| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Alaa H Sayed, Nadia S Mahmoud, Ola A M Mohawed, Hanaa H Ahme. Combined effect of pantoprazole and mesenchymal stem cells on experimentally induced gastric ulcer: implication of oxidative stress, inflammation and apoptosis pathways. Inflammopharmacology. 2024-04-23. PMID:38652367. |
moreover, the treated groups (panto, adscs and adscs + panto) displayed significant down-regulation (p < 0.05) in gastric nuclear factor kappa-light-chain-enhancer of activated b cells (nf-κb), tumor necrosis factor alpha (tnf-α), cyclooxygenase-2 (cox-2), intercellular adhesion molecule-1 (icam-1), matrix metallopeptidase 9 (mmp-9) and caspase-3 along with significant up-regulation (p < 0.05) in vascular endothelial growth factor (vegf) and peroxisome proliferator-activated receptor gamma (pparγ) genes expression compared to the untreated gu group. |
2024-04-23 |
2024-04-26 |
rat |
| Samia Mahmoud Manawy, Eman Mohamed Faruk, Rabab Fawzy Hindawy, Mahmoud M Hassan, Diaa M G Farrag, Mansour A E Bashar, Hanan Fouad, Rania Abubaker Bagabir, Dina Allam Abdelmaksoud Hassan, Ahmed Mohammed Zaazaa, Mohamed Ghazy Attia Hablas, K Mostafa Kama. Modulation of the Sirtuin-1 signaling pathway in doxorubicin-induced nephrotoxicity (synergistic amelioration by resveratrol and pirfenidone). Tissue & cell. vol 87. 2024-02-27. PMID:38412579. |
renal tissue was collected to assess matrix metalloproteinase-9 (mmp9), inflammatory and apoptotic markers: tumor necrosis factor-alpha (tnf- β, caspase-3, cyclo-oxygenase-2 (cox-2), and oxidative stress markers: nitric oxide (no), glutathione (gsh), malondialdehyde (mda), and superoxide dismutase (sod). |
2024-02-27 |
2024-03-01 |
rat |
| Chaohua Deng, Nathalie Presle, Anne Pizard, Cécile Guillaume, Arnaud Bianchi, Hervé Kemp. Beneficial Impact of Eicosapentaenoic Acid on the Adverse Effects Induced by Palmitate and Hyperglycemia on Healthy Rat Chondrocyte. International journal of molecular sciences. vol 25. issue 3. 2024-02-10. PMID:38339087. |
the expression of genes encoding proteins found in cartilage matrix (type 2 collagen and aggrecan) or involved in degenerative (metalloproteinases, mmps) or in inflammatory (cyclooxygenase-2, cox-2 and microsomal prostaglandin e synthase, mpges) processes was analyzed by qpcr. |
2024-02-10 |
2024-02-12 |
rat |
| Hong Su, Qiuju Yan, Wei Du, En Hu, Zhaoyu Yang, Wei Zhang, Yusheng Li, Tao Tang, Shushan Zhao, Yang Wan. Calycosin ameliorates osteoarthritis by regulating the imbalance between chondrocyte synthesis and catabolism. BMC complementary medicine and therapies. vol 24. issue 1. 2024-01-23. PMID:38254101. |
while cartilage matrix degradation index cyclooxygenase-2 (cox-2), phosphor-epidermal growth factor receptor (p-egfr), and matrix metalloproteinase-9 (mmp9) expression were decreased. |
2024-01-23 |
2024-01-25 |
mouse |
| Guozhong Wu, Shaik Althaf Hussain, Jayasimha Rayalu Daddam, Zhou Y. Anti-osteoarthritis, Bone Protective and Antiinflammatory Effect of Lusianthridin against Monosodium Iodoacetate Induced Osteoarthritis via Suppression of Inflammatory Pathway. Journal of oleo science. vol 73. issue 1. 2024-01-03. PMID:38171734. |
lusianthridin significantly (p < 0.001) decreased the level of cartilage oligometrix matrix protein (comp) and c-reactive protein (crp); cytokines such as tnf-α, il-1β, il-6, il-10; inflammatory parameters include 5- lipoxygenase (5-lox), cox-2, leukotriene b4 (ltb4), pge2; transforming growth factor beta (tgf-β); mmp level like mmp-1, 3, 9, 13, respectively. |
2024-01-03 |
2024-01-06 |
rat |
| Ying Yu, Sang-Min Kim, Kyeongsoon Park, Hak Jun Kim, Jae Gyoon Kim, Sung Eun Ki. Therapeutic Nanodiamonds Containing Icariin Ameliorate the Progression of Osteoarthritis in Rats. International journal of molecular sciences. vol 24. issue 21. 2023-11-14. PMID:37958960. |
ica/ta-nds inhibited the mrna levels of pro-inflammatory elements, including matrix metalloproteinases-3 (mmp-3), cyclooxygenase-2 (cox-2), interleukin-6 (il-6), and tumor necrosis factor-α (tnf-α), and increased the mrna levels of anti-inflammatory factors (i.e., il-4 and il-10) in lps-activated raw 264.7 macrophages. |
2023-11-14 |
2023-11-20 |
rat |
| Tian Mao, Junchi Fa. Myricetin Protects Against Rat Intervertebral Disc Degeneration Partly Through the Nrf2/HO-1/NF-κB Signaling Pathway. Biochemical genetics. 2023-07-28. PMID:37507641. |
rt-qpcr, western blotting, and elisa were applied to evaluate the levels of inflammatory factors (inos, cox-2, tnf-α, il-6, pge2, and nitrite) and extracellular matrix (ecm)-associated components (mmp13, adamts-5, aggrecan, and collagen ii) in npcs. |
2023-07-28 |
2023-08-14 |
rat |
| Xinyu Dou, Yunlong Ma, Qipeng Luo, Chunyu Song, Meijuan Liu, Xiao Liu, Donglin Jia, Shuiqing Li, Xiaoguang Li. Therapeutic potential of melatonin in the intervertebral disc degeneration through inhibiting the ferroptosis of nucleus pulpous cells. Journal of cellular and molecular medicine. 2023-06-17. PMID:37329158. |
current studies demonstrated that conditioned medium (cm) from the lipopolysaccharide (lps)-stimulated macrophages caused a series of changes about idd, including increased intracellular oxidative stress (increased reactive oxygen species and malondialdehyde levels, but decreased glutathione levels), upregulated expression of inflammation-associated factors (il-1β, cox-2 and inos), increased expression of key matrix catabolic molecules (mmp-13, adamts4 and adamts5), reduced the expression of major matrix anabolic molecules (col2a1 and acan), and increased ferroptosis (downregulated gpx4 and slc7a11 levels, but upregulated acsl4 and lpcat3 levels) in nucleus pulposus (np) cells. |
2023-06-17 |
2023-08-14 |
Not clear |
| Le Su, Jilong Liu, Qiulin Yue, Song Zhang, Chen Zhao, Xin Sun, Jing Xu, Xingtao Jiang, Kunlun Li, Baojun Li, Lin Zha. Evaluation of the effects of e-cigarette aerosol extracts and tobacco cigarette smoke extracts on human gingival epithelial cells. Toxicology in vitro : an international journal published in association with BIBRA. 2023-05-10. PMID:37164182. |
the levels of matrix metalloproteinase, cox-2, and inflammatory factors were higher in hgecs treated with csc than those treated with ecac. |
2023-05-10 |
2023-08-14 |
human |
| Lavanya Mude, Srikanth Jupudi, Akey Krishna Swaroop, Vyshnavi Tallapaneni, Veera Venkata Satyanarayana Reddy Karr. Molecular insights in repurposing selective COX-2 inhibitor celecoxib against matrix metalloproteinases in potentiating delayed wound healing: a molecular docking and MMPB/SA based analysis of molecular dynamic simulations. Journal of biomolecular structure & dynamics. 2023-05-09. PMID:37160705. |
molecular insights in repurposing selective cox-2 inhibitor celecoxib against matrix metalloproteinases in potentiating delayed wound healing: a molecular docking and mmpb/sa based analysis of molecular dynamic simulations. |
2023-05-09 |
2023-08-14 |
Not clear |
| Le Su, Jilong Liu, Qiulin Yue, Song Zhang, Chen Zhao, Xin Sun, Jing Xu, Xingtao Jiang, Kunlun Li, Baojun Li, Lin Zha. Evaluation of the Effects of E-Cigarette Aerosol Extracts and Tobacco Cigarette Smoke Extracts on Human Gingival Epithelial Cells. ACS omega. vol 8. issue 12. 2023-04-03. PMID:37008119. |
the levels of matrix metalloproteinase, cox-2, and inflammatory factors were higher in hgecs treated with csc than those treated with ecac. |
2023-04-03 |
2023-08-14 |
human |
| Connor Charles Gains, Antonios Giannapoulos, Danae Emilie Zamboulis, Jordi Lopez-Tremoleda, Hazel R C Scree. Development and application of a novel in vivo overload model of the Achilles tendon in rat. Journal of biomechanics. vol 151. 2023-03-23. PMID:36958089. |
staining for pro-inflammatory mediators (il-6 and cox-2) and matrix degradation markers (mmp-3 and -13) also suggests an initial cellular response to overload. |
2023-03-23 |
2023-08-14 |
rat |
| Xiaoyi Xia, Huang Zeng, Huilei Wang, Xin Li, Shengyuan Zhang, Li Yang, Junwei H. Revealing the Active Constituents and Mechanisms of Semiliquidambar cathayensis Chang Roots Against Rheumatoid Arthritis through Network Pharmacology, Molecular Docking, and in Vivo Experiment. Chemistry & biodiversity. 2022-11-24. PMID:36424369. |
rat experiment demonstrated that the extract of sc restored body weight loss, reduced arthritis score and the indices of thymus and spleen, alleviated ankle joint histopathology, decreased the levels of rheumatoid factor (rf), c-reactive protein (crp), il-17, tnf-α, il-1β, il-6, cyclooxygenase-2 (cox-2), 5-lipoxygenase (5-lox), and matrix metalloproteinase-2 (mmp-2), whereas elevated the levels of il-4 and il-10. |
2022-11-24 |
2023-08-14 |
rat |
| Mojgan Gharipour, Masoumeh Sadeghi, Shaghayegh Haghjooy-Javanmard, Homa Hamledari, Elham Khosravi, Minoo Dianatkhah, Golnaz Vasegh. Effects of selenium intake on the expression of prostaglandin-endoperoxide synthase 2 (cyclooxygenase-2) and matrix metallopeptidase-9 genes in the coronary artery disease: Selenegene study, a double-blind randomized controlled trial. ARYA atherosclerosis. vol 17. issue 2. 2022-11-07. PMID:36338532. |
cyclooxygenase-2 (cox-2) and matrix metallopeptidase-9 (mmp-9) are two of the important genes that are reported to be involved in the cardiovascular disease (cvd) development in the molecular and genetic association studies. |
2022-11-07 |
2023-08-14 |
Not clear |
| Amr Negm, Azza Sedky, Hany Elsaw. Capric Acid Behaves Agonistic Effect on Calcitriol to Control Inflammatory Mediators in Colon Cancer Cells. Molecules (Basel, Switzerland). vol 27. issue 19. 2022-10-14. PMID:36235161. |
these findings elucidate the activation of cox-2 and nf-κb via disruption of the cellular outer matrix could be considered a novel molecular target suitable for colorectal cancer therapy. |
2022-10-14 |
2023-08-14 |
human |
| Qi Wang, Jing Peng, Yang Liu, Yang Tian, Jie Li, Yao-Yao Ren, Jian Gu, Rui Ta. [Therapeutic effects of alkaloids in Tibetan medicine Bangna (Aconiti Penduli et Aconiti Flavi Radix) on osteoarthritis rats and mechanisms]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 47. issue 17. 2022-09-27. PMID:36164879. |
the protein expression of inflammatory factors cyclooxygenase-2(cox-2), inducible nitric oxide synthetase(inos), tumor necrosis factor-α(tnf-α), and interleukin-1β(il-1β) in each group were detected by western blot, and the protein expression of matrix metalloprotease-13(mmp-13), aggrecan, collagen Ⅱ, fibroblast growth factor 2(fgf2) by immunofluorescence staining. |
2022-09-27 |
2023-08-14 |
rat |
| Davorin Sef, Miljenko Kovacevic, Bojan Jernej, Karlo Novacic, Marko Slavica, Jelka Petrak, Igor Medved, Milan Milosevi. Immunohistochemical analysis of MMP-9 and COX-2 expression in carotid atherosclerotic plaques among patients undergoing carotid endarterectomy: A prospective study. Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association. vol 31. issue 11. 2022-09-08. PMID:36075131. |
matrix metalloproteinase-9 protein (mmp-9) and cyclooxygenase-2 (cox-2) proteins may have a role in remodelling of atherosclerotic plaques. |
2022-09-08 |
2023-08-14 |
Not clear |
| Cong Sui, Yichao Wu, Ran Zhang, Tiantian Zhang, Yang Zhang, Jiaojiao Xi, Yanyu Ding, Jiyue Wen, Yong H. Rutin Inhibits the Progression of Osteoarthritis Through DNA and cell biology. 2022-05-19. PMID:35588172. |
we found that rutin effectively reduced the expression levels of inducible nitric oxide synthase (inos), cyclooxygenase-2 (cox-2), tumor necrosis factor-α (tnf-α), and matrix metalloproteinase 13 (mmp-13) and increased the expression of col ii and aggrecan ( |
2022-05-19 |
2023-08-13 |
rat |
| Dinesh G Goswami, Satyendra K Singh, Omid Madadgar, Claire R Croutch, Erica L Noland, Jared Brown, Rajesh Agarwal, Neera Tewari-Sing. Mechanism of Phosgene Oxime Induced Skin Toxicity in C57BL/6 Mouse Model. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35554650. |
cx exposure also led to increased expression of inflammatory mediators, cyclooxygenase-2 (cox-2), matrix metallopeptidase-9 (mmp-9), myeloperoxidase (mpo), and map kinases jnk. |
2022-05-13 |
2023-08-13 |
mouse |
| Qingyu Meng, Luya Pu, Mingran Qi, Shuai Li, Banghao Sun, Yaru Wang, Bin Liu, Fan L. Laminar shear stress inhibits inflammation by activating autophagy in human aortic endothelial cells through HMGB1 nuclear translocation. Communications biology. vol 5. issue 1. 2022-05-06. PMID:35523945. |
in this study, we found that lss could inhibit the increased expression of intercellular adhesion molecule-1 (icam-1), vascular cell adhesion molecule-1 (vcam-1), cyclooxygenase-2 (cox-2), and matrix metallopeptidase-9 (mmp-9) caused by tnf-α in an autophagy-dependent pathway in human aortic endothelial cells (haecs) and human umbilical vein endothelial cells (huvecs). |
2022-05-06 |
2023-08-13 |
human |