| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Landon S Deru, Elizabeth Z Gipson, Katelynn E Hales, Benjamin T Bikman, Lance E Davidson, Benjamin D Horne, James D LeCheminant, Larry A Tucker, Bruce W Baile. The Effects of a High-Carbohydrate versus a High-Fat Shake on Biomarkers of Metabolism and Glycemic Control When Used to Interrupt a 38-h Fast: A Randomized Crossover Study. Nutrients. vol 16. issue 1. 2024-01-11. PMID:38201992. |
this study aimed to determine the impact of various fast-interrupting shakes on markers of glycemic control including glucose, β-hydroxybutyrate (bhb), insulin, glucagon, glp-1, and gip. |
2024-01-11 |
2024-01-13 |
Not clear |
| Vijaya Subramanian, Jonatan I Bagger, Vinayak Harihar, Jens J Holst, Filip K Knop, Tina Vilsbøl. An Extended Minimal Model of OGTT: Estimation of Alpha- and Beta-Cell Dysfunction, Insulin Resistance, and the Incretin Effect. American journal of physiology. Endocrinology and metabolism. 2023-12-13. PMID:38088864. |
the extended model describes glucose and hormone dynamics in ogtt including the contribution of the incretins, glucagon-like peptide-1 (glp-1) and glucose-dependent insulinotropic polypeptide (gip), to insulin secretion. |
2023-12-13 |
2023-12-17 |
human |
| Karlijn A C Meeks, Amy R Bentley, Themistocles L Assimes, Nora Franceschini, Adebowale A Adeyemo, Charles N Rotimi, Ayo P Doumate. Mendelian randomization analyses suggest a causal role for circulating GIP and IL-1RA levels in homeostatic model assessment-derived measures of β-cell function and insulin sensitivity in Africans without type 2 diabetes. Genome medicine. vol 15. issue 1. 2023-12-04. PMID:38049854. |
mendelian randomization analyses suggest a causal role for circulating gip and il-1ra levels in homeostatic model assessment-derived measures of β-cell function and insulin sensitivity in africans without type 2 diabetes. |
2023-12-04 |
2023-12-10 |
Not clear |
| Rikke Viggers, Nicklas Højgaard-Hessellund Rasmussen, Peter Vestergaar. Effects of Incretin Therapy on Skeletal Health in Type 2 Diabetes-A Systematic Review. JBMR plus. vol 7. issue 11. 2023-12-01. PMID:38025038. |
the group of hormones known as incretins, which includes gastric inhibitory peptide (gip) and glucagon-like peptide 1 (glp-1), play a role in regulating bowel function and insulin secretion during feeding. |
2023-12-01 |
2023-12-07 |
human |
| Rikke Viggers, Nicklas Højgaard-Hessellund Rasmussen, Peter Vestergaar. Effects of Incretin Therapy on Skeletal Health in Type 2 Diabetes-A Systematic Review. JBMR plus. vol 7. issue 11. 2023-12-01. PMID:38025038. |
the group of hormones known as incretins, which includes gastric inhibitory peptide (gip) and glucagon-like peptide 1 (glp-1), play a role in regulating bowel function and insulin secretion during feeding. |
2023-11-29 |
2023-12-07 |
human |
| Julia Herrou, Guillaume Mabilleau, Jean-Michel Lecerf, Thierry Thomas, Emmanuel Biver, Julien Pacco. Narrative Review of Effects of Glucagon-Like Peptide-1 Receptor Agonists on Bone Health in People Living with Obesity. Calcified tissue international. 2023-11-24. PMID:37999750. |
further studies are needed to investigate the bone impact of glp-1ra, dual- and triple-receptor agonists for glp-1, glucose-dependent insulin releasing polypeptide (gip), and glucagon in pwo. |
2023-11-24 |
2023-11-29 |
Not clear |
| Sara Becerril, Javier A Cienfuegos, Amaia Rodríguez, Victoria Catalán, Beatriz Ramírez, Víctor Valentí, Rafael Moncada, Xabier Unamuno, Javier Gómez-Ambrosi, Gema Frühbec. Single anastomosis duodeno-ileal bypass with sleeve gastrectomy generates sustained improvement of glycemic control compared with sleeve gastrectomy in the diet-induced obese rat model. Journal of physiology and biochemistry. 2023-11-07. PMID:37935948. |
body weight and food intake were weekly monitored, and 6 weeks after interventions, fasting plasma glucose, oral glucose and insulin tolerance tests, plasma insulin, adiponectin, gip, glp-1, and ghrelin levels were determined.the body weight of sadi-s rats was significantly (p < 0.001) lower as compared to the sham-operated, sg, and pair-fed groups. |
2023-11-07 |
2023-11-20 |
rat |
| Bijayashree Sahu, Sunil Pani, Gourabamani Swalsingh, Unmod Senapati, Punyadhara Pani, Benudhara Pati, Subhasmita Rout, Rimjhim Trivedi, Ritu Raj, Suchanda Dey, Amar Jeet, Dinesh Kumar, Naresh C Ba. Long-term physical inactivity induces significant changes in biochemical pathways related to metabolism of proteins and glycerophospholipids in mice. Molecular omics. 2023-11-01. PMID:37909389. |
our data suggest that cytokines linked to glycemic excursions (insulin, c-peptide, glucagon) and their passive regulators (leptin, bdnf, active ghrelin, and gip) exhibit changes in the sed group. |
2023-11-01 |
2023-11-08 |
mouse |
| Mohammad Mukul Hossain, Juscelino Tovar, Lieselotte Cloetens, Anne Nilsso. Inclusion of Oat Polar Lipids in a Solid Breakfast Improves Glucose Tolerance, Triglyceridemia, and Gut Hormone Responses Postprandially and after a Standardized Second Meal: A Randomized Crossover Study in Healthy Subjects. Nutrients. vol 15. issue 20. 2023-10-30. PMID:37892464. |
test variables (blood glucose, serum insulin, triglyceride (tg), free fatty acids (ffa), ghrelin, glp-1, pyy, and gip) were measured at fasting and repeatedly during the 5.5 h after ingestion of the breakfast. |
2023-10-30 |
2023-11-08 |
human |
| Emily Pusch, Małgorzata Krążek, Tatiana Wojciechowicz, Maciej Sassek, Paweł A Kołodziejski, Mathias Z Strowski, Krzysztof W Nowak, Marek Skrzypsk. GIP_HUMAN [22-51] Peptide Encoded by the Glucose-Dependent Insulinotropic Polypeptide (GIP) Gene Suppresses Insulin Expression and Secretion in INS-1E Cells and Rat Pancreatic Islets. Genes. vol 14. issue 10. 2023-10-30. PMID:37895259. |
gip_human [22-51] peptide encoded by the glucose-dependent insulinotropic polypeptide (gip) gene suppresses insulin expression and secretion in ins-1e cells and rat pancreatic islets. |
2023-10-30 |
2023-11-08 |
mouse |
| Mona Mashayekhi, Hui Nian, Dustin Mayfield, Jessica K Devin, Jorge L Gamboa, Chang Yu, Heidi J Silver, Kevin Niswender, James M Luther, Nancy J Brow. Weight Loss-Independent Effect of Liraglutide on Insulin Sensitivity in Individuals with Obesity and Pre-Diabetes. Diabetes. 2023-10-24. PMID:37874653. |
sitagliptin increased endogenous glp-1 and gip without altering insulin sensitivity or fasting glucose, but decreased post-prandial glucose and glucagon. |
2023-10-24 |
2023-11-08 |
Not clear |
| Jing Xu, Peng Chen, Dongzhi Wu, Qiang Zhou, Sijie Chen, Xiang Ding, Hongping Xion. The novel GLP-1/GIP dual agonist DA3-CH improves rat type 2 diabetes through activating AMPK/ACC signaling pathway. Aging. vol 15. 2023-10-18. PMID:37851373. |
da3-ch is a novel dual receptor agonist of glucagon like peptide-1 (glp-1) and glucose dependent insulin stimulating polypeptide (gip). |
2023-10-18 |
2023-11-08 |
rat |
| Christine B Christiansen, Per B Jeppesen, Kjeld Hermansen, Søren Gregerse. Aronia in the Type 2 Diabetes Treatment Regimen. Nutrients. vol 15. issue 19. 2023-10-14. PMID:37836472. |
pre- and post-treatment period, we did fasting blood samples, including hemoglobin a1c, fructosamine, insulin, glucose, glucagon-like peptide-1, glucose-dependent insulinotropic peptide (gip) and glucagon, oral glucose tolerance tests, and anthropometric measurements. |
2023-10-14 |
2023-10-15 |
human |
| Heba A Mubarak, Manal M Kamal, Yossra Mahmoud, Fatma S Abd-Elsamea, Eman Abdelbary, Marwa G Gamea, Reham I El-Mahd. The ameliorating effects of mesenchymal stem cells compared to α-tocopherol on apoptosis and autophagy in streptozotocin-induced diabetic rats: Implication of PI3K/Akt signaling pathway and entero-insular axis. Journal of cellular biochemistry. 2023-10-05. PMID:37796145. |
histopathological examination of the pancreas, the expression levels of insulin, cd44, caspase-3, autophagy markers, p13k/akt, and pancreas/duodenum homeobox protein 1, in pancreatic tissue, and glucose-dependent insulinotropic polypeptide (gip) in the duodenum were detected by hematoxylin and eosin staining, immunofluorescence labeling, and by quantitative real-time polymerase chain reaction. the diabetic rats showed reduced insulin, hyperglycemia, nitrosative stress (no, cat), augmented apoptosis (caspase 3), impaired autophagy (p62/sqstm1, lc3), downregulated pi3k/akt pathway and increased gip expression, and degeneration of pancreatic islets. |
2023-10-05 |
2023-10-07 |
rat |
| Heba A Mubarak, Manal M Kamal, Yossra Mahmoud, Fatma S Abd-Elsamea, Eman Abdelbary, Marwa G Gamea, Reham I El-Mahd. The ameliorating effects of mesenchymal stem cells compared to α-tocopherol on apoptosis and autophagy in streptozotocin-induced diabetic rats: Implication of PI3K/Akt signaling pathway and entero-insular axis. Journal of cellular biochemistry. 2023-10-05. PMID:37796145. |
treatment with either bm-mscs or α-toc suppressed the nitrosative stress, reduced apoptosis, recovered autophagy, upregulated pi3k/akt pathway, and subsequently increased insulin levels, decreased blood glucose, and downregulated gip expression with partial restoration of pancreatic islets. based on our findings, the cytoprotective effects of bm-mscs and α-toc in type 1-induced diabetes appeared to be related to repaired autophagy and recovered pi3k/akt signaling. |
2023-10-05 |
2023-10-07 |
rat |
| Dina Medina-Vera, Emma N Zambrana-Infantes, Antonio J López-Gambero, Julia Verheul-Campos, Luis J Santín, Elena Baixeras, Juan Suarez, Francisco J Pavon, Cristina Rosell-Valle, Fernando Rodríguez de Fonsec. Transcending the amyloid-beta dominance paradigm in Alzheimer's disease: An exploration of behavioural, metabolic, and gut microbiota phenotypes in 5xFAD mice. Neurobiology of disease. 2023-09-17. PMID:37717663. |
dysregulation of both insulin and insulin secretion-regulating gip peptide were observed at 5 months of age, disappearing later. |
2023-09-17 |
2023-10-07 |
mouse |
| Nan Wu, Guohua A. A Quantitative Systems Pharmacology Model of the Incretin Hormones GIP and GLP1, Glucagon, Glucose, Insulin, and the Small Molecule DPP-4 Inhibitor, Linagliptin. Journal of pharmaceutical sciences. 2023-09-16. PMID:37716531. |
a quantitative systems pharmacology model of the incretin hormones gip and glp1, glucagon, glucose, insulin, and the small molecule dpp-4 inhibitor, linagliptin. |
2023-09-16 |
2023-10-07 |
human |
| Nan Wu, Guohua A. A Quantitative Systems Pharmacology Model of the Incretin Hormones GIP and GLP1, Glucagon, Glucose, Insulin, and the Small Molecule DPP-4 Inhibitor, Linagliptin. Journal of pharmaceutical sciences. 2023-09-16. PMID:37716531. |
in the current study, we established a comprehensive quantitative systems pharmacology (qsp) model using linagliptin as the model drug, where drug disposition, drug intervention on dipeptidyl peptidase-4 (dpp-4), glucose-dependent insulinotropic peptide (gip), glucagon-like peptide-1 (glp-1), glucagon, glucose, and insulin are integrated together with the cross talk and feedback loops incorporated among the whole glycemic control system. |
2023-09-16 |
2023-10-07 |
human |
| Pamela Bowman, Kashyap A Patel, Timothy J McDonald, Jens J Holst, Bolette Hartmann, Maria Leveridge, Beverley M Shields, Suzie Hammersley, Steve R Spaull, Bridget A Knight, Sarah E Flanagan, Maggie H Shepherd, Rob C Andrews, Andrew T Hattersle. Incretin hormone responses to carbohydrate and protein/fat are preserved in adults with sulfonylurea-treated KCNJ11 neonatal diabetes. Journal of diabetes investigation. 2023-08-21. PMID:37602910. |
the incretin hormones glucagon-like peptide-1 (glp-1) and glucose-dependent insulinotropic polypeptide (gip), are thought to be the main drivers of insulin secretion in individuals with sulfonylurea (su)-treated kcnj11 permanent neonatal diabetes. |
2023-08-21 |
2023-09-07 |
human |
| Philip N Newsome, Phil Amber. Incretins (GLP1 r agonists and dual, triple agonists) and the liver. Journal of hepatology. 2023-08-10. PMID:37562748. |
alongside glp-1ra, newer combinations with glucagon agonism and/or with glucose-dependent insulinotropic peptide (gip) agonism have been explored in related patient groups with evidence of improvements in weight loss, insulin resistance and non-invasive liver parameters. |
2023-08-10 |
2023-08-16 |
Not clear |