| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Bowei Ni, Xiaojian Huang, Yang Xi, Zekai Mao, Xiangyu Chu, Rui Zhang, Xiaohu Ma, Hongbo Yo. Neferine Inhibits Expression of Inflammatory Mediators and Matrix Degrading Enzymes in IL-1β-Treated Rat Chondrocytes via Suppressing MAPK and NF-κB Signaling Pathways. Inflammation. vol 43. issue 4. 2021-06-10. PMID:32488683. |
expression of inducible nitric oxide synthase (inos), cyclooxygenase 2 (cox-2), matrix metalloproteinases (mmps), and thrombospondin motifs-5 (adamts5) was determined by quantitative real-time pcr and western blotting. |
2021-06-10 |
2023-08-13 |
rat |
| Lifeng Jiang, Xindie Zhou, Congxiang Huang, Jiapeng Bao, Jin Li, Kai Xu, Daihai Dong, Lidong W. The elevated expression of IL-38 serves as an anti-inflammatory factor in osteoarthritis and its protective effect in osteoarthritic chondrocytes. International immunopharmacology. vol 94. 2021-06-09. PMID:33774357. |
furthermore, overexpression of il-38 in vitro is shown to attenuate the expression of pro-inflammatory cytokines such as cox-2, il-6, il-8, il-36ra, il-36α/β/γ, inos, and tnf-α, as well as matrix degrading enzymes such as mmp3, mmp13, and adamts5, and apoptosis-related indicators bax/bcl-2, cleaved caspase 3/pro-caspase 3, and cleaved caspase 9/pro-caspase 9. |
2021-06-09 |
2023-08-13 |
human |
| Luciana S Altoé, Raul S Alves, Lyvia L Miranda, Mariáurea M Sarandy, Daniel S S Bastos, Elda Gonçalves-Santos, Rômulo D Novaes, Reggiani V Gonçalve. Doxycycline Hyclate Modulates Antioxidant Defenses, Matrix Metalloproteinases, and COX-2 Activity Accelerating Skin Wound Healing by Secondary Intention in Rats. Oxidative medicine and cellular longevity. vol 2021. 2021-05-28. PMID:33959214. |
doxycycline hyclate modulates antioxidant defenses, matrix metalloproteinases, and cox-2 activity accelerating skin wound healing by secondary intention in rats. |
2021-05-28 |
2023-08-13 |
rat |
| Chenxi Zhang, Zhenxuan Shao, Xiaofen Hu, Zhengtai Chen, Baolong Li, Renhao Jiang, Najeeb Bsoul, Jiaoxiang Chen, Cong Xu, Weiyang Ga. Inhibition of PI3K/Akt/NF-κB signaling by Aloin for ameliorating the progression of osteoarthritis: In vitro and in vivo studies. International immunopharmacology. vol 89. issue Pt B. 2021-05-25. PMID:33096361. |
in in-vitro experiments, the protective effect of aloin on the anabolism and catabolism of the extracellular matrix (ecm) induced by il-1 β in chondrocytes by inhibiting the expression of pro-inflammatory factors, including tnf-α (p = 0.016), il-6 (p = 0.006), inos (p = 0.001) and cox-2 (p = 0.006). |
2021-05-25 |
2023-08-13 |
Not clear |
| Jialong Fan, Bin Liu, Ying Long, Zhou Wang, Chunyi Tong, Wei Wang, Peidong You, Xuanming Li. Sequentially-targeted biomimetic nano drug system for triple-negative breast cancer ablation and lung metastasis inhibition. Acta biomaterialia. vol 113. 2021-05-14. PMID:32569637. |
moreover, comparing with the control, the average number of lung metastatic nodules in tumor-bearing mice reduced 84%, the molecular mechanism of which is related to the down expression of cox-2, matrix metalloproteinase 9 (mmp9) and vascular endothelial growth factor (vegf). |
2021-05-14 |
2023-08-13 |
mouse |
| Maria João Carvalho, Ana Sofia Pais, Ângela Rodrigues, Ana Luísa Areia, Margarida Figueiredo-Dia. Providing new insights into the endometriosisassociated cancer arising in episiotomy scars. Ginekologia polska. vol 92. issue 3. 2021-04-13. PMID:33751518. |
mechanisms of endometriosis implantation in scars include the influence of estrogens in the healing process and activation of cox-2, aromatase and matrix metalloproteinases. |
2021-04-13 |
2023-08-13 |
Not clear |
| Hong-Jie Zhu, Te Xu, Yong-Ming Yan, Yong-Xian Chen. Nonpeptidal compounds from the insect Polyphaga plancyi and their biological evaluation. Bioorganic chemistry. vol 104. 2021-03-29. PMID:32956876. |
biological activities of these isolates against extracellular matrix components in rat renal proximal tubular cells, ev71, cox-2, rock2, jak3, and tuberculosis were evaluated. |
2021-03-29 |
2023-08-13 |
rat |
| Zijian Yan, Zeng Lin, Yifan Wu, Jingdi Zhan, Weihui Qi, Jian Lin, Jiquan Shen, Xinghe Xue, Xiaoyun Pa. The protective effect of myricitrin in osteoarthritis: An in vitro and in vivo study. International immunopharmacology. vol 84. 2021-03-10. PMID:32361653. |
protein expression of inducible nitric oxide synthase (inos), cyclooxygenase-2 (cox-2), collagen-ii, matrix metalloproteinase(mmp)-13, mmp-3, thrombospondin motifs 5(adamts5), inhibitor ofnuclear factor kappa-b (iκb), p-iκb, p65, p-p65, c-jun-terminal kinase (jnk), p-jnk, extracellular regulated protein kinases (erk), p-erk, p38 and p-p38 were quantified using western blot analysis. |
2021-03-10 |
2023-08-13 |
mouse |
| Yong-Ming Yan, Te Xu, Zheng-Chao Tu, Hong-Jie Zhu, Yong-Xian Chen. Sulfur and nitrogen-containing compounds from the whole bodies of Blaps japanensis. Bioorganic chemistry. vol 102. 2021-03-02. PMID:32688114. |
biological activities of all the new compounds against extracellular matrix in rat renal proximal tubular cells, human cancer cells (a549, huh-7, and k562), cox-2, rock1, and jak3 were evaluated. |
2021-03-02 |
2023-08-13 |
human |
| Ling-Yuh Shyu, Ke-Min Chen, Cheng-You Lu, Shih-Chan La. Regulation of Proinflammatory Enzymes by Peroxisome Proliferator-Activated Receptor Gamma in Astroglia Infected with Toxoplasma gondii. The Journal of parasitology. vol 106. issue 5. 2021-02-02. PMID:32916705. |
our results showed that matrix metalloprotease (mmp)-2, mmp-9, cyclooxygenase-2 (cox-2), prostaglandin (pge)-2, inducible nitric-oxide synthase (inos), and nitric oxide (no) were significantly increased in t. gondii-infected astroglia. |
2021-02-02 |
2023-08-13 |
Not clear |
| Hong Joon Choi, Somang Choi, Jae Gyoon Kim, Mi Hyun Song, Kyu-Sik Shim, Youn-Mook Lim, Hak-Jun Kim, Kyeongsoon Park, Sung Eun Ki. Enhanced tendon restoration effects of anti-inflammatory, lactoferrin-immobilized, heparin-polymeric nanoparticles in an Achilles tendinitis rat model. Carbohydrate polymers. vol 241. 2021-01-20. PMID:32507170. |
long-term lf-deliverable nps (lf/hep-plga nps) remarkably decreased mrna levels of pro-inflammatory factors [cyclooxygenase-2 (cox-2), il-1β, matrix metalloproteinase-3 (mmp-3), mmp-13, il-6, and tumor necrosis factor-α (tnf-α)] and increased mrna levels of anti-inflammatory cytokines (il-4 and il-10) in both il-1β-treated tenocytes and the achilles tendons of a collagenase-induced achilles tendinitis rat model. |
2021-01-20 |
2023-08-13 |
rat |
| Heewon Song, Yong Yook Lee, Joonwoo Park, YoungJoo Le. Korean Red Ginseng suppresses bisphenol A-induced expression of cyclooxygenase-2 and cellular migration of A549 human lung cancer cell through inhibition of reactive oxygen species. Journal of ginseng research. vol 45. issue 1. 2021-01-14. PMID:33437163. |
here, in this study, we assessed the protective effect of krg on the bpa-induced reactive oxygen species (ros) and expression of cox-2 and matrix metalloproteinase-9 (mmp-9) in a549 cells. |
2021-01-14 |
2023-08-13 |
human |
| Sun Tae Hwang, Jae-Young Um, Arunachalam Chinnathambi, Sulaiman Ali Alharbi, Acharan S Narula, Ojas A Namjoshi, Bruce E Blough, Kwang Seok Ah. Evodiamine Mitigates Cellular Growth and Promotes Apoptosis by Targeting the c-Met Pathway in Prostate Cancer Cells. Molecules (Basel, Switzerland). vol 25. issue 6. 2020-12-16. PMID:32183146. |
then, we noted that evo arrested the cell cycle, caused apoptosis, and downregulated the expression of various carcinogenic markers such as b-cell lymphoma 2 (bcl-2), b-cell lymphoma-extra large (bcl-xl), cyclin d1, cyclooxygenase 2 (cox-2), survivin, vascular endothelial growth factor (vegf), and matrix metallopeptidases 9 (mmp-9). |
2020-12-16 |
2023-08-13 |
Not clear |
| Szilvia B László, Bernadette Lázár, Gábor B Brenner, András Makkos, Mihály Balogh, Mahmoud Al-Khrasani, Barbara Hutka, Amir Mohammadzadeh, Ágnes Kemény, Terézia László, Bálint Scheich, Tamara Szabados, Éva Kenyeres, Zoltán Giricz, Péter Bencsik, Zoltán V Varga, Julianna Novák, Zsuzsanna Helyes, Péter Ferdinandy, Klára Gyires, Zoltán S Zádor. Chronic treatment with rofecoxib but not ischemic preconditioning of the myocardium ameliorates early intestinal damage following cardiac ischemia/reperfusion injury in rats. Biochemical pharmacology. vol 178. 2020-12-04. PMID:32540483. |
we found that cardiac i/r injury induced histological changes in the small intestine within 2 h, which were accompanied by elevated tissue level of cox-2 and showed positive correlation with the activity of matrix metalloproteinase-2 (mmp-2), but not of mmp-9 in the plasma. |
2020-12-04 |
2023-08-13 |
rat |
| Gösel Bengi, Didem Keles, Ömer Topalak, Mustafa Yalçin, Rabia Kiyak, Gülgün Okta. Expressions of TIMP-1, COX-2 and MMP-7 in Colon Polyp and Colon Cancer. Euroasian journal of hepato-gastroenterology. vol 5. issue 2. 2020-10-01. PMID:29201696. |
we aimed to investigate the relationship of expression of matrix metalloproteinase-7 (mmp-7), tissue inhibitor of metalloproteinase-1 (timp-1) and cyclooxygenase-2 (cox-2) in colon cancer and its predecessor colon polyp. |
2020-10-01 |
2023-08-13 |
Not clear |
| Jun-Rong Lei, Xian-Kun Tu, Yang Wang, De-Wen Tu, Song-Sheng Sh. Resveratrol downregulates the TLR4 signaling pathway to reduce brain damage in a rat model of focal cerebral ischemia. Experimental and therapeutic medicine. vol 17. issue 4. 2020-10-01. PMID:30936996. |
additionally, the protein expression levels of toll-like receptor 4 (tlr4) and nuclear factor (nf)-κb p65 were detected using western blot analyses, the mrna expression levels of cyclooxygenase-2 (cox-2) and matrix metalloproteinase-9 (mmp-9) were examined by reverse-transcription polymerase chain reaction, and tumor necrosis factor (tnf)-α and interleukin (il)-1β blood levels were determined by elisa. |
2020-10-01 |
2023-08-13 |
rat |
| Claudia I Rivas-Ortiz, Yolanda Lopez-Vidal, Luis Jose Rene Arredondo-Hernandez, Gonzalo Castillo-Roja. Genetic Alterations in Gastric Cancer Associated with Frontiers in medicine. vol 4. 2020-09-30. PMID:28512631. |
recently, these genes (interleukin 10, il-17, mucin 1, β-catenin, cdx1, smad4, serpine1, hypoxia-inducible factor 1 subunit alpha, gsk3β, cdh17, matrix metalloproteinase 7, runx3, rassf1a, tff1, hai-2, and cox-2) have been studied in association with oncogenic activation or inactivation of tumor suppressor genes. |
2020-09-30 |
2023-08-13 |
Not clear |
| Young Yun Jung, Jong Hyun Lee, Dongwoo Nam, Acharan S Narula, Ojas A Namjoshi, Bruce E Blough, Jae-Young Um, Gautam Sethi, Kwang Seok Ah. Anti-myeloma Effects of Icariin Are Mediated Through the Attenuation of JAK/STAT3-Dependent Signaling Cascade. Frontiers in pharmacology. vol 9. 2020-09-30. PMID:29899697. |
we found that icariin downregulated the protein expression of stat3 downstream target gene products such as bcl-2, bcl-xl, survivin, iap-1/2, cox-2, vegf, and matrix metallopeptidase 9 (mmp-9) in a concentration-dependent manner. |
2020-09-30 |
2023-08-13 |
human |
| Mahmood Rasool, Arif Malik, Sulayman Waquar, Qura Tul-Ain, Tassadaq H Jafar, Rabia Rasool, Aasia Kalsoom, Muhammad A Ghafoor, Sheikh A Sehgal, Kalamegam Gauthaman, Muhammad I Naseer, Mohammed H Al-Qahtani, Peter N Pushpara. Frontiers in pharmacology. vol 9. 2020-09-30. PMID:30123124. |
the serum samples were further analyzed for biomarkers such as 8-hydroxydeoxyguanosine (8-ohdg), 4-hydroxynonenal (4-hne), tumor necrosis factor-alpha (tnf-α), cyclooxygenase-2 (cox-2), matrix metalloproteinase-8 (mmp-8), isoprostanes-2 alpha (isop-2α), and acetylcholine esterase (ache) using conventional enzyme linked immunosorbent assay (elisa) method. |
2020-09-30 |
2023-08-13 |
rat |
| M W Roomi, T Kalinovsky, J Cha, N W Roomi, A Niedzwiecki, M Rat. Effects of a nutrient mixture on immunohistochemical localization of cancer markers in human cervical cancer HeLa cell tumor xenografts in female nude mice. Experimental and therapeutic medicine. vol 9. issue 2. 2020-09-29. PMID:25574189. |
tumor growth was measured and immunohistochemical staining was evaluated for the following cancer markers: ki67 (proliferation); matrix metalloproteinase (mmp)-2 and -9 (invasion/metastasis); vascular endothelial growth factor (vegf) (angiogenesis); terminal deoxynucleotidyl transferase dutp nick end labeling (tunel) and b-cell lymphoma 2 (bcl-2) (apoptosis); cyclooxygenase 2 (cox-2) and inducible nitric oxide synthase (inos) (inflammation); and glutathione s-transferase π (gstπ) (a general cancer marker). |
2020-09-29 |
2023-08-13 |
mouse |