| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mohammad Elahi, Zahra Ebrahim Soltani, Arya Afrooghe, Elham Ahmadi, Ahmad Reza Dehpou. Sex Dimorphism in Pain Threshold and Neuroinflammatory Response: The Protective Effect of Female Sexual Hormones on Behavior and Seizures in an Allergic Rhinitis Model. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. vol 19. issue 1. 2024-04-23. PMID:38652402. |
this was along with decreased levels of dna methyl transferase 1 (dnmt1) and inflammatory cytokines in their hippocampus. |
2024-04-23 |
2024-04-26 |
mouse |
| Hong Chen, Chun-Jie Zhang, Zhi-Ying Zhao, Yang-Yang Gao, Jian-Tian Zhao, Xiao-Xu Li, Ming Zhang, He Wan. Mechanisms underlying LncRNA SNHG1 regulation of Alzheimer's disease involve DNA methylation. Journal of toxicology and environmental health. Part A. 2024-03-29. PMID:38551404. |
at 2 weeks mice were subjected to a morris water maze to determine any behavioral effects followed by sacrifice to extract hippocampal tissue for western blotting to measure protein expression of p-tau, dnmt1, dnmt3a, dnmt3b, tet1, and p-akt. |
2024-03-29 |
2024-03-31 |
mouse |
| Huixia Geng, Qihang An, Jie Song, Dongling He, Huimin Han, Lai Wan. Cadmium-induced global DNA hypermethylation promoting mitochondrial dynamics dysregulation in hippocampal neurons. Environmental toxicology. 2023-12-14. PMID:38095104. |
cadmium exposure increases the global methylation level of the genome and upregulates the expression of dnmt1 and dnmt3α in hippocampal neurons. |
2023-12-14 |
2023-12-17 |
Not clear |
| Karine Yu Sarkisova, Ekaterina A Fedosova, Alla B Shatskova, Margarita M Rudenok, Vera A Stanishevskaya, Petr A Slominsk. Maternal Methyl-Enriched Diet Increases DNMT1, HCN1, and TH Gene Expression and Suppresses Absence Seizures and Comorbid Depression in Offspring of WAG/Rij Rats. Diagnostics (Basel, Switzerland). vol 13. issue 3. 2023-02-11. PMID:36766503. |
disease-modifying effects of med were associated with increased expression of the dnmt1 and hcn1 genes in the ssc and hippocampus, as well as dnmt1, hcn1, and th genes in the nucleus accumbens. |
2023-02-11 |
2023-08-14 |
rat |
| Juliano Viana Borges, Vivian Naziaseno Pires, Betânia Souza de Freitas, Gabriel Rübensam, Vitória Corrêa Vieira, Cristophod de Souza Dos Santos, Nadja Schröder, Elke Bromber. Behavior, BDNF and epigenetic mechanisms in response to social isolation and social support in middle aged rats exposed to chronic stress. Behavioural brain research. 2023-01-19. PMID:36657665. |
more specifically, we investigated the behavioral responses, corticosterone levels, bdnf gene expression, and markers of hippocampal epigenetic alterations (levels of h3k9 acetylation and methylation, h3k27 methylation, hdac5, dnmt1, and dnmt3a gene expressions) in middle-aged adult rats maintained in different housing conditions (isolation or accompanied housing) and exposed to the chronic unpredictable stress protocol (cus). |
2023-01-19 |
2023-08-14 |
rat |
| Zhiguo Wu, Jian Tan, Lichang Lin, Wenting Zhang, Wanqiu Yua. microRNA-140-3p protects hippocampal neuron against pyroptosis to attenuate sevoflurane inhalation-induced post-operative cognitive dysfunction in rats via activation of HTR2A/ERK/Nrf2 axis by targeting DNMT1. Cell death discovery. vol 8. issue 1. 2022-06-16. PMID:35710537. |
microrna-140-3p protects hippocampal neuron against pyroptosis to attenuate sevoflurane inhalation-induced post-operative cognitive dysfunction in rats via activation of htr2a/erk/nrf2 axis by targeting dnmt1. |
2022-06-16 |
2023-08-14 |
rat |
| Sijin Duan, Chunmei Li, Yonglin Gao, Ping Meng, Shengmin Ji, Yangyang Xu, Yutong Mao, Hongbo Wang, Jingwei Tia. The tyrosine kinase inhibitor LPM4870108 impairs learning and memory and induces transcriptomic and gene‑specific DNA methylation changes in rats. Archives of toxicology. 2022-01-31. PMID:35098321. |
increased mrna and protein expression levels of hippocampal dnmt1 and dnmt3a were also observed in these rats. |
2022-01-31 |
2023-08-13 |
rat |
| Mei Yang, Jasson Barrios, Jiajie Yan, Weiwei Zhao, Shengtao Yuan, Erbo Dong, Xun A. Causal roles of stress kinase JNK2 in DNA methylation and binge alcohol withdrawal-evoked behavioral deficits. Pharmacological research. vol 164. 2021-06-14. PMID:33316384. |
in hhs mice, jnk2 in the pfc (but not hippocampus and amygdala) causally enhanced total genomic dna methylation via increased dnmt1 expression, which was regulated by enhanced binding of jnk downstream transcriptional factor c-jun to the dnmt1 promoter. |
2021-06-14 |
2023-08-13 |
mouse |
| Wei Sun, Qingnuan Kong, Meng Zhang, Xue Mi, Xiaomin Sun, Ming Yu, Tengbo Yu, Yu Zho. Virus-mediated Dnmt1 and Dnmt3a deletion disrupts excitatory synaptogenesis and synaptic function in primary cultured hippocampal neurons. Biochemical and biophysical research communications. vol 526. issue 2. 2021-04-20. PMID:32222282. |
virus-mediated dnmt1 and dnmt3a deletion disrupts excitatory synaptogenesis and synaptic function in primary cultured hippocampal neurons. |
2021-04-20 |
2023-08-13 |
Not clear |
| Wei Sun, Qingnuan Kong, Meng Zhang, Xue Mi, Xiaomin Sun, Ming Yu, Tengbo Yu, Yu Zho. Virus-mediated Dnmt1 and Dnmt3a deletion disrupts excitatory synaptogenesis and synaptic function in primary cultured hippocampal neurons. Biochemical and biophysical research communications. vol 526. issue 2. 2021-04-20. PMID:32222282. |
in this study, we selectively knocked down the expression of dnmt1 and dnmt3a in primary cultured hippocampal neurons derived from embryonic dnmt1,3a |
2021-04-20 |
2023-08-13 |
Not clear |
| Dan Xiang, Siqi Sun, Gaohua Wang, Zhongchun Li. Effects of CRMP2 DNA Methylation in the Hippocampus on Depressive-Like Behaviors and Cytoskeletal Proteins in Rats. Frontiers in cellular neuroscience. vol 15. 2021-04-06. PMID:33815064. |
we observed the upregulation of dnmt1 and dnmt3a in the hippocampus of stressed rats. |
2021-04-06 |
2023-08-13 |
rat |
| Shengjun Ji, Xin Ding, Jiang Ji, Haohao Wu, Rui Sun, Xiaoyang Li, Liyuan Zhang, Ye Tia. Cranial irradiation inhibits hippocampal neurogenesis via DNMT1 and DNMT3A. Oncology letters. vol 15. issue 3. 2020-10-01. PMID:29435016. |
cranial irradiation inhibits hippocampal neurogenesis via dnmt1 and dnmt3a. |
2020-10-01 |
2023-08-13 |
rat |
| Jing Yan, Ailin Luo, Jie Gao, Xiaole Tang, Yilin Zhao, Biyun Zhou, Zhiqiang Zhou, Shiyong L. The role of SIRT1 in neuroinflammation and cognitive dysfunction in aged rats after anesthesia and surgery. American journal of translational research. vol 11. issue 3. 2020-09-30. PMID:30972182. |
furthermore, we found that decreased sirt1 was associated with downregulated expression of dna methyltransferase 1 (dnmt1) and upregulated acetylated-nuclear factor kappa b (ac-nf-κb) expression, resulting in microglial activation and increased proinflammatory cytokines in the hippocampus of aged rats. |
2020-09-30 |
2023-08-13 |
rat |
| Rahul Kumar, Vishal Jain, Neetu Kushwah, Aastha Dheer, Kamla Prasad Mishra, Dipti Prasad, Shashi Bala Sing. Role of DNA Methylation in Hypobaric Hypoxia-Induced Neurodegeneration and Spatial Memory Impairment. Annals of neurosciences. vol 25. issue 4. 2020-09-29. PMID:31000957. |
real-time polymerase chain reaction was used for transcriptional expression of dna methyltransferases (dnmts) including dnmt1, dnmt3a and -dnmt3b, and immunoblotting was used for the translational expression of dnmt1, dnmt3a, dnmt3b, methyl cpg binding protein 2 (mecp2), pmecp2 and bdnf in rat hippocampus. |
2020-09-29 |
2023-08-13 |
rat |
| Xin-Yu Fan, Guang Shi, Ping Zha. Reversal of oxycodone conditioned place preference by oxytocin: Promoting global DNA methylation in the hippocampus. Neuropharmacology. vol 160. 2020-07-08. PMID:31526808. |
following restraint stress-induced reinstatement of oxycodone cpp, ot significantly increased mrna levels of dnmt1, decreased tet1 mrna, synaptic proteins and synaptic density in the hippocampus. |
2020-07-08 |
2023-08-13 |
rat |
| Laurence de Nijs, Kyonghwan Choe, Hellen Steinbusch, Olaf E M G Schijns, Jim Dings, Daniel L A van den Hove, Bart P F Rutten, Govert Hooglan. DNA methyltransferase isoforms expression in the temporal lobe of epilepsy patients with a history of febrile seizures. Clinical epigenetics. vol 11. issue 1. 2020-06-15. PMID:31426844. |
in an attempt to start exploring this notion, the present cross-sectional pilot study investigated whether global dna methylation levels (5-mc and 5-hmc markers) and dnmt isoforms (dnmt1, dnmt3a1, and dnmt3a2) expression would be different in hippocampal and neocortical tissues between controls and tle patients with or without a history of fs. |
2020-06-15 |
2023-08-13 |
Not clear |
| D Lucia, D Burgess, C L Cullen, E S Dorey, O Rawashdeh, K M Morit. Periconceptional maternal alcohol consumption leads to behavioural changes in adult and aged offspring and alters the expression of hippocampal genes associated with learning and memory and regulators of the epigenome. Behavioural brain research. vol 362. 2019-07-11. PMID:30633938. |
pc:etoh resulted in an upregulation of hippocampal mrna expression of bdnf, grin2a and grin2b at 18 months of age along with increased expression of epigenetic modifiers (dnmt1, dnmt3a and hdac2). |
2019-07-11 |
2023-08-13 |
rat |
| E Tunc-Ozcan, S L Wert, P H Lim, A Ferreira, E E Rede. Hippocampus-dependent memory and allele-specific gene expression in adult offspring of alcohol-consuming dams after neonatal treatment with thyroxin or metformin. Molecular psychiatry. vol 23. issue 7. 2019-06-17. PMID:28727687. |
the decreased hippocampal expression of dna methyltransferase 1 (dnmt1) that maintains the imprinting of dio3 and igf2 during development was normalized by both treatments. |
2019-06-17 |
2023-08-13 |
human |
| E Tunc-Ozcan, S L Wert, P H Lim, A Ferreira, E E Rede. Hippocampus-dependent memory and allele-specific gene expression in adult offspring of alcohol-consuming dams after neonatal treatment with thyroxin or metformin. Molecular psychiatry. vol 23. issue 7. 2019-06-17. PMID:28727687. |
administering dnmt1 inhibitor to control neonates resulted in fae-like deficits in fear memory and hippocampal allele-specific expression of igf2, which were reversed by metformin. |
2019-06-17 |
2023-08-13 |
human |
| E Tunc-Ozcan, S L Wert, P H Lim, A Ferreira, E E Rede. Hippocampus-dependent memory and allele-specific gene expression in adult offspring of alcohol-consuming dams after neonatal treatment with thyroxin or metformin. Molecular psychiatry. vol 23. issue 7. 2019-06-17. PMID:28727687. |
we propose that neonatal administration of t4 and metformin post fae affect memory via elevating dnmt1 and consequently normalizing hippocampal dio3 and igf2 expressions in the adult offspring. |
2019-06-17 |
2023-08-13 |
human |