| Reference |
Sentence |
Publish Date |
Extraction Date |
Species |
| Juan Zhuang, Zheng-Jun Pan, Ying Qin, Hui Liang, Wen-Feng Zhang, Ze-Yu Sun, Han-Bo Sh. Evaluation of BDE-47-induced neurodevelopmental toxicity in zebrafish embryos. Environmental science and pollution research international vol issue 2023 36869944 |
the results showed that bde-47 stimulated the production of dopamine and 5-hydroxytryptamine, but inhibited expression of nestin, gfap, gap43, and psd95 in 24 hpf embryos. |
2023-03-04 |
2023-03-06 |
zebrafish |
| Shukai Zheng, Qiong Zhang, Ruotong Wu, Xiaoling Shi, Jiajun Peng, Wei Tan, Wenlong Huang, Kusheng Wu, Caixia Li. Behavioral changes and transcriptomic effects at embryonic and post-embryonic stages reveal the toxic effects of 2,2',4,4'-tetrabromodiphenyl ether on neurodevelopment in zebrafish (Danio rerio). Ecotoxicology and environmental safety vol 248 issue 2022 36423367 |
consistent with the locomotion and kegg results, bde-47 affected the expression of genes for central nervous system (gfap, mbpa, bdnf & pomcb), early neurogenesis (neurog1 & elavl3), and axonal development (tuba1a, tuba1b, tuba1c, syn2a, gap43 & shha). |
2022-11-24 |
2023-01-30 |
zebrafish |
| Ha-Na Oh, Donggon Yoo, Seungmin Park, Sangwoo Lee, Woo-Keun Ki. Developmental neurotoxicity induced by glutaraldehyde in neuron/astrocyte co-cultured cells and zebrafish. Ecotoxicology and environmental safety vol 242 issue 2022 35868176 |
further studies showed that ga upregulated the mrna expression of the astrocyte markers gfap and s100\xce\xb2 and downregulated the expression of the neurodevelopmental genes nestin, \xce\xb2iii-tubulin, gap43, and map2. |
2022-07-22 |
2023-01-30 |
human |
| Sandra S Pereira, Eli\\xc3\\xa3 P Botelho, Juliana G M Soares, Mariana F Farias, Ricardo Gattas. Time course of dorsolateral geniculate nucleus plasticity in adult monkeys with laser-induced retinal lesions. The Journal of comparative neurology vol issue 2022 35650108 |
synaptogenesis (indicated by gap43 expression) appeared to be increased in all layers, while "cleansing" of the glial-damaged region (indicated by gfap expression) was markedly greater in the parvocellular layers, followed by the magnocellular layers. |
2022-06-01 |
2023-01-27 |
monkey |
| Sandra S Pereira, Eli\\xc3\\xa3 P Botelho, Juliana G M Soares, Mariana F Farias, Ricardo Gattas. Time course of dorsolateral geniculate nucleus plasticity in adult monkeys with laser-induced retinal lesions. The Journal of comparative neurology vol issue 2022 35650108 |
we studied changes in the expression of growth-associated protein 43 (gap43), glial fibrillary acidic protein (gfap), and calcium-binding proteins (calbindin [cb] and parvalbumin [pv]) in the dorsal lateral geniculate nucleus (dlgn) of four capuchin monkeys with laser-induced retinal lesions. |
2022-06-01 |
2023-01-27 |
monkey |
| Wei Wang, Mei-Feng Gu, Zhi-Fei Wang, Xiang-Min Shen, Jie Zhang, Liang Yan. Let-7a-5p regulated by lncRNA-MEG3 promotes functional differentiation to Schwann cells from adipose derived stem cells via directly inhibiting RBPJ-mediating Notch pathway. Apoptosis : an international journal on programmed cell death vol 26 issue 9-10 2021 34409556 |
elisa, immunostaining, western blotting, and qrt-pcr were employed to examine levels of sc-markers such as s100, gfap, sox10, p75ntr, gap43, mpz, \xce\xb2-ngf, bdnf, and ncam and let-7 family, meg3, rbpj, and notch signaling related proteins. |
2021-12-01 |
2023-01-26 |
Not clear |
| Wei Wang, Mei-Feng Gu, Zhi-Fei Wang, Xiang-Min Shen, Jie Zhang, Liang Yan. Let-7a-5p regulated by lncRNA-MEG3 promotes functional differentiation to Schwann cells from adipose derived stem cells via directly inhibiting RBPJ-mediating Notch pathway. Apoptosis : an international journal on programmed cell death vol 26 issue 9-10 2021 34409556 |
let-7a-5p mimics promoted adsc differentiation into scs and up-regulated the levels of sc-related markers including s100, gfap, sox10, p75ntr, gap43, mpz, \xce\xb2-ngf, and ncam, while rbpj or meg3 overexpression retarded the differentiation and reduced those levels. |
2021-12-01 |
2023-01-26 |
Not clear |
| Diego Iacono, Erin K Murphy, Soundarya S Avantsa, Daniel P Perl, Regina M Da. Reduction of pTau and APP levels in mammalian brain after low-dose radiation. Scientific reports vol 11 issue 1 2021 33500491 |
we analyzed possible molecular and neuropathology changes of phosphorylated-tau (ptau), all-tau forms, \xce\xb2-tubulin, amyloid precursor protein (app), glial fibrillary acidic protein (gfap), ionized calcium binding adaptor molecule 1 (iba-1), myelin basic protein (mbp), and gap43 in frontal cortex (fc), hippocampus (h) and cerebellum (crb) of swine brains following total-body low-dose radiation (1.79\xc2\xa0gy). |
2021-09-16 |
2023-01-26 |
Not clear |
| Sipin Zhu, Yibo Ying, Jiahui Ye, Min Chen, Qiuji Wu, Haicheng Dou, Wenfei Ni, Huazi Xu, Jiake X. AAV2-mediated and hypoxia response element-directed expression of bFGF in neural stem cells showed therapeutic effects on spinal cord injury in rats. Cell death & disease vol 12 issue 3 2021 33723238 |
mechanistic studies showed that aav2-5hre-bfgf-nscs treatment increased the expression of neuron-specific neuronal nuclei protein (neun), neuromodulin gap43, and neurofilament protein nf200 while decreased the expression of glial fibrillary acidic protein (gfap) as compared to the control group. |
2021-09-13 |
2023-01-26 |
rat |
| Sheng-Ya Guo, Yong Zhang, Xiao-Yu Zhu, Jia-Li Zhou, Jiao Li, Chun-Qi Li, Li-Ren W. Developmental neurotoxicity and toxic mechanisms induced by olaquindox in zebrafish. Journal of applied toxicology : JAT vol 41 issue 4 2021 33111391 |
quantitative polymerase chain reaction (q-pcr) showed that the expression levels of nine marker genes for nervous system functions or development, namely, \xce\xb11-tubulin, glial fibrillary acidic protein (gfap), myelin basic protein (mbp), synapsinii a (syn2a), sonic hedgehog a (shha), encoding huc (elavl3), mesencephalic astrocyte-derived neurotrophic factor (manf) growth associated protein 43 (gap43), and acetylcholinesterase (ache) were all down-regulated significantly in zebrafish after treated with ola. |
2021-07-16 |
2023-01-26 |
zebrafish |
| Xiao-Yu Zhu, Yu-Ying Wu, Bo Xia, Ming-Zhu Dai, Yan-Feng Huang, Hua Yang, Chun-Qi Li, Ping L. Fenobucarb-induced developmental neurotoxicity and mechanisms in zebrafish. Neurotoxicology vol 79 issue 2021 32247646 |
the expression of eight marker genes for nervous system function or development, namely, a1-tubulin, shha, elavl3, gap43, syn2a, gfap, mbp and manf, was significantly downregulated following bpmc exposure. |
2021-07-13 |
2023-01-26 |
zebrafish |
| Nagla A El-Sherbeeny, Afaf T Ibrahiem, Howaida S Ali, Noha E Farag, Eman A Toraih, Sawsan A Zaiton. Carbamazepine conquers spinal GAP43 deficiency and sciatic Nav1.5 upregulation in diabetic mice: novel mechanisms in alleviating allodynia and hyperalgesia. Archives of pharmacal research vol 43 issue 7 2021 32676893 |
the spinal cords were evaluated for synaptic plasticity (growth associated protein-43, gap43), microglia cell expression (by cd11b) and astrocyte expression (glial fibrillary acidic protein, gfap). |
2021-05-17 |
2023-01-26 |
mouse |
| Nagla A El-Sherbeeny, Afaf T Ibrahiem, Howaida S Ali, Noha E Farag, Eman A Toraih, Sawsan A Zaiton. Carbamazepine conquers spinal GAP43 deficiency and sciatic Nav1.5 upregulation in diabetic mice: novel mechanisms in alleviating allodynia and hyperalgesia. Archives of pharmacal research vol 43 issue 7 2021 32676893 |
spinal cord of carbamazepine-treated groups had enhanced expression of gap43 but lower content of cd11b and gfap. |
2021-05-17 |
2023-01-26 |
mouse |
| Arpita Konar, Rajkumar Singh Kalra, Anupama Chaudhary, Aashika Nayak, Kanive P Guruprasad, Kapaettu Satyamoorthy, Yoshiyuki Ishida, Keiji Terao, Sunil C Kaul, Renu Wadhw. Identification of Caffeic Acid Phenethyl Ester (CAPE) as a Potent Neurodifferentiating Natural Compound That Improves Cognitive and Physiological Functions in Animal Models of Neurodegenerative Diseases. Frontiers in aging neuroscience vol 12 issue 2020 33244299 |
analyses of control and cape-induced neurodifferentiated cells revealed: (i) modulation of several key proteins (nf200, map-2, neun, psd95, tuj1, gap43, and gfap) involved in neurodifferentiation process; and (ii) attenuation of neuronal stemness (hoxd13, wnt3, and msh-2) and proliferation-promoting (cdc-20, cdk-7, and bubr1) proteins. |
2020-11-28 |
2023-01-26 |
human |
| Rupali Sharma, Nathan P Cramer, Bayley Perry, Zahra Adahman, Erin K Murphy, Xiufen Xu, Bernard J Dardzinski, Zygmunt Galdzicki, Daniel P Perl, Dara L Dickstein, Diego Iacon. Chronic Exposure to High Altitude: Synaptic, Astroglial and Memory Changes. Scientific reports vol 9 issue 1 2020 31712561 |
specifically, we found decreased levels of synaptophysin (syp) (p\xe2\x80\x89<\xe2\x80\x890.05) and spinophilin (sph) (p\xe2\x80\x89<\xe2\x80\x890.05) in the olfactory cortex, post synaptic density-95 (psd-95) (p\xe2\x80\x89<\xe2\x80\x890.05), growth associated protein 43 (gap43) (p\xe2\x80\x89<\xe2\x80\x890.05), glial fibrillary acidic protein (gfap) (p\xe2\x80\x89<\xe2\x80\x890.05) in the cerebellum, and syp (p\xe2\x80\x89<\xe2\x80\x890.05) and psd-95 (p\xe2\x80\x89<\xe2\x80\x890.05) in the brainstem. |
2020-11-06 |
2023-01-26 |
mouse |
| Jiri Ruzicka, Lucia Machova Urdzikova, Barbora Svobodova, Anubhav G Amin, Kristyna Karova, Jana Dubisova, Kristyna Zaviskova, Sarka Kubinova, Meic Schmidt, Meena Jhanwar-Uniyal, Pavla Jendelov. Does combined therapy of curcumin and epigallocatechin gallate have a synergistic neuroprotective effect against spinal cord injury? Neural regeneration research vol 13 issue 1 2020 29451216 |
quantitative polymerase chain reaction was performed to determine the relative expression of genes (sort1, fgf2, irf5, mrc1, olig2, casp3, gap43, gfap, vegf, nf\xce\xbab, cntf) related to regenerative processes in injured spinal cord. |
2020-10-01 |
2023-01-26 |
rat |
| Petr Krupa, Barbora Svobodova, Jana Dubisova, Sarka Kubinova, Pavla Jendelova, Lucia Machova Urdzikov. Nano-formulated curcumin (Lipodisq\\xe2\\x84\\xa2) modulates the local inflammatory response, reduces glial scar and preserves the white matter after spinal cord injury in rats. Neuropharmacology vol 155 issue 2020 31108112 |
the expression of endogenous genes (sort1, fgf2, irf5, mrc1, olig2, casp3, gap43, gfap, vegf, nfk\xce\xb2) and interleukins (il-1\xce\xb2, tnf-\xce\xb1, il-6, il-12, ccl-5, il-11, il-10, il-13) was evaluated by qpcr and showed changes in the expression of the inflammatory cytokines in the first two weeks after sci. |
2020-02-28 |
2023-01-26 |
rat |
| Berrak Caglayan, Ertugrul Kilic, Arman Dalay, Serdar Altunay, Mehmet Tuzcu, Fusun Erten, Cemal Orhan, Mehmet Yalcin Gunal, Burak Yulug, Vijaya Juturu, Kazim Sahi. Allyl isothiocyanate attenuates oxidative stress and inflammation by modulating Nrf2/HO-1 and NF-\\xce\\xbaB pathways in traumatic brain injury in mice. Molecular biology reports vol 46 issue 1 2019 30406889 |
protein levels of proinflammatory cytokines interleukin-1\xce\xb2 (il1\xce\xb2) and interleukin-6 (il6), glial fibrillary acidic protein (gfap) and nf-\xce\xbab were decreased, while nrf2, growth-associated protein 43 (gap43) and neural cell adhesion molecule levels were increased with aitc when compared with vehicle control. |
2019-07-01 |
2023-01-26 |
mouse |
| Xiang Li, Haotian Kong, Xiuna Ji, Yan Gao, Meng Ji. Zebrafish behavioral phenomics applied for phenotyping aquatic neurotoxicity induced by lead contaminants of environmentally relevant level. Chemosphere vol 224 issue 2019 30831495 |
the alteration of entire behavioral profiles was further associated with the disturbed expression patterns of mrna level of key genes involved in neurodevelopment (gap43, syn2a, th, dat, and drd1b), neurotoxic effects (c-fos and gfap), and stress responses (tap, mt1, hsp70, and hsp90). |
2019-06-10 |
2023-01-26 |
human |
| E Couve, M Lovera, K Suzuki, O Schmachtenber. Schwann Cell Phenotype Changes in Aging Human Dental Pulp. Journal of dental research vol 97 issue 3 2019 28972819 |
schwann cell phenotypes are recognized by the expression of s100, glial fibrillary acidic protein (gfap), myelin basic protein (mbp), sox10, gap43, and p75ntr markers. |
2019-04-01 |
2023-01-26 |
human |