| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mary Sourial, Laurie C Doerin. Astrocyte-Secreted Factors Selectively Alter Neural Stem and Progenitor Cell Proliferation in the Fragile X Mouse. Frontiers in cellular neuroscience. vol 10. 2016-05-31. PMID:27242437. |
we used the neural colony forming cell assay to determine the effect of astrocyte conditioned media (acm) on the generation of neurospheres originating from either progenitor cells or functional stem cells in the knock out (ko) fragile x mouse model. |
2016-05-31 |
2023-08-13 |
mouse |
| Yang Gao, Siyi Xu, Zhenwen Cui, Mingkun Zhang, Yingying Lin, Lei Cai, Zhugang Wang, Xingguang Luo, Yan Zheng, Yong Wang, Qizhong Luo, Jiyao Jiang, Joseph H Neale, Chunlong Zhon. Mice lacking glutamate carboxypeptidase II develop normally, but are less susceptible to traumatic brain injury. Journal of neurochemistry. vol 134. issue 2. 2015-09-14. PMID:25872793. |
gcpii gene ko significantly lessened neuronal degeneration and astrocyte damage in the ca2 and ca3 regions of the hippocampus 24 h after moderate tbi. |
2015-09-14 |
2023-08-13 |
mouse |
| Khalil Bouyakdan, Bouchra Taïb, Lionel Budry, Shangang Zhao, Demetra Rodaros, Ditte Neess, Susanne Mandrup, Nils J Faergeman, Thierry Alquie. A novel role for central ACBP/DBI as a regulator of long-chain fatty acid metabolism in astrocytes. Journal of neurochemistry. vol 133. issue 2. 2015-06-12. PMID:25598214. |
using brain slices, cortical, and hypothalamic astrocyte cultures from acbp ko mice, we demonstrate that acbp mainly localizes in astrocytes and regulates unsaturated but not saturated long-chain fatty acids (lcfa) metabolism. |
2015-06-12 |
2023-08-13 |
mouse |
| Ingrid R Niesman, Jan M Schilling, Lee A Shapiro, Sarah E Kellerhals, Jacqueline A Bonds, Alexander M Kleschevnikov, Weihua Cui, April Voong, Stan Krajewski, Sameh S Ali, David M Roth, Hemal H Patel, Piyush M Patel, Brian P Hea. Traumatic brain injury enhances neuroinflammation and lesion volume in caveolin deficient mice. Journal of neuroinflammation. vol 11. 2014-09-16. PMID:24593993. |
previously we showed that astrocyte and microglial activation is increased in cav-1 knock-out (ko) mice and that cav-1 and cav-3 modulate microglial morphology. |
2014-09-16 |
2023-08-12 |
mouse |
| Albert Quintana, Maria Erta, Beatriz Ferrer, Gemma Comes, Mercedes Giralt, Juan Hidalg. Astrocyte-specific deficiency of interleukin-6 and its receptor reveal specific roles in survival, body weight and behavior. Brain, behavior, and immunity. vol 27. issue 1. 2013-05-23. PMID:23085146. |
our results suggest important roles of the astrocyte il-6 system on normal brain physiology, in some cases totally unexpected from previous results with total il-6 ko mice. |
2013-05-23 |
2023-08-12 |
mouse |
| Naiyan Chen, Hiroki Sugihara, Jitendra Sharma, Gertrudis Perea, Jeremy Petravicz, Chuong Le, Mriganka Su. Nucleus basalis-enabled stimulus-specific plasticity in the visual cortex is mediated by astrocytes. Proceedings of the National Academy of Sciences of the United States of America. vol 109. issue 41. 2013-01-08. PMID:23012414. |
the potentiation is absent in conditional inositol 1,4,5 trisphosphate receptor type 2 ko mice, which lack astrocyte calcium activation, and is stimulus-specific, because pairing nb stimulation with a specific visual orientation reveals a highly selective potentiation of responses to the paired orientation compared with unpaired orientations. |
2013-01-08 |
2023-08-12 |
mouse |
| Britto P Nathan, Michael Tonsor, Robert G Strubl. Acute responses to estradiol replacement in the olfactory system of apoE-deficient and wild-type mice. Brain research. vol 1343. 2011-02-15. PMID:20447382. |
estradiol treatment also increased cell proliferation, total cell numbers, number of mature neurons in the olfactory epithelium, and reactive astrocyte numbers in the olfactory bulb (ob) in both wt and ko mice. |
2011-02-15 |
2023-08-12 |
mouse |
| Shujun Ge, Nivetha Murugesan, Joel S Pachte. Astrocyte- and endothelial-targeted CCL2 conditional knockout mice: critical tools for studying the pathogenesis of neuroinflammation. Journal of molecular neuroscience : MN. vol 39. issue 1-2. 2010-02-12. PMID:19340610. |
specifically, mice containing a floxed ccl2 allele were intercrossed with gfap-cre or tie2-cre transgenic mice to generate mice with ccl2-deficient astrocytes (astrocyte ko) or endothelial cells (endothelial ko), respectively. |
2010-02-12 |
2023-08-12 |
mouse |
| Shujun Ge, Nivetha Murugesan, Joel S Pachte. Astrocyte- and endothelial-targeted CCL2 conditional knockout mice: critical tools for studying the pathogenesis of neuroinflammation. Journal of molecular neuroscience : MN. vol 39. issue 1-2. 2010-02-12. PMID:19340610. |
use of astrocyte ko and endothelial ko mice should prove critical in elaborating the pathogenic mechanisms of and optimizing the treatments for neuroinflammatory disease. |
2010-02-12 |
2023-08-12 |
mouse |
| Taizen Nakase, Yasuji Yoshida, Ken Nagat. Enhanced connexin 43 immunoreactivity in penumbral areas in the human brain following ischemia. Glia. vol 54. issue 5. 2006-11-01. PMID:16886200. |
heterozygote cx43 ko mice and astrocyte specific cx43 ko mice exhibited amplified brain damage after ischemic insults, suggesting a neuroprotective role for astrocytic gap junctions. |
2006-11-01 |
2023-08-12 |
mouse |
| Kristina H Holmberg, Paul H Patterso. Leukemia inhibitory factor is a key regulator of astrocytic, microglial and neuronal responses in a low-dose pilocarpine injury model. Brain research. vol 1075. issue 1. 2006-07-31. PMID:16458863. |
compared to wild type mice, the lif ko mouse displays reduced astrocyte and microglial activation in the hippocampus. |
2006-07-31 |
2023-08-12 |
mouse |
| Kristina H Holmberg, Paul H Patterso. Leukemia inhibitory factor is a key regulator of astrocytic, microglial and neuronal responses in a low-dose pilocarpine injury model. Brain research. vol 1075. issue 1. 2006-07-31. PMID:16458863. |
to test the hypothesis that lif regulates astrocyte, microglial and neuropeptide responses to a mild insult, we used a low-dose pilocarpine model to induce a brief seizure in lif knock-out (ko) mice. |
2006-07-31 |
2023-08-12 |
mouse |
| Takaya Miyawaki, Akiyoshi Uemura, Mari Dezawa, Ruth T Yu, Chizuka Ide, Shinichi Nishikawa, Yoshihito Honda, Yasuto Tanabe, Teruyo Tanab. Tlx, an orphan nuclear receptor, regulates cell numbers and astrocyte development in the developing retina. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 24. issue 37. 2005-05-17. PMID:15371513. |
the impaired astrocyte network formation on the inner retinal surface is accompanied by the loss of vasculogenesis in tlx ko retinas. |
2005-05-17 |
2023-08-12 |
mouse |
| Guang Jin, Takeshi Hayashi, Junichi Kawagoe, Toshiaki Takizawa, Tetsuya Nagata, Isao Nagano, Mikio Syoji, Koji Ab. Deficiency of PAR-2 gene increases acute focal ischemic brain injury. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 25. issue 3. 2005-03-30. PMID:15647743. |
the expression profile of the protease-activated receptor-2 (par-2) and effects of par-2 gene knockout (par-2 ko) on the infarct size were investigated after 60 minutes of transient middle cerebral artery occlusion (tmcao) in mice in relation to phosphorylated extracellular signal-regulated kinase (p-erk) and astrocyte activation. |
2005-03-30 |
2023-08-12 |
mouse |
| M Crisby, S M A Rahman, C Sylvén, B Winblad, M Schultzber. Effects of high cholesterol diet on gliosis in apolipoprotein E knockout mice. Implications for Alzheimer's disease and stroke. Neuroscience letters. vol 369. issue 2. 2004-12-30. PMID:15450674. |
furthermore, there was significant astrocyte activation in the apoe ko mice, as compared to the wt mice, on nd. |
2004-12-30 |
2023-08-12 |
mouse |
| M Zetterström, J Lundkvist, D Malinowsky, G Eriksson, T Bartfa. Interleukin-1-mediated febrile responses in mice and interleukin-1 beta activation of NFkappaB in mouse primary astrocytes, involves the interleukin-1 receptor accessory protein. European cytokine network. vol 9. issue 2. 1998-10-20. PMID:9681388. |
with the aim of investigating the importance of the il-1racp in il-1 signalling, il-1alpha and il-1beta induced febrile responses and il-1beta-mediated activation of nfkappab in primary astrocyte cultures were examined using il-1racp-deficient (il-1racp ko) and wild type mice, respectively. |
1998-10-20 |
2023-08-12 |
mouse |