| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Vishnu N Thakare, Rajesh R Patil, Anupama A Suralkar, Valmik D Dhakane, Bhoomika M Pate. Protocatechuic acid attenuate depressive-like behavior in olfactory bulbectomized rat model: behavioral and neurobiochemical investigations. Metabolic brain disease. vol 34. issue 3. 2020-05-11. PMID:30848471. |
behavioral (ambulatory and rearing activity and immobility time), neurochemical [serotonin (5-ht), dopamine (da), norepinephrine (ne) and brain derived neurotrophic factor (bdnf) expression], biochemical (mda formation, il-6, tnf-α and antioxidants) changes in hippocampus and cerebral cortex along with serum corticosterone were investigated. |
2020-05-11 |
2023-08-13 |
rat |
| Stefano Porcelli, Agnese Marsano, Elisabetta Caletti, Michela Sala, Vera Abbiati, Marcella Bellani, Cinzia Perlini, Maria Gloria Rossetti, Gian Mario Mandolini, Alessandro Pigoni, Riccardo Augusto Paoli, Sara Piccin, Matteo Lazzaretti, Dora Fabbro, Giuseppe Damante, Carolina Bonivento, Clarissa Ferrari, Roberta Rossi, Laura Pedrini, Alessandro Serretti, Paolo Brambill. Temperament and Character Inventory in Bipolar Disorder versus Healthy Controls and Modulatory Effects of 3 Key Functional Gene Variants. Neuropsychobiology. vol 76. issue 4. 2019-11-20. PMID:30041166. |
several studies investigated the genetic basis of temperament and character, identifying catechol-o-methyltransferase (comt), brain derived neurotrophic factor (bdnf), and serotonin transporter (5-htt) gene variants as strong candidates. |
2019-11-20 |
2023-08-13 |
Not clear |
| Mohammad Morshedi, Khadijeh Bavafa Valenlia, Elaheh Sadat Hosseinifard, Parviz Shahabi, Mehran Mesgari Abbasi, Meysam Ghorbani, Abolfazl Barzegari, Saeed Sadigh-Eteghad, Maryam Saghafi-As. Beneficial psychological effects of novel psychobiotics in diabetic rats: the interaction among the gut, blood and amygdala. The Journal of nutritional biochemistry. vol 57. 2019-10-29. PMID:29730508. |
the findings demonstrated the favorable effects of the psychobiotics (l. plantarum, inulin or their combination) on oxidative markers of the blood and amygdala (superoxide dismutase, glutathione peroxidase, malondialdehyde and total antioxidant capacity), as well as on concentrations of amygdala serotonin and brain-derived neurotrophic factor, in the diabetic rats. |
2019-10-29 |
2023-08-13 |
rat |
| Wei Hung Chang, I Hui Lee, Mei Hung Chi, Shih-Hsien Lin, Kao Chin Chen, Po See Chen, Nan Tsing Chiu, Wei Jen Yao, Yen Kuang Yan. Prefrontal cortex modulates the correlations between brain-derived neurotrophic factor level, serotonin, and the autonomic nervous system. Scientific reports. vol 8. issue 1. 2019-08-16. PMID:29416077. |
prefrontal cortex modulates the correlations between brain-derived neurotrophic factor level, serotonin, and the autonomic nervous system. |
2019-08-16 |
2023-08-13 |
human |
| Patrícia C R Rabelo, Nayara A C Horta, Letícia M S Cordeiro, Maristela O Poletini, Cândido C Coimbra, Raphael E Szawka, Danusa D Soare. Intrinsic exercise capacity in rats influences dopamine neuroplasticity induced by physical training. Journal of applied physiology (Bethesda, Md. : 1985). vol 123. issue 6. 2019-06-20. PMID:28883047. |
to evaluate the dopaminergic neuroplasticity, we analyzed mrna levels of d1 receptor, d2 receptor, dopamine transporter, tyrosine hydroxylase, glia cell line neurotrophic factor, and brain-derived neurotrophic factor as well as concentrations of dopamine, serotonin, and their metabolites. |
2019-06-20 |
2023-08-13 |
rat |
| V E Golimbet, Zh V Garakh, G I Korovaitseva, T V Lezheiko, Yu S Zaytsevac, I Ya Gurovich, A B Shmukler, G I Rodionov, V B Strelet. [The Association of Brain-Derived Neurotrophic Factor and Serotonin Transporter Genes with the Parameters of Early Event-Related Potentials During the Passive Perception of Words]. Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova. vol 66. issue 5. 2019-02-19. PMID:30695401. |
[the association of brain-derived neurotrophic factor and serotonin transporter genes with the parameters of early event-related potentials during the passive perception of words]. |
2019-02-19 |
2023-08-13 |
Not clear |
| Gao-Feng Wu, Shuang Ren, Ri-Yi Tang, Chang Xu, Jia-Qi Zhou, Shu-Mei Lin, Ying Feng, Qun-Hui Yang, Jian-Min Hu, Jian-Cheng Yan. Antidepressant effect of taurine in chronic unpredictable mild stress-induced depressive rats. Scientific reports. vol 7. issue 1. 2019-02-01. PMID:28694433. |
furthermore, the decreased levels of 5-hydroxytryptamine, dopamine, noradrenaline; the increased levels of glutamate, corticosterone; and the decreased expressions of fibroblast growth factor-2, vascular endothelial growth factor and brain derived neurotrophic factor in depressive rats were hindered by taurine pre-administration. |
2019-02-01 |
2023-08-13 |
rat |
| Jing Sun, Fangyan Wang, Xuezhen Hu, Changwei Yang, Hailing Xu, Ye Yao, Jiaming Li. Clostridium butyricum Attenuates Chronic Unpredictable Mild Stress-Induced Depressive-Like Behavior in Mice via the Gut-Brain Axis. Journal of agricultural and food chemistry. vol 66. issue 31. 2018-08-20. PMID:30040410. |
the levels of cerebral 5-hydroxytryptamine (5-ht), brain derived neurotrophic factor (bdnf), glucagon-like peptide-1 (glp-1) receptor and intestinal were measured. |
2018-08-20 |
2023-08-13 |
mouse |
| Sally A Abuelezz, Nevien Hendawy, Yosra Magd. The potential benefit of combined versus monotherapy of coenzyme Q10 and fluoxetine on depressive-like behaviors and intermediates coupled to Gsk-3β in rats. Toxicology and applied pharmacology. vol 340. 2018-07-24. PMID:29291430. |
as a part of the serotoninergic dysfunction implicated in neurobiology of depression, evidence has focused on serotonin (5-ht) receptors downstream signaling intermediates including glycogen synthase kinase-3β (gsk-3β), camp response element binding protein (creb) and brain derived neurotrophic factor (bdnf). |
2018-07-24 |
2023-08-13 |
rat |
| Vishnu N Thakare, Manoj K Aswar, Yogesh P Kulkarni, Rajesh R Patil, Bhoomika M Pate. Silymarin ameliorates experimentally induced depressive like behavior in rats: Involvement of hippocampal BDNF signaling, inflammatory cytokines and oxidative stress response. Physiology & behavior. vol 179. 2018-05-01. PMID:28711395. |
behavioral (ambulatory and rearing activity and immobility time), neurochemical [serotonin (5-ht), dopamine (da), norepinephrine (ne) and brain derived neurotrophic factor (bdnf) level], biochemical (mda formation, il-6, tnf-α and antioxidants) changes in hippocampus and cerebral cortex along with serum corticosterone were investigated. |
2018-05-01 |
2023-08-13 |
mouse |
| Nicolás Meza-Concha, Marcelo Arancibia, Felicia Salas, Rosa Behar, Germán Salas, Hernán Silva, Rocío Escoba. Towards a neurobiological understanding of alexithymia. Medwave. vol 17. issue 4. 2018-03-30. PMID:28622282. |
molecular genetics has detected polymorphisms in genes of the serotonin transporter, in the enzyme genes of dopaminergic metabolism and brain-derived neurotrophic factor, while the role of oxytocin is controversial. |
2018-03-30 |
2023-08-13 |
Not clear |
| Esther E Fröhlich, Aitak Farzi, Raphaela Mayerhofer, Florian Reichmann, Angela Jačan, Bernhard Wagner, Erwin Zinser, Natalie Bordag, Christoph Magnes, Eleonore Fröhlich, Karl Kashofer, Gregor Gorkiewicz, Peter Holze. Cognitive impairment by antibiotic-induced gut dysbiosis: Analysis of gut microbiota-brain communication. Brain, behavior, and immunity. vol 56. 2018-01-04. PMID:26923630. |
this cognitive deficit was associated with brain region-specific changes in the expression of cognition-relevant signaling molecules, notably brain-derived neurotrophic factor, n-methyl-d-aspartate receptor subunit 2b, serotonin transporter and neuropeptide y system. |
2018-01-04 |
2023-08-13 |
mouse |
| V Marasco, P Herzyk, J Robinson, K A Spence. Pre- and Post-Natal Stress Programming: Developmental Exposure to Glucocorticoids Causes Long-Term Brain-Region Specific Changes to Transcriptome in the Precocial Japanese Quail. Journal of neuroendocrinology. vol 28. issue 5. 2018-01-04. PMID:26999292. |
brain-derived neurotrophic factor and mineralocorticoid receptor within the hippocampus; corticotrophin-releasing hormone and serotonin receptors in the hypothalamus). |
2018-01-04 |
2023-08-13 |
Not clear |
| Sita Sharan Patel, Malairaman Udayaban. Effect of natural products on diabetes associated neurological disorders. Reviews in the neurosciences. vol 28. issue 3. 2018-01-02. PMID:28030360. |
natural products are known to modulate diabetes-mediated alterations in the level of acetylcholinesterase, choline acetyltransferase, monoamine oxidase, serotonin receptors, muscarinic receptors, insulin receptor, nerve growth factor, brain-derived neurotrophic factor, and neuropeptide in brain. |
2018-01-02 |
2023-08-13 |
Not clear |
| Marina Sagud, Matea Nikolac Perkovic, Bjanka Vuksan-Cusa, Anja Maravic, Dubravka Svob Strac, Alma Mihaljevic Peles, Maja Zivkovic, Zorana Kusevic, Nela Piva. A prospective, longitudinal study of platelet serotonin and plasma brain-derived neurotrophic factor concentrations in major depression: effects of vortioxetine treatment. Psychopharmacology. vol 233. issue 17. 2017-12-12. PMID:27356518. |
a prospective, longitudinal study of platelet serotonin and plasma brain-derived neurotrophic factor concentrations in major depression: effects of vortioxetine treatment. |
2017-12-12 |
2023-08-13 |
Not clear |
| Weam W Ibrahim, Marwa M Safar, Mahmoud M Khattab, Azza M Agh. 17β-Estradiol augments antidepressant efficacy of escitalopram in ovariectomized rats: Neuroprotective and serotonin reuptake transporter modulatory effects. Psychoneuroendocrinology. vol 74. 2017-12-08. PMID:27685339. |
17β-estradiol augmented the modulatory effects of escitalopram on the hippocampal levels of brain-derived neurotrophic factor and serotonin reuptake transporter as well as tumor necrosis factor-alpha without altering its effects on the gene expressions of serotonin receptor 1a, estrogen receptors alpha and beta, or acetylcholinestearase content. |
2017-12-08 |
2023-08-13 |
human |
| Erica L Tatham, Rajamannar Ramasubbu, Ismael Gaxiola-Valdez, Filomeno Cortese, Darren Clark, Bradley Goodyear, Jane Foster, Geoffrey B Hal. White matter integrity in major depressive disorder: Implications of childhood trauma, 5-HTTLPR and BDNF polymorphisms. Psychiatry research. Neuroimaging. vol 253. 2017-12-07. PMID:27261564. |
this study examined the impact of childhood neglect, serotonin transporter (5-httlpr) and brain derived neurotrophic factor (bdnf) polymorphisms on white matter (wm) integrity in major depressive disorder (mdd) using diffusion tensor imaging (dti). |
2017-12-07 |
2023-08-13 |
human |
| Sara Agnafors, Gunilla Sydsjö, Erika Comasco, Marie Bladh, Lars Oreland, Carl Göran Svedi. Early predictors of behavioural problems in pre-schoolers - a longitudinal study of constitutional and environmental main and interaction effects. BMC pediatrics. vol 16. 2017-11-27. PMID:27267363. |
gene-by-environment studies investigating the impact of the serotonin transporter gene-linked polymorphic region (5-httlpr) and the brain derived neurotrophic factor (bdnf) val66met polymorphisms by life events on mental health and behaviour problems have been inconclusive. |
2017-11-27 |
2023-08-13 |
Not clear |
| Martin Bares, Tomas Novak, Martin Brunovsky, Miloslav Kopecek, Cyril Hösch. The Comparison of Effectiveness of Various Potential Predictors of Response to Treatment With SSRIs in Patients With Depressive Disorder. The Journal of nervous and mental disease. vol 205. issue 8. 2017-09-04. PMID:27660994. |
the aim of this 6-week, open-label study was (1) to compare the efficacy of a priori defined predictors: ≥20% reduction in madrs score at week 1, ≥20% reduction in madrs score at week 2 (rm ≥ 20% w2), decrease of cordance (rc), and increase of serum and plasma level of brain-derived neurotrophic factor at week 1; and (2) to assess whether their combination yields higher efficacy in the prediction of response to selective serotonin re-uptake inhibitors (ssris) than when used singly. |
2017-09-04 |
2023-08-13 |
Not clear |
| N N Kudryavtseva, D A Smagin, I L Kovalenko, A G Galyamina, G B Vishnivetskaya, V N Babenko, Yu L Orlo. [Serotonergic genes in the development of anxiety/depression-like state and pathology of aggressive behavior in male mice: RNA-seq data]. Molekuliarnaia biologiia. vol 51. issue 2. 2017-08-14. PMID:28537235. |
using the data of whole transcriptome analysis (rna-seq), the changes in the expression of serotonergic genes involved in the synthesis, inactivation, and reception of serotonin, as well as of the creb1 (transcription factor) gene and the bdnf (brain-derived neurotrophic factor) gene were detected in the striatum (str), ventral tegmental area (vta), midbrain raphe nuclei (mrn), hypothalamus (hyp), and hippocampus (hip) of defeated and aggressive male mice. |
2017-08-14 |
2023-08-13 |
mouse |