| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Nathan Calzadilla, Dulari Jayawardena, Aisha Qazi, Anchal Sharma, Kai Mongan, Shane Comiskey, Abhijith Eathara, Seema Saksena, Pradeep K Dudeja, Waddah A Alrefai, Ravinder K Gil. Serotonin Transporter Deficiency Induces Metabolic Alterations in the Ileal Mucosa. International journal of molecular sciences. vol 25. issue 8. 2024-04-27. PMID:38674044. |
serotonin transporter (sert) deficiency has been implicated in metabolic syndrome, intestinal inflammation, and microbial dysbiosis. |
2024-04-27 |
2024-04-29 |
Not clear |
| Xiaoxian Xie, Lei Sun, Haoshen Xu, Mengya Zhang, Jiafeng Zhou, Shulin Du, Zhengwei Fu, Zezhi L. Exposure to hexafluoropropylene oxide trimer acid (HFPO-TA) impairs 5-HT metabolism by impacting the brain-gut axis in mice. Chemosphere. 2024-04-25. PMID:38663680. |
in keeping with this prediction, our findings confirmed that the levels of several neurotransmitters, including tryptophan (trp), 5-ht, 5-htp, and 5-hiaa, were all impaired by hfpo-ta exposure in the serum, colon, and hippocampus, as was the colonic and hippocampal expression of trp and 5-ht metabolism-related genes such as sert, mao-a, and ido. |
2024-04-25 |
2024-04-28 |
mouse |
| Eva Hellsberg, Danila Boytsov, Qingyang Chen, Marco Niello, Michael Freissmuth, Gary Rudnick, Yuan-Wei Zhang, Walter Sandtner, Lucy R Forres. Identification of the potassium-binding site in serotonin transporter. Proceedings of the National Academy of Sciences of the United States of America. vol 121. issue 18. 2024-04-23. PMID:38652746. |
clearance of serotonin (5-hydroxytryptamine, 5-ht) from the synaptic cleft after neuronal signaling is mediated by serotonin transporter (sert), which couples this process to the movement of a na |
2024-04-23 |
2024-04-26 |
Not clear |
| Amine Bah. Serotonin transporter knockdown relieves depression-like behavior and ethanol-induced CPP in mice after chronic social defeat stress. Behavioural brain research. 2024-04-13. PMID:38614210. |
although, the specific mechanisms involved in stress-triggered alcohol dependence and mdd comorbidities are not well understood, a large body of literature suggests that the serotonin transporter (sert) plays a critical role in these abnormalities. |
2024-04-13 |
2024-04-16 |
mouse |
| Sixiang Chen, Xingyu Huang, Xintong Zhang, Chan Li, Yuan-Wei Zhan. A Conserved Intramolecular Ion-Pair Plays a Critical but Divergent Role in Regulation of Dimerization and Transport Function among the Monoamine Transporters. International journal of molecular sciences. vol 25. issue 7. 2024-04-13. PMID:38612840. |
the monoamine transporters, including the serotonin transporter (sert), dopamine transporter (dat), and norepinephrine transporter (net), are the therapeutic targets for the treatment of many neuropsychiatric disorders. |
2024-04-13 |
2024-04-15 |
Not clear |
| Chuang-Hsin Chiu, Kuo-Hsing Ma, Eagle Yi-Kung Huang, Hsien-Wen Chang, Shao-Ju Weng, Tsung-Hsun Yu, Shiou-Shiow Farn, Yu-Yeh Kuo, Wen-Sheng Huang, Cheng-Yi Cheng, Pao-Luh Tao, Skye Hsin-Hsien Ye. Dextromethorphan moderates reward deficiency associated with central serotonin transporter availability in 3,4-methylenedioxy-methamphetamine-treated animals. Journal of the Chinese Medical Association : JCMA. 2024-04-08. PMID:38587377. |
dextromethorphan (dm), an antitussive drug, decreased morphine- or methamphetamine (ma)-induced reward in rats and may prevent mdma-induced serotonergic deficiency in primates, as indicated by increased serotonin transporter (sert) availability. |
2024-04-08 |
2024-04-10 |
rat |
| Xin Ye, Shubhamoy Ghosh, Bo-Chul Shin, Amit Ganguly, Liesbeth Maggiotto, Jonathan P Jacobs, Sherin U Devaska. Brain serotonin and serotonin transporter expression in male and female postnatal rat offspring in response to perturbed early life dietary exposures. Frontiers in neuroscience. vol 18. 2024-04-05. PMID:38576870. |
serotonin (5-ht) is critical for neurodevelopment and the serotonin transporter (sert) modulates serotonin levels. |
2024-04-05 |
2024-04-07 |
rat |
| Lina Bukowski, Markus Emanuel Strøm, Jens Lindengren Andersen, Jannick Bang Maesen, Lin Tian, Steffen Sinnin. 5-HT_FAsTR: a versatile, label-free, high-throughput, fluorescence-based microplate assay to quantify serotonin transport and release. Scientific reports. vol 14. issue 1. 2024-03-20. PMID:38504103. |
we demonstrate the applicability of the method for the study of a neuronal, high-affinity, low-capacity serotonin transporter (sert) as well as an extraneuronal low-affinity, high-capacity organic cation transporter and mutants thereof. |
2024-03-20 |
2024-03-23 |
Not clear |
| Kyung Oh Jeon, Oc-Hee Kim, Soo Yeon Seo, Jaesuk Yun, Choon-Gon Jang, Ri-Na Lim, Tae Wan Kim, Chae Ha Yang, Seong Shoon Yoon, Eun Young Jan. The psychomotor, reinforcing, and discriminative stimulus effects of synthetic cathinone mexedrone in male mice and rats. European journal of pharmacology. 2024-03-02. PMID:38431243. |
in addition, serotonin transporter (sert) levels were measured in the synaptosome of the dorsal striatum, and serotonin (5-ht) levels were measured in the dorsal striatum of acute mexedreone (50 mg/kg)-treated mice. |
2024-03-02 |
2024-03-06 |
mouse |
| Kyung Oh Jeon, Oc-Hee Kim, Soo Yeon Seo, Jaesuk Yun, Choon-Gon Jang, Ri-Na Lim, Tae Wan Kim, Chae Ha Yang, Seong Shoon Yoon, Eun Young Jan. The psychomotor, reinforcing, and discriminative stimulus effects of synthetic cathinone mexedrone in male mice and rats. European journal of pharmacology. 2024-03-02. PMID:38431243. |
acute mexedrone significantly increased c-fos expression in the dorsal striatum and decreased sert levels in the synaptosome of the dorsal striatum of mice, resulting in elevation of 5-ht levels. |
2024-03-02 |
2024-03-06 |
mouse |
| Mary Beth Bauer, Kevin P M Curri. Serotonin and the serotonin transporter in the adrenal gland. Vitamins and hormones. vol 124. 2024-02-28. PMID:38408804. |
in this article we review serotonin (5-ht) and the serotonin transporter (sert; slc6a4) in the adrenal gland. |
2024-02-28 |
2024-03-01 |
Not clear |
| Michael Tea, Yihang Kevin Pan, Joshua G R Lister, Steve F Perry, Kathleen M Gilmou. Effects of serta and sertb knockout on aggression in zebrafish (Danio rerio). Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology. 2024-02-28. PMID:38416162. |
zebrafish (danio rerio) are unusual in having two paralogues of the serotonin re-uptake transporter (sert), slc6a4a (serta) and slc6a4b (sertb), the transporter that serves in serotonin re-uptake from a synapse into the pre-synaptic cell or in serotonin uptake from the extracellular milieu into cells in the peripheral tissues. |
2024-02-28 |
2024-03-01 |
zebrafish |
| Samantha Alvarez-Herrera, Mauricio Rosel Vales, Gilberto Pérez-Sánchez, Enrique Becerril-Villanueva, Yvonne Flores-Medina, José Luis Maldonado-García, Ricardo Saracco-Alvarez, Raúl Escamilla, Lenin Pavó. Risperidone Decreases Expression of Serotonin Receptor-2A (5-HT2A) and Serotonin Transporter (SERT) but Not Dopamine Receptors and Dopamine Transporter (DAT) in PBMCs from Patients with Schizophrenia. Pharmaceuticals (Basel, Switzerland). vol 17. issue 2. 2024-02-24. PMID:38399382. |
risperidone decreases expression of serotonin receptor-2a (5-ht2a) and serotonin transporter (sert) but not dopamine receptors and dopamine transporter (dat) in pbmcs from patients with schizophrenia. |
2024-02-24 |
2024-02-26 |
Not clear |
| Fusun Kili. Serotonin Signaling and the Hyperpermeable Endothelial Barrier in Sepsis: Clues to a Molecular Mechanism. Journal of community medicine & public health. vol 7. issue 4. 2024-02-19. PMID:38371611. |
the actions of 5-ht are mediated by different types of receptors and terminated via an uptake mechanism of a 5-ht transporter (sert) on the platelet and endothelial cell. |
2024-02-19 |
2024-02-21 |
Not clear |
| Dongxue Yang, Eric Gouau. Illumination of serotonin transporter mechanism and role of the allosteric site. Science advances. vol 7. issue 49. 2024-02-14. PMID:34851672. |
the serotonin transporter (sert) terminates serotonin signaling by using sodium and chloride gradients to drive reuptake of serotonin into presynaptic neurons and is the target of widely used medications to treat neuropsychiatric disorders. |
2024-02-14 |
2024-02-16 |
Not clear |
| Dongxue Yang, Eric Gouau. Illumination of serotonin transporter mechanism and role of the allosteric site. Science advances. vol 7. issue 49. 2024-02-14. PMID:34851672. |
together with elucidation of multiple apo state conformations, we provide previously unseen structural understanding of allosteric modulation, demonstrating how sert binds serotonin from synaptic volumes and promotes unbinding into the presynaptic neurons. |
2024-02-14 |
2024-02-16 |
Not clear |
| Jia-Ya Zheng, Xue-Xin Li, Xiao Liu, Chen-Chen Zhang, Ya-Xin Sun, Yu-Nu Ma, Hong-Li Wang, Yun-Ai Su, Tian-Mei Si, Ji-Tao L. Fluoxetine reverses early-life stress-induced depressive-like behaviors and region-specific alterations of monoamine transporters in female mice. Pharmacology, biochemistry, and behavior. 2024-02-09. PMID:38336220. |
at the molecular level, we largely replicated the es effects, such as reduced serotonin transporter (sert) expression in the amygdala and increased norepinephrine transporter (net) expression in the medial prefrontal cortex (mpfc) and hippocampus. |
2024-02-09 |
2024-02-12 |
mouse |
| Fusun Kilic, Imane Moutkine, Luc Maroteau. Association with serotonin transporter enables the phosphorylation of insulin receptor in placenta. Current topics in biochemical research. vol 20. 2024-02-08. PMID:38327526. |
interestingly the cellular distribution of the serotonin transporter (sert), which utilizes the insulin signaling for posttranslational modification, shows tissue-type-dependent variation: sert function is impaired in gdm-associated placenta, but not in platelets. |
2024-02-08 |
2024-02-10 |
Not clear |
| Leticia Alves da Silva, Erika Lazzarin, Ralph Gradisch, Amy Clarke, Thomas Stockne. Free energy profile of the substrate-induced occlusion of the human serotonin transporter. Journal of neurochemistry. 2024-02-05. PMID:38316690. |
the serotonin transporter (sert) is a member of the solute carrier 6 (slc6) family and is responsible for maintaining the appropriate level of serotonin in the brain. |
2024-02-05 |
2024-02-09 |
human |
| Leticia Alves da Silva, Erika Lazzarin, Ralph Gradisch, Amy Clarke, Thomas Stockne. Free energy profile of the substrate-induced occlusion of the human serotonin transporter. Journal of neurochemistry. 2024-02-05. PMID:38316690. |
here, we constructed markov state models (msms) from extensive unbiased molecular dynamics simulations to quantify the free energy profile of serotonin (5ht) triggered sert occlusion and explored the driving forces of the mechanism of occlusion. |
2024-02-05 |
2024-02-09 |
human |