| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Adina Sophie Graffunder, Audrey Amber Julie Bresser, Valeria Fernandez Vallone, Matthias Megges, Harald Stachelscheid, Peter Kühnen, Robert Opit. Spatiotemporal expression of thyroid hormone transporter MCT8 and THRA mRNA in human cerebral organoids recapitulating first trimester cortex development. Scientific reports. vol 14. issue 1. 2024-04-23. PMID:38654093. |
thyroid hormones (th) play critical roles during nervous system development and patients carrying coding variants of mct8 (monocarboxylate transporter 8) or thra (thyroid hormone receptor alpha) present a spectrum of neurological phenotypes resulting from perturbed local th action during early brain development. |
2024-04-23 |
2024-04-26 |
human |
| Martina Capriati, Chunxiang Hao, Shereen Cynthia D'Cruz, Christine Monfort, Cecile Chevrier, Charline Warembourg, Fatima Smagulov. Genome-wide analysis of sex-specific differences in the mother-child PELAGIE cohort exposed to organophosphate metabolites. Scientific reports. vol 13. issue 1. 2023-05-17. PMID:37198424. |
we found an increase in h3k4me3 occupancy at the promoters of thyroid hormone receptor alpha (thra), 8-oxoguanine dna glycosylase (ogg1) and insulin-like growth factor (igf2) in de-exposed female placentas. |
2023-05-17 |
2023-08-14 |
mouse |
| Paola Aguiari, Yan-Yun Liu, Astgik Petrosyan, Sheue-Yann Cheng, Gregory A Brent, Laura Perin, Anna Milanes. Persistent COUP-TFII expression underlies the myopathy and impaired muscle regeneration observed in resistance to thyroid hormone-alpha. Scientific reports. vol 11. issue 1. 2021-11-16. PMID:33633251. |
thyroid hormone signaling plays an essential role in muscle development and function, in the maintenance of muscle mass, and in regeneration after injury, via activation of thyroid nuclear receptor alpha (thra). |
2021-11-16 |
2023-08-13 |
mouse |
| Ozlem Korkmaz, Samim Ozen, Taha Resid Ozdemir, Damla Goksen, Sukran Darca. A novel thyroid hormone receptor alpha gene mutation, clinic characteristics, and follow-up findings in a patient with thyroid hormone resistance. Hormones (Athens, Greece). vol 18. issue 2. 2020-01-21. PMID:30747412. |
thyroid hormone receptor alpha (thra) gene mutation is a thyroid hormone resistance syndrome characterized by near-normal thyroid function tests and tissue-specific hypothyroidism. |
2020-01-21 |
2023-08-13 |
Not clear |
| Yan-Yun Liu, Gregory A Bren. Thyroid hormone and the brain: Mechanisms of action in development and role in protection and promotion of recovery after brain injury. Pharmacology & therapeutics. vol 186. 2019-02-04. PMID:29378220. |
th acts predominantly through the nuclear receptors, th receptor alpha (thra) and beta (thrb). |
2019-02-04 |
2023-08-13 |
Not clear |
| Arturo Hernande. Thyroid Hormone Role and Economy in the Developing Testis. Vitamins and hormones. vol 106. 2018-10-05. PMID:29407445. |
these include the thyroid hormone receptor alpha (thra), the mct8 transporter, the th-activating deiodinase dio2, and the th-inactivating deiodinase dio3, all of which appear to modulate testicular th economy and testis outcomes. |
2018-10-05 |
2023-08-13 |
Not clear |
| Iván Lazcano, Aurea Orozc. Revisiting available knowledge on teleostean thyroid hormone receptors. General and comparative endocrinology. vol 265. 2018-09-10. PMID:29574147. |
in general terms, vertebrates express the functional thyroid hormone receptors alpha and beta, encoded by two distinct genes (thra and thrb, respectively). |
2018-09-10 |
2023-08-13 |
Not clear |
| Anja L M van Gucht, Carla Moran, Marcel E Meima, W Edward Visser, Krishna Chatterjee, Theo J Visser, Robin P Peeter. Resistance to Thyroid Hormone due to Heterozygous Mutations in Thyroid Hormone Receptor Alpha. Current topics in developmental biology. vol 125. 2018-03-29. PMID:28527577. |
scope of this review: this review describes the clinical and biochemical characteristics of patients with resistance to thyroid hormone alpha (rthα) due to heterozygous mutations in thra. |
2018-03-29 |
2023-08-13 |
Not clear |
| Federica Marelli, Silvia Carra, Giuditta Rurale, Franco Cotelli, Luca Persan. In vivo Functional Consequences of Human THRA Variants Expressed in the Zebrafish. Thyroid : official journal of the American Thyroid Association. vol 27. issue 2. 2018-02-26. PMID:27809680. |
heterozygous mutations in the thyroid hormone receptor alpha (thra) gene cause resistance to thyroid hormone alpha (rthα), a disease characterized by variable manifestations reminiscent of untreated congenital hypothyroidism but a raised triiodothyronine/thyroxine ratio and normal thyrotropin levels. |
2018-02-26 |
2023-08-13 |
human |
| J C Truter, J H van Wyk, P J Oberholster, A-M Botha, W J Luus-Powel. The expression of selected genes linked to metabolic homeostasis in obese pansteatitis-suffering Mozambique tilapia, Oreochromis mossambicus (Peters). Journal of fish diseases. vol 39. issue 1. 2016-12-13. PMID:25413848. |
the expression of thyroid hormone receptor alpha (thra) and type 2 deiodinase (dio2) was higher in lake loskop o. mossambicus than fish from another population, suggesting a degree of thyroid disruption. |
2016-12-13 |
2023-08-13 |
Not clear |
| Hidenobu Miyaso, Noriko Nakamura, Munekazu Naito, Shuichi Hirai, Yoshiharu Matsuno, Masahiro Itoh, Chisato Mor. Early postnatal exposure to a low dose of decabromodiphenyl ether affects expression of androgen and thyroid hormone receptor-alpha and its splicing variants in mouse Sertoli cells. PloS one. vol 9. issue 12. 2015-12-07. PMID:25479311. |
we hypothesized that postnatal exposure to decabde may alter levels of serum thyroid hormones (ths) and testosterone, or the level of th receptor alpha (thra) transcripts and its splicing variants and androgen receptor (ar) in sertoli cells, adversely affecting spermatogenesis. |
2015-12-07 |
2023-08-13 |
mouse |
| Pola Wojnarowicz, Olumuyiwa O Ogunlaja, Chen Xia, Wayne J Parker, Caren C Helbin. Impact of wastewater treatment configuration and seasonal conditions on thyroid hormone disruption and stress effects in Rana catesbeiana tailfin. Environmental science & technology. vol 47. issue 23. 2015-05-13. PMID:24180706. |
th-responsive (thyroid hormone receptors alpha (thra) and beta (thrb)) and stress-responsive (superoxide dismutase, catalase, and heat shock protein 30) mrna transcript levels were examined. |
2015-05-13 |
2023-08-12 |
Not clear |
| Elena Bochukova, Nadia Schoenmakers, Maura Agostini, Erik Schoenmakers, Odelia Rajanayagam, Julia M Keogh, Elana Henning, Jana Reinemund, Evelien Gevers, Margarita Sarri, Kate Downes, Amaka Offiah, Assunta Albanese, David Halsall, John W R Schwabe, Murray Bain, Keith Lindley, Francesco Muntoni, Faraneh Vargha-Khadem, Faraneh Vargha Khadem, Mehul Dattani, I Sadaf Farooqi, Mark Gurnell, Krishna Chatterje. A mutation in the thyroid hormone receptor alpha gene. The New England journal of medicine. vol 366. issue 3. 2012-01-27. PMID:22168587. |
using whole-exome sequencing, we identified a de novo heterozygous nonsense mutation in a gene encoding thyroid hormone receptor alpha (thra) and generating a mutant protein that inhibits wild-type receptor action in a dominant negative manner. |
2012-01-27 |
2023-08-12 |
human |
| Frédéric Flamant, Laure Quignodo. [Thyroid hormone and its receptors: have mouse genetics clarified the situation?]. Journal de la Societe de biologie. vol 202. issue 2. 2008-10-22. PMID:18547502. |
in vertebrates, the active form of thyroid hormone (t3) acts directly on transcription by changing the conformation of the tr nuclear receptors (tr alpha 1, tr beta 1 et tr beta 2) which are encoded by the thra and thrb genes. |
2008-10-22 |
2023-08-12 |
mouse |
| Santhi Sridharan, Liz Simon, Daryl D Meling, Daniel G Cyr, David E Gutstein, Glenn I Fishman, Florian Guillou, Paul S Cook. Proliferation of adult sertoli cells following conditional knockout of the Gap junctional protein GJA1 (connexin 43) in mice. Biology of reproduction. vol 76. issue 5. 2007-06-20. PMID:17229929. |
thyroid hormone receptor alpha (thra) is high in proliferating sertoli cells, then declines sharply in adulthood. |
2007-06-20 |
2023-08-12 |
mouse |
| J F Maddo. Linkage mapping of microsatellites associated with the glycosylation dependent cell adhesion molecule (GLYCAM1) and thyroid hormone receptor alpha chain (THRA) genes to ovine chromosomes 3 and 11. Animal genetics. vol 33. issue 3. 2002-09-16. PMID:12030938. |
linkage mapping of microsatellites associated with the glycosylation dependent cell adhesion molecule (glycam1) and thyroid hormone receptor alpha chain (thra) genes to ovine chromosomes 3 and 11. |
2002-09-16 |
2023-08-12 |
Not clear |
| L Ng, A Rüsch, L L Amma, K Nordström, L C Erway, B Vennström, D Forres. Suppression of the deafness and thyroid dysfunction in Thrb-null mice by an independent mutation in the Thra thyroid hormone receptor alpha gene. Human molecular genetics. vol 10. issue 23. 2002-01-31. PMID:11726557. |
thra(tm2/tm2) mice have normal auditory thresholds indicating that tr alpha 2 is dispensable for hearing, and have only marginally reduced thyroid activity. |
2002-01-31 |
2023-08-12 |
mouse |
| L Ng, A Rüsch, L L Amma, K Nordström, L C Erway, B Vennström, D Forres. Suppression of the deafness and thyroid dysfunction in Thrb-null mice by an independent mutation in the Thra thyroid hormone receptor alpha gene. Human molecular genetics. vol 10. issue 23. 2002-01-31. PMID:11726557. |
thra encodes a tr alpha 1 receptor which is non-essential for hearing and a tr alpha 2 splice variant of unknown function that neither binds thyroid hormone nor transactivates. |
2002-01-31 |
2023-08-12 |
mouse |
| L Ng, A Rüsch, L L Amma, K Nordström, L C Erway, B Vennström, D Forres. Suppression of the deafness and thyroid dysfunction in Thrb-null mice by an independent mutation in the Thra thyroid hormone receptor alpha gene. Human molecular genetics. vol 10. issue 23. 2002-01-31. PMID:11726557. |
suppression of the deafness and thyroid dysfunction in thrb-null mice by an independent mutation in the thra thyroid hormone receptor alpha gene. |
2002-01-31 |
2023-08-12 |
mouse |
| L Ng, A Rüsch, L L Amma, K Nordström, L C Erway, B Vennström, D Forres. Suppression of the deafness and thyroid dysfunction in Thrb-null mice by an independent mutation in the Thra thyroid hormone receptor alpha gene. Human molecular genetics. vol 10. issue 23. 2002-01-31. PMID:11726557. |
here, we have determined that a targeted mutation (thra(tm2)) in the related thra gene, encoding thyroid hormone receptor alpha suppresses these phenotypes in mice. |
2002-01-31 |
2023-08-12 |
mouse |