| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Y Mitsuuchi, S W Johnson, S Moonblatt, J R Test. Translocation and activation of AKT2 in response to stimulation by insulin. Journal of cellular biochemistry. vol 70. issue 4. 1998-10-15. PMID:9712142. |
both wild-type akt2 activated by insulin and constitutively active akt2, which has been targeted to the membrane by the addition of a myristoylation signal, were found to inactivate glycogen synthase kinase-3 (gsk-3) in vitro. |
1998-10-15 |
2023-08-12 |
human |
| Y Mitsuuchi, S W Johnson, S Moonblatt, J R Test. Translocation and activation of AKT2 in response to stimulation by insulin. Journal of cellular biochemistry. vol 70. issue 4. 1998-10-15. PMID:9712142. |
collectively, these data indicate that activation of akt2 by insulin is mediated by pi 3-kinase and that gsk-3 is a downstream target of akt2, suggesting a potentially important role of akt2 in glycogen synthesis and other gsk-3 signaling pathways. |
1998-10-15 |
2023-08-12 |
human |
| A X Liu, J R Testa, T C Hamilton, R Jove, S V Nicosia, J Q Chen. AKT2, a member of the protein kinase B family, is activated by growth factors, v-Ha-ras, and v-src through phosphatidylinositol 3-kinase in human ovarian epithelial cancer cells. Cancer research. vol 58. issue 14. 1998-08-07. PMID:9679957. |
here, we demonstrate the activation of akt2 with several growth factors, including epidermal growth factor, insulin-like growth factor 1, insulin-like growth factor ii, basic fibroblast growth factor, platelet-derived growth factor, and insulin, in human ovarian epithelial cancer cells. |
1998-08-07 |
2023-08-12 |
human |
| D A Altomare, G E Lyons, Y Mitsuuchi, J Q Cheng, J R Test. Akt2 mRNA is highly expressed in embryonic brown fat and the AKT2 kinase is activated by insulin. Oncogene. vol 16. issue 18. 1998-06-18. PMID:9620559. |
akt2 mrna is highly expressed in embryonic brown fat and the akt2 kinase is activated by insulin. |
1998-06-18 |
2023-08-12 |
mouse |
| D A Altomare, G E Lyons, Y Mitsuuchi, J Q Cheng, J R Test. Akt2 mRNA is highly expressed in embryonic brown fat and the AKT2 kinase is activated by insulin. Oncogene. vol 16. issue 18. 1998-06-18. PMID:9620559. |
this manuscript is the first to describe akt2 mrna expression in the developing mouse and the activation of akt2 by insulin. |
1998-06-18 |
2023-08-12 |
mouse |
| D A Altomare, G E Lyons, Y Mitsuuchi, J Q Cheng, J R Test. Akt2 mRNA is highly expressed in embryonic brown fat and the AKT2 kinase is activated by insulin. Oncogene. vol 16. issue 18. 1998-06-18. PMID:9620559. |
we show that ha-tagged akt2 is activated in response to insulin stimulation in vitro and that activation of akt2 is not induced in cells pretreated with wortmannin, an inhibitor of phosphatidylinositol 3-kinase. |
1998-06-18 |
2023-08-12 |
mouse |
| D A Altomare, G E Lyons, Y Mitsuuchi, J Q Cheng, J R Test. Akt2 mRNA is highly expressed in embryonic brown fat and the AKT2 kinase is activated by insulin. Oncogene. vol 16. issue 18. 1998-06-18. PMID:9620559. |
these data suggest that akt2 expression is fundamental to the differentiated state of fat and muscle cells and that activation of akt2 kinase by insulin is mediated through the phosphatidylinositol 3-kinase signaling pathway. |
1998-06-18 |
2023-08-12 |
mouse |