| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Arne Mørk, Liliana P Montezinho, Silke Miller, Crista Trippodi-Murphy, Niels Plath, Yan Li, Maria Gulinello, Connie Sanche. Vortioxetine (Lu AA21004), a novel multimodal antidepressant, enhances memory in rats. Pharmacology, biochemistry, and behavior. vol 105. 2013-10-23. PMID:23380522. |
vortioxetine (lu aa21004) in development as a novel multimodal antidepressant is a 5-ht3, 5-ht7 and 5-ht1d receptor antagonist, a 5-ht1b receptor partial agonist, a 5-ht1a receptor agonist and a 5-ht transporter (5-htt) inhibitor in vitro. |
2013-10-23 |
2023-08-12 |
rat |
| T Watanabe, H Aonum. Identification and expression analyses of a novel serotonin receptor gene, 5-HT2β, in the field cricket, Gryllus bimaculatus. Acta biologica Hungarica. vol 63 Suppl 2. 2012-09-17. PMID:22776473. |
in our previous report, in order to elucidate the molecular basis of the cricket 5-ht system, we identified three genes involved in 5-ht biosynthesis, as well as four 5-ht receptor genes (5-ht1a, 5-ht1b, 5-ht2α, and 5-ht7) expressed in the brain of the field cricket gryllus bimaculatus degeer [7]. |
2012-09-17 |
2023-08-12 |
cricket |
| Enric Alvarez, Victor Perez, Marianne Dragheim, Henrik Loft, Francesc Artiga. A double-blind, randomized, placebo-controlled, active reference study of Lu AA21004 in patients with major depressive disorder. The international journal of neuropsychopharmacology. vol 15. issue 5. 2012-09-06. PMID:21767441. |
lu aa21004 is a novel antidepressant that is a 5-ht3 and 5-ht7 receptor antagonist, 5-ht1a receptor agonist, 5-ht1b receptor partial agonist and inhibitor of the 5-ht transporter in recombinant cell lines. |
2012-09-06 |
2023-08-12 |
Not clear |
| Rosa I Caamaño Tubío, Jorge Pérez-Maceira, Manuel Aldegund. Homeostasis of glucose in the rainbow trout (Oncorhynchus mykiss Walbaum): the role of serotonin. The Journal of experimental biology. vol 213. issue 11. 2010-08-17. PMID:20472767. |
administration of tfmpp (a 5-ht1b agonist) did not increase the plasma levels of glucose, and the hyperglycaemic action of 5-ht was not blocked by antagonists of 5-ht1a (way 100635), 5-ht1d (brl 15572), 5-ht2b (sb 204741) or 5-ht7 (pimozide) receptors. |
2010-08-17 |
2023-08-12 |
Not clear |
| I Okun, S E Tkachenko, A Khvat, O Mitkin, V Kazey, A V Ivachtchenk. From anti-allergic to anti-Alzheimer's: Molecular pharmacology of Dimebon. Current Alzheimer research. vol 7. issue 2. 2010-06-21. PMID:19939222. |
within serotonergic receptor subtypes, dimebon shows highest affinity for 5-ht7 (ki=8 nm) and 5-ht6 (ki=34 nm) receptors, with the relative affinity rank-order of 5-ht7 > 5-ht6 > or = 5-ht2a = 5-ht2c > 5-ht1a = 5-ht1b > 5-ht2b=5-ht3. |
2010-06-21 |
2023-08-12 |
Not clear |
| M Shahid, G B Walker, S H Zorn, E H F Won. Asenapine: a novel psychopharmacologic agent with a unique human receptor signature. Journal of psychopharmacology (Oxford, England). vol 23. issue 1. 2009-04-03. PMID:18308814. |
in comparison with the antipsychotics, asenapine showed high affinity and a different rank order of binding affinities (pki) for serotonin receptors (5-ht1a [8.6], 5-ht1b [8.4], 5-ht2a [10.2], 5-ht2b [9.8], 5-ht2c [10.5], 5-ht5 [8.8], 5-ht6 [9.6] and 5-ht7 [9.9]), adrenoceptors (alpha1 [8.9], alpha2a [8.9], alpha2b [9.5] and alpha2c [8.9]), dopamine receptors (d1 [8.9], d2 [8.9], d3 [9.4] and d4 [9.0]) and histamine receptors (h1 [9.0] and h2 [8.2]). |
2009-04-03 |
2023-08-12 |
human |
| M Shahid, G B Walker, S H Zorn, E H F Won. Asenapine: a novel psychopharmacologic agent with a unique human receptor signature. Journal of psychopharmacology (Oxford, England). vol 23. issue 1. 2009-04-03. PMID:18308814. |
asenapine behaved as a potent antagonist (pkb) at 5-ht1a (7.4), 5-ht1b (8.1), 5-ht2a (9.0), 5-ht2b (9.3), 5-ht2c (9.0), 5-ht6 (8.0), 5-ht7 (8.5), d2 (9.1), d3 (9.1), alpha2a (7.3), alpha2b (8.3), alpha2c (6.8) and h1 (8.4) receptors. |
2009-04-03 |
2023-08-12 |
human |
| Andrew Holme. Genetic variation in cortico-amygdala serotonin function and risk for stress-related disease. Neuroscience and biobehavioral reviews. vol 32. issue 7. 2009-02-19. PMID:18439676. |
serotonergic modulation of the acute response to stress and the adaptation to chronic stress is mediated by a myriad of molecules controlling serotonin neuron development (pet-1), synthesis (tryptophan hydroxylase 1 and 2 isozymes), packaging (vesicular monoamine transporter 2), actions at presynaptic and postsynaptic receptors (5-ht1a, 5-ht1b, 5-ht2a, 5-ht2c, 5-ht3a, 5-ht4, 5-ht5a, 5-ht6, 5-ht7), reuptake (serotonin transporter), and degradation (monoamine oxidase a). |
2009-02-19 |
2023-08-12 |
mouse |
| Henrik Stig Jørgense. Studies on the neuroendocrine role of serotonin. Danish medical bulletin. vol 54. issue 4. 2008-02-14. PMID:18208678. |
the acth response to 5-ht is mediated via 5-ht1a, 5-ht1b, 5-ht2a and 5-ht2c receptors and an involvement of the 5-ht4, 5-ht5 and 5-ht7 receptors is proposed. |
2008-02-14 |
2023-08-12 |
rat |
| A Papageorgiou, C Dene. Stimulation of growth hormone release by 5-hydroxytryptamine (5-HT) in cultured rat anterior pituitary cell aggregates: evidence for mediation by 5-HT2B, 5-HT7, 5-HT1B, and ketanserin-sensitive receptors. Endocrinology. vol 148. issue 9. 2007-09-26. PMID:17584957. |
stimulation of growth hormone release by 5-hydroxytryptamine (5-ht) in cultured rat anterior pituitary cell aggregates: evidence for mediation by 5-ht2b, 5-ht7, 5-ht1b, and ketanserin-sensitive receptors. |
2007-09-26 |
2023-08-12 |
rat |
| Hitoshi Kita, Satomi Chiken, Yoshihisa Tachibana, Atsushi Namb. Serotonin modulates pallidal neuronal activity in the awake monkey. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 27. issue 1. 2007-01-29. PMID:17202474. |
previous anatomical studies and in vitro physiological studies in other brain areas have suggested the following possibilities: (1) 5-ht suppresses gabaergic inhibition through presynaptic 5-ht1b receptors; (2) 5-ht decreases the firing of pallidal neurons through postsynaptic 5-ht1a receptors; and (3) 5-ht postsynaptically excites pallidal neurons through activation of 5-ht2c, 5-ht4, or 5-ht7 receptors. |
2007-01-29 |
2023-08-12 |
monkey |
| H Elliott Albers, Mary Karom, Debra Smit. Serotonin and vasopressin interact in the hypothalamus to control communicative behavior. Neuroreport. vol 13. issue 7. 2002-07-16. PMID:12004193. |
in addition, the finding that 8-oh-dpat, cgs-12066a and sc53116 also inhibited avp-induced flank marking suggests that 5-ht could also inhibit flank marking by acting through 5-ht1a, 5-ht7, 5-ht1b and/or 5-ht4 receptor subtypes. |
2002-07-16 |
2023-08-12 |
Not clear |
| B N Smith, P J Sollars, F E Dudek, G E Pickar. Serotonergic modulation of retinal input to the mouse suprachiasmatic nucleus mediated by 5-HT1B and 5-HT7 receptors. Journal of biological rhythms. vol 16. issue 1. 2001-07-26. PMID:11220775. |
serotonergic modulation of retinal input to the mouse suprachiasmatic nucleus mediated by 5-ht1b and 5-ht7 receptors. |
2001-07-26 |
2023-08-12 |
mouse |
| J Yamada, Y Sugimoto, T Noma, T Yoshikaw. Effects of the non-selective 5-HT receptor agonist, 5-carboxamidotryptamine, on plasma glucose levels in rats. European journal of pharmacology. vol 359. issue 1. 1999-02-08. PMID:9831297. |
these results indicate that 5-ct-induced hyperglycemia is elicited by facilitation of adrenaline release from the adrenal gland and that 5-ct-induced hyperglycemia is mediated by the 5-ht7 receptor unrelated to 5-ht1a, 5-ht1b, 5-ht2, 5-ht3, 5-ht4 or 5-ht5 receptors. |
1999-02-08 |
2023-08-12 |
rat |
| M A Re. Photic entrainment of circadian rhythms in rodents. Chronobiology international. vol 15. issue 5. 1999-01-07. PMID:9787933. |
in addition, serotonin appears to regulate the response of the scn circadian clock to light through postsynaptic 5-ht1a or 5-ht7 receptors, as well as presynaptic 5-ht1b heteroreceptors on rht terminals. |
1999-01-07 |
2023-08-12 |
Not clear |
| G E Pickard, M A Re. Serotonergic innervation of the hypothalamic suprachiasmatic nucleus and photic regulation of circadian rhythms. Biology of the cell. vol 89. issue 8. 1998-07-16. PMID:9618901. |
in this paper, we review evidence suggesting that the serotonergic modulation of retinohypothalamic neurotransmission may be achieved via at least two different cellular mechanisms: 1) a postsynaptic mechanism mediated via 5ht1a or 5ht7 receptors located on scn neurons; and 2) a presynaptic mechanism mediated via 5ht1b receptors located on retinal axon terminals in the scn. |
1998-07-16 |
2023-08-12 |
Not clear |
| P A Pierce, G X Xie, J D Levine, S J Peroutk. 5-Hydroxytryptamine receptor subtype messenger RNAs in rat peripheral sensory and sympathetic ganglia: a polymerase chain reaction study. Neuroscience. vol 70. issue 2. 1996-10-22. PMID:8848158. |
within lumbar dorsal root ganglia, the presence of the 5-ht1b, 5-ht1d, 5-ht2a, 5-ht2c, 5-ht3 and 5-ht7 receptor subtype messenger rnas was detected. |
1996-10-22 |
2023-08-12 |
rat |
| R B Raffa, E E Cod. Lack of binding of acetaminophen to 5-HT receptor or uptake sites (or eleven other binding/uptake assays). Life sciences. vol 59. issue 2. 1996-08-30. PMID:8699917. |
in the present study, we measured the affinity of acetaminophen at 5-ht3, as well as 5-ht1a, 5-ht1b, 5-ht1d, 5-ht2, 5-ht2c, 5-ht4, 5-ht6, 5-ht7 and eleven other receptor sites and at serotonin and norepinephrine reuptake sites. |
1996-08-30 |
2023-08-12 |
Not clear |
| G J Molderings, D Frölich, J Likungu, M Göther. Inhibition of noradrenaline release via presynaptic 5-HT1D alpha receptors in human atrium. Naunyn-Schmiedeberg's archives of pharmacology. vol 353. issue 3. 1996-08-23. PMID:8692281. |
the inhibitory potency of the drugs was significantly correlated with their affinity for 5-htid receptors in human brain and for cloned human 5-ht1d alpha and 5-ht1d beta receptors, but not with their affinity for 5-ht1b, 5-ht1e, 5-ht1f, 5-ht2a, 5-ht2b, 5-ht2c, 5-ht3, 5-ht5a, 5-ht5b and 5-ht7 receptors. |
1996-08-23 |
2023-08-12 |
human |
| X C Li, J F Giot, D Kuhl, R Hen, E R Kande. Cloning and characterization of two related serotonergic receptors from the brain and the reproductive system of Aplysia that activate phospholipase C. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 15. issue 11. 1995-12-26. PMID:7472509. |
sequence comparison reveals that these receptors are 33.1 to 23.3% identical to the following 5-ht receptors: 5-htdro1 > 5-ht6 > 5-htlym > mouse 5-ht1b > 5-htdro2a > mouse 5-ht7 > rat 5-ht2a. |
1995-12-26 |
2023-08-12 |
mouse |