| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| B Bontempi, F R Shar. Systemic morphine-induced Fos protein in the rat striatum and nucleus accumbens is regulated by mu opioid receptors in the substantia nigra and ventral tegmental area. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 17. issue 21. 1997-11-20. PMID:9334431. |
this activates d1 dopamine receptors and coupled with the coactivation of nmda receptors possibly from cortical glutamate input induces fos in striatal and nac neurons. |
1997-11-20 |
2023-08-12 |
rat |
| A Gillissen, M Jaworska, M Orth, M Coffiner, P Maes, E M App, A M Cantin, G Schultze-Werninghau. Nacystelyn, a novel lysine salt of N-acetylcysteine, to augment cellular antioxidant defence in vitro. Respiratory medicine. vol 91. issue 3. 1997-05-27. PMID:9135855. |
the gsh precursor potency of cystine was about two-fold higher than that of nal and nac, indicating that the deacetylation process of nal and nac slows the ability of both drugs to induce cellular glut production and secretion. |
1997-05-27 |
2023-08-12 |
Not clear |
| X T Hu, F J Whit. Glutamate receptor regulation of rat nucleus accumbens neurons in vivo. Synapse (New York, N.Y.). vol 23. issue 3. 1997-03-24. PMID:8807749. |
extracellular single cell recording and microiontophoretic techniques were used to characterize the roles of ionotropic and metabotropic glutamate receptors (iglurs and mglurs) in glutamate-induced excitation of rat nucleus accumbens (nac) neurons in vivo. |
1997-03-24 |
2023-08-12 |
rat |
| X T Hu, F J Whit. Glutamate receptor regulation of rat nucleus accumbens neurons in vivo. Synapse (New York, N.Y.). vol 23. issue 3. 1997-03-24. PMID:8807749. |
pulse-ejected glutamate (16-128 na) induced a current-dependent increase in the firing of quiescent nac neurons. |
1997-03-24 |
2023-08-12 |
rat |
| X T Hu, F J Whit. Glutamate receptor regulation of rat nucleus accumbens neurons in vivo. Synapse (New York, N.Y.). vol 23. issue 3. 1997-03-24. PMID:8807749. |
these results indicate that the excitatory effects of glutamate on rat nac neurons in vivo are primarily mediated by non-nmda iglurs and that mglurs function to dampen excessive glutamate transmission through iglurs. |
1997-03-24 |
2023-08-12 |
rat |
| M T Taber, G B Baker, H C Fibige. Glutamate receptor agonists decrease extracellular dopamine in the rat nucleus accumbens in vivo. Synapse (New York, N.Y.). vol 24. issue 2. 1997-02-07. PMID:8890458. |
intracerebral microdialysis was used to investigate the effects of local application of l-glutamate, n-methyl-d-aspartate, and the glutamate uptake inhibitor 1-trans-pyrrolidine-2,4-dicarboxylic acid (pdc) in the nucleus accumbens (nac) on extracellular dopamine (da) concentrations. |
1997-02-07 |
2023-08-12 |
rat |
| M T Taber, G B Baker, H C Fibige. Glutamate receptor agonists decrease extracellular dopamine in the rat nucleus accumbens in vivo. Synapse (New York, N.Y.). vol 24. issue 2. 1997-02-07. PMID:8890458. |
furthermore, the results of these and other experiments suggest that glutamate's inhibitory effects on da release in the nac are not due to direct actions of this excitatory amino acid on da terminals. |
1997-02-07 |
2023-08-12 |
rat |
| M Noble, M Mayer-Prósche. On the track of cell survival pharmaceuticals in the oligodendrocyte type-2 astrocyte lineage. Perspectives on developmental neurobiology. vol 3. issue 2. 1996-12-16. PMID:8826530. |
in the former case, nac prevented the death of oligodendrocytes induced by glutamate or tumor necrosis factor-alpha (tnf-alpha), and also prevented tnf-alpha-induced death of l929 cells. |
1996-12-16 |
2023-08-12 |
Not clear |
| F J Wan, M A Geyer, N R Swerdlo. Presynaptic dopamine-glutamate interactions in the nucleus accumbens regulate sensorimotor gating. Psychopharmacology. vol 120. issue 4. 1996-02-07. PMID:8539324. |
the parsimonious interpretation of these data is that non-nmda glutamate receptors in the nac facilitate presynaptic da function, and that this da-glutamate interaction is a critical regulatory substrate of sensorimotor gating. |
1996-02-07 |
2023-08-12 |
rat |
| M T Taber, H C Fibige. Electrical stimulation of the prefrontal cortex increases dopamine release in the nucleus accumbens of the rat: modulation by metabotropic glutamate receptors. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 15. issue 5 Pt 2. 1995-06-21. PMID:7751954. |
additional experiments were performed to establish whether glutamate receptors in the nac mediated these effects. |
1995-06-21 |
2023-08-12 |
rat |
| M T Taber, H C Fibige. Electrical stimulation of the prefrontal cortex increases dopamine release in the nucleus accumbens of the rat: modulation by metabotropic glutamate receptors. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 15. issue 5 Pt 2. 1995-06-21. PMID:7751954. |
when a "subthreshold" concentration (i.e., the highest concentration employed that did not itself increase da release) of either compound was administered together with pfc stimulation, neither kynurenic acid (1 mm) nor mk-801 (1 microm) attenuated the effect of stimulation on da release, thereby indicating that this effect is not mediated by ionotropic glutamate receptors located within the nac. |
1995-06-21 |
2023-08-12 |
rat |
| L Pulvirenti, R Berrier, M Kreifeldt, G F Koo. Modulation of locomotor activity by NMDA receptors in the nucleus accumbens core and shell regions of the rat. Brain research. vol 664. issue 1-2. 1995-04-24. PMID:7895034. |
a major neural input to the nac is provided by glutamatergic afferents of allocortical origin and there is evidence that glutamate can modulate psychomotor activation and drug reinforcement. |
1995-04-24 |
2023-08-12 |
rat |
| A Schwacha, R A Bende. The product of the Klebsiella aerogenes nac (nitrogen assimilation control) gene is sufficient for activation of the hut operons and repression of the gdh operon. Journal of bacteriology. vol 175. issue 7. 1993-04-23. PMID:8458854. |
thus, nac is sufficient to regulate operons like hut (encoding histidase) and gdh (encoding glutamate dehydrogenase), confirming the model that the ntr system activates nac expression and nac activates hut and represses gdh. |
1993-04-23 |
2023-08-12 |
Not clear |
| A Schwacha, R A Bende. The product of the Klebsiella aerogenes nac (nitrogen assimilation control) gene is sufficient for activation of the hut operons and repression of the gdh operon. Journal of bacteriology. vol 175. issue 7. 1993-04-23. PMID:8458854. |
activation of urease formation occurred at a lower level of nac than that required for glutamate dehydrogenase repression, and activation of histidase formation required still more nac. |
1993-04-23 |
2023-08-12 |
Not clear |
| L Pulvirenti, N R Swerdlow, G F Koo. Nucleus accumbens NMDA antagonist decreases locomotor activity produced by cocaine, heroin or accumbens dopamine, but not caffeine. Pharmacology, biochemistry, and behavior. vol 40. issue 4. 1992-06-30. PMID:1687766. |
the purpose of this study was 1) to determine the importance of nucleus accumbens n-methyl-d-aspartate (nmda) glutamate receptors in the control of psychostimulant-induced locomotion, 2) to determine whether nmda receptor modulation of psychostimulant-induced locomotion occurs presynaptic to or postsynaptic to nac dopamine terminals, and 3) to determine whether nmda receptors also modulate opiate- and caffeine-induced locomotor activation. |
1992-06-30 |
2023-08-11 |
rat |
| L Pulvirenti, N R Swerdlow, G F Koo. Nucleus accumbens NMDA antagonist decreases locomotor activity produced by cocaine, heroin or accumbens dopamine, but not caffeine. Pharmacology, biochemistry, and behavior. vol 40. issue 4. 1992-06-30. PMID:1687766. |
these results suggest that nac glutamate modulates psychomotor stimulation at the level of the nac through an interaction with the integrated output of this region. |
1992-06-30 |
2023-08-11 |
rat |
| E A Best, R A Bende. Cloning of the Klebsiella aerogenes nac gene, which encodes a factor required for nitrogen regulation of the histidine utilization (hut) operons in Salmonella typhimurium. Journal of bacteriology. vol 172. issue 12. 1991-01-24. PMID:2254273. |
the nac (nitrogen assimilation control) gene from klebsiella aerogenes, cloned in a low-copy-number cloning vector, restored the ability of k. aerogenes nac mutants to activate histidase and repress glutamate dehydrogenase formation in response to nitrogen limitation and to limit the maximum expression of the nac promoter. |
1991-01-24 |
2023-08-11 |
Not clear |
| L Pulvirenti, N R Swerdlow, G F Koo. Microinjection of a glutamate antagonist into the nucleus accumbens reduces psychostimulant locomotion in rats. Neuroscience letters. vol 103. issue 2. 1989-10-12. PMID:2771183. |
in order to study a possible modulatory effect of glutamatergic afferents to the nucleus accumbens (nac) on psychostimulant-induced locomotion, l-glutamic acid diethyl ester (gdee), a glutamate antagonist, was injected in the nac of rats acutely treated with cocaine, amphetamine or caffeine. |
1989-10-12 |
2023-08-11 |
rat |
| R A Bender, P M Snyder, R Bueno, M Quinto, B Magasani. Nitrogen regulation system of Klebsiella aerogenes: the nac gene. Journal of bacteriology. vol 156. issue 1. 1983-11-23. PMID:6352688. |
in klebsiella aerogenes, the product of a his-linked gene, nac, appears to play a crucial role in tying the synthesis of enzymes activated or repressed by ammonia deprivation, such as histidase and glutamate dehydrogenase, to the known regulators of nitrogen assimilation, the products of glng and glnf. |
1983-11-23 |
2023-08-12 |
Not clear |