| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hyunsoo Kim, Han-Jong Kim, Kyunghee Lee, Jin-Man Kim, Hee Sun Kim, Jae-Ryong Kim, Chae-Myeong Ha, Young-Keun Choi, Sun Joo Lee, Joon-Young Kim, Robert A Harris, Daewon Jeong, In-Kyu Le. α-Lipoic acid attenuates vascular calcification via reversal of mitochondrial function and restoration of Gas6/Axl/Akt survival pathway. Journal of cellular and molecular medicine. vol 16. issue 2. 2012-06-25. PMID:21362131. |
moreover, ala inhibited pi-induced down-regulation of cell survival signals through the binding of growth arrest-specific gene 6 (gas6) to its cognate receptor axl and subsequent akt activation, resulting in increased survival and decreased apoptosis. |
2012-06-25 |
2023-08-12 |
mouse |
| Begoña Hurtado, Nerea Abasolo, Xavier Muñoz, Nadia García, Yolanda Benavente, Francisco Rubio, Pablo García de Frutos, Jerzy Krupinski, Núria Sal. Association study between polymorphims in GAS6-TAM genes and carotid atherosclerosis. Thrombosis and haemostasis. vol 104. issue 3. 2010-12-08. PMID:20664904. |
no association was observed with gas6 and axl variants, which suggests that ca is not the mechanism underlying the reported association between gas6 and stroke. |
2010-12-08 |
2023-08-12 |
human |
| Michele R Hutchison, Mary H Bassett, Perrin C Whit. SCF, BDNF, and Gas6 are regulators of growth plate chondrocyte proliferation and differentiation. Molecular endocrinology (Baltimore, Md.). vol 24. issue 1. 2010-03-19. PMID:19897599. |
to identify novel modifiers of igf-i action at the growth plate, we used microarray analyses to compare bovine hypertrophic and reserve zones and identified several receptors differentially expressed across the growth plate: ntrk2 [receptor for brain-derived neurotrophic factor (bdnf)], kit [receptor for stem cell factor (scf)], and mer and axl [two receptors for growth arrest-specific 6 (gas6)]. |
2010-03-19 |
2023-08-12 |
cattle |
| Lei Fan, Chang-Geng Rua. [Advance of study on Mer function]. Zhongguo shi yan xue ye xue za zhi. vol 15. issue 4. 2009-12-08. PMID:17708828. |
mer is one member of axl receptor tyrosine kinase family, and its ligand gas6 can stimulate activity of mer receptor tyrosine kinase after binding it, and then activate the downstream signal transduction pathway, mer participates in cell inflammation, apoptosis, tumorigenesis, thrombosis and hemostasis. |
2009-12-08 |
2023-08-12 |
Not clear |
| Lei Fan, Lan Dai, Fei Shen, Meng-Yun Zhou, Ning-Zheng Dong, Chang-Geng Rua. [Expression of Mer on Jurkat cells and its anti-apoptosis effect]. Ai zheng = Aizheng = Chinese journal of cancer. vol 26. issue 7. 2009-10-27. PMID:17626743. |
mer is a member of axl receptor tyrosine kinase family; its ligand gas6 can bind mer, then stimulate the tyrosine kinase activity and downstream cell signal pathway of mer, and take part in cell inflammation and apoptosis. |
2009-10-27 |
2023-08-12 |
Not clear |
| Sara Scutera, Tiziana Fraone, Tiziana Musso, Paola Cappello, Silvia Rossi, Daniele Pierobon, Zane Orinska, Ralf Paus, Silvia Bulfone-Paus, Mirella Giovarell. Survival and migration of human dendritic cells are regulated by an IFN-alpha-inducible Axl/Gas6 pathway. Journal of immunology (Baltimore, Md. : 1950). vol 183. issue 5. 2009-09-18. PMID:19657094. |
furthermore, stimulation of axl by its ligand, gas6, induced chemotaxis of human dc and rescued them from growth factor deprivation-induced apoptosis. |
2009-09-18 |
2023-08-12 |
human |
| Jason G Weinger, Kakuri M Omari, Kurt Marsden, Cedric S Raine, Bridget Shafit-Zagard. Up-regulation of soluble Axl and Mer receptor tyrosine kinases negatively correlates with Gas6 in established multiple sclerosis lesions. The American journal of pathology. vol 175. issue 1. 2009-07-15. PMID:19541935. |
up-regulation of soluble axl and mer receptor tyrosine kinases negatively correlates with gas6 in established multiple sclerosis lesions. |
2009-07-15 |
2023-08-12 |
Not clear |
| Jason G Weinger, Kakuri M Omari, Kurt Marsden, Cedric S Raine, Bridget Shafit-Zagard. Up-regulation of soluble Axl and Mer receptor tyrosine kinases negatively correlates with Gas6 in established multiple sclerosis lesions. The American journal of pathology. vol 175. issue 1. 2009-07-15. PMID:19541935. |
whereas in normal tissue gas6 positively correlated with soluble axl and mer, there was a negative correlation between gas6 and soluble axl and mer in established multiple sclerosis lesions. |
2009-07-15 |
2023-08-12 |
Not clear |
| Michele D Binder, Holly S Cate, Anne L Prieto, Dennis Kemper, Helmut Butzkueven, Melissa M Gresle, Tania Cipriani, Vilija G Jokubaitis, Peter Carmeliet, Trevor J Kilpatric. Gas6 deficiency increases oligodendrocyte loss and microglial activation in response to cuprizone-induced demyelination. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 28. issue 20. 2008-06-19. PMID:18480276. |
we found that the expression profiles of axl, mer, and gas6 mrna were increased in the corpus callosum in a temporal profile correlating with the increased migration and proliferation of microglia/macrophages in this model. |
2008-06-19 |
2023-08-12 |
mouse |
| Bo-Kyung Son, Koichi Kozaki, Katsuya Iijima, Masato Eto, Toru Nakano, Masahiro Akishita, Yasuyoshi Ouch. Gas6/Axl-PI3K/Akt pathway plays a central role in the effect of statins on inorganic phosphate-induced calcification of vascular smooth muscle cells. European journal of pharmacology. vol 556. issue 1-3. 2007-04-05. PMID:17196959. |
gas6 and its receptor, axl, expression were downregulated in the presence of pi, and recombinant human gas6 (rhgas6) significantly inhibited apoptosis and calcification in a concentration-dependent manner. |
2007-04-05 |
2023-08-12 |
human |
| Bo-Kyung Son, Koichi Kozaki, Katsuya Iijima, Masato Eto, Toru Nakano, Masahiro Akishita, Yasuyoshi Ouch. Gas6/Axl-PI3K/Akt pathway plays a central role in the effect of statins on inorganic phosphate-induced calcification of vascular smooth muscle cells. European journal of pharmacology. vol 556. issue 1-3. 2007-04-05. PMID:17196959. |
the inhibitory effect of statins on pi-induced apoptosis was accompanied by restoration of the gas6-mediated survival signal pathway: upregulation of gas6 and axl expression, increased phosphorylation of akt and bcl2, and inhibition of bad and caspase 3 activation. |
2007-04-05 |
2023-08-12 |
human |
| Tateo Sawabu, Hiroshi Seno, Tomoko Kawashima, Akihisa Fukuda, Yoshito Uenoyama, Mayumi Kawada, Naoki Kanda, Akira Sekikawa, Hirokazu Fukui, Motoko Yanagita, Hiroshi Yoshibayashi, Seiji Satoh, Yoshiharu Sakai, Toru Nakano, Tsutomu Chib. Growth arrest-specific gene 6 and Axl signaling enhances gastric cancer cell survival via Akt pathway. Molecular carcinogenesis. vol 46. issue 2. 2007-03-26. PMID:17186543. |
with recombinant gas6 and a decoy-receptor of axl in vitro, we demonstrated that gas6-axl signaling pathway enhanced cellular survival and invasion and suppressed apoptosis via akt pathway. |
2007-03-26 |
2023-08-12 |
human |
| Bo-Kyung Son, Koichi Kozaki, Katsuya Iijima, Masato Eto, Taro Kojima, Hidetaka Ota, Yuka Senda, Koji Maemura, Toru Nakano, Masahiro Akishita, Yasuyoshi Ouch. Statins protect human aortic smooth muscle cells from inorganic phosphate-induced calcification by restoring Gas6-Axl survival pathway. Circulation research. vol 98. issue 8. 2006-06-02. PMID:16556867. |
in this study, we investigated the effect of statins on vsmc calcification by testing their effect on apoptosis, focusing in particular on regulation of the survival pathway mediated by growth arrest-specific gene 6 (gas6), a member of the vitamin k-dependent protein family, and its receptor, axl. |
2006-06-02 |
2023-08-12 |
human |
| Matthew G Melaragno, Megan E Cavet, Chen Yan, Lung-Kuo Tai, Zheng-Gen Jin, Judith Haendeler, Bradford C Ber. Gas6 inhibits apoptosis in vascular smooth muscle: role of Axl kinase and Akt. Journal of molecular and cellular cardiology. vol 37. issue 4. 2005-03-01. PMID:15380678. |
gas6 inhibits apoptosis in vascular smooth muscle: role of axl kinase and akt. |
2005-03-01 |
2023-08-12 |
human |
| Matthew G Melaragno, Megan E Cavet, Chen Yan, Lung-Kuo Tai, Zheng-Gen Jin, Judith Haendeler, Bradford C Ber. Gas6 inhibits apoptosis in vascular smooth muscle: role of Axl kinase and Akt. Journal of molecular and cellular cardiology. vol 37. issue 4. 2005-03-01. PMID:15380678. |
treatment of vsmc with 100 ng/ml gas6 (the putative ligand for axl) decreased apoptosis to 8.9 +/- 0.7% (p = 0.002, n = 17) as compared to a decrease with 10% serum to 3.0 +/- 0.2% (p = 0.001, n = 17). |
2005-03-01 |
2023-08-12 |
human |
| Matthew G Melaragno, Megan E Cavet, Chen Yan, Lung-Kuo Tai, Zheng-Gen Jin, Judith Haendeler, Bradford C Ber. Gas6 inhibits apoptosis in vascular smooth muscle: role of Axl kinase and Akt. Journal of molecular and cellular cardiology. vol 37. issue 4. 2005-03-01. PMID:15380678. |
the ability of gas6 to prevent apoptosis required both gas6 binding to axl and axl kinase activity since treatment with a soluble, competitive axl extracellular domain protein or transfection of a kinase inactive mutant (axl-k567r) completely prevented the anti-apoptotic effect. |
2005-03-01 |
2023-08-12 |
human |
| Daniela D'Arcangelo, Carlo Gaetano, Maurizio C Capogross. Acidification prevents endothelial cell apoptosis by Axl activation. Circulation research. vol 91. issue 7. 2002-10-23. PMID:12364394. |
axl ligand, the survival factor growth arrest-specific gene 6 product (gas6), was released into the conditioned medium, and by western blot analysis, similar amounts of protein were found at ph 7.0 and 7.4. |
2002-10-23 |
2023-08-12 |
human |
| Hiroshi Funakoshi, Tomoko Yonemasu, Toru Nakano, Kunio Matumoto, Toshikazu Nakamur. Identification of Gas6, a putative ligand for Sky and Axl receptor tyrosine kinases, as a novel neurotrophic factor for hippocampal neurons. Journal of neuroscience research. vol 68. issue 2. 2002-05-03. PMID:11948660. |
identification of gas6, a putative ligand for sky and axl receptor tyrosine kinases, as a novel neurotrophic factor for hippocampal neurons. |
2002-05-03 |
2023-08-12 |
rat |
| Wei-Ping Lee, Yong Wen, Brian Varnum, Mien-Chie Hun. Akt is required for Axl-Gas6 signaling to protect cells from E1A-mediated apoptosis. Oncogene. vol 21. issue 3. 2002-02-14. PMID:11821945. |
to determine how the axl-gas6 interaction prevents e1a-mediated apoptosis, we analysed the expression of anti-apoptotic molecules and found that the activated form of akt was suppressed in the e1a transfectant ip 1-e1a and that gas6 was able to activate akt in ip 1-e1a cells reexpressing axl (ip 1-e1a-axl). |
2002-02-14 |
2023-08-12 |
Not clear |
| M Yanagita, H Arai, K Ishii, T Nakano, K Ohashi, K Mizuno, B Varnum, A Fukatsu, T Doi, T Kit. Gas6 regulates mesangial cell proliferation through Axl in experimental glomerulonephritis. The American journal of pathology. vol 158. issue 4. 2001-05-03. PMID:11290560. |
in thy1 gn, expression of gas6 and axl was markedly increased in glomeruli, and paralleled the progression of mesangial cell proliferation. |
2001-05-03 |
2023-08-12 |
human |