| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yoko Machida, Takashi Okada, Masaru Kurosawa, Fumitaka Oyama, Keiya Ozawa, Nobuyuki Nukin. rAAV-mediated shRNA ameliorated neuropathology in Huntington disease model mouse. Biochemical and biophysical research communications. vol 343. issue 1. 2006-05-24. PMID:16530728. |
huntington disease (hd) is a fatal progressive neurodegenerative disorder associated with expansion of a cag repeat in the first exon of the gene coding the protein huntingtin (htt). |
2006-05-24 |
2023-08-12 |
mouse |
| Jeremy M Van Raamsdonk, Zoe Murphy, Elizabeth J Slow, Blair R Leavitt, Michael R Hayde. Selective degeneration and nuclear localization of mutant huntingtin in the YAC128 mouse model of Huntington disease. Human molecular genetics. vol 14. issue 24. 2006-03-10. PMID:16278236. |
huntington disease (hd) is an adult onset neurodegenerative disorder that predominantly affects the striatum and cortex despite ubiquitous expression of mutant huntingtin (htt). |
2006-03-10 |
2023-08-12 |
mouse |
| Ji-Yeon Shin, Zhi-Hui Fang, Zhao-Xue Yu, Chuan-En Wang, Shi-Hua Li, Xiao-Jiang L. Expression of mutant huntingtin in glial cells contributes to neuronal excitotoxicity. The Journal of cell biology. vol 171. issue 6. 2006-03-09. PMID:16365166. |
as a result, mutant huntingtin (htt) reduces glutamate uptake in cultured astrocytes and hd mouse brains. |
2006-03-09 |
2023-08-12 |
mouse |
| Pieter H Anborgh, Christina Godin, Macarena Pampillo, Gurpreet K Dhami, Lianne B Dale, Sean P Cregan, Ray Truant, Stephen S G Ferguso. Inhibition of metabotropic glutamate receptor signaling by the huntingtin-binding protein optineurin. The Journal of biological chemistry. vol 280. issue 41. 2005-12-13. PMID:16091361. |
huntington disease is caused by a polyglutamine expansion in the huntingtin protein (htt) and is associated with excitotoxic death of striatal neurons. |
2005-12-13 |
2023-08-12 |
mouse |
| Simon C Warby, Edmond Y Chan, Martina Metzler, Lu Gan, Roshni R Singaraja, Susan F Crocker, Harold A Robertson, Michael R Hayde. Huntingtin phosphorylation on serine 421 is significantly reduced in the striatum and by polyglutamine expansion in vivo. Human molecular genetics. vol 14. issue 11. 2005-11-28. PMID:15843398. |
huntington disease (hd) results from polyglutamine expansion in the huntingtin protein (htt). |
2005-11-28 |
2023-08-12 |
mouse |
| Larissa Arning, Peter H Kraus, Carsten Saft, Jürgen Andrich, Jörg T Epple. Age at onset of Huntington disease is not modulated by the R72P variation in TP53 and the R196K variation in the gene coding for the human caspase activated DNase (hCAD). BMC medical genetics. vol 6. 2005-10-25. PMID:16202123. |
tp53 is an attractive candidate for modifying age of onset (ao) in huntington disease (hd): the amino-terminus of the mutated huntingtin (htt) exon 1 translation product has functional properties which may affect critically the tp53 pathway in hd neurons. |
2005-10-25 |
2023-08-12 |
human |
| Jeremy M Van Raamsdonk, Jacqueline Pearson, Daniel A Rogers, Nagat Bissada, A Wayne Vogl, Michael R Hayden, Blair R Leavit. Loss of wild-type huntingtin influences motor dysfunction and survival in the YAC128 mouse model of Huntington disease. Human molecular genetics. vol 14. issue 10. 2005-09-26. PMID:15829505. |
huntington disease (hd) is an adult-onset neurodegenerative disease caused by a toxic gain of function in the huntingtin (htt) protein. |
2005-09-26 |
2023-08-12 |
mouse |
| Bin Huang, Stefan Kochane. Adenovirus-mediated silencing of huntingtin expression by shRNA. Human gene therapy. vol 16. issue 5. 2005-08-08. PMID:15916486. |
huntington's disease (hd) is an inherited autosomal dominant, neurodegenerative disease that is caused by a gain of function mutation characterized by the expansion of a cag trinucleotide repeat in exon 1 of the huntingtin (htt) gene. |
2005-08-08 |
2023-08-12 |
Not clear |
| Ming-Chang Chiang, Yi-Chao Lee, Chuen-Lin Huang, Yijuang Cher. cAMP-response element-binding protein contributes to suppression of the A2A adenosine receptor promoter by mutant Huntingtin with expanded polyglutamine residues. The Journal of biological chemistry. vol 280. issue 14. 2005-06-21. PMID:15689617. |
huntington's disease is a neurodegenerative disease resulting from a cag (glutamine) trinucleotide expansion in exon 1 of the huntingtin (htt) gene. |
2005-06-21 |
2023-08-12 |
Not clear |
| Flaviano Giorgini, Paolo Guidetti, QuangVu Nguyen, Simone C Bennett, Paul J Muchowsk. A genomic screen in yeast implicates kynurenine 3-monooxygenase as a therapeutic target for Huntington disease. Nature genetics. vol 37. issue 5. 2005-06-03. PMID:15806102. |
huntington disease is a fatal neurodegenerative disorder caused by expansion of a polyglutamine tract in the protein huntingtin (htt), which leads to its aggregation in nuclear and cytoplasmic inclusion bodies. |
2005-06-03 |
2023-08-12 |
Not clear |
| Szu-Yi Chou, Yi-Chao Lee, Hui-Mei Chen, Ming-Chang Chiang, Hsing-Lin Lai, Hao-Hung Chang, Yi-Chih Wu, Chung-Nan Sun, Chen-Li Chien, Yow-Sien Lin, Shyi-Chyi Wang, Yu-Ying Tung, Chen Chang, Yijuang Cher. CGS21680 attenuates symptoms of Huntington's disease in a transgenic mouse model. Journal of neurochemistry. vol 93. issue 2. 2005-05-20. PMID:15816854. |
huntington's disease (hd) is an autosomal dominant neurodegenerative disease caused by a cag trinucleotide expansion in exon 1 of the huntingtin (htt) gene. |
2005-05-20 |
2023-08-12 |
mouse |
| Mariarosa A B Melone, Francesco P Jori, Gianfranco Pelus. Huntington's disease: new frontiers for molecular and cell therapy. Current drug targets. vol 6. issue 1. 2005-05-19. PMID:15720212. |
huntington's disease (hd) is an incurable, adult-onset, dominantly inherited neurodegenerative disease, caused by a cag expansion in the 5' coding region of the gene hd [encoding huntingtin (htt), which is ubiquitously expressed in all tissues]. |
2005-05-19 |
2023-08-12 |
human |
| Zongyu J Chen, Betsy T Kren, Phillip Y-P Wong, Walter C Low, Clifford J Stee. Sleeping Beauty-mediated down-regulation of huntingtin expression by RNA interference. Biochemical and biophysical research communications. vol 329. issue 2. 2005-05-05. PMID:15737634. |
huntington disease (hd) is a devastating neurologic disorder that is characterized by abnormal expansion of a cag nt repeat in the first exon of the huntingtin (htt) gene, producing a mutant protein with an elongated polyglutamine stretch. |
2005-05-05 |
2023-08-12 |
mouse |
| Kazuhiko Tagawa, Masataka Hoshino, Tomohiro Okuda, Hiroko Ueda, Hiroshi Hayashi, Sabine Engemann, Haruo Okado, Masumi Ichikawa, Erich E Wanker, Hitoshi Okazaw. Distinct aggregation and cell death patterns among different types of primary neurons induced by mutant huntingtin protein. Journal of neurochemistry. vol 89. issue 4. 2004-06-04. PMID:15140196. |
we investigated this question by expressing mutant huntingtin (htt) with a defective adenovirus in different types of neurons prepared from rat cerebral cortex, striatum or cerebellum. |
2004-06-04 |
2023-08-12 |
rat |
| Haibing Jiang, Frederick C Nucifora, Christopher A Ross, Donald B DeFranc. Cell death triggered by polyglutamine-expanded huntingtin in a neuronal cell line is associated with degradation of CREB-binding protein. Human molecular genetics. vol 12. issue 1. 2003-07-03. PMID:12490527. |
huntington's disease belongs to the cag repeat family of neurodegenerative diseases and is characterized by the presence of an expanded polyglutamine (polyq) repeat in the huntingtin (htt) gene product. |
2003-07-03 |
2023-08-12 |
Not clear |
| Sébastien Holbert, Alpaslan Dedeoglu, Sandrine Humbert, Frédéric Saudou, Robert J Ferrante, Christian Nér. Cdc42-interacting protein 4 binds to huntingtin: neuropathologic and biological evidence for a role in Huntington's disease. Proceedings of the National Academy of Sciences of the United States of America. vol 100. issue 5. 2003-05-13. PMID:12604778. |
huntington's disease (hd) is a neurodegenerative disease caused by polyglutamine (polyq) expansion in the protein huntingtin (htt). |
2003-05-13 |
2023-08-12 |
human |
| Roshni R Singaraja, Shinji Hadano, Martina Metzler, Scott Givan, Cheryl L Wellington, Simon Warby, Anat Yanai, Claire-Anne Gutekunst, Blair R Leavitt, Hong Yi, Keith Fichter, Lu Gan, Krista McCutcheon, Vikramjit Chopra, Jennifer Michel, Steven M Hersch, Joh-E Ikeda, Michael R Hayde. HIP14, a novel ankyrin domain-containing protein, links huntingtin to intracellular trafficking and endocytosis. Human molecular genetics. vol 11. issue 23. 2003-04-16. PMID:12393793. |
huntington disease (hd) is caused by polyglutamine [poly(q)] expansion in the protein huntingtin (htt). |
2003-04-16 |
2023-08-12 |
human |
| François G Gervais, Roshni Singaraja, Steven Xanthoudakis, Claire-Anne Gutekunst, Blair R Leavitt, Martina Metzler, Abigail S Hackam, John Tam, John P Vaillancourt, Vicky Houtzager, Dita M Rasper, Sophie Roy, Michael R Hayden, Donald W Nicholso. Recruitment and activation of caspase-8 by the Huntingtin-interacting protein Hip-1 and a novel partner Hippi. Nature cell biology. vol 4. issue 2. 2002-08-08. PMID:11788820. |
in huntington disease, polyglutamine expansion of the protein huntingtin (htt) leads to selective neurodegenerative loss of medium spiny neurons throughout the striatum by an unknown apoptotic mechanism. |
2002-08-08 |
2023-08-12 |
Not clear |
| Aleksey Kazantsev, Heli A Walker, Natalia Slepko, James E Bear, Elizabeth Preisinger, Joan S Steffan, Ya-Zhen Zhu, Frank B Gertler, David E Housman, J Lawrence Marsh, Leslie M Thompso. A bivalent Huntingtin binding peptide suppresses polyglutamine aggregation and pathogenesis in Drosophila. Nature genetics. vol 30. issue 4. 2002-05-02. PMID:11925563. |
huntington disease is caused by the expansion of a polyglutamine repeat in the huntingtin protein (htt) that leads to degeneration of neurons in the central nervous system and the appearance of visible aggregates within neurons. |
2002-05-02 |
2023-08-12 |
drosophila_melanogaster |
| J A Parker, J B Connolly, C Wellington, M Hayden, J Dausset, C Ner. Expanded polyglutamines in Caenorhabditis elegans cause axonal abnormalities and severe dysfunction of PLM mechanosensory neurons without cell death. Proceedings of the National Academy of Sciences of the United States of America. vol 98. issue 23. 2001-12-07. PMID:11687635. |
huntington's disease (hd) is a dominant neurodegenerative disease caused by polyglutamine (polyq) expansion in the protein huntingtin (htt). |
2001-12-07 |
2023-08-12 |
human |