| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Michele D Binder, Junhua Xiao, Dennis Kemper, Gerry Z M Ma, Simon S Murray, Trevor J Kilpatric. Gas6 increases myelination by oligodendrocytes and its deficiency delays recovery following cuprizone-induced demyelination. PloS one. vol 6. issue 3. 2011-07-05. PMID:21423702. |
we have identified a family of receptor protein tyrosine kinases, known as the tam receptors (tyro3, axl and mertk), as potentially important in regulating both the oligodendrocyte and immune responses. |
2011-07-05 |
2023-08-12 |
mouse |
| Zhihui Zhong, Yaoming Wang, Huang Guo, Abhay Sagare, José A Fernández, Robert D Bell, Theresa M Barrett, John H Griffin, Robert S Freeman, Berislav V Zlokovi. Protein S protects neurons from excitotoxic injury by activating the TAM receptor Tyro3-phosphatidylinositol 3-kinase-Akt pathway through its sex hormone-binding globulin-like region. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 46. 2010-12-23. PMID:21084607. |
in an in vivo model of nmda-induced excitotoxic lesions in the striatum, ps dose-dependently reduced the lesion volume in control mice (ec(50) = 22 ± 2 nm) and protected axl(-/-) and mer(-/-) transgenic mice, but not tyro3(-/-) transgenic mice. |
2010-12-23 |
2023-08-12 |
mouse |
| Angela Pierce, Brian Bliesner, Mei Xu, Sheila Nielsen-Preiss, Greg Lemke, Stuart Tobet, Margaret E Wierma. Axl and Tyro3 modulate female reproduction by influencing gonadotropin-releasing hormone neuron survival and migration. Molecular endocrinology (Baltimore, Md.). vol 22. issue 11. 2009-06-11. PMID:18787040. |
studies using caspase 3 cleavage as a marker of apoptosis showed that axl(-/-), tyro3(-/-) double-knockout mice had increased cell death in the nose and dorsal forebrain, supporting the underlying mechanism of cell loss. |
2009-06-11 |
2023-08-12 |
mouse |
| Angela Pierce, Brian Bliesner, Mei Xu, Sheila Nielsen-Preiss, Greg Lemke, Stuart Tobet, Margaret E Wierma. Axl and Tyro3 modulate female reproduction by influencing gonadotropin-releasing hormone neuron survival and migration. Molecular endocrinology (Baltimore, Md.). vol 22. issue 11. 2009-06-11. PMID:18787040. |
together these data suggest that axl and tyro3 mediate the survival and appropriate targeting of gnrh neurons to the ventral forebrain, thereby contributing to normal reproductive function and cyclicity in the female. |
2009-06-11 |
2023-08-12 |
mouse |
| Heather M Seitz, Todd D Camenisch, Greg Lemke, H Shelton Earp, Glenn K Matsushim. Macrophages and dendritic cells use different Axl/Mertk/Tyro3 receptors in clearance of apoptotic cells. Journal of immunology (Baltimore, Md. : 1950). vol 178. issue 9. 2007-06-18. PMID:17442946. |
thus, cell and organ type specificity is clearly delineated, with dcs relying on axl and tyro3, retina and thymus requiring mertk, and macrophages exhibiting an interaction that involves all three family members. |
2007-06-18 |
2023-08-12 |
mouse |