| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| I Rajan, C Gestblom, R P Kapu. RET(Men2B)-transgene produces sympathoadrenal tumors but does not prevent intestinal aganglionosis in gdnf-/- or gfr alpha-1(-/-) mice. Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society. vol 4. issue 5. 2002-01-25. PMID:11779046. |
ret(men2b)-transgene produces sympathoadrenal tumors but does not prevent intestinal aganglionosis in gdnf-/- or gfr alpha-1(-/-) mice. |
2002-01-25 |
2023-08-12 |
mouse |
| I Rajan, C Gestblom, R P Kapu. RET(Men2B)-transgene produces sympathoadrenal tumors but does not prevent intestinal aganglionosis in gdnf-/- or gfr alpha-1(-/-) mice. Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society. vol 4. issue 5. 2002-01-25. PMID:11779046. |
in vitro studies have shown that the kinase and mitogenic properties of ret(men2b) are enhanced by gdnf/gfr alpha-1 stimulation. |
2002-01-25 |
2023-08-12 |
mouse |
| I Rajan, C Gestblom, R P Kapu. RET(Men2B)-transgene produces sympathoadrenal tumors but does not prevent intestinal aganglionosis in gdnf-/- or gfr alpha-1(-/-) mice. Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society. vol 4. issue 5. 2002-01-25. PMID:11779046. |
loss-of-function mutations in ret, gdnf, or gfr alpha-1 cause pan-intestinal aganglionosis in mice. |
2002-01-25 |
2023-08-12 |
mouse |
| A Josephson, J Widenfalk, A Trifunovski, H R Widmer, L Olson, C Spenge. GDNF and NGF family members and receptors in human fetal and adult spinal cord and dorsal root ganglia. The Journal of comparative neurology. vol 440. issue 2. 2002-01-22. PMID:11745618. |
messenger rna was found encoding ret, gfr alpha-1, bdnf, trkb, and trkc in the adult human spinal cord and bdnf, nt-3, p75, trkb, and trkc in the fetal human spinal cord. |
2002-01-22 |
2023-08-12 |
human |
| A Josephson, J Widenfalk, A Trifunovski, H R Widmer, L Olson, C Spenge. GDNF and NGF family members and receptors in human fetal and adult spinal cord and dorsal root ganglia. The Journal of comparative neurology. vol 440. issue 2. 2002-01-22. PMID:11745618. |
gfr alpha-2 was expressed selectively in small, gfr alpha-3 principally in small and gfr alpha-1 and ret in both large and small adult human drg neurons. |
2002-01-22 |
2023-08-12 |
human |
| A Josephson, J Widenfalk, A Trifunovski, H R Widmer, L Olson, C Spenge. GDNF and NGF family members and receptors in human fetal and adult spinal cord and dorsal root ganglia. The Journal of comparative neurology. vol 440. issue 2. 2002-01-22. PMID:11745618. |
the percentage of adult human drg cells expressing p75, trka, trkb, or trkc was 57, 46, 29, and 24%, respectively, and that of drg cells expressing ret, gfr alpha-1, gfr alpha-2, or gfr alpha-3 was 79, 20, 51, and 32%, respectively. |
2002-01-22 |
2023-08-12 |
human |
| S Rémy, P Naveilhan, P Brachet, I Neve. Differential regulation of GDNF, neurturin, and their receptors in primary cultures of rat glial cells. Journal of neuroscience research. vol 64. issue 3. 2001-07-19. PMID:11319768. |
although gdnf, ntn and ret mrna levels were at the limit of detection, rnase protection assays revealed relatively high amounts of gfr alpha-1 and gfr alpha transcripts. |
2001-07-19 |
2023-08-12 |
rat |
| S Rémy, P Naveilhan, P Brachet, I Neve. Differential regulation of GDNF, neurturin, and their receptors in primary cultures of rat glial cells. Journal of neuroscience research. vol 64. issue 3. 2001-07-19. PMID:11319768. |
glial cell line-derived neurotrophic factor (gdnf) and neurturin (ntn) bind to gfr alpha-1 and gfr alpha-2 receptors, respectively, and their neurotrophic activity is mediated by the tyrosine kinase receptor, ret. |
2001-07-19 |
2023-08-12 |
rat |
| A Capes-Davis, S D Andrew, V J Hyland, S Twigg, D L Learoyd, T Dwight, D J Marsh, B G Robinso. Glucocorticoids differentially inhibit expression of the RET proto-oncogene. Gene expression. vol 8. issue 5-6. 2000-08-30. PMID:10947080. |
the ret proto-oncogene encodes a receptor tyrosine kinase activated by the binding of factors from the glial cell line-derived neurotrophic factor (gdnf) family to receptor-alpha components such as gdnf family receptor alpha-1 (gfr alpha-1). |
2000-08-30 |
2023-08-12 |
Not clear |
| J Widenfalk, M Parvinen, E Lindqvist, L Olso. Neurturin, RET, GFRalpha-1 and GFRalpha-2, but not GFRalpha-3, mRNA are expressed in mice gonads. Cell and tissue research. vol 299. issue 3. 2000-06-06. PMID:10772255. |
in testis, the transducing receptor ret as well as gdnf receptor alpha-1 (gfr)alpha-1 and gfralpha-2 were distributed in complementary and overlapping patterns, the former at stages xi-xii-i and the latter at stages vii and viii. |
2000-06-06 |
2023-08-12 |
mouse |
| T C Burazin, A L Gundlac. Localization of GDNF/neurturin receptor (c-ret, GFRalpha-1 and alpha-2) mRNAs in postnatal rat brain: differential regional and temporal expression in hippocampus, cortex and cerebellum. Brain research. Molecular brain research. vol 73. issue 1-2. 2000-02-14. PMID:10581409. |
recent studies have identified a multi-component receptor system for the neurotrophic factor, glial cell line-derived neurotrophic factor (gdnf) and its homolog, neurturin (ntn), comprising the signaling tyrosine kinase, ret and multiple gpi-linked binding proteins, gdnf family receptor alpha-1 and alpha-2 (gfralpha-1 and gfralpha-2). |
2000-02-14 |
2023-08-12 |
rat |
| S Homma, R W Oppenheim, H Yaginuma, S Kimur. Expression pattern of GDNF, c-ret, and GFRalphas suggests novel roles for GDNF ligands during early organogenesis in the chick embryo. Developmental biology. vol 217. issue 1. 2000-02-04. PMID:10625540. |
we have cloned a partial cdna of chicken glial cell line-derived neurotrophic factor (gdnf) and systematically examined its expression pattern as well as that of gdnf-binding components (gdnf family receptor alpha-1 and 2: gfralpha-1 and 2) and a common signal transduction receptor (c-ret protooncogene: ret) during very early developmental stages. |
2000-02-04 |
2023-08-12 |
chicken |
| S M Myers, R Salomon, A Goessling, A Pelet, C Eng, A von Deimling, S Lyonnet, L M Mulliga. Investigation of germline GFR alpha-1 mutations in Hirschsprung disease. Journal of medical genetics. vol 36. issue 3. 1999-06-11. PMID:10204848. |
we investigated the presence of mutations in another member of the ret signalling complex, gdnf family receptor alpha-1 (gfr alpha-1), in a panel of 269 independent cases of hscr. |
1999-06-11 |
2023-08-12 |
Not clear |
| R M Melillo, M V Barone, G Lupoli, A M Cirafici, F Carlomagno, R Visconti, B Matoskova, P P Di Fiore, G Vecchio, A Fusco, M Santor. Ret-mediated mitogenesis requires Src kinase activity. Cancer research. vol 59. issue 5. 1999-03-22. PMID:10070972. |
to test the involvement of c-src in ret-mediated signaling, we measured the levels of c-src activity in nih3t3 cells coexpressing ret and the accessory gfr alpha-1 receptor or an epidermal growth factor receptor/ret chimeric receptor when the cells were stimulated by glial cell line-derived neurotrophic factor or epidermal growth factor, respectively. |
1999-03-22 |
2023-08-12 |
human |
| B Franke, M Figiel, J Engel. CNS glia are targets for GDNF and neurturin. Histochemistry and cell biology. vol 110. issue 6. 1999-02-18. PMID:9860258. |
both gdnf and ntn signal through a receptor complex consisting of the signal transducing subunit, ret, and a ligand-specific binding subunit, termed gdnf family receptor (gfr)alpha-1 and gfralpha-2, respectively. |
1999-02-18 |
2023-08-12 |
Not clear |
| Y Enokido, F de Sauvage, J A Hongo, N Ninkina, A Rosenthal, V L Buchman, A M Davie. GFR alpha-4 and the tyrosine kinase Ret form a functional receptor complex for persephin. Current biology : CB. vol 8. issue 18. 1998-12-07. PMID:9740802. |
gdnf and neurturin signal through multicomponent receptors that consist of the ret receptor tyrosine kinase and one of two structurally related glycosyl-phosphatidylinositol (gpi)-linked ligand-binding subunits: gfr alpha-1 is the preferred ligand-binding subunit for gdnf, and gfr alpha-2 is the preferred ligand-binding subunit for neurturin. |
1998-12-07 |
2023-08-12 |
Not clear |
| L M Mulligan, T Timmer, S M Ivanchuk, B G Campling, L C Young, P H Rabbitts, V Sundaresan, R M Hofstra, C En. Investigation of the genes for RET and its ligand complex, GDNF/GFR alpha-I, in small cell lung carcinoma. Genes, chromosomes & cancer. vol 21. issue 4. 1998-05-20. PMID:9559344. |
ret activation may be mediated by a ligand complex comprising glial cell line-derived neurotrophic factor (gdnf) and gdnf family receptor alpha-1 (gfr alpha-1). |
1998-05-20 |
2023-08-12 |
Not clear |
| L M Mulligan, T Timmer, S M Ivanchuk, B G Campling, L C Young, P H Rabbitts, V Sundaresan, R M Hofstra, C En. Investigation of the genes for RET and its ligand complex, GDNF/GFR alpha-I, in small cell lung carcinoma. Genes, chromosomes & cancer. vol 21. issue 4. 1998-05-20. PMID:9559344. |
we further examined the expression pattern of ret and the genes encoding the components of its ligand complex gdnf and gfr alpha-1, in 21 sclc lines by using rt-pcr. |
1998-05-20 |
2023-08-12 |
Not clear |
| K Luukko, P Suvanto, M Saarma, I Theslef. Expression of GDNF and its receptors in developing tooth is developmentally regulated and suggests multiple roles in innervation and organogenesis. Developmental dynamics : an official publication of the American Association of Anatomists. vol 210. issue 4. 1998-02-19. PMID:9415430. |
to study the roles of gdnf in the regulation of tooth innervation and formation, we analyzed by in situ hybridization the expression patterns of gdnf and its receptors ret, gdnf family receptor alpha-1 (gfralpha-1), and gfralpha-2 from the initiation of first molar formation to the completion of crown morphogenesis. |
1998-02-19 |
2023-08-12 |
Not clear |