving cyclooxygenase-derived prostacyclin, nitric oxide synthesis/release and atp-sensitive k+ channels, respectively. |
2016-12-13 |
2023-08-13 |
rat |
| Jessica A Waller, Fenghua Chen, Connie Sánche. Vortioxetine promotes maturation of dendritic spines in vitro: A comparative study in hippocampal cultures. Neuropharmacology. vol 103. 2016-12-13. PMID:26702943. |
the multimodal-acting antidepressant vortioxetine is an antagonist at 5-ht3, 5-ht7, and 5-ht1d receptors, a partial agonist at 5-ht1b receptors, an agonist at 5-ht1a receptors, and an inhibitor of the serotonin (5-ht) transporter (sert) and has pro-cognitive properties. |
2016-12-13 |
2023-08-13 |
Not clear |
| D J David, L Tritschler, J-P Guilloux, A M Gardier, C Sanchez, R Gaillar. [Pharmacological properties of vortioxetine and its pre-clinical consequences]. L'Encephale. vol 42. issue 1 Suppl 1. 2016-12-13. PMID:26879252. |
compared to the ssris, vortioxetine is defined as a multimodal antidepressant drug since it is not only a serotonin reuptake inhibitor, but also a 5-ht1d, 5-ht3, 5-ht7 receptor antagonist, 5-ht1b receptor partial agonist and 5-ht1a receptor agonist. |
2016-12-13 |
2023-08-13 |
Not clear |
| Danielle A Diniz, Júlia Alvarenga Petrocchi, Larissa Caldeira Navarro, Tâmara Cristina Souza, Marina G M Castor, Andrea C Perez, Igor D G Duarte, Thiago R L Romer. Serotonin induces peripheral mechanical antihyperalgesic effects in mice. European journal of pharmacology. vol 767. 2016-10-05. PMID:26460149. |
we used selective antagonists of serotonin receptors (isamoltan 5-ht1b, brl 15572 5-ht1d, ketanserin 5-ht2a, ondansetron 5-ht3 and sb-269970 5-ht7). |
2016-10-05 |
2023-08-13 |
mouse |
| Steven C Leiser, Deborah Iglesias-Bregna, Ligia Westrich, Alan L Pehrson, Connie Sanche. Differentiated effects of the multimodal antidepressant vortioxetine on sleep architecture: Part 2, pharmacological interactions in rodents suggest a role of serotonin-3 receptor antagonism. Journal of psychopharmacology (Oxford, England). vol 29. issue 10. 2016-06-23. PMID:26174134. |
vortioxetine, a multimodal antidepressant acting through serotonin (5-ht) transporter (sert) inhibition, 5-ht3, 5-ht7 and 5-ht1d receptor antagonism, 5-ht1b receptor partial agonism, and 5-ht1a receptor agonism, had fewer incidences of sleep-related adverse events reported in depressed patients. |
2016-06-23 |
2023-08-13 |
human |
| José-Ángel García-Pedraza, Mónica García, María-Luisa Martín, Asunción Morá. 5-HT1D receptor inhibits renal sympathetic neurotransmission by nitric oxide pathway in anesthetized rats. Vascular pharmacology. vol 72. 2016-05-19. PMID:26003124. |
bolus of agonists α-methyl-5-ht (5-ht2), 1-pbg (5-ht3), cisapride (5-ht4), as-19 (5-ht7), cgs-12066b (5-ht1b) or 8-oh-dpat (5-ht1a) (0.0125μg/kg each). |
2016-05-19 |
2023-08-13 |
rat |
| Mostafa El Mansari, Maurice Lecours, Pierre Blie. Effects of acute and sustained administration of vortioxetine on the serotonin system in the hippocampus: electrophysiological studies in the rat brain. Psychopharmacology. vol 232. issue 13. 2016-02-02. PMID:25665528. |
vortioxetine is a novel multimodal antidepressant that is a 5-ht1b receptor partial agonist, a 5-ht1a receptor agonist, an inhibitor of the serotonin (5-ht) transporter, and a 5-ht1d, 5-ht3, and 5-ht7 receptor antagonist in vitro. |
2016-02-02 |
2023-08-13 |
rat |