All Relations between microtubule-associated protein tau and memory formation
Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
John C O'Leary, John Koren, Chad A Dicke. Neuronal life span versus health span: principles of natural selection at work in the degenerating brain. Journal of molecular neuroscience : MN. vol 45. issue 3. 2012-03-19. PMID:21559875. |
thus, once a neuron begins to accumulate tau, it may survive in a malfunctioning capacity, leading to impaired electrical signaling and memory formation in the brain. |
2012-03-19 |
2023-08-12 |
mouse |
Junko Fujio, Hiroaki Hosono, Koichi Ishiguro, Shiro Ikegami, Shinobu C Fujit. Tau phosphorylation in the mouse brain during aversive conditioning. Neurochemistry international. vol 51. issue 2-4. 2007-10-25. PMID:17597257. |
these results suggest involvement of tau and tpki/gsk3beta phosphorylation in an early phase of memory formation in the hippocampus and amygdala, raising a possibility that a dysregulation of tau phosphorylation may underlie memory impairment in incipient alzheimer's disease. |
2007-10-25 |
2023-08-12 |
mouse |
M Che. The Alzheimer's plaques, tangles and memory deficits may have a common origin; part I; a calcium deficit hypothesis. Frontiers in bioscience : a journal and virtual library. vol 3. 1998-08-13. PMID:9576681. |
these processes include normal processing of beta-amyloid precursor protein, dephosphorylation and degradation of tau, neurotransmitter release and memory formation. |
1998-08-13 |
2023-08-12 |
Not clear |