| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sweta Srivas, Mahendra K Thaku. Transcriptional co-repressor SIN3A silencing rescues decline in memory consolidation during scopolamine-induced amnesia. Journal of neurochemistry. vol 145. issue 3. 2019-05-08. PMID:29494759. |
earlier we demonstrated that scopolamine-induced decrease in memory consolidation is correlated with enhanced expression of hippocampal dna methyltransferase 1 (dnmt1) and histone deacetylase 2 (hdac2) in mice. |
2019-05-08 |
2023-08-13 |
mouse |
| Di Ye, Li Zhang, Weidong Fan, Xianquan Zhang, Erbo Don. Genipin normalizes depression-like behavior induced by prenatal stress through inhibiting DNMT1. Epigenetics. vol 13. issue 3. 2019-02-15. PMID:29522357. |
in further experiments, we found that the effect of genipin on prs mice occurs through dna demethylation by inhibiting dna methyltransferase 1 (dnmt1), normalizing the expression of reduced brain-derived neurotrophic factor (bdnf) in the hippocampus. |
2019-02-15 |
2023-08-13 |
mouse |
| Xia He, Juan Lu, Wanting Dong, Zhexiao Jiao, Chong Zhang, Ying Yu, Zhaohui Zhang, Hui Wang, Dan X. Prenatal nicotine exposure induces HPA axis-hypersensitivity in offspring rats via the intrauterine programming of up-regulation of hippocampal GAD67. Archives of toxicology. vol 91. issue 12. 2018-08-16. PMID:28555334. |
moreover, prenatal nicotine exposure enhanced the expression of hippocampal glutamic acid decarboxylase 67 (gad67), accompanied by a decreased methylation ratio within nt -1019 to -689 of the gad67 promoter, decreased expression of dnmt1, and an increased gaba content and density of gabaergic neurons. |
2018-08-16 |
2023-08-13 |
rat |
| Sohi Kang, Yeonghoon Son, Sueun Lee, Juhwan Kim, Jong-Choon Kim, Joong-Sun Kim, Uhee Jung, Sung-Ho Kim, Miyoung Yang, Changjong Moo. Changes in epigenetic markers, DNMT1 and HDAC1/2, in the adult mouse hippocampus after cranial irradiation. Neuroscience letters. vol 657. 2018-05-28. PMID:28780164. |
changes in epigenetic markers, dnmt1 and hdac1/2, in the adult mouse hippocampus after cranial irradiation. |
2018-05-28 |
2023-08-13 |
mouse |
| Sohi Kang, Yeonghoon Son, Sueun Lee, Juhwan Kim, Jong-Choon Kim, Joong-Sun Kim, Uhee Jung, Sung-Ho Kim, Miyoung Yang, Changjong Moo. Changes in epigenetic markers, DNMT1 and HDAC1/2, in the adult mouse hippocampus after cranial irradiation. Neuroscience letters. vol 657. 2018-05-28. PMID:28780164. |
we assessed changes in the levels of enzymes associated with the epigenetic modification of gene expression, including dnmt1, hdac1, hdac2, sirtuin 1 (sirt1), and acetylated histone h3 (ace-h3) in the mouse hippocampus 1 and 30days after a single exposure to cranial irradiation (0 or 10gy). |
2018-05-28 |
2023-08-13 |
mouse |
| Sweta Srivas, Mahendra K Thaku. Epigenetic regulation of neuronal immediate early genes is associated with decline in their expression and memory consolidation in scopolamine-induced amnesic mice. Molecular neurobiology. vol 54. issue 7. 2018-05-10. PMID:27553230. |
recently, we reported a correlation of scopolamine mediated decline in memory consolidation with increase in the expression of dna methyltransferase 1 (dnmt1) and histone deacetylase 2 (hdac2) in the mouse hippocampus. |
2018-05-10 |
2023-08-13 |
mouse |
| Richelle Mychasiuk, Harleen Hehar, Irene Ma, Sydney Candy, Michael J Esse. Reducing the time interval between concussion and voluntary exercise restores motor impairment, short-term memory, and alterations to gene expression. The European journal of neuroscience. vol 44. issue 7. 2018-02-01. PMID:27521273. |
using a translational rodent model of concussion, we examined the influence of exercise on injury-associated behaviours that comprise post-concussive syndrome (pcs) and gene expression changes (bdnf, dnmt1, igf-1, pgc1-a, tert) in prefrontal cortex and hippocampus. |
2018-02-01 |
2023-08-13 |
Not clear |
| Dhiraj Kumar, Mahendra Kumar Thaku. Effect of perinatal exposure to Bisphenol-A on DNA methylation and histone acetylation in cerebral cortex and hippocampus of postnatal male mice. The Journal of toxicological sciences. vol 42. issue 3. 2017-10-05. PMID:28496034. |
bpa exposure also increased mrna levels of dnmt1 and dnmt3a in cerebral cortex of 3 and 8 weeks; whereas in hippocampus dnmt1 mrna increased in 3 weeks but decreased in 8 weeks and dnmt3a showed no change. |
2017-10-05 |
2023-08-13 |
mouse |
| Yu Zheng, Weidong Fan, Xianquan Zhang, Erbo Don. Gestational stress induces depressive-like and anxiety-like phenotypes through epigenetic regulation of BDNF expression in offspring hippocampus. Epigenetics. vol 11. issue 2. 2016-12-13. PMID:26890656. |
biochemically, stress-offspring showed decreased expression of bdnf, increased expression of dnmt1, hdac1, and hdac2, and decreased expression of ach3k14 in the hippocampus as compared to non-stress offspring. |
2016-12-13 |
2023-08-13 |
Not clear |
| Kornél Demeter, Bibiána Török, Anna Fodor, János Varga, Szilamér Ferenczi, Krisztina J Kovács, Ildikó Eszik, Viktor Szegedi, Dóra Zelen. Possible contribution of epigenetic changes in the development of schizophrenia-like behavior in vasopressin-deficient Brattleboro rats. Behavioural brain research. vol 300. 2016-10-25. PMID:26704217. |
dna methyltransferase1 (dnmt1), dnmt3a, as well as comt, gad, vglut1, 5ht2a, bdnf mrna levels in prefrontal brain region and hippocampus were studied by qrt-pcr. |
2016-10-25 |
2023-08-13 |
rat |
| E Dong, P Tueting, F Matrisciano, D R Grayson, A Guidott. Behavioral and molecular neuroepigenetic alterations in prenatally stressed mice: relevance for the study of chromatin remodeling properties of antipsychotic drugs. Translational psychiatry. vol 6. 2016-10-17. PMID:26756904. |
furthermore, we have shown that the frontal cortex (fc) and hippocampus of adult prs mice, like that of postmortem chronic sz patients, are characterized by increases in dna-methyltransferase 1 (dnmt1), ten-eleven methylcytosine dioxygenase 1 (tet1) and exhibit an enrichment of 5-methylcytosine (5mc) and 5-hydroxymethylcytosine (5hmc) at neocortical gabaergic and glutamatergic gene promoters. |
2016-10-17 |
2023-08-13 |
mouse |
| R K Kashimoto, L V Toffoli, M H F Manfredo, V L Volpini, M C Martins-Pinge, G G Pelosi, M V Gome. Physical exercise affects the epigenetic programming of rat brain and modulates the adaptive response evoked by repeated restraint stress. Behavioural brain research. vol 296. 2016-09-15. PMID:26342282. |
furthermore, decreased expression of the dnmt1 gene was observed in the hippocampus and hypothalamus of animals from the ex-st group. |
2016-09-15 |
2023-08-13 |
rat |
| Cait M Williamson, Becca Franks, James P Curle. Mouse Social Network Dynamics and Community Structure are Associated with Plasticity-Related Brain Gene Expression. Frontiers in behavioral neuroscience. vol 10. 2016-08-19. PMID:27540359. |
finally, we determined that social network position is associated with variation in mrna levels of two neural plasticity genes, dnmt1 and dnmt3a, in the hippocampus but not the mpoa. |
2016-08-19 |
2023-08-13 |
mouse |
| Hirofumi Noguchi, Ayaka Kimura, Naoya Murao, Taito Matsuda, Masakazu Namihira, Kinichi Nakashim. Expression of DNMT1 in neural stem/precursor cells is critical for survival of newly generated neurons in the adult hippocampus. Neuroscience research. vol 95. 2016-01-19. PMID:25659757. |
expression of dnmt1 in neural stem/precursor cells is critical for survival of newly generated neurons in the adult hippocampus. |
2016-01-19 |
2023-08-13 |
Not clear |
| Hirofumi Noguchi, Ayaka Kimura, Naoya Murao, Taito Matsuda, Masakazu Namihira, Kinichi Nakashim. Expression of DNMT1 in neural stem/precursor cells is critical for survival of newly generated neurons in the adult hippocampus. Neuroscience research. vol 95. 2016-01-19. PMID:25659757. |
taken together, these findings suggest that the presence of dnmt1 in ans/pcs is crucial for the survival of newly generated neurons, but is dispensable once they accomplish neuronal differentiation in the adult hippocampus. |
2016-01-19 |
2023-08-13 |
Not clear |
| Chun-Chung Lui, Mei-Hsin Hsu, Ho-Chang Kuo, Chih-Cheng Chen, Jiunn-Ming Sheen, Hong-Ren Yu, Mao-Meng Tiao, You-Lin Tain, Kow-Aung Chang, Li-Tung Huan. Effects of melatonin on prenatal dexamethasone-induced epigenetic alterations in hippocampal morphology and reelin and glutamic acid decarboxylase 67 levels. Developmental neuroscience. vol 37. issue 2. 2016-01-12. PMID:25720733. |
thus, melatonin had a beneficial effect in restoring hippocampal reln mrna expression by reducing dnmt1 and mecp2 binding to the reln promoter. |
2016-01-12 |
2023-08-13 |
rat |
| Padmanabh Singh, Arpita Konar, Ashish Kumar, Sweta Srivas, Mahendra K Thaku. Hippocampal chromatin-modifying enzymes are pivotal for scopolamine-induced synaptic plasticity gene expression changes and memory impairment. Journal of neurochemistry. vol 134. issue 4. 2015-10-19. PMID:25982413. |
we propose the following putative pathway for scopolamine-mediated memory impairment; scopolamine up-regulates hippocampal dnmt1 and hdac2 expression, induces methylation and deacetylation of bdnf and arc promoter, represses gene expression and eventually impairs memory consolidation. |
2015-10-19 |
2023-08-13 |
Not clear |
| Jamie D Benoit, Pasko Rakic, Karyn M Fric. Prenatal stress induces spatial memory deficits and epigenetic changes in the hippocampus indicative of heterochromatin formation and reduced gene expression. Behavioural brain research. vol 281. 2015-08-31. PMID:25496779. |
male mice exposed to pns exhibited decreased hippocampal ach3, whereas female pns mice displayed a further reduction in ach3, as well as heightened hippocampal dnmt1 protein levels and corticosterone levels. |
2015-08-31 |
2023-08-13 |
mouse |
| Gelson M Rodrigues, Leandro V Toffoli, Marcelo H Manfredo, José Francis-Oliveira, Andrey S Silva, Hiviny A Raquel, Marli C Martins-Pinge, Estefânia G Moreira, Karen B Fernandes, Gislaine G Pelosi, Marcus V Gome. Acute stress affects the global DNA methylation profile in rat brain: modulation by physical exercise. Behavioural brain research. vol 279. 2015-08-20. PMID:25449846. |
thus, we used the rat model of acute restraint stress (ars) to evaluate the impact of stress on the global dna methylation and on the expression of the dnmt1 and bdnf genes of hippocampus, cortex, hypothalamus and periaqueductal gray (pag). |
2015-08-20 |
2023-08-13 |
rat |
| Padmanabh Singh, Mahendra K Thaku. Reduced recognition memory is correlated with decrease in DNA methyltransferase1 and increase in histone deacetylase2 protein expression in old male mice. Biogerontology. vol 15. issue 4. 2015-03-06. PMID:24924148. |
dnmt1 protein expression was high in the cerebral cortex and hippocampus of young male mice, but declined gradually with age. |
2015-03-06 |
2023-08-13 |
mouse |