| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Alastair D Green, Srividya Vasu, Neville H McClenaghan, Peter R Flat. Pseudoislet formation enhances gene expression, insulin secretion and cytoprotective mechanisms of clonal human insulin-secreting 1.1B4 cells. Pflugers Archiv : European journal of physiology. vol 467. issue 10. 2016-06-27. PMID:25559846. |
measurement of gene expression by reverse-transcription, real-time pcr showed that genes involved with insulin secretion (ins, pdx1, pcsk1, pcsk2, glp1r and gipr), cell-cell communication (gjd2, gja1 and cdh1) and antioxidant defence (sod1, sod2, gpx1 and cat) were significantly upregulated in pseudoislets compared to monolayers, whilst the expression of proapoptotic genes (nos2, mapk8, mapk10 and nfkb1) showed no significant differences. |
2016-06-27 |
2023-08-13 |
human |
| Jean-Pierre Louboutin, David Straye. Role of Oxidative Stress in HIV-1-Associated Neurocognitive Disorder and Protection by Gene Delivery of Antioxidant Enzymes. Antioxidants (Basel, Switzerland). vol 3. issue 4. 2016-01-20. PMID:26785240. |
we used sv40 vectors for gene delivery of antioxidant enzymes, cu/zn superoxide dismutase (sod1), or glutathione peroxidase (gpx1) into the rat caudate putamen (cp). |
2016-01-20 |
2023-08-13 |
rat |
| Jean-Pierre Louboutin, David Straye. Role of Oxidative Stress in HIV-1-Associated Neurocognitive Disorder and Protection by Gene Delivery of Antioxidant Enzymes. Antioxidants (Basel, Switzerland). vol 3. issue 4. 2016-01-20. PMID:26785240. |
intracerebral injection of sv (sod1) or sv (gpx1) protects neurons from apoptosis caused by subsequent inoculation of gp120 and tat at the same location. |
2016-01-20 |
2023-08-13 |
rat |
| Sarah A Tersey, Bernhard Maier, Yurika Nishiki, Aarthi V Maganti, Jerry L Nadler, Raghavendra G Mirmir. 12-lipoxygenase promotes obesity-induced oxidative stress in pancreatic islets. Molecular and cellular biology. vol 34. issue 19. 2014-11-11. PMID:25071151. |
at the molecular level, 12-lo deletion resulted in increases in islet antioxidant enzymes sod1 and gpx1 in response to high-fat feeding. |
2014-11-11 |
2023-08-13 |
mouse |
| J-P Louboutin, L Agrawal, B A S Reyes, E J van Bockstaele, D S Straye. Gene delivery of antioxidant enzymes inhibits human immunodeficiency virus type 1 gp120-induced expression of caspases. Neuroscience. vol 214. 2013-04-29. PMID:22531373. |
prior gene delivery of the antioxidant enzymes cu/zn superoxide dismutase (sod1) or glutathione peroxidase (gpx1) into the cp before injecting gp120 there reduced levels of gp120-induced caspases, recapitulating the effect of antioxidant enzymes on gp120-induced apoptosis observed by tunel. |
2013-04-29 |
2023-08-12 |
human |
| Lokesh Agrawal, Jean-Pierre Louboutin, Beverly A S Reyes, Elisabeth J Van Bockstaele, David S Straye. HIV-1 Tat neurotoxicity: a model of acute and chronic exposure, and neuroprotection by gene delivery of antioxidant enzymes. Neurobiology of disease. vol 45. issue 2. 2012-05-18. PMID:22036626. |
finally, prior administration of recombinant sv40 vectors carrying antioxidant enzymes, copper/zinc superoxide dismutase (sod1) or glutathione peroxidase (gpx1), protected from tat-induced apoptosis and oxidative injury. |
2012-05-18 |
2023-08-12 |
rat |
| b' B Zegura, G Gajski, A Straser, V Garaj-Vrhovac, M Filipi\\xc4\\x8. Microcystin-LR induced DNA damage in human peripheral blood lymphocytes. Mutation research. vol 726. issue 2. 2012-02-13. PMID:22001196.' |
after 24h, dna damage-responsive genes (p53, mdm2, gadd45a, cdkn1a), a gene involved in apoptosis (bax) and oxidative stress-responsive genes (cat, gpx1, sod1, gsr, gclc) were up-regulated. |
2012-02-13 |
2023-08-12 |
human |
| B Žegura, G Gajski, A Štraser, V Garaj-Vrhova. Cylindrospermopsin induced DNA damage and alteration in the expression of genes involved in the response to DNA damage, apoptosis and oxidative stress. Toxicon : official journal of the International Society on Toxinology. vol 58. issue 6-7. 2012-01-24. PMID:21867723. |
cyn induced changes in the mrna expression of p53 and its downstream regulated dna damage responsive genes mdm2, gadd45α and apoptosis genes, bcl-2 and bax, as well as oxidative stress responsive genes (gpx1, sod1, gsr, gclc), while no changes in the expression of genes cdkn1a and cat were observed. |
2012-01-24 |
2023-08-12 |
human |
| Xin Gen Lei, Marko Z Vatamaniu. Two tales of antioxidant enzymes on β cells and diabetes. Antioxidants & redox signaling. vol 14. issue 3. 2011-04-14. PMID:20618069. |
although knockouts of gpx1 and sod1 each alone or together decreased pancreatic β cell mass and plasma insulin concentrations, these knockouts improved body insulin sensitivity to different extents. |
2011-04-14 |
2023-08-12 |
mouse |
| Jian-Hong Zhu, Xin Gen Le. Lipopolysaccharide-induced hepatic oxidative injury is not potentiated by knockout of GPX1 and SOD1 in mice. Biochemical and biophysical research communications. vol 404. issue 1. 2011-02-14. PMID:21145306. |
because bacterial endotoxin lipopolysaccharide (lps) triggers inflammatory responses involving the release of cytokines, nitric oxide and superoxide in targeted organs such as liver, in this study we used sod1 knockout (sod1-/-), gpx1 knockout (gpx1-/-), gpx1 and sod1 double-knockout (dko) and their wild-type (wt) mice to investigate the role of these two antioxidant enzymes in lps-induced oxidative injury in liver. |
2011-02-14 |
2023-08-12 |
mouse |
| b' AnnaMaria Cimini, Sandra Moreno, Marcello D\'Amelio, Loredana Cristiano, Barbara D\'Angelo, Stefano Falone, Elisabetta Benedetti, Paolo Carrara, Francesca Fanelli, Francesco Cecconi, Fernanda Amicarelli, Maria Paola Cer\\xc3\\xb. Early biochemical and morphological modifications in the brain of a transgenic mouse model of Alzheimer\'s disease: a role for peroxisomes. Journal of Alzheimer\'s disease : JAD. vol 18. issue 4. 2010-09-16. PMID:19749434.' |
the expression and localization of peroxisomal (pmp70, cat, aox, and thl) and peroxisome-related proteins (pex5p, gpx1, sod1, and sod2) were studied in the neocortex and hippocampus of transgenic and wild-type animals. |
2010-09-16 |
2023-08-12 |
mouse |
| Jean-Pierre Louboutin, Beverly A S Reyes, Lokesh Agrawal, Elisabeth J Van Bockstaele, David S Straye. HIV-1 gp120-induced neuroinflammation: relationship to neuron loss and protection by rSV40-delivered antioxidant enzymes. Experimental neurology. vol 221. issue 1. 2010-02-16. PMID:19913017. |
sv(sod1) or sv(gpx1) significantly reduced mip-1alpha and limited neuroinflammation following gp120 administration into the cp, as well as microglia and astrocytes proliferation after injection of sv(gp120) in the striatum. |
2010-02-16 |
2023-08-12 |
rat |
| Preetha Rajaraman, Amy Hutchinson, Nathaniel Rothman, Peter M Black, Howard A Fine, Jay S Loeffler, Robert G Selker, William R Shapiro, Martha S Linet, Peter D Inski. Oxidative response gene polymorphisms and risk of adult brain tumors. Neuro-oncology. vol 10. issue 5. 2008-11-18. PMID:18682580. |
using data from non-hispanic whites in a hospital-based case-control study conducted by the national cancer institute between 1994 and 1998, we evaluated risk of glioma (n=362), meningioma (n=134), and acoustic neuroma (n=69) compared to noncancer controls (n=494) with respect to nine single nucleotide polymorphisms from seven genes involved in oxidative stress response (cat, gpx1, nos3, pon1, sod1, sod2, and sod3). |
2008-11-18 |
2023-08-12 |
cat |
| Nawel Hayder, Ines Bouhlel, Ines Skandrani, Malika Kadri, Régine Steiman, Pascale Guiraud, Anne-Marie Mariotte, Kamel Ghedira, Marie-Geneviève Dijoux-Franca, Leila Chekir-Ghedir. In vitro antioxidant and antigenotoxic potentials of myricetin-3-o-galactoside and myricetin-3-o-rhamnoside from Myrtus communis: modulation of expression of genes involved in cell defence system using cDNA microarray. Toxicology in vitro : an international journal published in association with BIBRA. vol 22. issue 3. 2008-07-10. PMID:18222061. |
myricetin-3-o-galactoside and myricetin-3-o-rhamnoside modulated the expression patterns of cellular genes involved in oxidative stress, respectively (gpx1, txn, aoe372, sepw1, shc1) and (txnrd1, txn, sod1 aoe372, sepw1), in dna damaging repair, respectively (xpc, lig4, rpa3, pcna, ddit3, pold1, xrcc5, mpg) and (tdg, pcna, lig4, xrcc5, ddit3, msh2, ercc5, rpa3, pold1), and in apoptosis (parp). |
2008-07-10 |
2023-08-12 |
Not clear |
| J-P Louboutin, L Agrawal, B A S Reyes, E J Van Bockstaele, D S Straye. Protecting neurons from HIV-1 gp120-induced oxidant stress using both localized intracerebral and generalized intraventricular administration of antioxidant enzymes delivered by SV40-derived vectors. Gene therapy. vol 14. issue 23. 2008-03-19. PMID:17914406. |
intracerebral injection of sv(sod1) or sv(gpx1) significantly protected neurons from gp120-induced apoptosis throughout the 24-week study. |
2008-03-19 |
2023-08-12 |
human |
| Lokesh Agrawal, Jean-Pierre Louboutin, David S Straye. Preventing HIV-1 Tat-induced neuronal apoptosis using antioxidant enzymes: mechanistic and therapeutic implications. Virology. vol 363. issue 2. 2007-07-06. PMID:17336361. |
we used antioxidant enzymes, cu/zn superoxide dismutase (sod1) and glutathione peroxidase (gpx1) to study signaling and neuroprotection from tat-induced apoptosis. |
2007-07-06 |
2023-08-12 |
human |
| Lokesh Agrawal, Jean-Pierre Louboutin, David S Straye. Preventing HIV-1 Tat-induced neuronal apoptosis using antioxidant enzymes: mechanistic and therapeutic implications. Virology. vol 363. issue 2. 2007-07-06. PMID:17336361. |
similarly, neither sv(sod1) nor sv(gpx1) protected neurons from tat-induced apoptosis, but both vectors together did. |
2007-07-06 |
2023-08-12 |
human |
| L Agrawal, J-P Louboutin, B A S Reyes, E J Van Bockstaele, D S Straye. Antioxidant enzyme gene delivery to protect from HIV-1 gp120-induced neuronal apoptosis. Gene therapy. vol 13. issue 23. 2007-05-21. PMID:16871233. |
gp120 induced apoptosis in a high percentage of unprotected nt2-n. transduction with sv(sod1) and sv(gpx1) before gp120 challenge reduced neuronal apoptosis by >90%. |
2007-05-21 |
2023-08-12 |
human |
| L Agrawal, J-P Louboutin, B A S Reyes, E J Van Bockstaele, D S Straye. Antioxidant enzyme gene delivery to protect from HIV-1 gp120-induced neuronal apoptosis. Gene therapy. vol 13. issue 23. 2007-05-21. PMID:16871233. |
we tested whether rsv40 s can deliver antioxidant enzymes to the cns in vivo: intracerebral injection of sv(sod1) or sv(gpx1) into the caudate putamen of rat brain yielded excellent transgene expression in neurons. |
2007-05-21 |
2023-08-12 |
human |
| Jian-Hong Zhu, Xiaomei Zhang, James P McClung, Xin Gen Le. Impact of Cu, Zn-superoxide dismutase and Se-dependent glutathione peroxidase-1 knockouts on acetaminophen-induced cell death and related signaling in murine liver. Experimental biology and medicine (Maywood, N.J.). vol 231. issue 11. 2007-01-23. PMID:17138759. |
the objective of this study was to compare the impacts of knockout of cu, zn-superoxide dismutase (sod1) and se-dependent glutathione peroxidase-1 (gpx1) on cell death and related signaling mediated by acetaminophen (apap), a rns inducer in liver. |
2007-01-23 |
2023-08-12 |
mouse |