| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Chenxi Lu, Yanbin Song, Xiaopeng Wu, Wangrui Lei, Junmin Chen, Xin Zhang, Qiong Liu, Chao Deng, Zhenxing Liang, Ying Chen, Jun Ren, Yang Yan. Pleiotropic role of GAS6 in cardioprotection against ischemia-reperfusion injury. Journal of advanced research. 2024-04-23. PMID:38653371. |
growth arrest-specific gene 6 (gas6) is vitamin k-dependent secretory protein, to promote cell proliferation and inhibit inflammation and apoptosis through binding with tyro3, axl, and mertk (tam) receptors. |
2024-04-23 |
2024-04-26 |
Not clear |
| Wangrui Lei, Songdi Wu, Aizhen Zhao, Zhen Wu, Baoping Ding, Wenwen Yang, Chenxi Lu, Xue Wu, Xiyang Li, Shaofei Zhang, Ye Tian, Yang Yan. Psoralidin protects against cerebral hypoxia/reoxygenation injury: Role of GAS6/Axl signaling. Phytotherapy research : PTR. 2022-05-18. PMID:35583809. |
growth arrest-specific gene 6 (gas6) and its receptor, axl, modulate cellular oxidative stress, apoptosis, survival, proliferation, migration, and mitogenesis. |
2022-05-18 |
2023-08-13 |
Not clear |
| Xiaochen Niu, Ye Cheng, Meng Zhang, Luyang Du, Xue Wu, Chenxi Lu, Xiyang Li, Shuai Liu, Aizhen Zhao, Shaofei Zhang, Zhen Wu, Baoping Ding, Wenzhen Shi, Changyu Wang, Yang Yang, Ye Tia. Neuroprotective Effects of Omentin-1 Against Cerebral Hypoxia/Reoxygenation Injury via Activating GAS6/Axl Signaling Pathway in Neuroblastoma Cells. Frontiers in cell and developmental biology. vol 9. 2022-02-10. PMID:35141232. |
the biological functions of gas6 are mediated by the interaction with tam (tyro3, axl and mertk) receptors, including cell survival and proliferation, immune regulation and apoptosis. |
2022-02-10 |
2023-08-13 |
human |
| Juwen C DuBois, Alex K Ray, Peter Davies, Bridget Shafit-Zagard. Anti-Axl antibody treatment reduces the severity of experimental autoimmune encephalomyelitis. Journal of neuroinflammation. vol 17. issue 1. 2021-09-16. PMID:33121494. |
during experimental autoimmune encephalomyelitis (eae), the mrna expression of mertk, gas6, and axl significantly increase, whereas tyro3 and pros1 remain unchanged. |
2021-09-16 |
2023-08-13 |
Not clear |
| Youtong Huang, Kaisa E Happonen, Patrick G Burrola, Carolyn O'Connor, Nasun Hah, Ling Huang, Axel Nimmerjahn, Greg Lemk. Microglia use TAM receptors to detect and engulf amyloid β plaques. Nature immunology. vol 22. issue 5. 2021-07-21. PMID:33859405. |
we find that in alzheimer's disease and its mouse models, induced expression of axl and mer in amyloid plaque-associated microglia was coupled to induced plaque decoration by the tam ligand gas6 and its co-ligand phosphatidylserine. |
2021-07-21 |
2023-08-13 |
mouse |
| Salman Goudarzi, Shannon E Gilchrist, Sassan Hafiz. Gas6 Induces Myelination through Anti-Inflammatory IL-10 and TGF-β Upregulation in White Matter and Glia. Cells. vol 9. issue 8. 2021-03-31. PMID:32722558. |
here, we characterised the expression of tam receptors and ligands in individual cns glial cell types, observing high expression of gas6 and the tam receptors, mer and axl, in microglia, and high expression of tyro3 in astrocytes. |
2021-03-31 |
2023-08-13 |
mouse |
| Mengfang Li, Jingjing Ye, Guangju Zhao, Guangliang Hong, Xiyi Hu, Kaiqiang Cao, You Wu, Zhongqiu L. Gas6 attenuates lipopolysaccharide‑induced TNF‑α expression and apoptosis in H9C2 cells through NF‑κB and MAPK inhibition via the Axl/PI3K/Akt pathway. International journal of molecular medicine. vol 44. issue 3. 2020-02-04. PMID:31524235. |
furthermore, the cardioprotective properties of gas6 on the suppression of lps‑induced tnf‑α release and apoptosis were abolished by treatment with tp‑0903 (an axl inhibitor) and wortmannin (a pi3k inhibitor). |
2020-02-04 |
2023-08-13 |
Not clear |
| Yu-Huei Li, Chieh-Hua Lu, Fu-Huang Lin, Sheng-Chiang Su, Jhih-Syuan Liu, Chang-Hsun Hsieh, Yi-Jen Hung, Yi-Shing Shieh, Chien-Hsing Le. Plasma Growth Arrest-Specific 6 Protein and Genetic Variations in the GAS6 Gene in Patients with Metabolic Syndrome. Metabolic syndrome and related disorders. vol 17. issue 1. 2019-10-25. PMID:30346880. |
recent studies indicate that gas6 and receptors of the tam (tyro3, axl, and mer) family may be involved in the pathogenesis of obesity, systemic inflammation, and insulin resistance. |
2019-10-25 |
2023-08-13 |
Not clear |
| Rainer Akkermann, Andrea Aprico, Ashwyn A Perera, Helena Bujalka, Alistair E Cole, Junhua Xiao, Judith Field, Trevor J Kilpatrick, Michele D Binde. The TAM receptor Tyro3 regulates myelination in the central nervous system. Glia. vol 65. issue 4. 2018-01-12. PMID:28145605. |
we have previously identified that the protein gas6, a ligand for a family of tyrosine kinase receptors known as the tam (tyro3, axl, and mertk) receptors, directly increases oligodendrocyte induced myelination in vitro. |
2018-01-12 |
2023-08-13 |
Not clear |
| Guiling Wu, Zhiqiang Ma, Wei Hu, Dongjin Wang, Bing Gong, Chongxi Fan, Shuai Jiang, Tian Li, Jianyuan Gao, Yang Yan. Molecular insights of Gas6/TAM in cancer development and therapy. Cell death & disease. vol 8. issue 3. 2017-11-13. PMID:28333143. |
since growth arrest-specific gene 6 (gas6) was discovered in 1988, numerous studies have highlighted the role of the gas6 protein and its receptors tyro3, axl and mer (collectively referred to as tam), in proliferation, apoptosis, efferocytosis, leukocyte migration, sequestration and platelet aggregation. |
2017-11-13 |
2023-08-13 |
Not clear |
| Miao Wu, Shijuan Lu, Jianghua Zhong, Kang Huang, Saidan Zhan. Protective Effects of Pterostilbene Against Myocardial Ischemia/Reperfusion Injury in Rats. Inflammation. vol 40. issue 2. 2017-05-03. PMID:28054238. |
our findings suggest that ptb treatment exerts cardioprotection against mi/r injury via attenuating inflammatory response, oxidative stress, and apoptosis and up-regulating the expression of gas6 and axl. |
2017-05-03 |
2023-08-13 |
rat |
| Xiaoyu Jiang, Huiren Tao, Cuiting Qiu, Xiaolei Ma, Shan Li, Xian Guo, Anlin Lv, Huan L. Vitamin K2 regression aortic calcification induced by warfarin via Gas6/Axl survival pathway in rats. European journal of pharmacology. vol 786. 2017-03-10. PMID:27212383. |
alizarin red s staining measured aortic calcium depositions; alkaline phosphatase activity in serum was measured by a kit; apoptosis was evaluated by tunel assay; protein expression levels of gas6, axl, phosphorylated akt (p-akt), and bcl-2 were determined by western blotting. |
2017-03-10 |
2023-08-13 |
rat |
| Xiaoyu Jiang, Huiren Tao, Cuiting Qiu, Xiaolei Ma, Shan Li, Xian Guo, Anlin Lv, Huan L. Vitamin K2 regression aortic calcification induced by warfarin via Gas6/Axl survival pathway in rats. European journal of pharmacology. vol 786. 2017-03-10. PMID:27212383. |
100μg/g vitamin k2 treatment decreased calcium depositions, alp activity and apoptosis significantly, but increased gas6, axl, p-akt and bcl-2 expression. |
2017-03-10 |
2023-08-13 |
rat |
| Lawrence Fourgeaud, Paqui G Través, Yusuf Tufail, Humberto Leal-Bailey, Erin D Lew, Patrick G Burrola, Perri Callaway, Anna Zagórska, Carla V Rothlin, Axel Nimmerjahn, Greg Lemk. TAM receptors regulate multiple features of microglial physiology. Nature. vol 532. issue 7598. 2016-04-27. PMID:27049947. |
we find that adult mice deficient in microglial mer and axl exhibit a marked accumulation of apoptotic cells specifically in neurogenic regions of the cns, and that microglial phagocytosis of the apoptotic cells generated during adult neurogenesis is normally driven by both tam receptor ligands gas6 and protein s. using live two-photon imaging, we demonstrate that the microglial response to brain damage is also tam-regulated, as tam-deficient microglia display reduced process motility and delayed convergence to sites of injury. |
2016-04-27 |
2023-08-13 |
mouse |
| Ross C Gruber, Alex K Ray, Christopher T Johndrow, Hillary Guzik, Dominika Burek, Pablo García de Frutos, Bridget Shafit-Zagard. Targeted GAS6 delivery to the CNS protects axons from damage during experimental autoimmune encephalomyelitis. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 34. issue 49. 2015-02-19. PMID:25471571. |
during experimental autoimmune encephalomyelitis (eae), wild-type (wt) mice demonstrate a significant induction of gas6, axl, and mertk but not pros1 or tyro3 mrna. |
2015-02-19 |
2023-08-13 |
mouse |
| Fone-Ching Hsiao, Yuh-Feng Lin, Po-Shiuan Hsieh, Nain-Feng Chu, Yii-Der Ida Chen, Yi-Shing Shieh, Chang-Hsun Hsieh, Chien-Hsing Lee, Ting-I Lee, Yi-Jen Hun. Effect of GAS6 and AXL Gene Polymorphisms on Adiposity, Systemic Inflammation, and Insulin Resistance in Adolescents. International journal of endocrinology. vol 2014. 2014-04-03. PMID:24696684. |
effect of gas6 and axl gene polymorphisms on adiposity, systemic inflammation, and insulin resistance in adolescents. |
2014-04-03 |
2023-08-13 |
Not clear |
| Fone-Ching Hsiao, Yuh-Feng Lin, Po-Shiuan Hsieh, Nain-Feng Chu, Yii-Der Ida Chen, Yi-Shing Shieh, Chang-Hsun Hsieh, Chien-Hsing Lee, Ting-I Lee, Yi-Jen Hun. Effect of GAS6 and AXL Gene Polymorphisms on Adiposity, Systemic Inflammation, and Insulin Resistance in Adolescents. International journal of endocrinology. vol 2014. 2014-04-03. PMID:24696684. |
the present study was designed to explore the effects of gas6 and axl gene polymorphisms on adiposity, systemic inflammation, and insulin resistance in adolescents. |
2014-04-03 |
2023-08-13 |
Not clear |
| Fone-Ching Hsiao, Yuh-Feng Lin, Po-Shiuan Hsieh, Nain-Feng Chu, Yii-Der Ida Chen, Yi-Shing Shieh, Chang-Hsun Hsieh, Chien-Hsing Lee, Ting-I Lee, Yi-Jen Hun. Effect of GAS6 and AXL Gene Polymorphisms on Adiposity, Systemic Inflammation, and Insulin Resistance in Adolescents. International journal of endocrinology. vol 2014. 2014-04-03. PMID:24696684. |
significantly higher body mass index (bmi), waist circumference (wc), and hscrp levels were found in boys with the gg genotype of gas6 rs8191974 than a allele carriers; higher il-6 and insulin levels and increased homa-ir were found in boys with the gg genotype of axl rs2304232 than the a allele carriers. |
2014-04-03 |
2023-08-13 |
Not clear |
| Fone-Ching Hsiao, Yuh-Feng Lin, Po-Shiuan Hsieh, Nain-Feng Chu, Yii-Der Ida Chen, Yi-Shing Shieh, Chang-Hsun Hsieh, Chien-Hsing Lee, Ting-I Lee, Yi-Jen Hun. Effect of GAS6 and AXL Gene Polymorphisms on Adiposity, Systemic Inflammation, and Insulin Resistance in Adolescents. International journal of endocrinology. vol 2014. 2014-04-03. PMID:24696684. |
in conclusion, gas6 and axl polymorphisms are associated with adiposity, systemic inflammation, and insulin resistance in adolescents, especially in boys. |
2014-04-03 |
2023-08-13 |
Not clear |
| Fone-Ching Hsiao, Yuh-Feng Lin, Po-Shiuan Hsieh, Nain-Feng Chu, Yi-Shing Shieh, Chang-Hsun Hsieh, Chien-Hsing Lee, Yi-Jen Hun. Circulating growth arrest-specific 6 protein is associated with adiposity, systemic inflammation, and insulin resistance among overweight and obese adolescents. The Journal of clinical endocrinology and metabolism. vol 98. issue 2. 2013-04-10. PMID:23341490. |
preclinical studies indicate that gas6 and its receptors of the tam (tyro-3, axl, mer) family may be involved in the pathogenesis of obesity and its complications, including systemic inflammation and insulin resistance. |
2013-04-10 |
2023-08-12 |
Not clear |