| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| K Pong, R Y Xu, K D Beck, T J Zhang, J C Loui. Inhibition of glial cell line-derived neurotrophic factor induced intracellular activity by K-252b on dopaminergic neurons. Journal of neurochemistry. vol 69. issue 3. 1997-09-25. PMID:9282920. |
the c-ret protooncogene encodes ret, the functional tyrosine kinase receptor for glial cell line-derived neurotrophic factor (gdnf). |
1997-09-25 |
2023-08-12 |
Not clear |
| E R Woodward, C Eng, R McMahon, R Voutilainen, N A Affara, B A Ponder, E R Mahe. Genetic predisposition to phaeochromocytoma: analysis of candidate genes GDNF, RET and VHL. Human molecular genetics. vol 6. issue 7. 1997-08-28. PMID:9215674. |
glial cell line-derived neurotrophic factor (gdnf) has been recently identified as a natural ligand for ret. |
1997-08-28 |
2023-08-12 |
Not clear |
| M Sanicola, C Hession, D Worley, P Carmillo, C Ehrenfels, L Walus, S Robinson, G Jaworski, H Wei, R Tizard, A Whitty, R B Pepinsky, R L Cat. Glial cell line-derived neurotrophic factor-dependent RET activation can be mediated by two different cell-surface accessory proteins. Proceedings of the National Academy of Sciences of the United States of America. vol 94. issue 12. 1997-07-10. PMID:9177201. |
glial cell line-derived neurotrophic factor (gdnf)-dependent activation of the tyrosine kinase receptor ret is necessary for kidney and enteric neuron development, and mutations in ret are associated with human diseases. |
1997-07-10 |
2023-08-12 |
human |
| R H Baloh, M G Tansey, J P Golden, D J Creedon, R O Heuckeroth, C L Keck, D B Zimonjic, N C Popescu, E M Johnson, J Milbrand. TrnR2, a novel receptor that mediates neurturin and GDNF signaling through Ret. Neuron. vol 18. issue 5. 1997-06-30. PMID:9182803. |
a receptor complex comprised of trnr1 (gdnfr alpha) and ret was recently identified and found to be capable of mediating both gdnf and ntn signaling. |
1997-06-30 |
2023-08-12 |
Not clear |
| M Trupp, N Belluardo, H Funakoshi, C F Ibáñe. Complementary and overlapping expression of glial cell line-derived neurotrophic factor (GDNF), c-ret proto-oncogene, and GDNF receptor-alpha indicates multiple mechanisms of trophic actions in the adult rat CNS. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 17. issue 10. 1997-06-02. PMID:9133379. |
glial cell line-derived neurotrophic factor (gdnf), the most potent trophic factor yet described for both dopaminergic neurons of the substantia nigra and spinal motorneurons, has recently been shown to signal through a multireceptor complex composed of a novel glycosylphosphatidylinositol-anchored gdnf receptor-alpha (gdnfr-alpha) and the receptor tyrosine kinase product of the c-ret proto-oncogene (ret). |
1997-06-02 |
2023-08-12 |
rat |
| V Gattei, A Celetti, A Cerrato, M Degan, A De Iuliis, F M Rossi, G Chiappetta, C Consales, S Improta, V Zagonel, D Aldinucci, V Agosti, M Santoro, G Vecchio, A Pinto, M Griec. Expression of the RET receptor tyrosine kinase and GDNFR-alpha in normal and leukemic human hematopoietic cells and stromal cells of the bone marrow microenvironment. Blood. vol 89. issue 8. 1997-05-19. PMID:9108413. |
the ret proto-oncogene product is a receptor tyrosine kinase representing the signal-transducing molecule of a multisubunit surface receptor complex for the glial cell line-derived neurotrophic factor (gdnf), in which a novel glycosyl-phosphatidylinositol (pi)-linked protein (termed gdnfr-alpha) acts as the ligand-binding component. |
1997-05-19 |
2023-08-12 |
human |
| K J Bär, P Facer, N S Williams, P K Tam, P Anan. Glial-derived neurotrophic factor in human adult and fetal intestine and in Hirschsprung's disease. Gastroenterology. vol 112. issue 4. 1997-05-01. PMID:9098026. |
glial cell line-derived neurotrophic factor (gdnf) signals through the product of the ret proto-oncogene, which is known to be mutated in hirschsprung's disease and other conditions with gut dysmotility. |
1997-05-01 |
2023-08-12 |
human |
| X Morin, H Cremer, M R Hirsch, R P Kapur, C Goridis, J F Brune. Defects in sensory and autonomic ganglia and absence of locus coeruleus in mice deficient for the homeobox gene Phox2a. Neuron. vol 18. issue 3. 1997-04-24. PMID:9115735. |
second, the expression of the gdnf receptor subunit ret is dramatically reduced, and there is a massive increase in apoptosis of ganglion cells, which are known to depend on gdnf in vivo. |
1997-04-24 |
2023-08-12 |
mouse |
| S M Ivanchuk, S M Myers, C Eng, L M Mulliga. De novo mutation of GDNF, ligand for the RET/GDNFR-alpha receptor complex, in Hirschsprung disease. Human molecular genetics. vol 5. issue 12. 1997-03-14. PMID:8968758. |
to investigate this role, we examined the gene for glial cell line-derived neurotrophic factor (gdnf), the circulating ligand of the ret receptor complex, for mutations in a panel of sporadic and familial hscr. |
1997-03-14 |
2023-08-12 |
Not clear |
| D H van Weering, J L Bo. Glial cell line-derived neurotrophic factor induces Ret-mediated lamellipodia formation. The Journal of biological chemistry. vol 272. issue 1. 1997-02-18. PMID:8995255. |
recently, glial cell line-derived neurotrophic factor (gdnf) has been identified as a ligand for ret. |
1997-02-18 |
2023-08-12 |
Not clear |
| P L Dahia, S P Toledo, L M Mulligan, E R Maher, A B Grossman, C En. Mutation analysis of glial cell line-derived neurotrophic factor (GDNF), a ligand for the RET/GDNF receptor alpha complex, in sporadic phaeochromocytomas. Cancer research. vol 57. issue 2. 1997-02-11. PMID:9000574. |
recent data have suggested that glial cell line-derived neurotrophic factor (gdnf) is a ligand for ret and acts via a heterotetrameric receptor complex that includes gdnf receptor alpha, which provides ligand binding capabilities, and ret, which provides the signaling component. |
1997-02-11 |
2023-08-12 |
Not clear |
| M Angrist, S Bolk, M Halushka, P A Lapchak, A Chakravart. Germline mutations in glial cell line-derived neurotrophic factor (GDNF) and RET in a Hirschsprung disease patient. Nature genetics. vol 14. issue 3. 1996-12-16. PMID:8896568. |
germline mutations in glial cell line-derived neurotrophic factor (gdnf) and ret in a hirschsprung disease patient. |
1996-12-16 |
2023-08-12 |
mouse |
| R Salomon, T Attié, A Pelet, C Bidaud, C Eng, J Amiel, S Sarnacki, O Goulet, C Ricour, C Nihoul-Fékété, A Munnich, S Lyonne. Germline mutations of the RET ligand GDNF are not sufficient to cause Hirschsprung disease. Nature genetics. vol 14. issue 3. 1996-12-16. PMID:8896569. |
recently, the glial cell line-derived neurotrophic factor (gdnf) has been identified to be a ligand for ret. |
1996-12-16 |
2023-08-12 |
mouse |
| Q C Vega, C A Worby, M S Lechner, J E Dixon, G R Dressle. Glial cell line-derived neurotrophic factor activates the receptor tyrosine kinase RET and promotes kidney morphogenesis. Proceedings of the National Academy of Sciences of the United States of America. vol 93. issue 20. 1996-11-25. PMID:8855235. |
this report demonstrates that the glial cell line-derived neurotrophic factor (gdnf) activates ret, as measured by tyrosine phosphorylation of the intracellular catalytic domain. |
1996-11-25 |
2023-08-12 |
Not clear |
| P Durbec, C V Marcos-Gutierrez, C Kilkenny, M Grigoriou, K Wartiowaara, P Suvanto, D Smith, B Ponder, F Costantini, M Saarm. GDNF signalling through the Ret receptor tyrosine kinase. Nature. vol 381. issue 6585. 1996-08-01. PMID:8657282. |
our data strongly suggest that ret is a functional receptor for gdnf, and that gdnf, in addition to its potential role in the differentiation and survival of central nervous system neurons, has profound effects on kidney organogenesis and the development of the peripheral nervous system. |
1996-08-01 |
2023-08-12 |
mouse |