| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A Rabinovitch, W Sumoski, R V Rajotte, G L Warnoc. Cytotoxic effects of cytokines on human pancreatic islet cells in monolayer culture. The Journal of clinical endocrinology and metabolism. vol 71. issue 1. 1990-08-23. PMID:2115042. |
interleukin-1 (il-1), tumor necrosis factor (tnf), and interferon-gamma (ifn gamma) inhibit insulin release and may be cytotoxic to isolated rodent pancreatic islets. |
1990-08-23 |
2023-08-11 |
human |
| A Rabinovitch, W Sumoski, R V Rajotte, G L Warnoc. Cytotoxic effects of cytokines on human pancreatic islet cells in monolayer culture. The Journal of clinical endocrinology and metabolism. vol 71. issue 1. 1990-08-23. PMID:2115042. |
assay of insulin and glucagon in the islet monolayers revealed that il-1, tnf, and ifn gamma inhibited both b- and a-cell secretory functions; however, only il-1 and tnf produced permanent decreases in insulin and glucagon contents in the islet cultures. |
1990-08-23 |
2023-08-11 |
human |
| L E Bermudez, M Wu, L S Youn. Effect of stress-related hormones on macrophage receptors and response to tumor necrosis factor. Lymphokine research. vol 9. issue 2. 1990-06-19. PMID:1971032. |
to examine whether stress-related hormones have any effect on macrophage activation by tnf, human monocyte-derived macrophages were exposed to somatostatin (s), acth, angiotensin (an), insulin (i), epinephrine (e), and glucagon (g) at physiologic concentrations. |
1990-06-19 |
2023-08-11 |
human |
| S K Fried, R Zechne. Cachectin/tumor necrosis factor decreases human adipose tissue lipoprotein lipase mRNA levels, synthesis, and activity. Journal of lipid research. vol 30. issue 12. 1990-03-27. PMID:2695592. |
tnf effects were studied in human adipose tissue fragments maintained in organ culture in the presence of insulin and dexamethasone to induce high lpl activity. |
1990-03-27 |
2023-08-11 |
human |
| S K Fried, R Zechne. Cachectin/tumor necrosis factor decreases human adipose tissue lipoprotein lipase mRNA levels, synthesis, and activity. Journal of lipid research. vol 30. issue 12. 1990-03-27. PMID:2695592. |
comparable decreases in lpl activity were observed when tnf was added to adipose tissue cultured solely in the presence of insulin. |
1990-03-27 |
2023-08-11 |
human |
| D A Evans, D O Jacobs, D W Wilmor. Tumor necrosis factor enhances glucose uptake by peripheral tissues. The American journal of physiology. vol 257. issue 5 Pt 2. 1989-12-28. PMID:2589544. |
there is an increased uptake of glucose across the hindlimb; this response appears to be independent of insulin concentrations and may be related to direct effects of tnf. |
1989-12-28 |
2023-08-11 |
Not clear |
| H Vlassara, M Brownlee, A Ceram. Macrophage receptor-mediated processing and regulation of advanced glycosylation endproduct (AGE)-modified proteins: role in diabetes and aging. Progress in clinical and biological research. vol 304. 1989-10-19. PMID:2550952. |
insulin appears to be a potent suppressor of this macrophage age removal activity, while tnf acts as a stimulant. |
1989-10-19 |
2023-08-11 |
mouse |
| K R Feingold, M Soued, I Staprans, L A Gavin, M E Donahue, B J Huang, A H Moser, R Gulli, C Grunfel. Effect of tumor necrosis factor (TNF) on lipid metabolism in the diabetic rat. Evidence that inhibition of adipose tissue lipoprotein lipase activity is not required for TNF-induced hyperlipidemia. The Journal of clinical investigation. vol 83. issue 4. 1989-05-15. PMID:2703526. |
in addition, tnf administration to diabetic animals leads to an elevation in serum glucose levels (73% at 17 h) without a change in serum insulin levels. |
1989-05-15 |
2023-08-11 |
rat |
| K R Feingold, M Soued, I Staprans, L A Gavin, M E Donahue, B J Huang, A H Moser, R Gulli, C Grunfel. Effect of tumor necrosis factor (TNF) on lipid metabolism in the diabetic rat. Evidence that inhibition of adipose tissue lipoprotein lipase activity is not required for TNF-induced hyperlipidemia. The Journal of clinical investigation. vol 83. issue 4. 1989-05-15. PMID:2703526. |
thus, tnf stimulation of hepatic lipogenesis is independent of changes in insulin. |
1989-05-15 |
2023-08-11 |
rat |
| K C Klasin. Nutritional aspects of leukocytic cytokines. The Journal of nutrition. vol 118. issue 12. 1989-02-23. PMID:3062144. |
il-1, tnf alpha and il-6 also affect changes in metabolism by changing levels of circulating insulin, glucagon and corticosterone. |
1989-02-23 |
2023-08-11 |
Not clear |
| A W Hamburger, H Parnes, G B Gordon, L M Shantz, K A O'Donnell, J Aisne. Megestrol acetate-induced differentiation of 3T3-L1 adipocytes in vitro. Seminars in oncology. vol 15. issue 2 Suppl 1. 1988-06-16. PMID:2453082. |
tumor necrosis factor (tnf) alpha blocked the adipocyte differentiation induced by the combination of insulin, dexamethasone, and methyl-isobutylxanthine. |
1988-06-16 |
2023-08-11 |
mouse |
| M Kirstein, C Baglion. Tumor necrosis factor stimulates proliferation of human osteosarcoma cells and accumulation of c-myc messenger RNA. Journal of cellular physiology. vol 134. issue 3. 1988-05-03. PMID:2450880. |
furthermore, tnf did not show synergism with insulin or epidermal growth factor in stimulating growth of these cells. |
1988-05-03 |
2023-08-11 |
human |
| S Sandler, A Andersson, C Hellerströ. Inhibitory effects of interleukin 1 on insulin secretion, insulin biosynthesis, and oxidative metabolism of isolated rat pancreatic islets. Endocrinology. vol 121. issue 4. 1987-11-04. PMID:3308437. |
in the present study we have investigated the effects of il-1 and two other cytokines, namely tumor necrosis factor (tnf) and interferon-gamma (ifn-gamma) on the pancreatic b cell paying particular attention to insulin production and glucose metabolism. |
1987-11-04 |
2023-08-11 |
human |
| J Vilcek, V J Palombella, D Henriksen-DeStefano, C Swenson, R Feinman, M Hirai, M Tsujimot. Fibroblast growth enhancing activity of tumor necrosis factor and its relationship to other polypeptide growth factors. The Journal of experimental medicine. vol 163. issue 3. 1986-04-02. PMID:3512757. |
stimulation of confluent cultures by tnf in serum-free medium was enhanced by insulin, suggesting that insulin or insulin-like growth factor(s) in the serum can act synergistically with tnf in producing growth stimulation. |
1986-04-02 |
2023-08-11 |
human |
| J Vilcek, V J Palombella, D Henriksen-DeStefano, C Swenson, R Feinman, M Hirai, M Tsujimot. Fibroblast growth enhancing activity of tumor necrosis factor and its relationship to other polypeptide growth factors. The Journal of experimental medicine. vol 163. issue 3. 1986-04-02. PMID:3512757. |
while the growth-stimulatory effects of tnf and insulin were synergistic, the actions of tnf and epidermal growth factor (egf) were less than additive, suggesting that tnf and egf may activate identical or similar pathways. |
1986-04-02 |
2023-08-11 |
human |
| N Satomi, A Sakurai, K Haranak. Relationship of hypoglycemia to tumor necrosis factor production and antitumor activity: role of glucose, insulin, and macrophages. Journal of the National Cancer Institute. vol 74. issue 6. 1985-07-24. PMID:3889459. |
exogenous insulin injection inhibited tnf production in a dose-related manner. |
1985-07-24 |
2023-08-11 |
mouse |
| N Satomi, A Sakurai, K Haranak. Relationship of hypoglycemia to tumor necrosis factor production and antitumor activity: role of glucose, insulin, and macrophages. Journal of the National Cancer Institute. vol 74. issue 6. 1985-07-24. PMID:3889459. |
insulin addition to the culture medium caused inhibition of tnf production from pec, which indicated that insulin may block tnf production from macrophages. |
1985-07-24 |
2023-08-11 |
mouse |
| N Satomi, A Sakurai, K Haranak. Relationship of hypoglycemia to tumor necrosis factor production and antitumor activity: role of glucose, insulin, and macrophages. Journal of the National Cancer Institute. vol 74. issue 6. 1985-07-24. PMID:3889459. |
administration of highly purified tnf (without concomitant lps) induced extensive tumor necrosis but did not induce hypoglycemia; lps induced moderate necrosis with accompanying hypoglycemia; insulin induced hypoglycemia but did not induce tumor necrosis. |
1985-07-24 |
2023-08-11 |
mouse |
| K Orit. [The possible modes of action of TNF (tumor necrosis factor)]. Gan to kagaku ryoho. Cancer & chemotherapy. vol 11. issue 7. 1984-08-20. PMID:6742864. |
first, the tnf molecule binds to the corresponding receptor on the cell surface, and then is transferred to the lysosome in a similar manner to the internalization of growth hormone and insulin. |
1984-08-20 |
2023-08-12 |
mouse |