| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kathryn E Reynolds, Eileen Huang, Monica Sabbineni, Eliza Wiseman, Nadeem Murtaza, Desmond Ahuja, Matt Napier, Kathryn M Murphy, Karun K Singh, Angela L Scot. Purinergic Signalling Mediates Aberrant Excitability of Developing Neuronal Circuits in the Fmr1 Knockout Mouse Model. Molecular neurobiology. 2024-04-23. PMID:38652351. |
in this study, we examined whether elevated astrocyte purinergic signalling also impacts neuronal morphology and connectivity of fmr1 ko cortical neurons. |
2024-04-23 |
2024-04-26 |
mouse |
| Antonio Cibelli, Maria Grazia Mola, Emanuela Saracino, Barbara Barile, Pasqua Abbrescia, Guido Mogni, David C Spray, Eliana Scemes, Andrea Rossi, Diletta Spennato, Maria Svelto, Antonio Frigeri, Valentina Benfenati, Grazia Paola Nicchi. Aquaporin-4 and transient receptor potential vanilloid 4 balance in early postnatal neurodevelopment. Glia. 2024-02-16. PMID:38362923. |
the present study aimed at investigating the contribution of aqp4 and trpv4 to cns early postnatal development using wt and aqp4 ko brain and retina and neuronal stem cells (nscs), as an in vitro model of astrocyte differentiation. |
2024-02-16 |
2024-02-18 |
Not clear |
| Alice Capuz, Sylvain Osien, Tristan Cardon, Mélodie Anne Karnoub, Soulaimane Aboulouard, Antonella Raffo-Romero, Marie Duhamel, Dasa Cizkova, Marco Trerotola, David Devos, Firas Kobeissy, Fabien Van den Abelle, Amélie Bonnefond, Isabelle Fournier, Franck Rodet, Michel Salze. Heimdall, an alternative protein issued from a ncRNA related to kappa light chain variable region of immunoglobulins from astrocytes: a new player in neural proteome. Cell death & disease. vol 14. issue 8. 2023-08-16. PMID:37587118. |
interestingly, depolarization assays and intracellular calcium measurements in heimdall ko, established a depolarization effect on astrocyte membranes ko cells were more likely that the one found in neuroprogenitors. |
2023-08-16 |
2023-09-07 |
rat |
| Eleonora Centonze, Antonella Marte, Martina Albini, Anna Rocchi, Fabrizia Cesca, Martina Chiacchiaretta, Thomas Floss, Pietro Baldelli, Stefano Ferroni, Fabio Benfenati, Pierluigi Valent. Neuron-restrictive silencer factor/repressor element 1-silencing transcription factor (NRSF/REST) controls spatial K Journal of neurochemistry. 2023-01-13. PMID:36636908. |
we found that nrsf/rest ko astrocyte displayed a markedly reduced activity of inward rectifying k |
2023-01-13 |
2023-08-14 |
mouse |
| Ana Belen Lopez-Rodriguez, Céline Decouty-Perez, Victor Farré-Alins, Alejandra Palomino-Antolín, Paloma Narros-Fernández, Javier Ege. Activation of NLRP3 Is Required for a Functional and Beneficial Microglia Response after Brain Trauma. Pharmaceutics. vol 14. issue 8. 2022-07-27. PMID:35893807. |
however, some microglia and astrocyte markers were overexpressed in ko mice, resulting in an exacerbated cytokine expression. |
2022-07-27 |
2023-08-14 |
mouse |
| Jiyun Peng, Min-Hee Yi, Heejin Jeong, Przemyslaw Peter McEwan, Jiaying Zheng, Gongxiong Wu, Shashank Ganatra, Yi Ren, Jason R Richardson, Seog Bae Oh, Long-Jun W. The voltage-gated proton channel Hv1 promotes microglia-astrocyte communication and neuropathic pain after peripheral nerve injury. Molecular brain. vol 14. issue 1. 2021-08-12. PMID:34183051. |
in addition, microglial production of reactive oxygen species (ros) and subsequent astrocyte activation in the spinal cord was reduced in hv1 ko mice after snt. |
2021-08-12 |
2023-08-13 |
mouse |
| Alexandru Tatomir, Austin Beltrand, Vinh Nguyen, Dallas Boodhoo, Armugam Mekala, Cornelia Cudrici, Tudor C Badea, Dafin F Muresanu, Violeta Rus, Horea Ru. RGC-32 Regulates Generation of Reactive Astrocytes in Experimental Autoimmune Encephalomyelitis. Frontiers in immunology. vol 11. 2021-06-23. PMID:33569054. |
in control mice, gfap expression and astrocyte density were also significantly higher in the wt group, whereas the number of vimentin and fabp7-positive radial glia was significantly higher in the rgc-32 ko group. |
2021-06-23 |
2023-08-13 |
mouse |
| Alexandru Tatomir, Austin Beltrand, Vinh Nguyen, Dallas Boodhoo, Armugam Mekala, Cornelia Cudrici, Tudor C Badea, Dafin F Muresanu, Violeta Rus, Horea Ru. RGC-32 Regulates Generation of Reactive Astrocytes in Experimental Autoimmune Encephalomyelitis. Frontiers in immunology. vol 11. 2021-06-23. PMID:33569054. |
in this study, we analyzed the expression and distribution of astrocytes and astrocyte progenitors by immunohistochemistry in spinal cords of wild-type (wt) and rgc-32-knockout (ko) mice with eae and of normal adult mice. |
2021-06-23 |
2023-08-13 |
mouse |
| Miao-Miao Chen, Zhao-Li Hu, Jian-Hua Ding, Ren-Hong Du, Gang H. Astrocytic Kir6.1 deletion aggravates neurodegeneration in the lipopolysaccharide-induced mouse model of Parkinson's disease via astrocyte-neuron cross talk through complement C3-C3R signaling. Brain, behavior, and immunity. vol 95. 2021-06-23. PMID:33838249. |
here, we found that astrocytic kir6.1 ko mice showed more dopaminergic neuron loss and more astrocyte reactivity in substantia nigra compacta than controls. |
2021-06-23 |
2023-08-13 |
mouse |
| Kathryn E Reynolds, Chloe R Wong, Angela L Scot. Astrocyte-mediated purinergic signaling is upregulated in a mouse model of Fragile X syndrome. Glia. vol 69. issue 7. 2021-05-11. PMID:33754385. |
in primary astrocyte cultures derived from the fmr1 knockout (ko) mouse model of fxs, we found that application of exogenous atp and utp evoked elevated intracellular calcium responses compared to wildtype levels. |
2021-05-11 |
2023-08-13 |
mouse |
| Nanshan Song, Hong Zhu, Rong Xu, Jiaqi Liu, Yinquan Fang, Jing Zhang, Jianhua Ding, Gang Hu, Ming L. Induced Expression of kir6.2 in A1 Astrocytes Propagates Inflammatory Neurodegeneration via Drp1-dependent Mitochondrial Fission. Frontiers in pharmacology. vol 11. 2021-02-16. PMID:33584303. |
using kir6.2 knockout (ko) mice, we find reversal effects of kir6.2 deficiency on a1-like astrocyte activation and death of dopaminergic neurons in lipopolysaccharide (lps)-induced mouse models for pd. |
2021-02-16 |
2023-08-13 |
mouse |
| Roberta Fusco, Enrico Gugliandolo, Rosalba Siracusa, Maria Scuto, Marika Cordaro, Ramona D'Amico, Maurizio Evangelista, Angelo Peli, Alessio Filippo Peritore, Daniela Impellizzeri, Rosalia Crupi, Salvatore Cuzzocrea, Rosanna Di Paol. Formyl Peptide Receptor 1 Signaling in Acute Inflammation and Neural Differentiation Induced by Traumatic Brain Injury. Biology. vol 9. issue 9. 2020-10-28. PMID:32825368. |
moreover, tbi fpr1 ko animals displayed reduced neural differentiation (evaluated by beta-iii tubulin expression) and upregulation of astrocyte differentiation (evaluated by gfap expression). |
2020-10-28 |
2023-08-13 |
mouse |
| Xiao Yang, Keyi Geng, Jinfan Zhang, Yanshuang Zhang, Jiaxiang Shao, Weiliang Xi. Sirt3 Mediates the Inhibitory Effect of Adjudin on Astrocyte Activation and Glial Scar Formation following Ischemic Stroke. Frontiers in pharmacology. vol 8. 2020-09-30. PMID:29311941. |
to investigate the potential inhibitory effect and mechanism of adjudin on astrocyte activation, we used a transient middle cerebral artery occlusion (tmcao) model with or without adjudin treatment in wild type (wt) and sirt3 knockout (ko) mice and performed a wound healing experiment in vitro. |
2020-09-30 |
2023-08-13 |
mouse |
| Frankie H F Lee, Terence K Y Lai, Ping Su, Fang Li. Altered cortical Cytoarchitecture in the Fmr1 knockout mouse. Molecular brain. vol 12. issue 1. 2020-05-26. PMID:31200759. |
using primary astrocytes derived from ko mice, we further demonstrated the presence of astrogliosis characterized by an increase in gfap expression and astrocyte hypertrophy. |
2020-05-26 |
2023-08-13 |
mouse |
| Leanne M Holt, Raymundo D Hernandez, Natasha L Pacheco, Beatriz Torres Ceja, Muhannah Hossain, Michelle L Olse. Astrocyte morphogenesis is dependent on BDNF signaling via astrocytic TrkB.T1. eLife. vol 8. 2020-02-11. PMID:31433295. |
indicating a role for functional astrocyte maturation via bdnf/trkb.t1 signaling, trkb.t1 ko astrocytes do not support normal excitatory synaptogenesis or function. |
2020-02-11 |
2023-08-13 |
mouse |
| Moises Freitas-Andrade, John F Bechberger, Brian A MacVicar, Victor Viau, Christian C Nau. Pannexin1 knockout and blockade reduces ischemic stroke injury in female, but not in male mice. Oncotarget. vol 8. issue 23. 2018-03-19. PMID:28445139. |
this sex-specific effect of panx1 ko was recapitulated by significant reductions in peri-infarct inflammation and astrocyte reactivity, as well as smaller infarct volumes in probenecid treated females, but not males. |
2018-03-19 |
2023-08-13 |
mouse |
| Moises Freitas-Andrade, John F Bechberger, Brian A MacVicar, Victor Viau, Christian C Nau. Pannexin1 knockout and blockade reduces ischemic stroke injury in female, but not in male mice. Oncotarget. vol 8. issue 23. 2018-03-19. PMID:28445139. |
middle-aged, 8-9 month old male and female wild type and panx1 ko mice were subjected to permanent middle cerebral artery (mca) occlusion, and infarct size and astrocyte and microglia activation were assessed 4 days later. |
2018-03-19 |
2023-08-13 |
mouse |
| Emily M Jobe, Yu Gao, Brian E Eisinger, Janessa K Mladucky, Charles C Giuliani, Laurel E Kelnhofer, Xinyu Zha. Methyl-CpG-Binding Protein MBD1 Regulates Neuronal Lineage Commitment through Maintaining Adult Neural Stem Cell Identity. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 37. issue 3. 2017-08-01. PMID:28100736. |
transcriptome analysis of neural stem and progenitor cells isolated directly from the dentate gyrus of mbd1 mutant (ko) and wt mice showed that gene sets related to cell differentiation, particularly astrocyte lineage genes, were upregulated in ko cells. |
2017-08-01 |
2023-08-13 |
mouse |
| Xin Qi, Brandon Davis, Yung-Hsiao Chiang, Emily Filichia, Austin Barnett, Nigel H Greig, Barry Hoffer, Yu Lu. Dopaminergic neuron-specific deletion of p53 gene is neuroprotective in an experimental Parkinson's disease model. Journal of neurochemistry. vol 138. issue 5. 2017-06-14. PMID:27317935. |
astrocyte activation measured by gfap positive cells and gfap gene up-regulation in the striatum shows no difference between wt and da-p53 ko mice. |
2017-06-14 |
2023-08-13 |
mouse |
| Maria Grazia Mola, Angelo Sparaneo, Concetta Domenica Gargano, David C Spray, Maria Svelto, Antonio Frigeri, Eliana Scemes, Grazia Paola Nicchi. The speed of swelling kinetics modulates cell volume regulation and calcium signaling in astrocytes: A different point of view on the role of aquaporins. Glia. vol 64. issue 1. 2016-10-20. PMID:26413835. |
using biophysical techniques to measure water flux through the plasma membrane of wild-type (wt) and aqp4 knockout (ko) astrocytes and of an astrocyte cell line (di tnc1) transfected with aqp4 or aqp1, we here show that aqp-mediated fast swelling kinetics play a key role in triggering and accelerating rvd. |
2016-10-20 |
2023-08-13 |
Not clear |