| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Chenxi Lu, Yanbin Song, Xiaopeng Wu, Wangrui Lei, Junmin Chen, Xin Zhang, Qiong Liu, Chao Deng, Zhenxing Liang, Ying Chen, Jun Ren, Yang Yan. Pleiotropic role of GAS6 in cardioprotection against ischemia-reperfusion injury. Journal of advanced research. 2024-04-23. PMID:38653371. |
growth arrest-specific gene 6 (gas6) is vitamin k-dependent secretory protein, to promote cell proliferation and inhibit inflammation and apoptosis through binding with tyro3, axl, and mertk (tam) receptors. |
2024-04-23 |
2024-04-26 |
Not clear |
| Kangkan Sarma, Md Habban Akther, Irfan Ahmad, Obaid Afzal, Abdulmalik S A Altamimi, Manal A Alossaimi, Mariusz Jaremko, Abdul-Hamid Emwas, Preety Gauta. Adjuvant Novel Nanocarrier-Based Targeted Therapy for Lung Cancer. Molecules (Basel, Switzerland). vol 29. issue 5. 2024-03-13. PMID:38474590. |
stroma, hypoxia, ph, and immunity-modulating agents conjugated or modified nanocarriers co-administered with pathway-blocking or condition-modulating agents can regulate extracellular matrix (ecm), cancer-associated fibroblasts (caf),tyro3, axl, and mertk receptors (tam) regulation, regulatory t-cell (treg) inhibition, and myeloid-derived suppressor cells (mdsc) inhibition. |
2024-03-13 |
2024-03-15 |
Not clear |
| Yandan Zhou, Zhili Feng, Jie Wen, Chi Yang, Qiancheng Jin. Aberrant expressions of TAM receptors are associated with postoperative recurrence in chronic rhinosinusitis with nasal polyps. European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery. 2024-01-17. PMID:38233691. |
tam receptors (tyro3, axl, and mer) play important roles in inflammatory responses, but their effects in chronic rhinosinusitis with nasal polyps (crswnp) remain elucidated. |
2024-01-17 |
2024-01-20 |
Not clear |
| Zhen Wang, Deng Liu, Qi Yan, Fang Liu, Mengting Zhan, Shunli Qi, Qi Fang, Lei Yao, Weizhi Wang, Ruixin Zhang, Jian Du, Lijian Che. Activated AXL Protects Against Hepatic Ischemia-reperfusion Injury by Upregulating SOCS-1 Expression. Transplantation. 2022-05-12. PMID:35546091. |
axl is a member of the tyro3, axl, mertk family and is involved in immune and apoptosis processes in multiple organs. |
2022-05-12 |
2023-08-13 |
Not clear |
| Xiaochen Niu, Ye Cheng, Meng Zhang, Luyang Du, Xue Wu, Chenxi Lu, Xiyang Li, Shuai Liu, Aizhen Zhao, Shaofei Zhang, Zhen Wu, Baoping Ding, Wenzhen Shi, Changyu Wang, Yang Yang, Ye Tia. Neuroprotective Effects of Omentin-1 Against Cerebral Hypoxia/Reoxygenation Injury via Activating GAS6/Axl Signaling Pathway in Neuroblastoma Cells. Frontiers in cell and developmental biology. vol 9. 2022-02-10. PMID:35141232. |
the biological functions of gas6 are mediated by the interaction with tam (tyro3, axl and mertk) receptors, including cell survival and proliferation, immune regulation and apoptosis. |
2022-02-10 |
2023-08-13 |
human |
| Juwen C DuBois, Alex K Ray, Peter Davies, Bridget Shafit-Zagard. Anti-Axl antibody treatment reduces the severity of experimental autoimmune encephalomyelitis. Journal of neuroinflammation. vol 17. issue 1. 2021-09-16. PMID:33121494. |
during experimental autoimmune encephalomyelitis (eae), the mrna expression of mertk, gas6, and axl significantly increase, whereas tyro3 and pros1 remain unchanged. |
2021-09-16 |
2023-08-13 |
Not clear |
| Qian Jiang, Christopher R Stone, Kenneth Elkin, Xiaokun Geng, Yuchuan Din. Immunosuppression and Neuroinflammation in Stroke Pathobiology. Experimental neurobiology. vol 30. issue 2. 2021-05-25. PMID:33972464. |
the release of danger-/damage-associated molecular patterns (damps) activates toll-like receptors (tlrs), contributing to the harmful inflammatory effects of ischemia/reperfusion injury after stroke; the tyro3, axl, and mertk (tam)/gas6 system, however, has been shown to suppress inflammation via downstream signaling molecules that inhibit tlr signaling. |
2021-05-25 |
2023-08-13 |
Not clear |
| Salman Goudarzi, Shannon E Gilchrist, Sassan Hafiz. Gas6 Induces Myelination through Anti-Inflammatory IL-10 and TGF-β Upregulation in White Matter and Glia. Cells. vol 9. issue 8. 2021-03-31. PMID:32722558. |
the gas6-tam (tyro3, axl, mer) ligand-receptor system is believed to promote central nervous system (cns) (re)myelination and glial cell development. |
2021-03-31 |
2023-08-13 |
mouse |
| Salman Goudarzi, Shannon E Gilchrist, Sassan Hafiz. Gas6 Induces Myelination through Anti-Inflammatory IL-10 and TGF-β Upregulation in White Matter and Glia. Cells. vol 9. issue 8. 2021-03-31. PMID:32722558. |
here, we characterised the expression of tam receptors and ligands in individual cns glial cell types, observing high expression of gas6 and the tam receptors, mer and axl, in microglia, and high expression of tyro3 in astrocytes. |
2021-03-31 |
2023-08-13 |
mouse |
| Nam-Yi Kim, Young-Ah Suh, Soyoung Kim, ChuHee Le. Bufalin down-regulates Axl expression to inhibit cell proliferation and induce apoptosis in non-small-cell lung cancer cells. Bioscience reports. vol 40. issue 4. 2021-03-29. PMID:32219334. |
axl, a member of the tam (tyro3, axl, mer) receptor tyrosine kinase family, plays critical roles in cell growth, proliferation, apoptosis, and migration. |
2021-03-29 |
2023-08-13 |
Not clear |
| Zaofeng Zou, Jingxian Sun, Zheng Kang, Yumeng Wang, Hui Zhao, Keying Zhu, Jun Wan. Tyrosine Kinase Receptors Axl and MerTK Mediate the Beneficial Effect of Electroacupuncture in a Cuprizone-Induced Demyelinating Model. Evidence-based complementary and alternative medicine : eCAM. vol 2020. 2020-09-28. PMID:32714402. |
it has been revealed that tam receptor tyrosine kinases (tyro3, axl, and mertk) play pivotal roles in regulating multiple features of microglia, including the phagocytic function and myelin clearance. |
2020-09-28 |
2023-08-13 |
mouse |
| Yu-Huei Li, Chieh-Hua Lu, Fu-Huang Lin, Sheng-Chiang Su, Jhih-Syuan Liu, Chang-Hsun Hsieh, Yi-Jen Hung, Yi-Shing Shieh, Chien-Hsing Le. Plasma Growth Arrest-Specific 6 Protein and Genetic Variations in the GAS6 Gene in Patients with Metabolic Syndrome. Metabolic syndrome and related disorders. vol 17. issue 1. 2019-10-25. PMID:30346880. |
recent studies indicate that gas6 and receptors of the tam (tyro3, axl, and mer) family may be involved in the pathogenesis of obesity, systemic inflammation, and insulin resistance. |
2019-10-25 |
2023-08-13 |
Not clear |
| Cheng Huang, Yu-Ling Huang, Chia-Chi Wang, Yi-Ling Pan, Yu-Heng Lai, Hsiu-Chen Huan. Ampelopsins A and C Induce Apoptosis and Metastasis through Downregulating AxL, TYRO3, and FYN Expressions in MDA-MB-231 Breast Cancer Cells. Journal of agricultural and food chemistry. vol 67. issue 10. 2019-03-22. PMID:30789269. |
ampelopsins a and c induce apoptosis and metastasis through downregulating axl, tyro3, and fyn expressions in mda-mb-231 breast cancer cells. |
2019-03-22 |
2023-08-13 |
Not clear |
| Amanda Brosius Lutz, Won-Suk Chung, Steven A Sloan, Glenn A Carson, Lu Zhou, Emilie Lovelett, Sean Posada, J Bradley Zuchero, Ben A Barre. Schwann cells use TAM receptor-mediated phagocytosis in addition to autophagy to clear myelin in a mouse model of nerve injury. Proceedings of the National Academy of Sciences of the United States of America. vol 114. issue 38. 2018-06-05. PMID:28874532. |
here we show that schwann cells, the myelinating glia of the pns, collaborate with hematogenous macrophages to clear myelin debris using tam (tyro3, axl, mer) receptor-mediated phagocytosis as well as autophagy. |
2018-06-05 |
2023-08-13 |
mouse |
| Rainer Akkermann, Andrea Aprico, Ashwyn A Perera, Helena Bujalka, Alistair E Cole, Junhua Xiao, Judith Field, Trevor J Kilpatrick, Michele D Binde. The TAM receptor Tyro3 regulates myelination in the central nervous system. Glia. vol 65. issue 4. 2018-01-12. PMID:28145605. |
we have previously identified that the protein gas6, a ligand for a family of tyrosine kinase receptors known as the tam (tyro3, axl, and mertk) receptors, directly increases oligodendrocyte induced myelination in vitro. |
2018-01-12 |
2023-08-13 |
Not clear |
| Guiling Wu, Zhiqiang Ma, Wei Hu, Dongjin Wang, Bing Gong, Chongxi Fan, Shuai Jiang, Tian Li, Jianyuan Gao, Yang Yan. Molecular insights of Gas6/TAM in cancer development and therapy. Cell death & disease. vol 8. issue 3. 2017-11-13. PMID:28333143. |
since growth arrest-specific gene 6 (gas6) was discovered in 1988, numerous studies have highlighted the role of the gas6 protein and its receptors tyro3, axl and mer (collectively referred to as tam), in proliferation, apoptosis, efferocytosis, leukocyte migration, sequestration and platelet aggregation. |
2017-11-13 |
2023-08-13 |
Not clear |
| Jonathan J Miner, Brian P Daniels, Bimmi Shrestha, Jose L Proenca-Modena, Erin D Lew, Helen M Lazear, Matthew J Gorman, Greg Lemke, Robyn S Klein, Michael S Diamon. The TAM receptor Mertk protects against neuroinvasive viral infection by maintaining blood-brain barrier integrity. Nature medicine. vol 21. issue 12. 2016-05-13. PMID:26523970. |
unexpectedly, mice lacking mertk and/or axl, but not tyro3, exhibited greater vulnerability to infection with neuroinvasive west nile and la crosse encephalitis viruses. |
2016-05-13 |
2023-08-13 |
mouse |
| Ross C Gruber, Alex K Ray, Christopher T Johndrow, Hillary Guzik, Dominika Burek, Pablo García de Frutos, Bridget Shafit-Zagard. Targeted GAS6 delivery to the CNS protects axons from damage during experimental autoimmune encephalomyelitis. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 34. issue 49. 2015-02-19. PMID:25471571. |
during experimental autoimmune encephalomyelitis (eae), wild-type (wt) mice demonstrate a significant induction of gas6, axl, and mertk but not pros1 or tyro3 mrna. |
2015-02-19 |
2023-08-13 |
mouse |
| Jessica E Brown, Meredith Krodel, Mauricio Pazos, Cary Lai, Anne L Priet. Cross-phosphorylation, signaling and proliferative functions of the Tyro3 and Axl receptors in Rat2 cells. PloS one. vol 7. issue 5. 2012-10-16. PMID:22606290. |
in this study we analyzed the consequences of tyro3 overexpression on cell proliferation, activation of signaling pathways and its functional interactions with axl. |
2012-10-16 |
2023-08-12 |
Not clear |
| Fei Ye, Lixia Han, Qingjun Lu, Wanwei Dong, Zhenwen Chen, Hui Shao, Henry J Kaplan, Qiutang Li, Qingxian L. Retinal self-antigen induces a predominantly Th1 effector response in Axl and Mertk double-knockout mice. Journal of immunology (Baltimore, Md. : 1950). vol 187. issue 8. 2011-11-15. PMID:21918185. |
the tam family of receptors (tyro3, axl, and mertk) plays an important role in the negative regulation of response of dendritic cells (dcs) and macrophages to pathogenic stimuli, and mice lacking this receptor family develop spontaneous lupus-like systemic autoimmunity against a variety of tissues, including retina. |
2011-11-15 |
2023-08-12 |
mouse |