All Relations between sert and serotonin
Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
Y Qian, H E Melikian, D B Rye, A I Levey, R D Blakel. Identification and characterization of antidepressant-sensitive serotonin transporter proteins using site-specific antibodies. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 15. issue 2. 1995-03-29. PMID:7869097. |
immunocytochemistry performed on rat brain sections with ct-2 antibody revealed sert expression associated with brainstem raphe nuclei in a pattern virtually identical to that obtained by labeling adjacent sections with 5ht antisera. |
1995-03-29 |
2023-08-12 |
human |
E L Barker, H L Kimmel, R D Blakel. Chimeric human and rat serotonin transporters reveal domains involved in recognition of transporter ligands. Molecular pharmacology. vol 46. issue 5. 1994-12-29. PMID:7969065. |
the serotonin transporter (sert) is a target for many clinically significant drugs, such as cocaine, amphetamine, and antidepressants. |
1994-12-29 |
2023-08-12 |
human |
E L Barker, H L Kimmel, R D Blakel. Chimeric human and rat serotonin transporters reveal domains involved in recognition of transporter ligands. Molecular pharmacology. vol 46. issue 5. 1994-12-29. PMID:7969065. |
serotonin uptake and radioligand binding assays revealed that rat and human serts show different sensitivities to some but not all transporter ligands; most tricyclic antidepressants were significantly more potent at the human sert, relative to rat sert, whereas d-amphetamine was a more potent inhibitor of rat sert. |
1994-12-29 |
2023-08-12 |
human |
L L Demchyshyn, Z B Pristupa, K S Sugamori, E L Barker, R D Blakely, W J Wolfgang, M A Forte, H B Nizni. Cloning, expression, and localization of a chloride-facilitated, cocaine-sensitive serotonin transporter from Drosophila melanogaster. Proceedings of the National Academy of Sciences of the United States of America. vol 91. issue 11. 1994-06-27. PMID:8197200. |
in marked contrast to the human sert (hsert), 5ht-mediated transport by dsert was not absolutely dependent on extracellular cl-, while the sodium-dependent uptake of 5ht was facilitated by increased extracellular cl- concentrations. |
1994-06-27 |
2023-08-12 |
human |